sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4utm | FNR | Xenobiotic reductase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4utm | FNR | Xenobiotic reductase | / | 1.000 | |
| 4uth | FMN | Xenobiotic reductase | / | 0.749 | |
| 3l67 | FMN | Xenobiotic reductase | / | 0.682 | |
| 2h8x | FMN | XenA | / | 0.643 | |
| 1cq7 | PY5 | Aspartate aminotransferase | 2.6.1.1 | 0.515 | |
| 2qll | GLY_PRO_TYR_TYR | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.514 | |
| 4xcz | T3Q | Qdtf | / | 0.508 | |
| 1uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.505 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.504 | |
| 3zns | NU7 | Histone deacetylase 7 | 3.5.1.98 | 0.504 | |
| 2vqj | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.497 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.494 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.491 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.490 | |
| 4nhy | PD2 | Prolyl 3-hydroxylase OGFOD1 | 1.14.11 | 0.490 | |
| 1maq | PGU | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.489 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.488 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.486 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.485 | |
| 1cq8 | PY6 | Aspartate aminotransferase | 2.6.1.1 | 0.484 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.483 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.482 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.482 | |
| 2x1e | X1E | Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form | 2.3.1.164 | 0.481 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.479 | |
| 3c10 | TSN | Histone deacetylase 7 | 3.5.1.98 | 0.479 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.478 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.478 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.477 | |
| 3e8x | NAP | BH1520 protein | / | 0.477 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.477 | |
| 4es5 | MGT | Polymerase basic protein 2 | / | 0.477 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.475 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.475 | |
| 3zo7 | K6H | Muconolactone Delta-isomerase | / | 0.475 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.474 | |
| 2r2l | PB9 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.474 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1wua | AP8 | Actin, alpha skeletal muscle | / | 0.473 | |
| 3qh2 | 3NM | Thiazole tautomerase | / | 0.473 | |
| 4f6s | 0SQ | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.473 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.473 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.472 | |
| 2x86 | ADP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.472 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.471 | |
| 2imk | GTX | AGAP009194-PA | / | 0.470 | |
| 3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.470 | |
| 3ho2 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.470 | |
| 1eyy | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.469 | |
| 1vhn | FMN | tRNA-dihydrouridine synthase | / | 0.469 | |
| 1dmw | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.468 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.468 | |
| 2wgs | 1AZ | Glutamine synthetase | 6.3.1.2 | 0.468 | |
| 2ydx | STL | Methionine adenosyltransferase 2 subunit beta | / | 0.468 | |
| 3h03 | UBP | Glutamate receptor 2 | / | 0.468 | |
| 3nhj | A2Z | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.468 | |
| 1asc | NPL | Aspartate aminotransferase | 2.6.1.1 | 0.467 | |
| 2bxm | IMN | Serum albumin | / | 0.467 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.467 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.467 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.467 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.467 | |
| 4ho8 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.467 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.467 | |
| 1og4 | NAI | T-cell ecto-ADP-ribosyltransferase 2 | / | 0.466 | |
| 1t9c | 1SM | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.466 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.466 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.466 | |
| 3iog | SDF | Metallo-beta-lactamase type 2 | / | 0.466 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.465 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.465 | |
| 4pah | LNR | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.465 | |
| 1mdl | SMN | Mandelate racemase | / | 0.464 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.464 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.464 | |
| 2mm3 | CHO | Gastrotropin | / | 0.464 | |
| 3glu | LYS_VAL_MET | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.464 | |
| 4pzs | ACO | Histone acetyltransferase p300 | / | 0.464 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.463 | |
| 3up3 | XCA | aceDAF-12 | / | 0.463 | |
| 4f1y | CNI | Glutamate receptor 3 | / | 0.463 | |
| 4pb2 | 5UD | Nucleoside permease | / | 0.463 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.463 | |
| 5agy | GTB | Tau class glutathione S-transferase | / | 0.463 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.462 | |
| 3l06 | SN0 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.462 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.462 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 5dxj | SFG | Histone-arginine methyltransferase CARM1 | / | 0.462 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4ai8 | DZA | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.461 | |
| 4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.460 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.460 | |
| 3ae4 | N1M | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 0.460 | |
| 3ae4 | N1M | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial | / | 0.460 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.460 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.460 | |
| 1gve | NAP | Aflatoxin B1 aldehyde reductase member 3 | 1 | 0.459 | |
| 1swt | BTN | Streptavidin | / | 0.459 | |
| 2o1o | RIS | Putative farnesyl pyrophosphate synthase | / | 0.459 | |
| 2rki | TT1 | Gag-Pol polyprotein | 2.7.7.49 | 0.459 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.459 | |
| 4ag9 | COA | Glucosamine 6-phosphate N-acetyltransferase | / | 0.459 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 4xd1 | T3Q | Qdtf | / | 0.459 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.458 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.458 | |
| 1ftl | DNQ | Glutamate receptor 2 | / | 0.458 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 1map | KET | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.458 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.458 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.458 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.458 | |
| 2y67 | N21 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.458 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 3hxf | BD9 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.458 | |
| 3l5d | BDV | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1k4h | APQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.457 | |
| 2amv | BIN | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.457 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.457 | |
| 3iex | GMP | Purine nucleoside phosphorylase | / | 0.457 | |
| 3rbv | NAP | Sugar 3-ketoreductase | / | 0.457 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.457 | |
| 4wqm | FAD | Toluene-4-monooxygenase electron transfer component | 1.18.1.3 | 0.457 | |
| 1tg2 | H2B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.456 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.456 | |
| 2aj8 | SC3 | Dipeptidyl peptidase 4 | / | 0.456 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.456 | |
| 2jav | 5Z5 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.456 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3nt2 | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.456 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.456 | |
| 4lv5 | ADP | Rhoptry protein 5B | / | 0.456 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.456 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.455 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.455 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2f0y | 3MN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.455 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.455 | |
| 3ryk | TYD | dTDP-4-dehydrorhamnose 3,5-epimerase | / | 0.455 | |
| 3sfy | 3FY | Uncharacterized protein | / | 0.455 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.455 | |
| 4el9 | AFE | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.455 | |
| 4l0o | PLP | Cystathionine gamma-synthase | 2.5.1.48 | 0.455 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.455 | |
| 1g2v | TTP | Glucose-1-phosphate thymidylyltransferase | / | 0.454 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.454 | |
| 1kf6 | HQO | Fumarate reductase iron-sulfur subunit | 1.3.5.1 | 0.454 | |
| 1kf6 | HQO | Fumarate reductase subunit C | / | 0.454 | |
| 1kf6 | HQO | Fumarate reductase subunit D | / | 0.454 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.454 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.454 | |
| 2jib | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.454 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.454 | |
| 3juq | AKD | Phenazine biosynthesis protein A/B | / | 0.454 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 4b1i | A8P | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.454 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.454 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.454 | |
| 1p4a | PCP | Pur operon repressor | / | 0.453 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.453 | |
| 2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.453 | |
| 2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.453 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.453 | |
| 3vv8 | B02 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.453 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1e79 | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.452 | |
| 1e79 | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.452 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.452 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.452 | |
| 3dho | B2M | Streptogramin A acetyltransferase | 2.3.1 | 0.452 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.452 | |
| 3hgs | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.452 | |
| 5iqa | GNP | Bifunctional AAC/APH | 2.3.1 | 0.452 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.451 | |
| 1n06 | ADP | Riboflavin kinase | 2.7.1.26 | 0.451 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.451 | |
| 1sir | NBC | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.451 | |
| 1syn | F89 | Thymidylate synthase | / | 0.451 | |
| 1u70 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2qta | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.451 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.451 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.451 | |
| 4j0j | E35 | Tannase | / | 0.451 | |
| 4jxz | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.451 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 1mdl | RMN | Mandelate racemase | / | 0.450 | |
| 1qjg | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.450 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.450 | |
| 2iej | S48 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.450 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.450 | |
| 2qbs | 024 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.450 | |
| 2vcx | D26 | Hematopoietic prostaglandin D synthase | / | 0.450 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.450 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.450 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.450 | |
| 3vi7 | CBD | Hematopoietic prostaglandin D synthase | / | 0.450 | |
| 4a33 | PS8 | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4aoa | IK2 | Beta-phenylalanine transaminase | 2.6.1 | 0.450 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.450 | |
| 4m48 | 21B | Sodium-dependent dopamine transporter | / | 0.450 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.449 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.449 | |
| 3biy | 01K | Histone acetyltransferase p300 | / | 0.449 | |
| 3ceh | AVE | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.449 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.449 | |
| 4dlv | GNP | GTPase HRas | / | 0.449 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1cq6 | PY4 | Aspartate aminotransferase | 2.6.1.1 | 0.448 | |
| 1f9a | ATP | Nicotinamide-nucleotide adenylyltransferase | / | 0.448 | |
| 1jdz | FMB | Purine nucleoside phosphorylase | / | 0.448 | |
| 1n5t | OAL | ActVA 6 protein | / | 0.448 | |
| 1xxj | UNC | Uricase | 1.7.3.3 | 0.448 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.448 | |
| 2q0g | UPU | Poly(A) polymerase, putative | / | 0.448 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.448 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 4azm | T4B | Fatty acid-binding protein, epidermal | / | 0.448 | |
| 1ake | AP5 | Adenylate kinase | / | 0.447 | |
| 1dib | L34 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.447 | |
| 1dig | L37 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.447 | |
| 1g9c | BAB | Botulinum neurotoxin type B | 3.4.24.69 | 0.447 | |
| 1lbb | KAI | Glutamate receptor 2 | / | 0.447 | |
| 1lrm | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.447 | |
| 1qh0 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.447 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.447 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.447 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.447 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.447 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.447 | |
| 2uw5 | GVN | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 3hfb | ML4 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.447 | |
| 3ho9 | N3A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.447 | |
| 3n0y | APC | Adenylate cyclase 2 | / | 0.447 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.447 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.447 | |
| 4dwb | 0M7 | Farnesyl pyrophosphate synthase | / | 0.447 | |
| 4mwz | SAM | Phosphoethanolamine N-methyltransferase, putative | / | 0.447 | |
| 4qbh | AP5 | Adenylate kinase | / | 0.447 | |
| 4uz6 | SCR | Palmitoleoyl-protein carboxylesterase NOTUM | / | 0.447 | |
| 4zp1 | TPP | Pyruvate decarboxylase | 4.1.1.1 | 0.447 | |
| 1h85 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.446 | |
| 1pke | 2FD | Purine nucleoside phosphorylase DeoD-type | / | 0.446 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.446 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.446 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2c5l | GTP | GTPase HRas | / | 0.446 | |
| 3b9l | AZZ | Serum albumin | / | 0.446 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3dyh | 721 | Farnesyl pyrophosphate synthase | / | 0.446 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 3ihz | FK5 | Peptidylprolyl isomerase | / | 0.446 | |
| 3q33 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.446 | |
| 3s41 | S41 | Glucokinase | 2.7.1.2 | 0.446 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 3t58 | FAD | Sulfhydryl oxidase 1 | 1.8.3.2 | 0.446 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.446 | |
| 4fkx | CDP | Nucleoside diphosphate kinase | / | 0.446 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.445 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 1pnq | NDP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.445 | |
| 1vfs | DCS | Alanine racemase | / | 0.445 | |
| 1wkl | ATP | Nucleoside diphosphate kinase | / | 0.445 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.445 | |
| 2v7q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.445 | |
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 | 0.445 | |
| 3c1o | NAP | Eugenol synthase | / | 0.445 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.445 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3zlm | ANP | Adenosine monophosphate-protein transferase NmFic | 2.7.7.n1 | 0.445 | |
| 4ag7 | COA | Glucosamine 6-phosphate N-acetyltransferase | / | 0.445 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.445 | |
| 4hl2 | ZZ7 | Metallo-beta-lactamase type 2 | / | 0.445 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.445 | |
| 5iqb | GNP | Bifunctional AAC/APH | 2.3.1 | 0.445 | |
| 1a8t | 061 | Metallo-beta-lactamase type 2 | / | 0.444 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1dia | L24 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.444 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.444 | |
| 1mx0 | ANP | Type 2 DNA topoisomerase 6 subunit B | / | 0.444 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.444 | |
| 1w29 | TS0 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 2f2s | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.444 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.444 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 3cmp | EB4 | Neutrophil gelatinase-associated lipocalin | / | 0.444 | |
| 4h3i | 10V | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.444 | |
| 4l3q | 926 | Glucokinase | 2.7.1.2 | 0.444 | |
| 4o7n | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.444 | |
| 5c1h | GDU | Histo-blood group ABO system transferase | / | 0.444 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.443 | |
| 1ozq | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 1rxj | BNI | Streptavidin | / | 0.443 | |
| 1s4e | ADP | Galactokinase | / | 0.443 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.443 | |
| 2apc | UDM | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.443 | |
| 2cf8 | ESH | Prothrombin | 3.4.21.5 | 0.443 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.443 | |
| 2w93 | TPP | Pyruvate decarboxylase isozyme 1 | / | 0.443 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3dwb | RDF | Endothelin-converting enzyme 1 | 3.4.24.71 | 0.443 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.443 | |
| 3l05 | SN0 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.443 | |
| 3pch | CHB | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.443 | |
| 3rs0 | GNP | GTPase HRas | / | 0.443 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.443 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.443 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4c43 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 4uoh | ADP | Nucleoside diphosphate kinase | / | 0.443 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.443 | |
| 4zm3 | PLP | Aminotransferase | / | 0.443 | |
| 5ify | TRH | Glucose-1-phosphate thymidylyltransferase | / | 0.443 | |
| 1jg0 | DDT | Thymidylate synthase | / | 0.442 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.442 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.442 | |
| 2lbv | EB4 | Extracellular fatty acid-binding protein | / | 0.442 | |
| 2wge | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.442 | |
| 2xk6 | EQH | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.442 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.442 | |
| 3gy9 | COA | GCN5-related N-acetyltransferase | / | 0.442 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 3qgi | 33F | Genome polyprotein | 2.7.7.48 | 0.442 | |
| 3x21 | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.442 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.442 | |
| 4hmv | WUB | Phenazine biosynthesis protein PhzG | 1.4 | 0.442 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.442 | |
| 1b2r | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 1e64 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.441 | |
| 1qin | GIP | Lactoylglutathione lyase | 4.4.1.5 | 0.441 | |
| 2bgi | FAD | NADPH:ferredoxin reductase | / | 0.441 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3kzo | AN0 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.441 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.441 | |
| 4b05 | 32D | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4cby | KEE | Histone deacetylase 4 | 3.5.1.98 | 0.441 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.441 | |
| 1ee1 | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.440 | |
| 2az3 | CDP | Nucleoside diphosphate kinase | / | 0.440 | |
| 2c1a | I5S | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2fb3 | 5AD | GTP 3',8-cyclase | 4.1.99.18 | 0.440 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.440 | |
| 2iu8 | UD1 | UDP-3-O-acylglucosamine N-acyltransferase | 2.3.1 | 0.440 | |
| 2iyp | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.440 | |
| 2qqf | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.440 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.440 | |
| 2vi5 | Y19 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2vo4 | GTB | 2,4-D inducible glutathione S-transferase | / | 0.440 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2xkf | BX1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 3ae4 | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.440 | |
| 3ex8 | AIF | Riboflavin biosynthesis protein RibD | 1.1.1.193 | 0.440 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.440 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.440 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3ubd | SL0 | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.440 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4dru | 0LN | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 4qx5 | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.440 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.440 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.440 | |
| 4ztv | TA7 | Anthranilate phosphoribosyltransferase | / | 0.440 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.440 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.440 |