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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qa2 FAD Polyketide oxygenase CabE

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
2qa2 FADPolyketide oxygenase CabE / 1.342
2qa1 FADPgaE / 1.103
4icy FADPgaE / 0.996
4k2x FADPolyketide oxygenase/hydroxylase / 0.937
4hb9 FADUncharacterized protein / 0.909
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.901
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.848
4k5r FADOxygenase / 0.843
4j2w FADKynurenine 3-monooxygenase / 0.842
3fmw FADOxygenase / 0.831
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.830
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.826
5dbj FADFADH2-dependent halogenase PltA / 0.818
4j33 FADKynurenine 3-monooxygenase / 0.814
4x4j FADPutative oxygenase / 0.807
1zk7 FADMercuric reductase 1.16.1.1 0.801
1zx9 FADMercuric reductase 1.16.1.1 0.800
2xdo FADTetX family tetracycline inactivation enzyme / 0.800
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.795
3bg7 FADPyranose 2-oxidase / 0.794
4j31 FADKynurenine 3-monooxygenase / 0.793
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.792
4j36 FADKynurenine 3-monooxygenase / 0.792
1k0l FADp-hydroxybenzoate hydroxylase / 0.788
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.787
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.786
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.785
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.781
4bk3 FADProbable salicylate monooxygenase / 0.781
3icr FADCoenzyme A disulfide reductase / 0.780
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.779
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.779
3cgc FADCoenzyme A disulfide reductase / 0.779
4j34 FADKynurenine 3-monooxygenase / 0.779
4bk2 FADProbable salicylate monooxygenase / 0.778
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.776
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.775
3p9u FADTetX family tetracycline inactivation enzyme / 0.775
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.773
2eq8 FADDihydrolipoyl dehydrogenase / 0.772
4a99 FADTetX family tetracycline inactivation enzyme / 0.772
2eq6 FADDihydrolipoyl dehydrogenase / 0.771
3atq FDAConserved Archaeal protein / 0.771
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.770
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.770
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.769
4a6n FADTetX family tetracycline inactivation enzyme / 0.768
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.766
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.764
3bi2 FADPolyamine oxidase FMS1 / 0.763
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.763
4guv FADTetX family tetracycline inactivation enzyme / 0.762
2rab FADGlutathione amide reductase / 0.761
3cgd FADCoenzyme A disulfide reductase / 0.761
3cge FADCoenzyme A disulfide reductase / 0.761
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.761
2eq7 FADDihydrolipoyl dehydrogenase / 0.759
1d7l RFLp-hydroxybenzoate hydroxylase / 0.758
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.757
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.757
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.756
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.756
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.755
1nhr FADNADH peroxidase 1.11.1.1 0.754
1get FADGlutathione reductase 1.8.1.7 0.753
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.751
1pdh FASp-hydroxybenzoate hydroxylase / 0.751
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.751
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.750
3lad FADDihydrolipoyl dehydrogenase / 0.750
4bjz FADProbable salicylate monooxygenase / 0.750
4em3 FADCoenzyme A disulfide reductase / 0.750
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.748
3atr FDAConserved Archaeal protein / 0.748
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.746
3ict FADCoenzyme A disulfide reductase / 0.746
4opg FDAConserved Archaeal protein / 0.746
1nhp FADNADH peroxidase 1.11.1.1 0.744
3ish FADThioredoxin reductase 1.8.1.9 0.744
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.743
3cgb FADCoenzyme A disulfide reductase / 0.742
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.742
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.741
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.741
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.741
1k0j FADp-hydroxybenzoate hydroxylase / 0.740
1ryi FADGlycine oxidase 1.4.3.19 0.740
1nhq FADNADH peroxidase 1.11.1.1 0.739
4opi FDAConserved Archaeal protein / 0.739
2r9z FADGlutathione amide reductase / 0.737
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.737
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.736
1f8w FADNADH peroxidase 1.11.1.1 0.735
4em4 FADCoenzyme A disulfide reductase / 0.735
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.734
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.733
1yqz FADCoenzyme A disulfide reductase / 0.731
4opd FDAConserved Archaeal protein / 0.731
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.730
4eqw FADCoenzyme A disulfide reductase / 0.730
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.729
3ihg FADAklavinone 12-hydroxylase RdmE / 0.729
2eq9 FADDihydrolipoyl dehydrogenase / 0.728
2npx FADNADH peroxidase 1.11.1.1 0.728
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.727
2yqu FADDihydrolipoyl dehydrogenase / 0.726
5buk FADFADH2-dependent halogenase / 0.726
1nhs FADNADH peroxidase 1.11.1.1 0.725
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.725
4b1b FADThioredoxin reductase 1.8.1.9 0.725
2hqm FADGlutathione reductase 1.8.1.7 0.724
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.723
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.723
3lsh FADPyranose 2-oxidase / 0.723
4gcm FADThioredoxin reductase 1.8.1.9 0.723
4u8n FDAUDP-galactopyranose mutase / 0.723
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.722
3k30 ADPHistamine dehydrogenase / 0.722
4eqx FADCoenzyme A disulfide reductase / 0.722
4u8j FDAUDP-galactopyranose mutase / 0.722
1ger FADGlutathione reductase 1.8.1.7 0.721
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.721
2zbw FADFerredoxin--NADP reductase / 0.720
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.718
4cnk FADL-amino acid oxidase / 0.717
4opu FDAConserved Archaeal protein / 0.717
1ges FADGlutathione reductase 1.8.1.7 0.715
2q7v FADThioredoxin reductase / 0.715
2yg4 FADPutrescine oxidase / 0.713
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.713
4jq9 FADDihydrolipoyl dehydrogenase / 0.712
4ntd FADThioredoxin reductase / 0.712
4opc FDAConserved Archaeal protein / 0.711
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.711
3ics FADCoenzyme A disulfide reductase / 0.710
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.710
4nte FADDepH / 0.710
2gqw FADFerredoxin reductase / 0.709
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.709
3cty FADProbable thioredoxin reductase / 0.707
1trb FADThioredoxin reductase 1.8.1.9 0.706
3kkj FADRenalase / 0.706
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.706
3ept FDAPutative FAD-monooxygenase / 0.705
3fbs FADOxidoreductase / 0.705
4dna FADProbable glutathione reductase / 0.705
4j57 FADThioredoxin reductase 2 1.8.1.9 0.705
4opt FDAConserved Archaeal protein / 0.704
3cnd FADPolyamine oxidase FMS1 / 0.703
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.702
4u8o FDAUDP-galactopyranose mutase / 0.702
3rp8 FADFAD-dependent urate hydroxylase / 0.701
1fea FADTrypanothione reductase 1.8.1.12 0.700
4tm0 FADKtzI / 0.700
4dsh FDAUncharacterized protein / 0.699
1npx FADNADH peroxidase 1.11.1.1 0.698
1tdf FADThioredoxin reductase 1.8.1.9 0.698
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.697
2eq7 NADDihydrolipoyl dehydrogenase / 0.697
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.697
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.696
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.695
1tdk FADL-amino-acid oxidase 1.4.3.2 0.695
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.695
4a5l FADThioredoxin reductase / 0.695
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.695
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.694
1qo8 FADFumarate reductase flavoprotein subunit / 0.694
2gr0 FADFerredoxin reductase / 0.694
4tlz FADKtzI / 0.694
5ccx SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.694
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.694
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.693
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.692
2wba FADTrypanothione reductase 1.8.1.12 0.692
3uth FDAUDP-galactopyranose mutase / 0.692
3q9t FAYUncharacterized protein / 0.691
1tdo FADL-amino-acid oxidase 1.4.3.2 0.690
2x8h FADThioredoxin glutathione reductase / 0.690
4wx1 FDAUDP-galactopyranose mutase / 0.690
5ccb SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.690
2r0c FADPutative FAD-monooxygenase / 0.689
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.689
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.689
1reo FADL-amino-acid oxidase 1.4.3.2 0.688
3s5w FADL-ornithine N(5)-monooxygenase / 0.688
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.687
2wow FADTrypanothione reductase / 0.687
3vqr FADPutative oxidoreductase / 0.686
4ccq FADThioredoxin reductase / 0.686
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.686
2igo FADPyranose 2-oxidase / 0.685
2x8g FADThioredoxin glutathione reductase / 0.685
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.685
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.684
4u8l FDAUDP-galactopyranose mutase / 0.684
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.683
4c3x FAD3-ketosteroid dehydrogenase / 0.683
1fec FADTrypanothione reductase 1.8.1.12 0.682
3b6d FAECholesterol oxidase 1.1.3.6 0.682
4gut FADLysine-specific histone demethylase 1B 1 0.682
4ntc FADThioredoxin reductase gliT / 0.682
2cdu ADPNADH oxidase / 0.681
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.681
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.680
5cku FADL-ornithine N(5)-monooxygenase / 0.680
1tdn FADL-amino-acid oxidase 1.4.3.2 0.679
1d7y FADFerredoxin reductase / 0.678
1gxf FADTrypanothione reductase 1.8.1.12 0.678
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.678
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.678
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.678
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.678
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.677
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.677
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.677
2w0h FADTrypanothione reductase / 0.677
2xyo FADTetX family tetracycline inactivation enzyme / 0.677
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 0.677
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.677
3utg FDAUDP-galactopyranose mutase / 0.677
4guu FA9Lysine-specific histone demethylase 1B 1 0.677
1joa FADNADH peroxidase 1.11.1.1 0.676
2xve FADPutative flavin-containing monooxygenase / 0.676
3r9u FADThioredoxin reductase / 0.676
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.676
4oa5 SAHO-methyltransferase family protein / 0.676
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.676
3pl8 FADPyranose 2-oxidase / 0.674
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.673
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.673
2tpr FADTrypanothione reductase 1.8.1.12 0.673
3f8p NADNADH oxidase/thioredoxin reductase / 0.673
3if9 FADGlycine oxidase 1.4.3.19 0.673
3oe4 610Catechol O-methyltransferase 2.1.1.6 0.673
3t37 FADPyridoxine 4-oxidase / 0.673
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.672
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.672
4ynt FDAGlucose oxidase, putative / 0.672
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.671
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.671
4x9n FADUncharacterized protein MG039 homolog / 0.671
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.670
3mht SAHModification methylase HhaI 2.1.1.37 0.670
3qvr FADGlucose oxidase 1.1.3.4 0.670
4azw SAMO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.670
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.670
4opl FDAConserved Archaeal protein / 0.670
1rsg FADPolyamine oxidase FMS1 / 0.669
3k4c FADPyranose 2-oxidase / 0.669
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.669
1f8r FADL-amino-acid oxidase 1.4.3.2 0.668
1tyt FADTrypanothione reductase 1.8.1.12 0.668
3ad9 FADSubunit beta of sarcosine oxidase / 0.668
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.668
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.668
4yac NAIC alpha-dehydrogenase / 0.668
1mxt FAECholesterol oxidase 1.1.3.6 0.667
2v6o FADThioredoxin glutathione reductase / 0.667
4rek FADCholesterol oxidase 1.1.3.6 0.667
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.666
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.666
2x3n FADProbable FAD-dependent monooxygenase / 0.666
3cox FADCholesterol oxidase 1.1.3.6 0.666
4u8i FDAUDP-galactopyranose mutase / 0.666
1feb FADTrypanothione reductase 1.8.1.12 0.665
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.665
4c3y FAD3-ketosteroid dehydrogenase / 0.665
4tm3 FADKtzI / 0.665
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.664
1n4v FADCholesterol oxidase 1.1.3.6 0.664
2hms NAIKtr system potassium uptake protein A / 0.664
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.664
4j56 FADThioredoxin reductase 2 1.8.1.9 0.664
4xxg FADCholesterol oxidase 1.1.3.6 0.664
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.663
2okc SAMProbable type I restriction enzyme BthVORF4518P M protein 2.1.1.72 0.663
3c4a FADProtodeoxyviolaceinate monooxygenase 1 0.663
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.663
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.663
4pyn SAHCatechol O-methyltransferase 2.1.1.6 0.663
2o06 MTASpermidine synthase 2.5.1.16 0.662
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.662
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.661
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.661
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.661
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.660
4eqr FADCoenzyme A disulfide reductase / 0.660
4la1 FADThioredoxin glutathione reductase / 0.660
1phh FADp-hydroxybenzoate hydroxylase / 0.659
2wp5 FADTrypanothione reductase / 0.659
1i9g SAMtRNA (adenine(58)-N(1))-methyltransferase TrmI / 0.657
3f8r NAPNADH oxidase/thioredoxin reductase / 0.657
3fg2 FADPutative rubredoxin reductase / 0.657
4emw FADCoenzyme A disulfide reductase / 0.657
1f3p FADFerredoxin reductase / 0.656
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.656
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.656
1cl0 FADThioredoxin reductase 1.8.1.9 0.655
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.655
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.655
3urh FADDihydrolipoyl dehydrogenase / 0.655
4u8k FDAUDP-galactopyranose mutase / 0.655
9mht SAHModification methylase HhaI 2.1.1.37 0.655
1skm SAHModification methylase HhaI 2.1.1.37 0.654
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.654
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.653
2rgo FADAlpha-Glycerophosphate Oxidase / 0.653
3dme FADPutative conserved exported protein / 0.653
4b66 FADL-ornithine N(5)-monooxygenase / 0.653
2i9k SAHModification methylase HhaI 2.1.1.37 0.652
3nlc FADUncharacterized protein / 0.652
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.651
2vqb FADPutative flavin-containing monooxygenase / 0.651
2z6u SAHModification methylase HhaI 2.1.1.37 0.651
3he3 FADUDP-galactopyranose mutase / 0.651
4eet FMNPhototropin-2 2.7.11.1 0.651
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.650
1geu FADGlutathione reductase 1.8.1.7 0.650
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.650
1p1c SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.650
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.650
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.650
3t2k FADSulfide-quinone reductase / 0.650
3ust FADAcMNPV orf92 / 0.650
4fwe FADLysine-specific histone demethylase 1B 1 0.650