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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4g3f0WBMitogen-activated protein kinase kinase kinase 142.7.11.25

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4g3f0WBMitogen-activated protein kinase kinase kinase 142.7.11.251.000
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.554
3zls92PDual specificity mitogen-activated protein kinase kinase 12.7.12.20.524
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.523
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.519
4fv7E94Mitogen-activated protein kinase 12.7.11.240.505
5dt4ATPAurora kinase A2.7.11.10.504
4c02TAKActivin receptor type-12.7.11.300.503
4xumIMNPeroxisome proliferator-activated receptor gamma/0.503
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.502
1ol7ADPAurora kinase A2.7.11.10.499
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.498
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.497
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.496
1y4lSVRBasic phospholipase A2 homolog 2/0.495
3gxlQIGTGF-beta receptor type-12.7.11.300.495
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.494
4gk3L87Ephrin type-A receptor 32.7.10.10.493
3hmm855TGF-beta receptor type-12.7.11.300.492
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.488
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.486
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.485
4utdACPAurora kinase A2.7.11.10.485
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.485
1ia1NDPDihydrofolate reductase1.5.1.30.483
1u4dDBQActivated CDC42 kinase 1/0.483
1vjy460TGF-beta receptor type-12.7.11.300.483
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.483
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.483
3qt62P0Mevalonate diphosphate decarboxylase/0.483
4g170VNCasein kinase I isoform gamma-32.7.11.10.483
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.482
1m78NDPDihydrofolate reductase1.5.1.30.481
2zdt46CMitogen-activated protein kinase 102.7.11.240.481
4njvRITProtease/0.481
5dr9SKEAurora kinase A2.7.11.10.481
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.480
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.480
2xikJ60Serine/threonine-protein kinase 252.7.11.10.480
4dpuAGSMevalonate diphosphate decarboxylase/0.480
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.479
3fwjCAMCamphor 5-monooxygenase1.14.15.10.479
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.477
4dgo0JWCasein kinase II subunit alpha2.7.11.10.477
4dx7DM2Multidrug efflux pump subunit AcrB/0.477
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.477
4qgiROCGag-Pol polyprotein3.4.23.160.477
3nwq2NCGag-Pol polyprotein3.4.23.160.476
4riyADPEpidermal growth factor receptor2.7.10.10.476
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.476
4y93746Tyrosine-protein kinase/0.475
2dwbANPAurora kinase A2.7.11.10.474
3eljGS7Mitogen-activated protein kinase 82.7.11.240.474
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.474
4bgg844Activin receptor type-12.7.11.300.474
4dhyS41Glucokinase2.7.1.20.474
4jloADPAdenylate kinase/0.474
5e8xSTUTGF-beta receptor type-12.7.11.300.474
1lp4ANPCasein kinase II subunit alpha2.7.11.10.473
2uzeC95Cyclin-dependent kinase 22.7.11.220.473
3bbrBHYGlutamate receptor 2/0.473
3c50ADPRhodopsin kinase/0.473
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.473
4mwhATPCasein kinase II subunit alpha2.7.11.10.473
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.472
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.472
1bxoPP7Penicillopepsin-13.4.23.200.471
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.471
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.471
1dr3TAPDihydrofolate reductase1.5.1.30.470
1ebyBEBGag-Pol polyprotein3.4.23.160.470
1u54ACPActivated CDC42 kinase 1/0.470
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.470
3s1h56ZCyclin-dependent kinase 22.7.11.220.470
4yuqKS1Calmodulin-like domain protein kinase/0.470
5drdATPAurora kinase A2.7.11.10.470
1jld0PPGag-Pol polyprotein/0.469
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.469
4aotGW8Serine/threonine-protein kinase 102.7.11.10.469
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.469
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.469
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.468
2ekaSAHDiphthine synthase/0.468
4e4m0NHTyrosine-protein kinase JAK2/0.468
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.468
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.468
4zseANPEpidermal growth factor receptor2.7.10.10.468
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
1sxjADPReplication factor C subunit 5/0.467
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.467
1zys199Serine/threonine-protein kinase Chk12.7.11.10.467
2y6o1N1Ephrin type-A receptor 42.7.10.10.467
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.467
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.467
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.467
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.467
4jl5ADPAdenylate kinase/0.467
4jr7GNPCasein kinase II subunit alpha2.7.11.10.467
5dpvSKEAurora kinase A2.7.11.10.467
5e92ANPTGF-beta receptor type-22.7.11.300.467
1bxqPP8Penicillopepsin-13.4.23.200.466
1eyqNARChalcone--flavonone isomerase 15.5.1.60.466
1jpaANPEphrin type-B receptor 22.7.10.10.466
1mq4ADPAurora kinase A2.7.11.10.466
2j0k4STFocal adhesion kinase 12.7.10.20.466
3i60E86Mitogen-activated protein kinase 12.7.11.240.466
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.466
3oriAGSSerine/threonine protein kinase/0.466
3ttjJBIMitogen-activated protein kinase 102.7.11.240.466
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.466
4nb6444Nuclear receptor ROR-gamma/0.466
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.466
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.465
3ggfGVDSerine/threonine-protein kinase 26/0.465
3ocpCMPcGMP-dependent protein kinase 12.7.11.120.465
4jbpYPHAurora kinase A2.7.11.10.465
1c0lFADD-amino-acid oxidase1.4.3.30.464
1py5PY1TGF-beta receptor type-12.7.11.300.464
1s0xC3SNuclear receptor ROR-alpha/0.464
2c6iDT1Cyclin-dependent kinase 22.7.11.220.464
2ghlLIBMitogen-activated protein kinase 14/0.464
2y9qANPMitogen-activated protein kinase 12.7.11.240.464
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.464
3c4wATPRhodopsin kinase/0.464
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.464
3r9uFADThioredoxin reductase/0.464
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.464
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.464
3rmf20ZCyclin-dependent kinase 22.7.11.220.463
3ti1B49Cyclin-dependent kinase 22.7.11.220.463
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.463
4ng5PFBAlcohol dehydrogenase E chain1.1.1.10.463
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.462
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.462
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.462
3fz1B98Cyclin-dependent kinase 22.7.11.220.462
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.462
3pxyJWSCyclin-dependent kinase 22.7.11.220.462
1rw8580TGF-beta receptor type-12.7.11.300.461
2btsU32Cyclin-dependent kinase 22.7.11.220.461
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.461
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.461
3sheI85MAP kinase-activated protein kinase 32.7.11.10.461
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.461
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.461
3vryB43Tyrosine-protein kinase HCK2.7.10.20.461
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.461
4loqSB4Mitogen-activated protein kinase 14/0.461
1phhFADp-hydroxybenzoate hydroxylase/0.460
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.460
2vttLZDCyclin-dependent kinase 22.7.11.220.460
3kytHC2Nuclear receptor ROR-gamma/0.460
3mtlFEFCyclin-dependent kinase 162.7.11.220.460
3unj0BXCyclin-dependent kinase 22.7.11.220.460
3zpsEQMGag-Pol polyprotein3.4.23.160.460
4e8yIHAD-beta-D-heptose 7-phosphate kinase/0.460
4hgt15GCasein kinase I isoform delta2.7.11.10.460
4nakPBQ2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic2.7.7.600.460
5dosATPAurora kinase A2.7.11.10.460
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.459
2q61SF1Peroxisome proliferator-activated receptor gamma/0.459
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.459
4j97ACPFibroblast growth factor receptor 2/0.459
4tuvCPZCytochrome P450 1191.140.459
4uyg73BBromodomain-containing protein 2/0.459
4zohFADPutative oxidoreductase FAD-binding subunit/0.459
1xelUPGUDP-glucose 4-epimerase5.1.3.20.458
2b7aIZATyrosine-protein kinase JAK2/0.458
2o0uC0MMitogen-activated protein kinase 102.7.11.240.458
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.458
2w9hTOPDihydrofolate reductase1.5.1.30.458
2zjwREFCasein kinase II subunit alpha2.7.11.10.458
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.458
3ortAGSSerine/threonine protein kinase/0.458
3qu0X40Cyclin-dependent kinase 22.7.11.220.458
4bcpT3CCyclin-dependent kinase 22.7.11.220.458
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.458
4du82P0Mevalonate diphosphate decarboxylase/0.458
4g2fC07Ephrin type-A receptor 32.7.10.10.458
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.458
4hjoAQ4Epidermal growth factor receptor2.7.10.10.458
1h0w207Cyclin-dependent kinase 22.7.11.220.457
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.457
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.457
2i0aMUIProtease/0.457
3rk708ZCyclin-dependent kinase 22.7.11.220.457
3t3c017Gag-Pol polyprotein3.4.23.160.457
4f7l0SOCyclin-dependent kinase 82.7.11.220.457
4jqeANPCasein kinase II subunit alpha2.7.11.10.457
4o1pANPRibonuclease L/0.457
4wudANPDNA gyrase subunit B/0.457
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
1rx8FOLDihydrofolate reductase1.5.1.30.456
2egsSAHDiphthine synthase/0.456
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.456
2wotZZGTGF-beta receptor type-12.7.11.300.456
2xuuADPDeath-associated protein kinase 12.7.11.10.456
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.456
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.456
3nxxNDPDihydrofolate reductase1.5.1.30.456
3uli1N3Cyclin-dependent kinase 22.7.11.220.456
4cegADPAurora kinase A2.7.11.10.456
4eji0QACytochrome P450 2A131.14.14.10.456
4fi1ATPCasein kinase II subunit alpha2.7.11.10.456
4ih8B43Calmodulin-domain protein kinase 1/0.456
4r38RBFBlue-light-activated histidine kinase 22.7.13.30.456
5dt3ATPAurora kinase A2.7.11.10.456
1bwlFMNNADPH dehydrogenase 11.6.99.10.455
1np7FADCryptochrome DASH/0.455
2a87FADThioredoxin reductase1.8.1.90.455
2ed5SAHDiphthine synthase/0.455
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.455
2itzIREEpidermal growth factor receptor2.7.10.10.455
3flyFLYMitogen-activated protein kinase 14/0.455
3gggNADPrephenate dehydrogenase/0.455
3l0lHC3Nuclear receptor ROR-gamma/0.455
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.455
4fx360KCyclin-dependent kinase 22.7.11.220.455
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.455
4qmlANPSerine/threonine-protein kinase 242.7.11.10.455
5e8wSTUTGF-beta receptor type-12.7.11.300.455
1oiyN41Cyclin-dependent kinase 22.7.11.220.454
1vikBAYGag-Pol polyprotein/0.454
2e8qSAHDiphthine synthase/0.454
2eniSAHDiphthine synthase/0.454
2qo9ANPEphrin type-A receptor 32.7.10.10.454
3at3ATKCasein kinase II subunit alpha2.7.11.10.454
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.454
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.454
3nwxKVSGag-Pol polyprotein3.4.23.160.454
4h4yNAPBiphenyl dioxygenase ferredoxin reductase subunit/0.454
1cdeGARPhosphoribosylglycinamide formyltransferase/0.453
1dayGNPCasein kinase II subunit alpha2.7.11.10.453
1dirNADDihydropteridine reductase1.5.1.340.453
1disBDMDihydrofolate reductase1.5.1.30.453
1gqtACPRibokinase/0.453
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.453
1t88CAMCamphor 5-monooxygenase1.14.15.10.453
2j5xGSPADP-ribosylation factor 6/0.453
2j9mPY8Cyclin-dependent kinase 22.7.11.220.453
2x1nX1NCyclin-dependent kinase 22.7.11.220.453
3gbuATPUncharacterized sugar kinase PH14592.7.10.453
3hvcGG5Mitogen-activated protein kinase 14/0.453
3hx4ANPCalmodulin-domain protein kinase 1/0.453
3il1B5DGlutamate receptor 2/0.453
3iok1P6Tyrosine-protein kinase JAK2/0.453
3nu3478Gag-Pol polyprotein3.4.23.160.453
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.453
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.453
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.453
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.453
1ay0TPPTransketolase 12.2.1.10.452
1likADNAdenosine kinase2.7.1.200.452
1sxjAGSReplication factor C subunit 1/0.452
1uyuCAMCamphor 5-monooxygenase1.14.15.10.452
2dv7SAHDiphthine synthase/0.452
2excJNKMitogen-activated protein kinase 102.7.11.240.452
2izsBRQCasein kinase I isoform gamma-32.7.11.10.452
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.452
2qnqQN3Gag-Pol polyprotein3.4.23.160.452
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.452
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
3cgoJNOMitogen-activated protein kinase 102.7.11.240.452
3gu83GUDeath-associated protein kinase 12.7.11.10.452
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.452
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.452
3ndxRITGag-Pol polyprotein3.4.23.160.452
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
4c4jX21Dual specificity protein kinase TTK2.7.12.10.452
5c8yACPTubulin tyrosine ligase/0.452
1i00D16Thymidylate synthase2.1.1.450.451
2egbSAHDiphthine synthase/0.451
2f3mGTDGlutathione S-transferase Mu 12.5.1.180.451
2q54MU1Protease/0.451
2r64740Cyclin-dependent kinase 22.7.11.220.451
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.451
2x9dITCTetracycline repressor protein class D/0.451
3fklFKLMitogen-activated protein kinase 14/0.451
3gstGPRGlutathione S-transferase Mu 12.5.1.180.451
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.451
3r8vZ62Cyclin-dependent kinase 22.7.11.220.451
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4c4f7CEDual specificity protein kinase TTK2.7.12.10.451
4jbqVX6Aurora kinase A2.7.11.10.451
4jkyADPAdenylate kinase/0.451
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.451
4kugNAD3-hydroxybutyryl-CoA dehydrogenase/0.451
6gswGPSGlutathione S-transferase Mu 12.5.1.180.451
1cdeDZFPhosphoribosylglycinamide formyltransferase/0.450
1ml6GBXGlutathione S-transferase A22.5.1.180.450
1pxlCK4Cyclin-dependent kinase 22.7.11.220.450
2ephASP_TRP_ASNFructose-bisphosphate aldolase4.1.2.130.450
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.450
2qi5MZ7Gag-Pol polyprotein/0.450
2uzlC94Cyclin-dependent kinase 22.7.11.220.450
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.450
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.450
2znpK55Peroxisome proliferator-activated receptor delta/0.450
3ekwDR7Gag-Pol polyprotein3.4.23.160.450
3fsySCA2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase/0.450
3fwiCAMCamphor 5-monooxygenase1.14.15.10.450
3qtuX44Cyclin-dependent kinase 22.7.11.220.450
3rpeFADPutative modulator of drug activity/0.450
3zep1NXTyrosine-protein kinase JAK32.7.10.20.450
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.450
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.450
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.450
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.450
4lxhC1EAlpha/beta hydrolase fold/0.450
1dr5NAPDihydrofolate reductase1.5.1.30.449
1om1IQACasein kinase II subunit alpha2.7.11.10.449
1p2a5BNCyclin-dependent kinase 22.7.11.220.449
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.449
2c5nCK8Cyclin-dependent kinase 22.7.11.220.449
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.449
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.449
2om9AJAPeroxisome proliferator-activated receptor gamma/0.449
2vtrLZBCyclin-dependent kinase 22.7.11.220.449
2y5s78HDihydropteroate synthase/0.449
3ge6FMNNitroreductase/0.449
3kfs3TLGag-Pol polyprotein/0.449
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.449
3mjeNDPAmphB/0.449
3oom507Activin receptor type-12.7.11.300.449
3qp0NI8Gag-Pol polyprotein3.4.23.160.449
3qtzX42Cyclin-dependent kinase 22.7.11.220.449
3rpv26ZCyclin-dependent kinase 22.7.11.220.449
3w18N13Aurora kinase A2.7.11.10.449
4i22IREEpidermal growth factor receptor2.7.10.10.449
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
1menGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.448
1rbmKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.448
1vceSAHDiphthine synthase/0.448
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.448
2ek2SAHDiphthine synthase/0.448
2f2cAP9Cyclin-dependent kinase 62.7.11.220.448
2hk9NAPShikimate dehydrogenase (NADP(+))/0.448
2w4jADPDeath-associated protein kinase 12.7.11.10.448
2wouZZFTGF-beta receptor type-12.7.11.300.448
2xyuQ9GEphrin type-A receptor 42.7.10.10.448
3h1vTK1Glucokinase2.7.1.20.448
3rak03ZCyclin-dependent kinase 22.7.11.220.448
3t113T1Gag-Pol polyprotein3.4.23.160.448
3vf9477Tyrosine-protein kinase SYK2.7.10.20.448
4f650S9Fibroblast growth factor receptor 1/0.448
4fod0UVALK tyrosine kinase receptor2.7.10.10.448
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.448
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.448
4jajXU1Aurora kinase A2.7.11.10.448
4kba1QMCasein kinase I isoform delta2.7.11.10.448
4lopSB4Mitogen-activated protein kinase 14/0.448
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.448
1mezGDPAdenylosuccinate synthetase isozyme 1/0.447
1ol5ADPAurora kinase A2.7.11.10.447
1pdhFASp-hydroxybenzoate hydroxylase/0.447
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.447
1q1rFADPutidaredoxin reductase1.18.1.50.447
2bfyH1NAurora kinase B-A2.7.11.10.447
2fxeDR7Gag-Pol polyprotein3.4.23.160.447
2p2xSAHDiphthine synthase/0.447
2p3b3TLV-1 PROTEASE protein/0.447
2p3b3TLV-1 protease/0.447
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.447
2znnS44Peroxisome proliferator-activated receptor alpha/0.447
3ajrNADNDP-sugar epimerase/0.447
3hllI45Mitogen-activated protein kinase 14/0.447
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
3iqfE4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.447
3lqfNADGalactitol dehydrogenase/0.447
3poz03PEpidermal growth factor receptor2.7.10.10.447
3zh8C58Protein kinase C iota type2.7.11.130.447
4b8wNAPGDP-L-fucose synthase1.1.1.2710.447
4btjATPTau-tubulin kinase 12.7.11.10.447
4fko20KCyclin-dependent kinase 22.7.11.220.447
4kb81QOCasein kinase I isoform delta2.7.11.10.447
4kuoRBFPutative blue-light photoreceptor/0.447
4l49CAMCamphor 5-monooxygenase1.14.15.10.447
4r1lADPPhenylacetate-coenzyme A ligase/0.447
4yryNADGlutamate synthase, beta subunit/0.447
1p0pBCHCholinesterase3.1.1.80.446
1qr6NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.446
1s3zCOAAminoglycoside N(6')-acetyltransferase type 1/0.446
1t85CAMCamphor 5-monooxygenase1.14.15.10.446
1yw2PGJMitogen-activated protein kinase 14/0.446
2pziAXXSerine/threonine-protein kinase PknG2.7.11.10.446
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.446
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.446
3a60STURibosomal protein S6 kinase beta-12.7.11.10.446
3f63GTXGlutathione transferase GST1-4/0.446
3kvxFMYMitogen-activated protein kinase 102.7.11.240.446
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.446
3oibFDAPutative acyl-CoA dehydrogenase/0.446
3rnnRNNGlutamate receptor 2/0.446
3ruvANPChaperonin/0.446
3t8vBTJM1 family aminopeptidase3.4.110.446
3wrjCAMCamphor 5-monooxygenase1.14.15.10.446
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.446
4a99FADTetX family tetracycline inactivation enzyme/0.446
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4c3rACPAurora kinase A2.7.11.10.446
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.446
4g090VDHistidinol dehydrogenase/0.446
4hvh19RTyrosine-protein kinase JAK32.7.10.20.446
4nfn2KCTau-tubulin kinase 12.7.11.10.446
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.446
4xldBRLPeroxisome proliferator-activated receptor gamma/0.446
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.446
5av4GENDeath-associated protein kinase 12.7.11.10.446
1ao0ADPAmidophosphoribosyltransferase/0.445
1bygSTUTyrosine-protein kinase CSK/0.445
1civNAPMalate dehydrogenase [NADP], chloroplastic1.1.1.820.445
1eioGCHGastrotropin/0.445
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.445
2p5fSAHDiphthine synthase/0.445
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.445
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.445
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.445
3ijdC2FMethylenetetrahydrofolate reductase/0.445
3m6vSAMRibosomal RNA small subunit methyltransferase F/0.445
3oroAGSSerine/threonine protein kinase/0.445
3pgpACOUncharacterized protein/0.445
3sw418KCyclin-dependent kinase 22.7.11.220.445
3vt7VDXVitamin D3 receptor/0.445
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.445
4b1vATPActin, alpha skeletal muscle/0.445
4bb432WEphrin type-B receptor 42.7.10.10.445
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.445
4c04SFGProtein arginine N-methyltransferase 6/0.445
4dc32FAPutative adenosine kinase/0.445
4e730NRMitogen-activated protein kinase 82.7.11.240.445
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.445
4i6gFADCryptochrome-2/0.445
4ivb1J5Tyrosine-protein kinase JAK1/0.445
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.445
4jboWPHAurora kinase A2.7.11.10.445
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.445
4k33ACPFibroblast growth factor receptor 32.7.10.10.445
4kwhNAPReductase homolog/0.445
4rvj478Protease/0.445
1di8DTQCyclin-dependent kinase 22.7.11.220.444
1hw5CMPcAMP-activated global transcriptional regulator CRP/0.444
1m2rMNYCasein kinase II subunit alpha2.7.11.10.444
1s5kCOAAminoglycoside N(6')-acetyltransferase type 1/0.444
2b1pAIZMitogen-activated protein kinase 102.7.11.240.444
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.444
2c6tDT5Cyclin-dependent kinase 22.7.11.220.444
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.444
2h96893Mitogen-activated protein kinase 82.7.11.240.444
2he5NDPAldo-keto reductase family 1 member C211.1.10.444
2hk51BMTyrosine-protein kinase HCK2.7.10.20.444
2ozuACOHistone acetyltransferase KAT6A/0.444
2vgoAD5Aurora kinase B-A2.7.11.10.444
2xrwANPMitogen-activated protein kinase 82.7.11.240.444
3bptQUE3-hydroxyisobutyryl-CoA hydrolase, mitochondrial3.1.2.40.444
3iggEFQCyclin-dependent kinase 22.7.11.220.444
3l9hEMQKinesin-like protein KIF11/0.444
3p82FMNPentaerythritol tetranitrate reductase/0.444
3r3sNADPutative oxidoreductase/0.444
4aua4AUCyclin-dependent kinase 62.7.11.220.444
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4c58824Cyclin-G-associated kinase2.7.11.10.444
4dpmCOAMalonyl-CoA reductase1.2.1.750.444
4f630S7Fibroblast growth factor receptor 1/0.444
4fks46KCyclin-dependent kinase 22.7.11.220.444
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.444
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.444
4k6z1Q3Tyrosine-protein kinase JAK1/0.444
4kb81QNCasein kinase I isoform delta2.7.11.10.444
4kwi1TJReductase homolog/0.444
4ly91YYGlucokinase regulatory protein/0.444
4mihFADPyranose 2-oxidase1.1.3.100.444
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.444
6cp4CAMCamphor 5-monooxygenase1.14.15.10.444
6upjNIUGag-Pol polyprotein/0.444
1cx2S58Prostaglandin G/H synthase 21.14.99.10.443
1w0xOLOCyclin-dependent kinase 22.7.11.220.443
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.443
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.443
2e08SAHDiphthine synthase/0.443
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.443
2eh4SAHDiphthine synthase/0.443
2el0SAHDiphthine synthase/0.443
2uy0HV1Gag-Pol polyprotein3.4.23.160.443
2v1aFMNNPH1-1/0.443
2vx07X7Ephrin type-B receptor 42.7.10.10.443
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.443
2xneASHAurora kinase A2.7.11.10.443
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.443
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.443
3a9wNADNDP-sugar epimerase/0.443
3bxzADPProtein translocase subunit SecA/0.443
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.443
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.443
3gqvNAPEnoyl reductase LovC10.443
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.443
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.443
3ndtROCGag-Pol polyprotein3.4.23.160.443
3nynSGVG protein-coupled receptor kinase 62.7.11.160.443
3pwm017Gag-Pol polyprotein3.4.23.160.443
3rn8RN8Glutamate receptor 2/0.443
3wrmCAMCamphor 5-monooxygenase1.14.15.10.443
4ax8ADPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.443
4dplNAPMalonyl-CoA reductase1.2.1.750.443
4eol1ROCyclin-dependent kinase 22.7.11.220.443
4fob0USALK tyrosine kinase receptor2.7.10.10.443
4gk2L66Ephrin type-A receptor 32.7.10.10.443
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.443
4ivd15TTyrosine-protein kinase JAK1/0.443
4kl9NDPDihydrofolate reductase1.5.1.30.443
5kj6PFBAlcohol dehydrogenase E chain1.1.1.10.443
1diuBDMDihydrofolate reductase1.5.1.30.442
1dnpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.442
1dr2TAPDihydrofolate reductase1.5.1.30.442
1jn0NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.442
1m0b0ZQGag-Pol polyprotein3.4.23.160.442
1p9wANPType II secretion system protein E/0.442
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.442
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.442
2pchSAHDiphthine synthase/0.442
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.442
2pvyACPFibroblast growth factor receptor 2/0.442
2qk8MTXDihydrofolate reductase/0.442
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.442
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3etgGWDGlutamate dehydrogenase 1, mitochondrial1.4.1.30.442
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
3h0aD30Peroxisome proliferator-activated receptor gamma/0.442
3h6vNS6Glutamate receptor 2/0.442
3hyoADPPyridoxal kinase/0.442
3i81EBIInsulin-like growth factor 1 receptor2.7.10.10.442
3iaeD7KBenzaldehyde lyase/0.442
3kb1ADPIron-sulfur cluster carrier protein/0.442
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.442
3s1dZIRCytokinin dehydrogenase 11.5.99.120.442
3sdkP3NProteasome subunit beta type-53.4.25.10.442
3sdkP3NProteasome subunit beta type-63.4.25.10.442
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.442
3wtkTH4Acetylcholine-binding protein/0.442
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.442
4ez30S0Cyclin-dependent kinase 22.7.11.220.442
4ez8DHFThymidylate synthase2.1.1.450.442
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.442
4fkt48KCyclin-dependent kinase 22.7.11.220.442
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.442
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4ienCOAPutative acyl-CoA hydrolase/0.442
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.442
4x4lNAIRetinal dehydrogenase 11.2.1.360.442
5eccNAPDehydrofolate reductase type I/0.442
5fbhTCRExtracellular calcium-sensing receptor/0.442
1dr3HBIDihydrofolate reductase1.5.1.30.441
1hiiC20Gag-Pol polyprotein/0.441
1k6cMK1Gag-Pol polyprotein3.4.23.160.441
1pxmCK5Cyclin-dependent kinase 22.7.11.220.441
1t3r017Gag-Pol polyprotein3.4.23.160.441
1th6OINBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.441
1ykdCMPAdenylate cyclase/0.441
1zemNADXylitol dehydrogenase/0.441
1zrzBI1Protein kinase C iota type2.7.11.130.441
2a94AP0L-lactate dehydrogenase1.1.1.270.441
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.441
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.441
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.441
2emuSAHDiphthine synthase/0.441
2exmZIPCyclin-dependent kinase 22.7.11.220.441
2gtk208Peroxisome proliferator-activated receptor gamma/0.441
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
2j14GNIPeroxisome proliferator-activated receptor delta/0.441
2j6xFMNLactate oxidase/0.441
3a62STURibosomal protein S6 kinase beta-12.7.11.10.441
3bhy7CPDeath-associated protein kinase 3/0.441
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3cyxROCGag-Pol polyprotein3.4.23.160.441
3gcoVAL_TYR_GLN_PHESerine endoprotease DegS3.4.21.1070.441
3gdvTYR_GLN_PHESerine endoprotease DegS3.4.21.1070.441
3ictFADCoenzyme A disulfide reductase/0.441
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3o3jBB4Peptide deformylase 1B, chloroplastic/mitochondrial3.5.1.880.441
3pd3A3TThreonine--tRNA ligase6.1.1.30.441
3s41S41Glucokinase2.7.1.20.441
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.441
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.441
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
4dgmAGICasein kinase II subunit alpha2.7.11.10.441
4emjFADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.441
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.441
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.441
4gevCB3Thymidylate synthase/0.441
4joa3DKALK tyrosine kinase receptor2.7.10.10.441
4wkqIREEpidermal growth factor receptor2.7.10.10.441
1c2tGARPhosphoribosylglycinamide formyltransferase/0.440
1ebk0Q4Gag-Pol polyprotein3.4.23.160.440
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.440
2aquDR7Gag-Pol polyprotein3.4.23.160.440
2dxxSAHDiphthine synthase/0.440
2hckQUETyrosine-protein kinase HCK2.7.10.20.440
2owuSAHDiphthine synthase/0.440
2p6dSAHDiphthine synthase/0.440
2pmoHMDProtein kinase 7/0.440
2pvkP45Casein kinase II subunit alpha2.7.11.10.440
2pwlACPFibroblast growth factor receptor 2/0.440
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.440
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.440
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.440
3a4tSFGtRNA (cytosine(48)-C(5))-methyltransferase2.1.10.440
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.440
3cjfSAVVascular endothelial growth factor receptor 22.7.10.10.440
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.440
3ggxGGXGag-Pol polyprotein/0.440
3lfqA28Cyclin-dependent kinase 22.7.11.220.440
3qqkX02Cyclin-dependent kinase 22.7.11.220.440
3r73X87Cyclin-dependent kinase 22.7.11.220.440
3rpo24ZCyclin-dependent kinase 22.7.11.220.440
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.440
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4bcoT6QCyclin-dependent kinase 22.7.11.220.440
4jazSTLPeroxisome proliferator-activated receptor gamma/0.440
4kbc1QJCasein kinase I isoform delta2.7.11.10.440
4looSB4Mitogen-activated protein kinase 14/0.440
4rnuFMNNADPH dehydrogenase 11.6.99.10.440
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.440
5ca0ACPTubulin tyrosine ligase/0.440