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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1gv4 FAD Apoptosis-inducing factor 1, mitochondrial 1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.406
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.324
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.245
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.240
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.207
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.148
1d7y FADFerredoxin reductase / 1.142
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.099
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.095
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.089
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.057
2gr0 FADFerredoxin reductase / 1.056
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.046
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.045
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 1.042
2gqw FADFerredoxin reductase / 1.041
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 1.009
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.987
2gr3 FADFerredoxin reductase / 0.984
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.963
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.951
1f3p FADFerredoxin reductase / 0.948
1q1r FADPutidaredoxin reductase 1.18.1.5 0.917
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.879
2gr1 FADFerredoxin reductase / 0.861
1q1w FADPutidaredoxin reductase 1.18.1.5 0.859
3fg2 FADPutative rubredoxin reductase / 0.856
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.852
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.845
2yvf FADFerredoxin reductase / 0.844
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.844
2yvj FADFerredoxin reductase / 0.843
3atr FDAConserved Archaeal protein / 0.827
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.825
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.824
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.823
3cgb FADCoenzyme A disulfide reductase / 0.813
3atq FDAConserved Archaeal protein / 0.811
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.808
4opi FDAConserved Archaeal protein / 0.806
3cge FADCoenzyme A disulfide reductase / 0.802
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.801
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.796
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.796
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.795
4opc FDAConserved Archaeal protein / 0.794
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.793
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.792
2v6o FADThioredoxin glutathione reductase / 0.791
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.791
4em3 FADCoenzyme A disulfide reductase / 0.787
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.784
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.783
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.783
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.781
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.781
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.780
4hb9 FADUncharacterized protein / 0.780
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.779
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.779
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.778
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.776
4opg FDAConserved Archaeal protein / 0.775
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.774
1rsg FADPolyamine oxidase FMS1 / 0.774
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.774
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.769
5buk FADFADH2-dependent halogenase / 0.767
2q7v FADThioredoxin reductase / 0.766
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.765
3fbs FADOxidoreductase / 0.761
3kve FADL-amino-acid oxidase / 0.761
4opd FDAConserved Archaeal protein / 0.759
1yqz FADCoenzyme A disulfide reductase / 0.758
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.758
4k5r FADOxygenase / 0.758
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.756
3cgc FADCoenzyme A disulfide reductase / 0.756
4opt FDAConserved Archaeal protein / 0.755
4opu FDAConserved Archaeal protein / 0.755
4opl FDAConserved Archaeal protein / 0.753
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.752
3cgd FADCoenzyme A disulfide reductase / 0.750
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.749
1ger FADGlutathione reductase 1.8.1.7 0.749
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.749
4b1b FADThioredoxin reductase 1.8.1.9 0.748
4gdp FADPolyamine oxidase FMS1 / 0.747
4bjz FADProbable salicylate monooxygenase / 0.746
3rp8 FADFAD-dependent urate hydroxylase / 0.744
4j33 FADKynurenine 3-monooxygenase / 0.743
4jn9 FADDepH / 0.743
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.742
2eq8 FADDihydrolipoyl dehydrogenase / 0.742
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.742
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.741
4fwf FADLysine-specific histone demethylase 1B 1 0.741
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.740
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.740
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.739
2bab FADPutative aminooxidase / 0.739
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.738
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.737
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.736
4j2w FADKynurenine 3-monooxygenase / 0.735
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.734
2q0l FADThioredoxin reductase 1.8.1.9 0.733
3f8d FADNADH oxidase/thioredoxin reductase / 0.732
4icy FADPgaE / 0.732
4j34 FADKynurenine 3-monooxygenase / 0.731
1reo FADL-amino-acid oxidase 1.4.3.2 0.730
1nhq FADNADH peroxidase 1.11.1.1 0.729
1npx FADNADH peroxidase 1.11.1.1 0.729
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.728
1zk7 FADMercuric reductase 1.16.1.1 0.728
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.728
2r9z FADGlutathione amide reductase / 0.727
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.727
2npx FADNADH peroxidase 1.11.1.1 0.726
4emw FADCoenzyme A disulfide reductase / 0.726
1zx9 FADMercuric reductase 1.16.1.1 0.725
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.725
4jq9 FADDihydrolipoyl dehydrogenase / 0.724
3kpf FADPolyamine oxidase 1.5.3.14 0.723
4nte FADDepH / 0.723
2x8h FADThioredoxin glutathione reductase / 0.722
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.722
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.721
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.720
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.719
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.719
1geu FADGlutathione reductase 1.8.1.7 0.719
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.719
2xdo FADTetX family tetracycline inactivation enzyme / 0.719
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.719
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.719
4z2t FAD2-hydroxybiphenyl-3-monooxygenase / 0.719
1f8w FADNADH peroxidase 1.11.1.1 0.718
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.718
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.718
3nlc FADUncharacterized protein / 0.717
4eqw FADCoenzyme A disulfide reductase / 0.717
2yqu FADDihydrolipoyl dehydrogenase / 0.716
4ntc FADThioredoxin reductase gliT / 0.716
4yry FADGlutamate synthase, beta subunit / 0.716
1ges FADGlutathione reductase 1.8.1.7 0.715
2dw4 FADLysine-specific histone demethylase 1A 1 0.714
4gut FADLysine-specific histone demethylase 1B 1 0.714
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.713
4eqx FADCoenzyme A disulfide reductase / 0.713
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.713
4usr FADMonooxygenase / 0.713
2yg4 FADPutrescine oxidase / 0.711
3icr FADCoenzyme A disulfide reductase / 0.711
3bg7 FADPyranose 2-oxidase / 0.710
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.709
2cdu FADNADH oxidase / 0.708
3ada NADSubunit alpha of sarocosine oxidase / 0.708
4em4 FADCoenzyme A disulfide reductase / 0.708
4gcm FADThioredoxin reductase 1.8.1.9 0.708
1nhr FADNADH peroxidase 1.11.1.1 0.707
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.706
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.705
2eq7 FADDihydrolipoyl dehydrogenase / 0.705
3bi5 FADPolyamine oxidase FMS1 / 0.705
2jb2 FADL-amino acid oxidase / 0.704
3ics FADCoenzyme A disulfide reductase / 0.704
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.703
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.702
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.702
3k4c FADPyranose 2-oxidase / 0.701
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.701
3r9u FADThioredoxin reductase / 0.701
4gus FADLysine-specific histone demethylase 1B 1 0.701
1tdn FADL-amino-acid oxidase 1.4.3.2 0.700
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.700
3lad FADDihydrolipoyl dehydrogenase / 0.700
4bk3 FADProbable salicylate monooxygenase / 0.700
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.698
1pdh FASp-hydroxybenzoate hydroxylase / 0.698
4xbf FADLysine-specific histone demethylase 1A 1 0.698
1get FADGlutathione reductase 1.8.1.7 0.697
1yy5 FADPolyamine oxidase FMS1 / 0.697
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.696
1tdk FADL-amino-acid oxidase 1.4.3.2 0.696
1nhs FADNADH peroxidase 1.11.1.1 0.695
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.694
3gwf FADCyclohexanone monooxygenase / 0.694
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.694
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.694
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.693
3ish FADThioredoxin reductase 1.8.1.9 0.693
1joa FADNADH peroxidase 1.11.1.1 0.692
2b9y FADPutative aminooxidase / 0.692
2jae FADL-amino acid oxidase / 0.692
2x8g FADThioredoxin glutathione reductase / 0.692
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.691
2jk6 FADTrypanothione reductase / 0.691
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.691
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.691
4tm3 FADKtzI / 0.691
2eq9 FADDihydrolipoyl dehydrogenase / 0.690
2vvl FADMonoamine oxidase N 1.4.3.4 0.690
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.689
1qo8 FADFumarate reductase flavoprotein subunit / 0.689
3t37 FADPyridoxine 4-oxidase / 0.689
4b63 FADL-ornithine N(5)-monooxygenase / 0.689
1fea FADTrypanothione reductase 1.8.1.12 0.688
2rab FADGlutathione amide reductase / 0.688
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.687
3mj4 FADUDP-galactopyranose mutase / 0.687
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.687
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.687
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.686
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.686
2wba FADTrypanothione reductase 1.8.1.12 0.686
5dbj FADFADH2-dependent halogenase PltA / 0.686
1fec FADTrypanothione reductase 1.8.1.12 0.685
2eq6 FADDihydrolipoyl dehydrogenase / 0.685
2qa1 FADPgaE / 0.685
3cnd FADPolyamine oxidase FMS1 / 0.685
1gxf FADTrypanothione reductase 1.8.1.12 0.684
1tde FADThioredoxin reductase 1.8.1.9 0.684
2bac FADPutative aminooxidase / 0.684
4eqr FADCoenzyme A disulfide reductase / 0.684
3qj4 FADRenalase / 0.683
1feb FADTrypanothione reductase 1.8.1.12 0.682
2x3n FADProbable FAD-dependent monooxygenase / 0.682
4x4j FADPutative oxygenase / 0.682
2e1m FADL-glutamate oxidase / 0.680
2jb1 FADL-amino acid oxidase / 0.680
2tpr FADTrypanothione reductase 1.8.1.12 0.680
4bk2 FADProbable salicylate monooxygenase / 0.680
4j57 FADThioredoxin reductase 2 1.8.1.9 0.680
4nev FADTrypanothione reductase / 0.680
4a5l FADThioredoxin reductase / 0.679
4cnk FADL-amino acid oxidase / 0.679
4eqs FADCoenzyme A disulfide reductase / 0.678
1h83 FADPolyamine oxidase 1.5.3.14 0.677
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.677
3ict FADCoenzyme A disulfide reductase / 0.676
4tlz FADKtzI / 0.676
2y48 FADLysine-specific histone demethylase 1A 1 0.675
3f8r NAPNADH oxidase/thioredoxin reductase / 0.675
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.674
2hqm FADGlutathione reductase 1.8.1.7 0.674
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.674
4at0 FADPossible succinate dehydrogenase / 0.673
4guu FA9Lysine-specific histone demethylase 1B 1 0.673
4u8i FDAUDP-galactopyranose mutase / 0.673
4ynt FDAGlucose oxidase, putative / 0.673
2rgh FADAlpha-Glycerophosphate Oxidase / 0.672
4fwj FADLysine-specific histone demethylase 1B 1 0.672
1cl0 FADThioredoxin reductase 1.8.1.9 0.671
1h81 FADPolyamine oxidase 1.5.3.14 0.671
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.671
2zbw FADFerredoxin--NADP reductase / 0.671
3cty FADProbable thioredoxin reductase / 0.671
3utf FDAUDP-galactopyranose mutase / 0.671
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.671
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.670
2wow FADTrypanothione reductase / 0.670
4b68 FADL-ornithine N(5)-monooxygenase / 0.669
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.669
4u8k FDAUDP-galactopyranose mutase / 0.669
1typ FADTrypanothione reductase 1.8.1.12 0.668
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.668
4i58 FADCyclohexylamine Oxidase / 0.668
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.667
3uth FDAUDP-galactopyranose mutase / 0.667
1k0j FADp-hydroxybenzoate hydroxylase / 0.666
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.666
2gv8 FADThiol-specific monooxygenase 1.14.13 0.666
2q0k FADThioredoxin reductase 1.8.1.9 0.666
3utg FDAUDP-galactopyranose mutase / 0.665
1tdo FADL-amino-acid oxidase 1.4.3.2 0.664
2qa2 FADPolyketide oxygenase CabE / 0.664
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.664
4up3 FADThioredoxin reductase / 0.664
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.663
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.663
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.663
3pl8 FADPyranose 2-oxidase / 0.662
2b9w FADPutative aminooxidase / 0.661
3bi2 FADPolyamine oxidase FMS1 / 0.661
4a99 FADTetX family tetracycline inactivation enzyme / 0.661
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.659
2ign FADPyranose 2-oxidase / 0.658
3q9t FAYUncharacterized protein / 0.658
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.658
4j31 FADKynurenine 3-monooxygenase / 0.658
3f8p NADNADH oxidase/thioredoxin reductase / 0.657
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.656
3axb FADPutative oxidoreductase / 0.656
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.656
5j60 FADThioredoxin reductase / 0.656
4gur FADLysine-specific histone demethylase 1B 1 0.655
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.654
1tdf FADThioredoxin reductase 1.8.1.9 0.654
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.654
3urh FADDihydrolipoyl dehydrogenase / 0.654
4gde FDAUDP-galactopyranose mutase / 0.654
1tyt FADTrypanothione reductase 1.8.1.12 0.653
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.653
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.653
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.652
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.652
2wp5 FADTrypanothione reductase / 0.652
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.652
4dsg FADUncharacterized protein / 0.652
4guv FADTetX family tetracycline inactivation enzyme / 0.651
4u8l FDAUDP-galactopyranose mutase / 0.651
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.650
1w34 FADFerredoxin--NADP reductase 1.18.1.2 0.650
1w35 FADFerredoxin--NADP reductase 1.18.1.2 0.650
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.650
3hdy FDAUDP-galactopyranose mutase / 0.650