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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2iqdLPAAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2iqdLPAAldose reductase1.1.1.211.000
2inzOHPAldose reductase1.1.1.210.887
2pdyFIDAldose reductase1.1.1.210.700
2iki388Aldose reductase1.1.1.210.681
3ghrLDTAldose reductase1.1.1.210.667
2fz8ZSTAldose reductase1.1.1.210.661
2dv0ZSTAldose reductase1.1.1.210.659
3ghsLDTAldose reductase1.1.1.210.655
3ld5LDTAldose reductase1.1.1.210.645
2pdwFIDAldose reductase1.1.1.210.638
1el3I84Aldose reductase1.1.1.210.633
2f2kTGGAldose reductase1.1.1.210.629
3s3gTLTAldose reductase1.1.1.210.629
2fz9ZSTAldose reductase1.1.1.210.628
3m64393Aldose reductase1.1.1.210.628
3u2cSUZAldose reductase1.1.1.210.627
2i17LDTAldose reductase1.1.1.210.625
4gca2X9Aldose reductase1.1.1.210.622
2ikj393Aldose reductase1.1.1.210.621
2i16LDTAldose reductase1.1.1.210.614
2agtFIDAldose reductase1.1.1.210.613
2hv5ZSTAldose reductase1.1.1.210.610
1z3n3NAAldose reductase1.1.1.210.600
1ieiZESAldose reductase1.1.1.210.598
2pdmZSTAldose reductase1.1.1.210.586
2is72CLAldose reductase1.1.1.210.585
4ga8SBIAldo-keto reductase family 1 member B101.1.10.583
1z8962PAldose reductase1.1.1.210.582
2pdkSBIAldose reductase1.1.1.210.582
5liu388Aldo-keto reductase family 1 member B101.1.10.582
1t40ID5Aldose reductase1.1.1.210.577
2pdp393Aldose reductase1.1.1.210.577
3lz5LDTAldose reductase1.1.1.210.574
3p2vDOYAldose reductase1.1.1.210.570
2pzn393Aldose reductase1.1.1.210.565
1ah0SBIAldose reductase1.1.1.210.564
2pdu393Aldose reductase1.1.1.210.563
3v35NTIAldose reductase1.1.1.210.562
2nvcITAAldose reductase1.1.1.210.561
3m4h388Aldose reductase1.1.1.210.561
3lenZSTAldose reductase1.1.1.210.556
3lqlLDTAldose reductase1.1.1.210.556
2pd9FIDAldose reductase1.1.1.210.552
3g5eQ74Aldose reductase1.1.1.210.551
1t41ID5Aldose reductase1.1.1.210.550
1pwlBFIAldose reductase1.1.1.210.549
4gabFIDAldo-keto reductase family 1 member B101.1.10.548
2qxwLDTAldose reductase1.1.1.210.547
2pdxZSTAldose reductase1.1.1.210.544
3ghuLDTAldose reductase1.1.1.210.543
4wevSUZAldo-keto reductase family 1 member B101.1.10.542
4yu153NAldose reductase1.1.1.210.542
2fzdTOLAldose reductase1.1.1.210.539
3mc5393Aldose reductase1.1.1.210.539
2ikhLITAldose reductase1.1.1.210.538
4dbs0HVAldo-keto reductase family 1 member C3/0.532
1us0LDTAldose reductase1.1.1.210.530
2duxZSTAldose reductase1.1.1.210.530
3t423T4Aldose reductase1.1.1.210.530
2pdbZSTAldose reductase1.1.1.210.527
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.523
4xo7ASDAldo-keto reductase family 1 member C2/0.522
2pdc393Aldose reductase1.1.1.210.519
3m0iZSTAldose reductase1.1.1.210.518
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.518
4i5xFLFAldo-keto reductase family 1 member B101.1.10.512
1obnASVIsopenicillin N synthase1.21.3.10.510
1frbZSTAldose reductase-related protein 2/0.508
2f3815MAldo-keto reductase family 1 member C3/0.508
2pb1NFGGlucan 1,3-beta-glucosidase/0.508
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.508
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.507
1xf0ASDAldo-keto reductase family 1 member C3/0.502
2ckmAA7Acetylcholinesterase3.1.1.70.502
2pd5ZSTAldose reductase1.1.1.210.502
4jtrIBPAldo-keto reductase family 1 member C2/0.501
1bk0ACVIsopenicillin N synthase1.21.3.10.499
4c49HCYCorticosteroid-binding globulin/0.498
1zq5E04Aldo-keto reductase family 1 member C3/0.497
2fzbTOLAldose reductase1.1.1.210.497
3zkyWT4Isopenicillin N synthase1.21.3.10.497
2gg0U11Methionine aminopeptidase/0.496
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.496
4jq4IMNAldo-keto reductase family 1 member C2/0.494
3qeoLLTDeoxycytidine kinase2.7.1.740.493
1ry0PG2Aldo-keto reductase family 1 member C3/0.492
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.492
2vbpVB1Isopenicillin N synthase1.21.3.10.491
4fa30SLAldo-keto reductase family 1 member C3/0.491
4dbw511Aldo-keto reductase family 1 member C3/0.490
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.490
2jf0HBPAcetylcholinesterase3.1.1.70.489
4u150HKMuscarinic acetylcholine receptor M3/0.489
2gg8U15Methionine aminopeptidase/0.488
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.488
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.488
2cbqTH2Neocarzinostatin/0.487
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.487
1w4lGL8Acetylcholinesterase3.1.1.70.486
4wljIK2Kynurenine--oxoglutarate transaminase 12.6.1.70.486
1ah3TOLAldose reductase1.1.1.210.485
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.485
1ry8RUTAldo-keto reductase family 1 member C3/0.485
2bjsACVIsopenicillin N synthase1.21.3.10.485
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.485
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.485
2iviACWIsopenicillin N synthase1.21.3.10.484
2vcmM11Isopenicillin N synthase1.21.3.10.484
3uonQNBMuscarinic acetylcholine receptor M2/0.483
1qtiGNTAcetylcholinesterase3.1.1.70.482
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.482
4kfqKFQGlutamate receptor ionotropic, NMDA 1/0.482
1pqc444Oxysterols receptor LXR-beta/0.481
1s36CEIObelin/0.481
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.481
1hb3SCVIsopenicillin N synthase1.21.3.10.480
1mrqSTRAldo-keto reductase family 1 member C1/0.480
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.480
2cekN8TAcetylcholinesterase3.1.1.70.480
2gg3U13Methionine aminopeptidase/0.480
2w6qOA5Biotin carboxylase6.3.4.140.480
2xugTZ4Acetylcholinesterase3.1.1.70.479
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.479
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.479
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.478
3uyk0CXProbable NDP-rhamnosyltransferase/0.478
2xujTZ5Acetylcholinesterase3.1.1.70.477
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.477
3pkdY10Methionine aminopeptidase 2/0.477
4kn0MTXFolate receptor beta/0.477
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.476
1p0pBCHCholinesterase3.1.1.80.476
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.476
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.476
3iu9T07Methionine aminopeptidase 2/0.476
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.475
2qimZEAClass 10 plant pathogenesis-related protein/0.475
2xuhTZ4Acetylcholinesterase3.1.1.70.475
3fvuIACKynurenine--oxoglutarate transaminase 12.6.1.70.475
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.475
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.475
5dsg0HKMuscarinic acetylcholine receptor M4/0.475
3pkeY10Methionine aminopeptidase 2/0.474
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.474
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
4ey6GNTAcetylcholinesterase3.1.1.70.474
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.473
2c2bSAMThreonine synthase 1, chloroplastic4.2.3.10.473
3iu7FCDMethionine aminopeptidase 2/0.473
1dx6GNTAcetylcholinesterase3.1.1.70.472
2xnvVU3Soluble acetylcholine receptor/0.472
4hcy0YNTransketolase/0.472
4mqt2CUMuscarinic acetylcholine receptor M2/0.472
1afsTES3-alpha-hydroxysteroid dehydrogenase1.1.1.500.471
1el4CTZObelin/0.471
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.471
1qiqACCIsopenicillin N synthase1.21.3.10.471
1rxjBNIStreptavidin/0.471
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.471
4bfsZVSPantothenate kinase2.7.1.330.471
4paaTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.471
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.470
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.470
1jumBERHTH-type transcriptional regulator QacR/0.470
1t7o152Carnitine O-acetyltransferase2.3.1.70.470
1yw8A75Methionine aminopeptidase 2/0.470
2g263LGRenin3.4.23.150.470
3iu8T03Methionine aminopeptidase 2/0.470
3r6iJMSAldo-keto reductase family 1 member C3/0.470
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.470
2fs4PZ1Renin3.4.23.150.469
4fam0SZAldo-keto reductase family 1 member C3/0.469
1kmsLIHDihydrofolate reductase1.5.1.30.468
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.468
1upw444Oxysterols receptor LXR-beta/0.468
2q94A04Methionine aminopeptidase/0.468
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.468
4q0kGA3Phytohormone-binding protein/0.468
1blzACVIsopenicillin N synthase1.21.3.10.467
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.467
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.467
2jl1NAPTriphenylmethane reductase/0.467
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.467
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.300.467
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.467
3q9bB3NAcetylpolyamine amidohydrolase/0.467
1lnmDTXBilin-binding protein/0.466
1q83TZ5Acetylcholinesterase3.1.1.70.466
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.466
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
1zuaTOLAldo-keto reductase family 1 member B101.1.10.466
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.466
2xukTZ5Acetylcholinesterase3.1.1.70.466
2xuqTZ4Acetylcholinesterase3.1.1.70.466
3r8hZOMAldo-keto reductase family 1 member C3/0.466
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.466
3zv7NHGAcetylcholinesterase3.1.1.70.466
4iksTFDMethionine aminopeptidase 1/0.466
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.465
1kw6BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.465
1qv0CZHObelin/0.465
1uzwCDHIsopenicillin N synthase1.21.3.10.465
1w6rGNTAcetylcholinesterase3.1.1.70.465
2gmuPDGPutative pyridoxamine 5-phosphate-dependent dehydrase/0.465
2gywOBIAcetylcholinesterase3.1.1.70.465
2xupTZ5Acetylcholinesterase3.1.1.70.465
3gyf51PDihydrofolate reductase1.5.1.30.465
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.465
4hmn16JAldo-keto reductase family 1 member C3/0.465
4n9qFMNFMN-dependent NADH-azoreductase 1/0.465
1hfrMOTDihydrofolate reductase1.5.1.30.464
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
2evmFC2Methionine aminopeptidase/0.464
2ha6SCKAcetylcholinesterase3.1.1.70.464
2y60M8FIsopenicillin N synthase1.21.3.10.464
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
3n0hTOPDihydrofolate reductase1.5.1.30.464
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.464
3znqSS8D-amino-acid oxidase1.4.3.30.464
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
1ihiIU5Aldo-keto reductase family 1 member C2/0.463
2ggbU17Methionine aminopeptidase/0.463
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.463
2nvdITBAldose reductase1.1.1.210.463
2w6cBM4Acetylcholinesterase3.1.1.70.463
2xlpNAPPutative flavin-containing monooxygenase/0.463
2xuoTZ4Acetylcholinesterase3.1.1.70.463
3aosJH2Hemolymph juvenile hormone binding protein/0.463
3rgzBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.463
1vfsDCSAlanine racemase/0.462
2cmfF11Acetylcholinesterase3.1.1.70.462
2ct8MSPMethionine--tRNA ligase6.1.1.100.462
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.462
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.462
3cv7C2UAlcohol dehydrogenase [NADP(+)]1.1.1.20.462
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.462
3mjrAC2Deoxycytidine kinase2.7.1.740.462
4dyp0MSNucleoprotein/0.462
4qtnNNRNicotinamide riboside transporter PnuC/0.462
1acjTHAAcetylcholinesterase3.1.1.70.461
1kw8BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.461
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
4pnmNU1Tankyrase-22.4.2.300.461
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.460
2aot2PMHistamine N-methyltransferase2.1.1.80.460
2ipjFFAAldo-keto reductase family 1 member C2/0.460
2y6fM9FIsopenicillin N synthase1.21.3.10.460
3b9gIMHIAG-nucleoside hydrolase/0.460
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.460
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
4dyn0MRNucleoprotein/0.460
4nqgCZHMitrocomin/0.460
4u140HKMuscarinic acetylcholine receptor M3/0.460
1ef3FIDAldose reductase1.1.1.210.459
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.459
1rkwPNTHTH-type transcriptional regulator QacR/0.459
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.459
2ipw2CLAldose reductase1.1.1.210.459
2wo7ASVIsopenicillin N synthase1.21.3.10.459
2xufTZ4Acetylcholinesterase3.1.1.70.459
3jq7DX2Pteridine reductase, putative/0.459
3ug8IMNAldo-keto reductase family 1 member C3/0.459
4lngJANCaaX farnesyltransferase beta subunit Ram1/0.459
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.459
5ds309LPoly [ADP-ribose] polymerase 12.4.2.300.459
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.458
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.458
2d06ESTSulfotransferase 1A12.8.2.10.458
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.458
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.458
4m0f1YKAcetylcholinesterase3.1.1.70.458
4usqFADPyridine nucleotide-disulfide oxidoreductase/0.458
1hb1OCVIsopenicillin N synthase1.21.3.10.457
1s1rNAPAldo-keto reductase family 1 member C3/0.457
1zgbA1EAcetylcholinesterase3.1.1.70.457
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.457
3s3vTOPDihydrofolate reductase1.5.1.30.457
3sfxJANUncharacterized protein/0.457
3stdMQ0Scytalone dehydratase4.2.1.940.457
4iktTFVMethionine aminopeptidase 1/0.457
4m6l21VDihydrofolate reductase1.5.1.30.457
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.456
2aovC2MHistamine N-methyltransferase2.1.1.80.456
3c3xNAPEugenol synthase 11.1.1.3180.456
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.456
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.456
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
3sfy3FYUncharacterized protein/0.456
4g8cC6LAlpha/beta hydrolase fold protein/0.456
4itxIN5Cystathionine beta-lyase MetC4.4.1.80.456
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4tjy3GNTankyrase-22.4.2.300.456
1amoFMNNADPH--cytochrome P450 reductase/0.455
1oc1ASVIsopenicillin N synthase1.21.3.10.455
1sjwNGVNogalonic acid methyl ester cyclase/0.455
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.455
2hvoZSTAldose reductase1.1.1.210.455
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.455
2q92B23Methionine aminopeptidase/0.455
3dr7GPDGDP-perosamine synthase/0.455
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.455
1fxvPNNPenicillin G acylase3.5.1.110.454
1gpnHUBAcetylcholinesterase3.1.1.70.454
1qvtPRLHTH-type transcriptional regulator QacR/0.454
2g1o2IGRenin3.4.23.150.454
2g5w8PG12-oxophytodienoate reductase 31.3.1.420.454
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.454
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
3q7fED2Uncharacterized protein/0.454
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.454
4bfwZVWPantothenate kinase2.7.1.330.454
4bjcRPBTankyrase-22.4.2.300.454
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.454
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.454
4qa0SHHHistone deacetylase 83.5.1.980.454
5cxv0HKMuscarinic acetylcholine receptor M1/0.454
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.580.453
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.453
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.453
2q93B21Methionine aminopeptidase/0.453
3zkuHCVIsopenicillin N synthase1.21.3.10.453
4dya0MFNucleoprotein/0.453
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.453
1az1ALRAldose reductase1.1.1.210.452
1swtBTNStreptavidin/0.452
2bd0BIOSepiapterin reductase/0.452
3f3y4OABile salt sulfotransferase2.8.2.140.452
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.452
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
3pqbVGPPutative oxidoreductase/0.452
4dk70KSOxysterols receptor LXR-beta/0.452
4jq3ZOMAldo-keto reductase family 1 member C2/0.452
5stdUNNScytalone dehydratase4.2.1.940.452
1h22E10Acetylcholinesterase3.1.1.70.451
1ohjCOPDihydrofolate reductase1.5.1.30.451
1s7gNADNAD-dependent protein deacylase 2/0.451
2jb4A14Isopenicillin N synthase1.21.3.10.451
2zsbADPPantothenate kinase2.7.1.330.451
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.451
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.451
3zoiM2WIsopenicillin N synthase1.21.3.10.451
4arbC57Acetylcholinesterase3.1.1.70.451
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.451
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.451
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.451
1gjrFADFerredoxin--NADP reductase1.18.1.20.450
1m2xMCOMetallo-beta-lactamase type 2/0.450
1q84TZ4Acetylcholinesterase3.1.1.70.450
1rkpIBMcGMP-specific 3',5'-cyclic phosphodiesterase/0.450
2evcFC3Methionine aminopeptidase/0.450
2jgsBTNAvidin/0.450
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
2p99YE6Methionine aminopeptidase/0.450
2v9cMREFMN-dependent NADH-azoreductase 1/0.450
2wmdZZ0NmrA-like family domain-containing protein 1/0.450
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4jlm1NNDeoxycytidine kinase2.7.1.740.450
4jtqFLPAldo-keto reductase family 1 member C2/0.450
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.450
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.449
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.449
1xngDNDNH(3)-dependent NAD(+) synthetase6.3.1.50.449
2tplHPPTyrosine phenol-lyase4.1.99.20.449
3r8gIZPAldo-keto reductase family 1 member C3/0.449
4bb3KKAIsopenicillin N synthase1.21.3.10.449
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
4ikuSHXMethionine aminopeptidase 1/0.449
4jqaID8Aldo-keto reductase family 1 member C2/0.449
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
4mv1ADPBiotin carboxylase6.3.4.140.449
4u163C0Muscarinic acetylcholine receptor M3/0.449
1ej3CZHAequorin-2/0.448
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.448
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.448
1osvCHCBile acid receptor/0.448
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
1x2bSTXProline iminopeptidase3.4.11.50.448
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.448
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.448
2xuiTZ5Acetylcholinesterase3.1.1.70.448
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.448
3pkbY16Methionine aminopeptidase 2/0.448
3t0kDCQSulfide-quinone reductase/0.448
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
4jq2SUZAldo-keto reductase family 1 member C2/0.448
4qofFMNRibosyldihydronicotinamide dehydrogenase [quinone]/0.448
1ot7IU5Bile acid receptor/0.447
1pwyAC2Purine nucleoside phosphorylase2.4.2.10.447
1s63778Protein farnesyltransferase subunit beta2.5.1.580.447
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.447
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.447
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
2pdfZSTAldose reductase1.1.1.210.447
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.447
3i9kNADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase3.2.2.60.447
4fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.447
4fapARDSerine/threonine-protein kinase mTOR2.7.11.10.447
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.447
4m4821BSodium-dependent dopamine transporter/0.447
1dpmEBPParathion hydrolase3.1.8.10.446
1enpNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.446
2gevCOKPantothenate kinase2.7.1.330.446
2vroNDP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase/0.446
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3nmpPYVAbscisic acid receptor PYL2/0.446
3pkaY02Methionine aminopeptidase 2/0.446
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4b7zQ4QAcetylcholinesterase3.1.1.70.446
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4bftZVTPantothenate kinase2.7.1.330.446
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.446
3d4sTIMBeta-2 adrenergic receptor/0.446
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.445
1gm8SOXPenicillin G acylase3.5.1.110.445
1pq6965Oxysterols receptor LXR-beta/0.445
1w06W05Isopenicillin N synthase1.21.3.10.445
1x8lOXRRetinol dehydratase/0.445
2j3qTFLAcetylcholinesterase3.1.1.70.445
2q96A18Methionine aminopeptidase/0.445
3g72A6TRenin3.4.23.150.445
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.445
3szfDCQSulfide-quinone reductase/0.445
4a33PS8Glycylpeptide N-tetradecanoyltransferase/0.445
4dbuBT9Aldo-keto reductase family 1 member C3/0.445
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
4jtrIZPAldo-keto reductase family 1 member C2/0.445
4p9dTMPDeoxycytidylate deaminase/0.445
4stdBFSScytalone dehydratase4.2.1.940.445
1mvsDTMDihydrofolate reductase1.5.1.30.444
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.444
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.444
1vkgCRIHistone deacetylase 83.5.1.980.444
1x2eATXProline iminopeptidase3.4.11.50.444
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.444
2w3mFOLDihydrofolate reductase1.5.1.30.444
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.444
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.444
4f79P53Putative phospho-beta-glucosidase/0.444
4xczT3QQdtf/0.444
4yfy0FXVioF/0.444
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.444
5jqhCAUBeta-2 adrenergic receptor/0.444
1gt5BZQOdorant-binding protein/0.443
1lkeDOGBilin-binding protein/0.443
1odnAPVIsopenicillin N synthase1.21.3.10.443
1qv1CZHObelin/0.443
1sm4FADFerredoxin--NADP reductase/0.443
1u65CP0Acetylcholinesterase3.1.1.70.443
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.443
1votHUPAcetylcholinesterase3.1.1.70.443
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2hpsCTZCa2+-triggered coelenterazine-binding protein 1/0.443
2vq7NAPPutative flavin-containing monooxygenase/0.443
2vrbNAPTriphenylmethane reductase/0.443
2xi4AFTAcetylcholinesterase3.1.1.70.443
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3l3lL3LPoly [ADP-ribose] polymerase 12.4.2.300.443
3qftFADNADPH--cytochrome P450 reductase/0.443
4b65NDPL-ornithine N(5)-monooxygenase/0.443
4n65FMNFMN-dependent NADH-azoreductase 1/0.443
3emlZMAAdenosine receptor A2a/0.443
1odcA8BAcetylcholinesterase3.1.1.70.442
1xnzFCDMethionine aminopeptidase/0.442
2aj4ANPGalactokinase2.7.1.60.442
2gvcFADThiol-specific monooxygenase1.14.130.442
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.442
2pdiZSTAldose reductase1.1.1.210.442
2pdlTOLAldose reductase1.1.1.210.442
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.442
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.442
3aklADPSerine/threonine-protein kinase CtkA2.7.11.10.442
3d27W29Methionine aminopeptidase/0.442
3hggCHDCmeR/0.442
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.442
4b5nFMNNAD(P)H:flavin oxidoreductase Sye4/0.442
4dz5NAPAldo-keto reductase family 1 member C3/0.442
1cjkFOKAdenylate cyclase type 2/0.441
1cjkFOKAdenylate cyclase type 5/0.441
1dlsMTXDihydrofolate reductase1.5.1.30.441
1fmlRTLRetinol dehydratase/0.441
1o5gCR9Prothrombin3.4.21.50.441
1pq944BOxysterols receptor LXR-beta/0.441
2fzjDH3Dihydrofolate reductase1.5.1.30.441
2g1n1IGRenin3.4.23.150.441
2g274LGRenin3.4.23.150.441
2vt4P32Beta-1 adrenergic receptor/0.441
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.441
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.441
4lrrCF9Thymidylate synthase/0.441
4x9dU5PUncharacterized protein MJ1435/0.441
4zvlFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.441
1c23MPHMethionine aminopeptidase/0.440
1ja1FMNNADPH--cytochrome P450 reductase/0.440
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.440
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
1pwmFIDAldose reductase1.1.1.210.440
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2aouCQAHistamine N-methyltransferase2.1.1.80.440
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.440
2gv8NDPThiol-specific monooxygenase1.14.130.440
2gyuHI6Acetylcholinesterase3.1.1.70.440
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.440
2zseACPPantothenate kinase2.7.1.330.440
3ekuCY9Actin-5C/0.440
3gamMXXRibosyldihydronicotinamide dehydrogenase [quinone]/0.440
3nfrEWQRibosyldihydronicotinamide dehydrogenase [quinone]/0.440
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4fllYZ6Methionine aminopeptidase 1/0.440
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
4rxrDCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.440