sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 1.000 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.535 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.516 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.514 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.502 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.499 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 2dxw | SAH | Diphthine synthase | / | 0.493 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.492 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.491 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.490 | |
| 2p5c | SAH | Diphthine synthase | / | 0.488 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.487 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.487 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.486 | |
| 2dxv | SAH | Diphthine synthase | / | 0.485 | |
| 1wng | SAH | Diphthine synthase | / | 0.484 | |
| 2el0 | SAH | Diphthine synthase | / | 0.483 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.483 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.483 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.483 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.482 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.482 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.482 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.481 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.481 | |
| 2emr | SAH | Diphthine synthase | / | 0.481 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.481 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.480 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.480 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.480 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.480 | |
| 2p6k | SAH | Diphthine synthase | / | 0.479 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.479 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.479 | |
| 2huq | SAH | Diphthine synthase | / | 0.478 | |
| 2owg | SAH | Diphthine synthase | / | 0.478 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.478 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.478 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.477 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.476 | |
| 2egl | SAH | Diphthine synthase | / | 0.476 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.476 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.476 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.475 | |
| 2dsi | SAH | Diphthine synthase | / | 0.475 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.475 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.475 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.475 | |
| 2hux | SAH | Diphthine synthase | / | 0.475 | |
| 2p9d | SAH | Diphthine synthase | / | 0.475 | |
| 2dxx | SAH | Diphthine synthase | / | 0.474 | |
| 2e16 | SAH | Diphthine synthase | / | 0.473 | |
| 2p5f | SAH | Diphthine synthase | / | 0.473 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.473 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.472 | |
| 2ejk | SAH | Diphthine synthase | / | 0.472 | |
| 2pb5 | SAH | Diphthine synthase | / | 0.472 | |
| 2pcm | SAH | Diphthine synthase | / | 0.472 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.472 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.472 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.472 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.471 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.471 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.471 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.471 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.471 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.471 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.471 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.470 | |
| 2egs | SAH | Diphthine synthase | / | 0.470 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.470 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.470 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.470 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.470 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.469 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.469 | |
| 2eni | SAH | Diphthine synthase | / | 0.469 | |
| 2owk | SAH | Diphthine synthase | / | 0.469 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.469 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.468 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.468 | |
| 2e07 | SAH | Diphthine synthase | / | 0.468 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.468 | |
| 3suf | SUE | Polyprotein | / | 0.468 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.468 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.467 | |
| 2e8s | SAH | Diphthine synthase | / | 0.467 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.467 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.467 | |
| 2z6r | SAH | Diphthine synthase | / | 0.467 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.467 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.467 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.466 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.466 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.466 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.466 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 2e17 | SAH | Diphthine synthase | / | 0.465 | |
| 2fhj | H4Z | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.465 | |
| 4dja | FAD | (6-4) photolyase | / | 0.465 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.465 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.464 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.464 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.464 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.464 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.464 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.464 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.464 | |
| 2dsg | SAH | Diphthine synthase | / | 0.463 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.463 | |
| 2owu | SAH | Diphthine synthase | / | 0.463 | |
| 3a3g | DLZ | Lumazine protein | / | 0.463 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.463 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.463 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.462 | |
| 2p2x | SAH | Diphthine synthase | / | 0.462 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.461 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 2ele | SAH | Diphthine synthase | / | 0.461 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.461 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.461 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.461 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.461 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.461 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.460 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.460 | |
| 2dek | SAH | Diphthine synthase | / | 0.460 | |
| 2e8h | SAH | Diphthine synthase | / | 0.460 | |
| 2en5 | SAH | Diphthine synthase | / | 0.460 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.460 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.460 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.460 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.460 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.460 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.460 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.459 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.459 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.459 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.459 | |
| 1vce | SAH | Diphthine synthase | / | 0.458 | |
| 2ejj | SAH | Diphthine synthase | / | 0.458 | |
| 2hut | SAH | Diphthine synthase | / | 0.458 | |
| 2huv | SAH | Diphthine synthase | / | 0.458 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.458 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.458 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.458 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.458 | |
| 4irn | FAD | AnaB | / | 0.458 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.457 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.457 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.457 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.457 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.457 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.457 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.457 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.457 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.457 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.456 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.456 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 1qr6 | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.456 | |
| 2pca | SAH | Diphthine synthase | / | 0.456 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.456 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.456 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.456 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.456 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.456 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.456 | |
| 1gal | FAD | Glucose oxidase | 1.1.3.4 | 0.455 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 1ja0 | FMN | NADPH--cytochrome P450 reductase | / | 0.455 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.455 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.455 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.455 | |
| 2e8q | SAH | Diphthine synthase | / | 0.455 | |
| 2eka | SAH | Diphthine synthase | / | 0.455 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.455 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.455 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.455 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.455 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.454 | |
| 2p6i | SAH | Diphthine synthase | / | 0.454 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.454 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.454 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.453 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.453 | |
| 2e08 | SAH | Diphthine synthase | / | 0.453 | |
| 2emu | SAH | Diphthine synthase | / | 0.453 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.453 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.453 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.453 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.453 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.453 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.453 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.452 | |
| 2e8r | SAH | Diphthine synthase | / | 0.452 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.452 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.452 | |
| 2p6d | SAH | Diphthine synthase | / | 0.452 | |
| 2qn7 | HBZ | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.452 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.452 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.452 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.452 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.452 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.452 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.452 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.452 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.452 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.452 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.452 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.452 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.451 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2e15 | SAH | Diphthine synthase | / | 0.451 | |
| 2e4n | SAH | Diphthine synthase | / | 0.451 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.451 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.451 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.451 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.451 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.451 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.451 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.451 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.451 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.450 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.450 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.450 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.450 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.450 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.450 | |
| 5ez7 | FAD | Probable FAD-dependent oxidoreductase PA4991 | / | 0.450 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.449 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.449 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 1r2j | FAD | FkbI | / | 0.449 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.449 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.449 | |
| 2e7r | SAH | Diphthine synthase | / | 0.449 | |
| 2eeq | SAH | Diphthine synthase | / | 0.449 | |
| 2ek3 | SAH | Diphthine synthase | / | 0.449 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.449 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.449 | |
| 2qen | ADP | Walker-Type ATPase | / | 0.449 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.449 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.449 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.449 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.449 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.448 | |
| 1u33 | LM2 | Pancreatic alpha-amylase | / | 0.448 | |
| 1uxk | NAD | Malate dehydrogenase | / | 0.448 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.448 | |
| 2ek4 | SAH | Diphthine synthase | / | 0.448 | |
| 2pci | SAH | Diphthine synthase | / | 0.448 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.448 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.448 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.448 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.448 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.447 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.447 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.447 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.447 | |
| 2ehl | SAH | Diphthine synthase | / | 0.447 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.447 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.447 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.447 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.447 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.447 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.447 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.447 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.447 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.447 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.447 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.447 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.446 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.446 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 2egb | SAH | Diphthine synthase | / | 0.446 | |
| 2eld | SAH | Diphthine synthase | / | 0.446 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.446 | |
| 2o12 | FMN | Chorismate synthase | / | 0.446 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.446 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.446 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.446 | |
| 2xy3 | DUP | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.446 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.446 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.446 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.446 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.446 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 5a01 | 12V | O-glycosyltransferase | / | 0.446 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.446 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.445 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.445 | |
| 2qw0 | 34Z | 4-chlorobenzoyl CoA ligase | / | 0.445 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.445 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.445 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.445 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.445 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.445 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.445 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.445 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.445 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.444 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.444 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.444 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.444 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.444 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.444 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.444 | |
| 2y3s | TIR | TamL | / | 0.444 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.444 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.444 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.444 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.444 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.443 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.443 | |
| 2el3 | SAH | Diphthine synthase | / | 0.443 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.443 | |
| 2o4c | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.443 | |
| 2pcg | SAH | Diphthine synthase | / | 0.443 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.443 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.443 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.443 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.443 | |
| 3fst | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.443 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.443 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.443 | |
| 4hxy | NDP | Plm1 | / | 0.443 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.443 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.442 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.442 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.442 | |
| 1nbo | NAD | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.442 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.442 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.442 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.442 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.442 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.442 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.442 | |
| 3zhb | NAP | Putative dehydrogenase | / | 0.442 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.442 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.442 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1ie3 | NAD | Malate dehydrogenase | / | 0.441 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.441 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.441 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.441 | |
| 2eh2 | SAH | Diphthine synthase | / | 0.441 | |
| 2ohv | NHL | Glutamate racemase | / | 0.441 | |
| 2pck | SAH | Diphthine synthase | / | 0.441 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.441 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.441 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.441 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.441 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.441 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.440 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.440 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.440 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.440 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.440 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.440 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.440 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.440 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.440 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.440 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.440 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.440 | |
| 2owv | SAH | Diphthine synthase | / | 0.440 | |
| 2pch | SAH | Diphthine synthase | / | 0.440 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.440 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.440 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.440 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.440 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.440 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.440 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.440 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.440 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.440 |