sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1xms | ANP | Protein RecA |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1xms | ANP | Protein RecA | / | 1.000 | |
| 1xmv | ADP | Protein RecA | / | 0.670 | |
| 3uko | NAD | Alcohol dehydrogenase class-3 | / | 0.513 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.499 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.495 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.492 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.491 | |
| 2zre | AGS | Protein RecA | / | 0.491 | |
| 5dp2 | NAP | CurF | / | 0.491 | |
| 2zrj | AGS | Protein RecA | / | 0.486 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.485 | |
| 3ih0 | ANP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.484 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.484 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.483 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.482 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.480 | |
| 5c3a | URM | Histo-blood group ABO system transferase | / | 0.480 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.479 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.479 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 3rfa | SAM | Dual-specificity RNA methyltransferase RlmN | / | 0.479 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.479 | |
| 2ejz | SAH | Diphthine synthase | / | 0.478 | |
| 3blo | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.478 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.477 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.476 | |
| 4yao | 2AM | NADPH--cytochrome P450 reductase | / | 0.476 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.475 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.474 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.474 | |
| 4azm | T4B | Fatty acid-binding protein, epidermal | / | 0.474 | |
| 1xp8 | AGS | Protein RecA | / | 0.473 | |
| 1zdw | FLV | Prenyltransferase | / | 0.473 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.473 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.472 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.472 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.471 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.471 | |
| 2zrf | DTP | Protein RecA | / | 0.471 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.471 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.470 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.470 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.470 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.470 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.470 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.470 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.469 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.469 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.468 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.468 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.467 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.467 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.467 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.467 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.467 | |
| 5f54 | TMP | Single-stranded-DNA-specific exonuclease | / | 0.467 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.466 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.466 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.466 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 4in4 | 4ID | Kelch-like ECH-associated protein 1 | / | 0.466 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.466 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.465 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.465 | |
| 2q3o | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.465 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.465 | |
| 4d0l | GSP | Ras-related protein Rab-11A | / | 0.465 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.465 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.464 | |
| 1rq1 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.464 | |
| 2pj4 | 414 | Carboxypeptidase B | / | 0.464 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.464 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.464 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.464 | |
| 4hdg | GTP | Genome polyprotein | 2.7.7.48 | 0.464 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.464 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.463 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.463 | |
| 2eix | FAD | NADH-cytochrome b5 reductase | / | 0.463 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.463 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.463 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.463 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.462 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 2po3 | T4K | 4-dehydrase | / | 0.462 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.462 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 3zgf | IUG | Histo-blood group ABO system transferase | / | 0.462 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.462 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.462 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.461 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.461 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.461 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.461 | |
| 4k39 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.461 | |
| 4nwi | CTN | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.461 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.460 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.460 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.460 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.460 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.460 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.460 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.460 | |
| 3arv | SAU | Chitinase A | / | 0.460 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.460 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.460 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.460 | |
| 1uhh | CZP | Aequorin-2 | / | 0.459 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.459 | |
| 2o98 | FSC | 14-3-3-like protein C | / | 0.459 | |
| 3b04 | OOP | Isopentenyl-diphosphate delta-isomerase | / | 0.459 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.459 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.459 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.459 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.459 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.458 | |
| 1h6b | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.458 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.458 | |
| 2bxf | DZP | Serum albumin | / | 0.458 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.458 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.458 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.458 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.458 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.458 | |
| 2zwa | SAH | tRNA wybutosine-synthesizing protein 4 | 2.1.1.290 | 0.458 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.458 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.457 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.457 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.457 | |
| 2zro | ADP | Protein RecA | / | 0.457 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.457 | |
| 3qdl | FMN | Oxygen-insensitive NADPH nitroreductase | / | 0.457 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.457 | |
| 4iil | RBF | Membrane lipoprotein TpN38(b) | / | 0.457 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.456 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.456 | |
| 2qw0 | 34Z | 4-chlorobenzoyl CoA ligase | / | 0.456 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.456 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.455 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.455 | |
| 4fh5 | UTP | Terminal uridylyltransferase cid1 | / | 0.455 | |
| 1b9i | PXG | 3-amino-5-hydroxybenzoate synthase | 4.2.1.144 | 0.454 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 1m9k | 7NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.454 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.454 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.454 | |
| 2zts | ADP | Uncharacterized protein | / | 0.454 | |
| 3gb4 | D3M | DdmC | / | 0.454 | |
| 4e2x | SAH | Methyltransferase | / | 0.454 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.454 | |
| 4pl0 | ANP | Microcin-J25 export ATP-binding/permease protein McjD | / | 0.454 | |
| 1rfq | LAR | Actin, alpha skeletal muscle | / | 0.453 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.453 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.453 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.453 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 4c4o | NAD | SADH | / | 0.453 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.453 | |
| 4jji | NAD | Alcohol dehydrogenase class-3 | / | 0.453 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.453 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.453 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.453 | |
| 5ero | 210 | Fusicoccadiene synthase | 2.5.1.29 | 0.453 | |
| 1j8u | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.452 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.452 | |
| 2bxq | IMN | Serum albumin | / | 0.452 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.452 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.452 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3ndj | JHZ | Methyltransferase | / | 0.452 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.452 | |
| 4xug | F9F | Tryptophan synthase alpha chain | / | 0.452 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.451 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.451 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.451 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.451 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.451 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.451 | |
| 2glr | GTX | Glutathione S-transferase P 1 | 2.5.1.18 | 0.451 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.451 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.451 | |
| 2jla | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.451 | |
| 2ok8 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.451 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.451 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.451 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.451 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 3hgg | CHD | CmeR | / | 0.451 | |
| 3klb | FMN | Uncharacterized protein | / | 0.451 | |
| 3v2u | ATP | Protein GAL3 | / | 0.451 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.451 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.450 | |
| 1krh | FAD | Benzoate 1,2-dioxygenase electron transfer component | 1.18.1.3 | 0.450 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.450 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.450 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.450 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.450 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.450 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.450 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3wth | IM4 | Acetylcholine-binding protein | / | 0.450 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.450 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.450 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.450 | |
| 4rr7 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.450 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.449 | |
| 2gqp | PA7 | Endoplasmin | / | 0.449 | |
| 2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.449 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.449 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.449 | |
| 2xvq | 9DS | Serum albumin | / | 0.449 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.449 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.449 | |
| 3pah | XDE | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.449 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4bis | 8HQ | Lysine-specific demethylase 4A | 1.14.11 | 0.449 | |
| 4utl | FNR | Xenobiotic reductase | / | 0.449 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.449 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.449 | |
| 1ppj | ANY | Cytochrome b | / | 0.448 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.448 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.448 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.448 | |
| 2ieg | FRY | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.448 | |
| 2r8v | ACO | Amino-acid acetyltransferase | / | 0.448 | |
| 2vnj | FAD | NADPH:ferredoxin reductase | / | 0.448 | |
| 2xw1 | 9NV | Serum albumin | / | 0.448 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.448 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.448 | |
| 3f6s | FMN | Flavodoxin | / | 0.448 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.448 | |
| 4e2y | JHZ | Methyltransferase | / | 0.448 | |
| 4l7g | 1W0 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.448 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.448 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.448 | |
| 1b4p | GPS | Glutathione S-transferase Mu 2 | / | 0.447 | |
| 1jut | LYD | Thymidylate synthase | / | 0.447 | |
| 1odj | GMP | Purine nucleoside phosphorylase | / | 0.447 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.447 | |
| 1wl4 | COA | Acetyl-CoA acetyltransferase, cytosolic | 2.3.1.9 | 0.447 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.447 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.447 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.447 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.447 | |
| 2v57 | PRL | TetR family transcriptional regulator | / | 0.447 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.447 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.447 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.447 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.447 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.447 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 3fzf | ATP | Heat shock cognate 71 kDa protein | / | 0.447 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.447 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.447 | |
| 4a6e | ASE | Acetylserotonin O-methyltransferase | 2.1.1.4 | 0.447 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.447 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.447 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.447 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.447 | |
| 4k38 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.447 | |
| 4z87 | GDP | Inosine-5'-monophosphate dehydrogenase | / | 0.447 | |
| 5doz | NDP | JamJ | / | 0.447 | |
| 5im3 | DTP | Ribonucleoside-diphosphate reductase | / | 0.447 | |
| 1c7o | PPG | Hemolysin | / | 0.446 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.446 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.446 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 2iei | FRX | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.446 | |
| 2ji9 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.446 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.446 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.446 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.446 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.446 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3vnh | FUU | Kelch-like ECH-associated protein 1 | / | 0.446 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.446 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.446 | |
| 5ej4 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.446 | |
| 1aqx | GTD | Glutathione S-transferase P | 2.5.1.18 | 0.445 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.445 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.445 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.445 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.445 | |
| 1m8k | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.445 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.445 | |
| 1r2j | FAD | FkbI | / | 0.445 | |
| 1s64 | 778 | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.445 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.445 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.445 | |
| 2nr4 | FMN | Conserved protein | / | 0.445 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.445 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.445 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.445 | |
| 3hgs | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.445 | |
| 3ho2 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.445 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.445 | |
| 3n87 | N87 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.445 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.445 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.445 | |
| 4b6r | 3DQ | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.445 | |
| 4b6s | 2HN | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.445 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.445 | |
| 4c04 | SFG | Protein arginine N-methyltransferase 6 | / | 0.445 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4fs4 | H24 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.445 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.445 | |
| 1e1q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.444 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.444 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.444 | |
| 1sdw | IYT | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.444 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.444 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.444 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.444 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.444 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.444 | |
| 2j83 | BAT | Ulilysin | 3.4.24 | 0.444 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2y66 | N04 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.444 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.444 | |
| 3muo | ZPR | Prolyl endopeptidase | / | 0.444 | |
| 3u5s | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.444 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4h1q | 0XX | Matrix metalloproteinase-9 | 3.4.24.35 | 0.444 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.444 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.444 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.444 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.443 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.443 | |
| 1sui | FRE | Caffeoyl-CoA O-methyltransferase | 2.1.1.104 | 0.443 | |
| 1tj2 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.443 | |
| 1wnz | 2VA | Isoleucine--tRNA ligase | 6.1.1.5 | 0.443 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.443 | |
| 2xvv | 9DN | Serum albumin | / | 0.443 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.443 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.443 | |
| 3hu1 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.443 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.443 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3s2o | EV6 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.443 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4brg | GNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.443 | |
| 4eix | NIM | Phospholipase A2 VRV-PL-VIIIa | / | 0.443 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.443 | |
| 4uth | FMN | Xenobiotic reductase | / | 0.443 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.443 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.443 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.442 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.442 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.442 | |
| 1gsf | EAA | Glutathione S-transferase A1 | 2.5.1.18 | 0.442 | |
| 1jqi | CAA | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.442 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.442 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1r6t | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.442 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.442 | |
| 2qs1 | UB1 | Glutamate receptor ionotropic, kainate 1 | / | 0.442 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.442 | |
| 2zse | ACP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.442 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.442 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.442 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4hmv | WUB | Phenazine biosynthesis protein PhzG | 1.4 | 0.442 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.442 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.442 | |
| 4yer | ADP | Antibiotic ABC transporter, ATP-binding protein, putative | / | 0.442 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1g9r | UPF | LgtC | / | 0.441 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.441 | |
| 1thz | 326 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.441 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.441 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.441 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.441 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
| 2rgo | FAD | Alpha-Glycerophosphate Oxidase | / | 0.441 | |
| 2xb9 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.441 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.441 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.441 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.441 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.441 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.441 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4ayv | 9MQ | Prothrombin | 3.4.21.5 | 0.441 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.441 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.441 | |
| 4eh8 | IRG | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.441 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.441 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.441 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1dfo | PLG | Serine hydroxymethyltransferase | 2.1.2.1 | 0.440 | |
| 1muu | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.440 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.440 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.440 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.440 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.440 | |
| 2cv1 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.440 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 2o12 | FMN | Chorismate synthase | / | 0.440 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.440 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.440 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.440 | |
| 3ha3 | SAH | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.440 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3zkn | WZV | Beta-secretase 2 | 3.4.23.45 | 0.440 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.440 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.440 |