sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1p84 | UQ6 | Cytochrome b |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1p84 | UQ6 | Cytochrome b | / | 1.000 | |
| 1ezv | UQ6 | Cytochrome b | / | 0.647 | |
| 2ibz | UQ6 | Cytochrome b | / | 0.642 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.495 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.489 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.485 | |
| 1gth | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.484 | |
| 3ivg | FG5 | Pantothenate synthetase | 6.3.2.1 | 0.484 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.484 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.483 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.482 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.482 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.482 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.482 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.481 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.480 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.479 | |
| 5fkm | TDC | Tetracycline repressor protein class D | / | 0.478 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.477 | |
| 2trt | TAC | Tetracycline repressor protein class D | / | 0.476 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.476 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.475 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.475 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.474 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.474 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.473 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.472 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.471 | |
| 2xpv | MIY | Tetracycline repressor protein class D | / | 0.471 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.471 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.471 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.470 | |
| 2jk6 | FAD | Trypanothione reductase | / | 0.470 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.470 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.470 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.470 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.470 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.469 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.469 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.469 | |
| 4g3p | UD1 | Bifunctional protein GlmU | / | 0.468 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.468 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.468 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.467 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.467 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.467 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.467 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.467 | |
| 4ihl | 1F5 | 14-3-3 protein zeta/delta | / | 0.467 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.466 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.466 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.465 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.465 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.465 | |
| 4xj4 | 3AT | Cyclic GMP-AMP synthase | / | 0.465 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.464 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.464 | |
| 4d7m | TDC | Tetracycline repressor protein class D | / | 0.464 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.463 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.463 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.463 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.463 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 3bl7 | DD1 | m7GpppX diphosphatase | 3.6.1.59 | 0.462 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.462 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.461 | |
| 2vkv | TDC | Tetracycline repressor protein class D | / | 0.461 | |
| 2y3s | TIR | TamL | / | 0.461 | |
| 4abz | T1C | Tetracycline repressor protein class D | / | 0.461 | |
| 4h0y | LAR | Actin, alpha skeletal muscle | / | 0.461 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.461 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.460 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.460 | |
| 3ezr | EZR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 3fpj | SAM | Uncharacterized protein | / | 0.460 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.460 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.460 | |
| 5fkl | TDC | Tetracycline repressor protein class D | / | 0.460 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.459 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.459 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.459 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.459 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.459 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.459 | |
| 5emh | NAP | Iridoid synthase | 1.3.1.99 | 0.459 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.458 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.458 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.458 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.458 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.458 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.458 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.458 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.458 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.458 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.458 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.458 | |
| 5dcy | NAP | Iridoid synthase | 1.3.1.99 | 0.458 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1p0f | NAP | NADP-dependent alcohol dehydrogenase | 1.1.1.2 | 0.457 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.457 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.457 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.457 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.457 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.457 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.457 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.457 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.456 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.456 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.456 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.456 | |
| 2b56 | UTP | RNA editing complex protein MP57 | / | 0.456 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.456 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.456 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.455 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.455 | |
| 1hdg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.455 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.455 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.455 | |
| 3gst | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.455 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.455 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.455 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.455 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.455 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.455 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.454 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.454 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.454 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.454 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.454 | |
| 4yvz | 3AT | DNA integrity scanning protein DisA | / | 0.454 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.453 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.453 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.453 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.453 | |
| 3zuy | TCH | Transporter | / | 0.453 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.453 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.453 | |
| 5aga | ANP | DNA polymerase theta | / | 0.453 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.452 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.452 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.452 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.452 | |
| 3nyr | MLC | Putative fatty acid synthase | / | 0.452 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.452 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.452 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.451 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.451 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.451 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.451 | |
| 3mpt | 1GK | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 4die | C5P | Cytidylate kinase | / | 0.451 | |
| 4ng4 | ADP | Phosphoglycerate kinase | / | 0.451 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.451 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.450 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.450 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.450 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.450 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.450 | |
| 4f9f | GDP | Putative glycosyltransferase | / | 0.450 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.450 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.450 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.450 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.449 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.449 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.449 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.449 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.449 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.449 | |
| 3bmo | NAP | Pteridine reductase | / | 0.449 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.449 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.449 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.449 | |
| 3gob | HXX | DdmC | / | 0.449 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.449 | |
| 3id8 | MRK | Glucokinase | 2.7.1.2 | 0.449 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.449 | |
| 3u9e | COA | Lmo1369 protein | / | 0.449 | |
| 4l4x | NDP | AmphI | / | 0.449 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.449 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.449 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2eq6 | FAD | Dihydrolipoyl dehydrogenase | / | 0.448 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.448 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.448 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.448 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.448 | |
| 4aux | XTC | Tetracycline repressor protein class D | / | 0.448 | |
| 4dx9 | SER_ALA_VAL_THR | Integrin beta-1 | / | 0.448 | |
| 4dx9 | SER_ALA_VAL_THR | Integrin beta-1-binding protein 1 | / | 0.448 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.448 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.448 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1gii | 1PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 1p31 | EPU | UDP-N-acetylmuramate--L-alanine ligase | 6.3.2.8 | 0.447 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.447 | |
| 2gst | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.447 | |
| 2vzz | SCA | Putative succinyl-CoA transferase Rv0802c | 2.8.3 | 0.447 | |
| 2zja | ACP | ATP-dependent DNA helicase Hel308 | / | 0.447 | |
| 2zno | S44 | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.447 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.447 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.447 | |
| 4jnm | 1LJ | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.447 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.447 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.447 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.447 | |
| 1iy8 | NAD | Levodione reductase | / | 0.446 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.446 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.446 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.446 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.446 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.446 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.446 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.446 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.446 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.446 | |
| 4j97 | ACP | Fibroblast growth factor receptor 2 | / | 0.446 | |
| 4la1 | FAD | Thioredoxin glutathione reductase | / | 0.446 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.445 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.445 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.445 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.445 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.445 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.445 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.445 | |
| 1p2a | 5BN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.445 | |
| 1u28 | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.445 | |
| 1w0k | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.445 | |
| 1w0k | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.445 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.445 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.445 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3cin | NAD | Myo-inositol-1-phosphate synthase-related protein | / | 0.445 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.445 | |
| 3qw2 | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.445 | |
| 3tuc | FPW | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.445 | |
| 4bhw | 01K | Histone acetyltransferase p300 | / | 0.445 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.445 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.445 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4kto | FAD | Putative isovaleryl-CoA dehydrogenase protein | / | 0.445 | |
| 4lk3 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.445 | |
| 4o67 | 1SY | Cyclic GMP-AMP synthase | / | 0.445 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.444 | |
| 1c1b | GCA | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 1ihx | SND | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.444 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 1l8a | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.444 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.444 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.444 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.444 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.444 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.444 | |
| 3ezv | EZV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.444 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.444 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.444 | |
| 3q33 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.444 | |
| 3t58 | FAD | Sulfhydryl oxidase 1 | 1.8.3.2 | 0.444 | |
| 3zcs | CAW | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.444 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.444 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.444 | |
| 4j57 | FAD | Thioredoxin reductase 2 | 1.8.1.9 | 0.444 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.444 | |
| 5fs7 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.444 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.443 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.443 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1l3i | SAH | Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) | / | 0.443 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.443 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.443 | |
| 2ywl | FAD | Thioredoxin reductase related protein | / | 0.443 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.443 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3ncr | ADP | Nitrogen regulatory protein P-II (GlnB-2) | / | 0.443 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.443 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 4aos | FAD | Steroid monooxygenase | / | 0.443 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.443 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.443 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.443 | |
| 4hy0 | 1AQ | E3 ubiquitin-protein ligase XIAP | 6.3.2 | 0.443 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.443 | |
| 4qmy | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.443 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.443 | |
| 4djh | JDC | Kappa-type opioid receptor | / | 0.443 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.442 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.442 | |
| 2emu | SAH | Diphthine synthase | / | 0.442 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.442 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.442 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.442 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.442 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.442 | |
| 3gep | 24H | Hypoxanthine-guanine phosphoribosyltransferase | 2.4.2.8 | 0.442 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.442 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.442 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.442 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 4dx7 | DM2 | Multidrug efflux pump subunit AcrB | / | 0.442 | |
| 4e0h | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.442 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.442 | |
| 5a3c | NAD | SIR2 family protein | / | 0.442 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.442 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.441 | |
| 1gjv | AGS | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | 2.7.11.4 | 0.441 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1ptj | SND | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.441 | |
| 1rdw | LAR | Actin, alpha skeletal muscle | / | 0.441 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2jdt | I5S | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.441 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.441 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.441 | |
| 3dzv | ADP | Hydroxyethylthiazole kinase | / | 0.441 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.441 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.441 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.441 | |
| 4czt | CPS | CBL-interacting serine/threonine-protein kinase 23 | 2.7.11.1 | 0.441 | |
| 4dna | FAD | Probable glutathione reductase | / | 0.441 | |
| 4ebf | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.441 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.441 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.441 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.441 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.441 | |
| 4zse | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 5dn1 | AMZ | Phosphoribosyl isomerase A | 5.3.1.16 | 0.441 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.441 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.441 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.440 | |
| 1t0l | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.440 | |
| 1tyt | FAD | Trypanothione reductase | 1.8.1.12 | 0.440 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1zoy | UQ1 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 0.440 | |
| 1zoy | UQ1 | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial | / | 0.440 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.440 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2hqm | FAD | Glutathione reductase | 1.8.1.7 | 0.440 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.440 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 3ldo | ANP | 78 kDa glucose-regulated protein | / | 0.440 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.440 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.440 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.440 | |
| 4eu5 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.440 | |
| 4m52 | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.440 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4o28 | 1QS | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.440 | |
| 4u7w | NDP | MxaA | / | 0.440 | |
| 4up3 | NDP | Thioredoxin reductase | / | 0.440 | |
| 4y8v | ADP | Acyl-CoA synthetase (NDP forming) | / | 0.440 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 6gsw | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.440 |