sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.820 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.800 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.793 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.781 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.780 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.777 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.770 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.768 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.765 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.761 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.758 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.758 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.754 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.748 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.748 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.745 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.743 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.742 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.739 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.735 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.733 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.730 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.729 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.728 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.727 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.726 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.723 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.722 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.722 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.719 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.718 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.718 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.718 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.717 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.716 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.713 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.711 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.709 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.709 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.708 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.707 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.707 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.706 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.703 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.702 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.701 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.701 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.701 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.701 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.700 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.697 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.694 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.692 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.688 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.686 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.685 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.683 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.681 | |
| 1i9m | INW | Carbonic anhydrase 2 | 4.2.1.1 | 0.680 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.679 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.679 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.678 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.675 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.675 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.673 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.673 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.671 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.670 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.668 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.667 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.662 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.660 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.658 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.658 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.655 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.653 | |
| 1a42 | BZU | Carbonic anhydrase 2 | 4.2.1.1 | 0.652 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.652 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.650 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.649 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.649 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.649 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.649 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.648 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.648 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.647 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.644 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.641 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.641 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.634 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.634 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.633 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.629 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.622 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.622 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.616 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.614 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.607 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.607 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.605 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.603 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.596 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.587 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.582 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.581 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.572 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.572 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.568 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.567 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.565 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.563 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.561 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.559 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.550 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.543 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.537 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.533 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.530 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.525 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.523 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.520 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.517 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.514 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.512 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.509 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.507 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.500 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.496 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.491 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.490 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.489 | |
| 4knn | E1F | Carbonic anhydrase 13 | 4.2.1.1 | 0.489 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.488 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.488 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.482 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.482 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.481 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.481 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.480 | |
| 1typ | FAD | Trypanothione reductase | 1.8.1.12 | 0.479 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.478 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.478 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.477 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.476 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.475 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.475 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.475 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.474 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.474 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.473 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.473 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.473 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.472 | |
| 4g8j | THM | Uridine phosphorylase | / | 0.472 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 3eks | CY9 | Actin-5C | / | 0.471 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.471 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.470 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.470 | |
| 4boe | CLR | Japanin | / | 0.470 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.469 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.469 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.469 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.468 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.468 | |
| 1o1s | 1NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.468 | |
| 4xba | GMP | Aprataxin-like protein | 3 | 0.468 | |
| 2fbw | CBE | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 0.467 | |
| 2fbw | CBE | Succinate dehydrogenase cytochrome b, large subunit | / | 0.467 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.467 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.467 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.467 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 1c9w | NAP | Aldose reductase-related protein 2 | / | 0.465 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.465 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.465 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.465 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.465 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.465 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.464 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.464 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.464 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.464 | |
| 4pzr | COA | Histone acetyltransferase p300 | / | 0.464 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3zs7 | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.463 | |
| 3juo | AJD | Phenazine biosynthesis protein A/B | / | 0.462 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.462 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.461 | |
| 1c7o | PPG | Hemolysin | / | 0.461 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.461 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.461 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 3b9x | NOS | Pyrimidine-specific ribonucleoside hydrolase RihB | 3.2.2.8 | 0.461 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.461 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.461 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.460 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.460 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.460 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.460 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3myt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.460 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.460 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.459 | |
| 3biy | 01K | Histone acetyltransferase p300 | / | 0.459 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.459 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.459 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.459 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.459 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.458 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.458 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.458 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.458 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.458 | |
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.457 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.457 | |
| 2dxv | SAH | Diphthine synthase | / | 0.457 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.457 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.457 | |
| 1bzm | MZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.456 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2g0b | NLT | Long-chain N-acyl amino acid synthase | / | 0.456 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3b4p | 3B4 | Phenazine biosynthesis protein A/B | / | 0.456 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.456 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.456 | |
| 4bqu | CLR | Japanin | / | 0.456 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.456 | |
| 1i05 | LTL | Major urinary protein 6 | / | 0.455 | |
| 2dxw | SAH | Diphthine synthase | / | 0.455 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.455 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.455 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.455 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.454 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.454 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.454 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.454 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.454 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.454 | |
| 4bcs | BTN | Avidin-related protein 4/5 | / | 0.454 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.454 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.454 | |
| 4e2w | JHZ | Methyltransferase | / | 0.454 | |
| 1j4h | SUB | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.453 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.453 | |
| 4n1g | CEI | Obelin | / | 0.453 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.453 | |
| 1swg | BTN | Streptavidin | / | 0.452 | |
| 1yqs | BSA | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.452 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.452 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.452 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.452 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.452 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.452 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.452 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 3eku | CY9 | Actin-5C | / | 0.451 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.451 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.451 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.451 | |
| 1gw2 | FER | Peroxidase C1A | 1.11.1.7 | 0.450 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.450 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.450 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.450 | |
| 2dxx | SAH | Diphthine synthase | / | 0.450 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.450 | |
| 2pcm | SAH | Diphthine synthase | / | 0.450 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.450 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.450 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.450 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.450 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.450 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.450 | |
| 4e2d | FMN | Dehydrogenase | / | 0.450 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.450 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.449 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.449 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.449 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.449 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.449 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.449 | |
| 3t2w | BTN | Avidin/streptavidin | / | 0.449 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.449 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.449 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.449 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.449 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.449 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.449 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.448 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.448 | |
| 1y1r | ANU | Uridine phosphorylase | 2.4.2.3 | 0.448 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.448 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.448 | |
| 4rel | KMP | Glycosyltransferase | / | 0.448 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.448 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.447 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.447 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.447 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.447 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4isg | 1FY | Glucokinase | 2.7.1.2 | 0.447 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.446 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.446 | |
| 2emr | SAH | Diphthine synthase | / | 0.446 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.446 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.446 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.446 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.446 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3qi1 | C6A | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.446 | |
| 4e32 | DWN | Methyltransferase | / | 0.446 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.446 | |
| 4pnr | G18 | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 4xba | 5GP | Aprataxin-like protein | 3 | 0.446 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.446 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.445 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 2dg4 | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.445 | |
| 2q3o | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.445 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.445 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.445 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.445 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.445 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.445 | |
| 1gtr | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.444 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.444 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.444 | |
| 1q51 | CAA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.444 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.444 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.444 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.444 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2vi5 | Y19 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.444 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 3ryk | TYD | dTDP-4-dehydrorhamnose 3,5-epimerase | / | 0.444 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 4bhw | 01K | Histone acetyltransferase p300 | / | 0.444 | |
| 4cfa | WOP | Integrase | / | 0.444 | |
| 4drk | I63 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.444 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 4h6k | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.444 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.444 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.444 | |
| 4hrq | AZG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.444 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.444 | |
| 1eio | GCH | Gastrotropin | / | 0.443 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.443 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.443 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.443 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.443 | |
| 2ewv | ADP | Twitching motility protein PilT | / | 0.443 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.443 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3e33 | ED7 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.443 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.443 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.443 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.442 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.442 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.442 | |
| 2ejk | SAH | Diphthine synthase | / | 0.442 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.442 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.442 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3kjg | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.442 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.442 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.442 | |
| 4jiq | 1L5 | GTN Reductase | / | 0.442 | |
| 4rri | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.442 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.442 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.441 | |
| 1o1t | 2NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.441 | |
| 2e8q | SAH | Diphthine synthase | / | 0.441 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.441 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.441 | |
| 2yj4 | ATP | Copper-transporting ATPase | / | 0.441 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.441 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.441 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.441 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.441 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.440 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.440 | |
| 1s36 | CEI | Obelin | / | 0.440 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.440 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 2a2s | GSN | Glutathione S-transferase P | 2.5.1.18 | 0.440 | |
| 2e16 | SAH | Diphthine synthase | / | 0.440 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.440 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.440 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.440 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.440 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.440 |