sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2gg2 | U12 | Methionine aminopeptidase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2gg2 | U12 | Methionine aminopeptidase | / | 1.000 | |
| 2q96 | A18 | Methionine aminopeptidase | / | 0.753 | |
| 2q93 | B21 | Methionine aminopeptidase | / | 0.726 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.674 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.670 | |
| 2p98 | YE7 | Methionine aminopeptidase | / | 0.663 | |
| 2gg3 | U13 | Methionine aminopeptidase | / | 0.661 | |
| 1xnz | FCD | Methionine aminopeptidase | / | 0.651 | |
| 2evc | FC3 | Methionine aminopeptidase | / | 0.646 | |
| 2q92 | B23 | Methionine aminopeptidase | / | 0.644 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.636 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.627 | |
| 2ggb | U17 | Methionine aminopeptidase | / | 0.627 | |
| 3d27 | W29 | Methionine aminopeptidase | / | 0.611 | |
| 3iu8 | T03 | Methionine aminopeptidase 2 | / | 0.611 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.603 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.593 | |
| 2gg9 | U16 | Methionine aminopeptidase | / | 0.590 | |
| 2g6p | HM2 | Methionine aminopeptidase 1 | / | 0.583 | |
| 2gg8 | U15 | Methionine aminopeptidase | / | 0.572 | |
| 4iks | TFD | Methionine aminopeptidase 1 | / | 0.566 | |
| 4iku | SHX | Methionine aminopeptidase 1 | / | 0.564 | |
| 4ikt | TFV | Methionine aminopeptidase 1 | / | 0.561 | |
| 1c23 | MPH | Methionine aminopeptidase | / | 0.559 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.558 | |
| 4hxx | 1AY | Methionine aminopeptidase 1 | / | 0.552 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.542 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.541 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.538 | |
| 2nq7 | HM5 | Methionine aminopeptidase 1 | / | 0.534 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.531 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.529 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.524 | |
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.521 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.521 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.520 | |
| 3pkc | Y08 | Methionine aminopeptidase 2 | / | 0.520 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.520 | |
| 4ikr | PVP | Methionine aminopeptidase 1 | / | 0.519 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.518 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.517 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.516 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.512 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.511 | |
| 4flj | Y08 | Methionine aminopeptidase 1 | / | 0.510 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.507 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.503 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.500 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.500 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.498 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.497 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.496 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.496 | |
| 4fli | Y16 | Methionine aminopeptidase 1 | / | 0.492 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.490 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.490 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.489 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.488 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.487 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.487 | |
| 5fmm | MGT | Polymerase basic protein 2 | / | 0.487 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.486 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.486 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.485 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.485 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.484 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.484 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.484 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.484 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.483 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.482 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.481 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.479 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.479 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.479 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.478 | |
| 5erm | 210 | Fusicoccadiene synthase | 4.2.3.43 | 0.478 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.477 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.475 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.473 | |
| 2v57 | PRL | TetR family transcriptional regulator | / | 0.473 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.472 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.472 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.472 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.472 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.471 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.471 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.471 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.470 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.469 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.469 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.468 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.468 | |
| 3qdz | PRO_ALA_PRO_ARG | Prothrombin | 3.4.21.5 | 0.468 | |
| 2v9c | MRE | FMN-dependent NADH-azoreductase 1 | / | 0.467 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.467 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.467 | |
| 3zj6 | VM2 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.467 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.465 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.465 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.465 | |
| 3g5i | DNB | Pyrimidine-specific ribonucleoside hydrolase RihA | / | 0.465 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.464 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.464 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
| 4rxr | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.464 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 1qzy | TDE | Methionine aminopeptidase 2 | / | 0.463 | |
| 3myu | VIB | High affinity transport system protein p37 | / | 0.463 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.462 | |
| 4to0 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.462 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.461 | |
| 4q7f | 3D1 | Uncharacterized protein | / | 0.461 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.460 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.460 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 2wca | NP6 | O-GlcNAcase BT_4395 | / | 0.459 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.458 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.458 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.458 | |
| 5c80 | URI | Uridine phosphorylase | / | 0.458 | |
| 5ief | NBV | Neutral alpha-glucosidase AB | 3.2.1.84 | 0.458 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.457 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.456 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.456 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 4h0x | NAD | Iota toxin component Ia | / | 0.456 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3ab1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.455 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.455 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2bf4 | FMN | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 2rd6 | 78P | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.454 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.454 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.454 | |
| 3qbj | NXZ | Dipeptidyl peptidase 4 | / | 0.454 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.454 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.453 | |
| 2x91 | LPR | Angiotensin-converting enzyme | 3.4.15.1 | 0.453 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.453 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.453 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.453 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.453 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3vf2 | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.453 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 1by5 | GLY_GLY_GLY_AHO_AHO_AHO_FE | Ferrichrome-iron receptor | / | 0.452 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.452 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.452 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.452 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.452 | |
| 3oe9 | ITD | C-X-C chemokine receptor type 4 | / | 0.452 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.451 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.451 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.451 | |
| 2vd7 | PD2 | Lysine-specific demethylase 4A | 1.14.11 | 0.451 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.450 | |
| 1qpf | 858 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.450 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 3zm9 | QMQ | Choline kinase alpha | 2.7.1.32 | 0.450 | |
| 4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.450 | |
| 4tny | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.450 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 3hr4 | FMN | Nitric oxide synthase, inducible | 1.14.13.39 | 0.449 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.449 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.449 | |
| 3s8p | SAM | Histone-lysine N-methyltransferase KMT5B | 2.1.1.43 | 0.449 | |
| 3t0i | SAH | Putative methyltransferase | / | 0.449 | |
| 4cb5 | 93G | Polymerase basic protein 2 | / | 0.449 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.449 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.449 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.448 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.448 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.448 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.448 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.447 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.447 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.446 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.446 | |
| 2y1x | 845 | Histone-arginine methyltransferase CARM1 | / | 0.446 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.446 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 4d2d | ALA_ALA_ALA | Di-or tripeptide:H+ symporter | / | 0.446 | |
| 4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.446 | |
| 4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.446 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.445 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.445 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 3qfr | FMN | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.445 | |
| 4rxp | DTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.445 | |
| 4rxq | DUT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.445 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.445 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.444 | |
| 4m48 | 21B | Sodium-dependent dopamine transporter | / | 0.444 | |
| 4to4 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.443 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.443 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.443 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3lm1 | LEC | Agglutinin alpha chain | / | 0.443 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.442 | |
| 1xr2 | C2F | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase | 2.1.1.14 | 0.442 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.442 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3e78 | TPP | High affinity transport system protein p37 | / | 0.442 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.442 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.442 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.442 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.442 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.442 | |
| 1nl4 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1swg | BTN | Streptavidin | / | 0.441 | |
| 2a4x | BLM | Mitomycin-binding protein | / | 0.441 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3f8s | PF2 | Dipeptidyl peptidase 4 | / | 0.441 | |
| 3f90 | FMN | Flavodoxin | / | 0.441 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.441 | |
| 3juo | AJD | Phenazine biosynthesis protein A/B | / | 0.441 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.441 | |
| 4br3 | U85 | Choline kinase alpha | 2.7.1.32 | 0.441 | |
| 4drn | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.441 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.440 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.440 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.440 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4g1f | 0WG | Dipeptidyl peptidase 4 | / | 0.440 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.440 |