sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1u0y | PA7 | Endoplasmin |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1u0y | PA7 | Endoplasmin | / | 1.000 | |
| 1qy5 | NEC | Endoplasmin | / | 0.640 | |
| 1qy8 | RDI | Endoplasmin | / | 0.619 | |
| 1u2o | NEC | Endoplasmin | / | 0.585 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.584 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.584 | |
| 1ysz | NEC | Endoplasmin | / | 0.582 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.580 | |
| 1u0z | RDC | Endoplasmin | / | 0.575 | |
| 2hch | N5A | Endoplasmin | / | 0.570 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.569 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.567 | |
| 2gqp | PA7 | Endoplasmin | / | 0.566 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.563 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.562 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.561 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.561 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.559 | |
| 2hg1 | N5O | Endoplasmin | / | 0.555 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.554 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.554 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.552 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.551 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.551 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.548 | |
| 2fyp | RDE | Endoplasmin | / | 0.547 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.546 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.543 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.539 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.537 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.532 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.529 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.528 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 2gfd | RDA | Endoplasmin | / | 0.524 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.519 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.518 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.518 | |
| 3eko | PYU | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.517 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.517 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.516 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.515 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.514 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.512 | |
| 2qfo | A51 | Heat shock protein HSP 90-alpha | / | 0.512 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.511 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.510 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.509 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.508 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.507 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.506 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.506 | |
| 4ce3 | L4V | ATP-dependent molecular chaperone HSP82 | / | 0.505 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.504 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.504 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.500 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.500 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.496 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 1vsv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.495 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.493 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.493 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.493 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.489 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.489 | |
| 2yi5 | YI5 | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 3t0z | ATP | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.487 | |
| 2cgf | P2N | ATP-dependent molecular chaperone HSP82 | / | 0.487 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.486 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.483 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.480 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.479 | |
| 2exl | GDM | Endoplasmin | / | 0.478 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.478 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.477 | |
| 3ied | AN2 | HSP90 | / | 0.476 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.476 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.475 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.475 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.474 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.472 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.471 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.470 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.470 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.469 | |
| 3a3b | RBF | Lumazine protein | / | 0.469 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 3u9e | COA | Lmo1369 protein | / | 0.469 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.467 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.467 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.466 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.465 | |
| 1r2j | FAD | FkbI | / | 0.465 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.465 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.463 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.463 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.463 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.463 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.463 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1gad | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.462 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.461 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.460 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.460 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.460 | |
| 3eku | CY9 | Actin-5C | / | 0.460 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.460 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.459 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.459 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.459 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.459 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.459 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.458 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.458 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.458 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.457 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.457 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.456 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.456 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.456 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.456 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.456 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.456 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.456 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.456 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.455 | |
| 2wq7 | FAD | RE11660p | / | 0.455 | |
| 3eo8 | FMN | Putative nitroreductase | / | 0.455 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.455 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.454 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.454 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.454 | |
| 4jva | 1OR | cAMP-dependent protein kinase type II-beta regulatory subunit | / | 0.454 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.453 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 0.453 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.453 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.453 | |
| 3toh | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 4aac | AAV | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.453 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.453 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.452 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.452 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.452 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.452 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.452 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.452 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 4n9i | PCG | Catabolite expression activator | / | 0.452 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.451 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.451 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.451 | |
| 2y4g | TIR | TamL | / | 0.451 | |
| 3ieu | GDP | GTPase Era | / | 0.451 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.451 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.451 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.451 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.451 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.451 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.451 | |
| 5a3c | NAD | SIR2 family protein | / | 0.451 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1kfc | IPL | Tryptophan synthase alpha chain | / | 0.450 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.450 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.450 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.450 | |
| 4q5j | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.450 | |
| 4z0h | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic | 1.2.1.12 | 0.450 | |
| 1yt0 | ADP | Endoplasmin | / | 0.449 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.449 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.449 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.449 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.449 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.449 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 4f65 | 0S9 | Fibroblast growth factor receptor 1 | / | 0.449 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.448 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.448 | |
| 2zv2 | 609 | Calcium/calmodulin-dependent protein kinase kinase 2 | 2.7.11.17 | 0.448 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3pj8 | 404 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 1c70 | L75 | Protease | / | 0.447 | |
| 1ha3 | MAU | Elongation factor Tu-A | / | 0.447 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.447 | |
| 2cgv | 3B3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.447 | |
| 3ha3 | SAH | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.447 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.447 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 4ein | NOH | Thymidylate synthase | 2.1.1.45 | 0.447 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.447 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.446 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.446 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2qa2 | FAD | Polyketide oxygenase CabE | / | 0.446 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.446 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.446 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.446 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.446 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.446 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.445 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.445 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.445 | |
| 1kzk | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1me8 | RVP | Inosine-5'-monophosphate dehydrogenase | / | 0.445 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2ejz | SAH | Diphthine synthase | / | 0.445 | |
| 2ohv | NHL | Glutamate racemase | / | 0.445 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.445 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.445 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.445 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.444 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.444 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.444 | |
| 3hwr | NDP | 2-dehydropantoate 2-reductase | / | 0.444 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.444 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.444 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.444 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.444 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.444 | |
| 4rnu | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.444 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.444 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.443 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.443 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.443 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.443 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.443 | |
| 4er7 | AW3 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.443 | |
| 4fg8 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.443 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.443 | |
| 4kc4 | WS3 | Histo-blood group ABO system transferase | / | 0.443 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.443 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.442 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.442 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 2avv | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.442 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.442 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.442 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3a6r | FMN | FMN-binding protein | / | 0.442 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3ime | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.442 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4tmb | FMN | Old yellow enzyme | / | 0.442 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 5c41 | ACP | Ribokinase | / | 0.442 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.441 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 1vc2 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.441 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.441 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.441 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.441 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3ggx | GGX | Gag-Pol polyprotein | / | 0.441 | |
| 3kfr | 3TL | Gag-Pol polyprotein | / | 0.441 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.441 | |
| 3upf | 0BU | Polyprotein | / | 0.441 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.441 | |
| 4fv6 | E57 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.441 | |
| 4oae | CLM | Uncharacterized protein | / | 0.441 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.441 | |
| 4u03 | GTP | Cyclic GMP-AMP synthase | / | 0.441 | |
| 5eyp | LOC | Tubulin beta chain | / | 0.441 | |
| 1dc6 | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.440 | |
| 1ihx | SND | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.440 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.440 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.440 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 2pvy | ACP | Fibroblast growth factor receptor 2 | / | 0.440 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.440 | |
| 3hrc | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.440 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.440 |