sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ust | FAD | AcMNPV orf92 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3ust | FAD | AcMNPV orf92 | / | 1.000 | |
| 3qzy | FAD | FAD-linked sulfhydryl oxidase | / | 0.564 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.504 | |
| 3nhw | ZXZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.499 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.498 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.496 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.496 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.493 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.493 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.490 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.490 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.486 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.485 | |
| 4wct | FAD | Fructosyl amine:oxygen oxidoreductase | / | 0.485 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.484 | |
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.483 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.481 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 1rp4 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.480 | |
| 1lke | DOG | Bilin-binding protein | / | 0.479 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.479 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.478 | |
| 4gqi | M49 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.478 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.476 | |
| 4d9f | DCS | D-cysteine desulfhydrase | / | 0.474 | |
| 2xvv | 9DN | Serum albumin | / | 0.473 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 4zvm | DM2 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.473 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.472 | |
| 3nfr | EWQ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.472 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.470 | |
| 2bxq | IMN | Serum albumin | / | 0.470 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 2xvw | 9NR | Serum albumin | / | 0.470 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.470 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.469 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.469 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.469 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3cem | AVD | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.468 | |
| 4d03 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.468 | |
| 4z87 | GDP | Inosine-5'-monophosphate dehydrogenase | / | 0.468 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 4gtt | 7TQ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.467 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.466 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.465 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2vyx | FMN | Dodecin | / | 0.464 | |
| 3mbg | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.464 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 2z52 | H23 | Geranylgeranyl pyrophosphate synthase | / | 0.463 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.463 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.463 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.463 | |
| 3tk0 | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.463 | |
| 1jdz | FMB | Purine nucleoside phosphorylase | / | 0.462 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4c3x | FAD | 3-ketosteroid dehydrogenase | / | 0.462 | |
| 2a2s | GSN | Glutathione S-transferase P | 2.5.1.18 | 0.461 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.461 | |
| 3nhu | M42 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.461 | |
| 1jf0 | CZH | Obelin | / | 0.460 | |
| 1jr8 | FAD | FAD-linked sulfhydryl oxidase ERV2 | 1.8.3.2 | 0.460 | |
| 3b9l | AZZ | Serum albumin | / | 0.460 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.460 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.459 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.459 | |
| 3u2m | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.459 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 1g7v | PAI | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.458 | |
| 1k02 | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.458 | |
| 1kqf | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.458 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.458 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.457 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.457 | |
| 2c9b | PUG | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.457 | |
| 2vvl | FAD | Monoamine oxidase N | 1.4.3.4 | 0.457 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 3dt2 | GTP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.457 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.457 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.457 | |
| 1el4 | CTZ | Obelin | / | 0.456 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.456 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.456 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.456 | |
| 3nhf | VVV | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.456 | |
| 3u2l | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.456 | |
| 3u5s | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.456 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.456 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.455 | |
| 2ati | IHU | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.455 | |
| 2e91 | ZOL | Geranylgeranyl pyrophosphate synthase | / | 0.455 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.455 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.455 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4e0h | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.455 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 1n5q | TNC | ActVA 6 protein | / | 0.454 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.454 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.454 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1ej3 | CZH | Aequorin-2 | / | 0.453 | |
| 1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.453 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 1th6 | OIN | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.453 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.453 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.453 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.453 | |
| 2qbs | 024 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.453 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.453 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 4d9e | LCS | D-cysteine desulfhydrase | / | 0.453 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.453 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.453 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.453 | |
| 5hyn | SAH | Histone-lysine N-methyltransferase EZH2 | 2.1.1.43 | 0.453 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.452 | |
| 1xp8 | AGS | Protein RecA | / | 0.452 | |
| 2qf2 | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.452 | |
| 2ydb | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.451 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.451 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.451 | |
| 2z1x | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.451 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.450 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.450 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2qjp | ANJ | Cytochrome b | / | 0.450 | |
| 2wpw | ACO | Orf14 | / | 0.450 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 3cop | ADP | Glycogen synthase | 2.4.1.21 | 0.450 | |
| 3e8x | NAP | BH1520 protein | / | 0.450 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.450 | |
| 3nhk | VAP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.450 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4a6d | SAM | Acetylserotonin O-methyltransferase | 2.1.1.4 | 0.450 | |
| 4hs4 | FMN | Chromate reductase | / | 0.450 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.450 | |
| 1h83 | FAD | Polyamine oxidase | 1.5.3.14 | 0.449 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.449 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.449 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.449 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.449 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.449 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.449 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 5iqe | GNP | Bifunctional AAC/APH | 2.3.1 | 0.449 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.448 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.448 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.448 | |
| 2avx | HTF | Regulatory protein SdiA | / | 0.448 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.448 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.448 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3m31 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.448 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.448 | |
| 3t8v | BTJ | M1 family aminopeptidase | 3.4.11 | 0.448 | |
| 4y9x | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.448 | |
| 4yfy | 1YJ | VioF | / | 0.448 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1gul | GLY_GGL_ICY | Glutathione S-transferase A4 | 2.5.1.18 | 0.447 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.447 | |
| 1mab | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.447 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2oad | GTB | Glutathione S-transferase P 1 | 2.5.1.18 | 0.447 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.447 | |
| 2z4z | SC0 | Geranylgeranyl pyrophosphate synthase | / | 0.447 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3e6e | DCS | Alanine racemase | / | 0.447 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.447 | |
| 3hdy | GDU | UDP-galactopyranose mutase | / | 0.447 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.447 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.447 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.447 | |
| 4hhy | 15R | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.447 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.447 | |
| 4uco | IWH | DNA ligase | / | 0.447 | |
| 5agy | GTB | Tau class glutathione S-transferase | / | 0.447 | |
| 5efw | FMN | NPH1-1 | / | 0.447 | |
| 1t13 | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | / | 0.446 | |
| 2j9h | GTX | Glutathione S-transferase P | 2.5.1.18 | 0.446 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.446 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.446 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.446 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1gw2 | FER | Peroxidase C1A | 1.11.1.7 | 0.445 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.445 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.445 | |
| 2pgt | GPR | Glutathione S-transferase P | 2.5.1.18 | 0.445 | |
| 2tsr | UMP | Thymidylate synthase | 2.1.1.45 | 0.445 | |
| 3gus | N11 | Glutathione S-transferase P | 2.5.1.18 | 0.445 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.445 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.445 | |
| 1oqc | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.444 | |
| 1qv1 | CZH | Obelin | / | 0.444 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.444 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 2vi5 | Y19 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 2xb8 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.444 | |
| 2yg5 | FAD | Putrescine oxidase | / | 0.444 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.444 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.444 | |
| 3gwn | FAD | Probable FAD-linked sulfhydryl oxidase R596 | 1.8.3.2 | 0.444 | |
| 3kpf | FAD | Polyamine oxidase | 1.5.3.14 | 0.444 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4a6e | ASE | Acetylserotonin O-methyltransferase | 2.1.1.4 | 0.444 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 4fj2 | QSO | 17beta-hydroxysteroid dehydrogenase | / | 0.444 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.444 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.444 | |
| 4uz6 | SCR | Palmitoleoyl-protein carboxylesterase NOTUM | / | 0.444 | |
| 5e9e | ANP | Myosin heavy chain kinase A | 2.7.11.7 | 0.444 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.443 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1sdm | ADP | Kinesin heavy chain-like protein | / | 0.443 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.443 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.443 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.443 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4x9d | U5P | Uncharacterized protein MJ1435 | / | 0.443 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1e6v | COM | Methyl-coenzyme M reductase I subunit alpha | / | 0.442 | |
| 1e6v | COM | Methyl coenzyme M reductase, beta subunit | / | 0.442 | |
| 1pua | COA | HAT A1 | / | 0.442 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.442 | |
| 1uhh | CZP | Aequorin-2 | / | 0.442 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.442 | |
| 1z6l | FAD | Polyamine oxidase FMS1 | / | 0.442 | |
| 2cy2 | ACO | Probable acetyltransferase | / | 0.442 | |
| 2qmz | LDP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 2wvl | GDD | Mannosyl-3-phosphogylcerate synthase | / | 0.442 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.442 | |
| 2y02 | WHJ | Beta-1 adrenergic receptor | / | 0.442 | |
| 3dgq | EAA | Glutathione S-transferase P | 2.5.1.18 | 0.442 | |
| 3dlg | GWE | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.442 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.442 | |
| 3wip | ACH | Acetylcholine-binding protein | / | 0.442 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.442 | |
| 4g8c | C6L | Alpha/beta hydrolase fold protein | / | 0.442 | |
| 4gd9 | BTN | Streptavidin | / | 0.442 | |
| 4nqg | CZH | Mitrocomin | / | 0.442 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.442 | |
| 4v0s | 2HN | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.442 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.442 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.441 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.441 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.441 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.441 | |
| 1rt7 | UC4 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1s36 | CEI | Obelin | / | 0.441 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.441 | |
| 2yg3 | FAD | Putrescine oxidase | / | 0.441 | |
| 3gc5 | 2MQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.441 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.441 | |
| 3gwl | FAD | FAD-linked sulfhydryl oxidase | 1.8.3.2 | 0.441 | |
| 3h0w | N8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.441 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.441 | |
| 3ox3 | 4X4 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.441 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.440 | |
| 1e6z | NGO | Chitinase | / | 0.440 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.440 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.440 | |
| 2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.440 | |
| 2glr | GTX | Glutathione S-transferase P 1 | 2.5.1.18 | 0.440 | |
| 2hct | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.440 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2v19 | FMN | Dodecin | / | 0.440 | |
| 2ydd | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 3hy3 | 10F | 5-formyltetrahydrofolate cyclo-ligase | 6.3.3.2 | 0.440 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3rba | COD | Phosphopantetheine adenylyltransferase | / | 0.440 | |
| 4c3y | FAD | 3-ketosteroid dehydrogenase | / | 0.440 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.440 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.440 | |
| 4uga | H4B | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.440 | |
| 5dp2 | NAP | CurF | / | 0.440 |