sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3gz3 | ORO | Dihydroorotate dehydrogenase (fumarate) |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3gz3 | ORO | Dihydroorotate dehydrogenase (fumarate) | / | 1.000 | |
| 3w2l | VRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.511 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.501 | |
| 3w1t | WRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.495 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.495 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.494 | |
| 3w3o | ROE | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.494 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.493 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.492 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.489 | |
| 3coy | 53H | Pantothenate synthetase | 6.3.2.1 | 0.488 | |
| 3mtw | M3R | Xaa-Pro dipeptidase, putative | / | 0.488 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.487 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.486 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.484 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.483 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.481 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.479 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.479 | |
| 2ejz | SAH | Diphthine synthase | / | 0.479 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.479 | |
| 3ens | ENS | Coagulation factor X | 3.4.21.6 | 0.479 | |
| 3w23 | 3RO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.479 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.478 | |
| 1n2h | PAJ | Pantothenate synthetase | 6.3.2.1 | 0.478 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.478 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.478 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.477 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.476 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.476 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.476 | |
| 4iax | LIZ | Neutrophil gelatinase-associated lipocalin | / | 0.476 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.476 | |
| 4tmb | FMN | Old yellow enzyme | / | 0.476 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.475 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.475 | |
| 2anb | 5GP | Guanylate kinase | 2.7.4.8 | 0.474 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.474 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.473 | |
| 3w1q | YRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.473 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.472 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.472 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.472 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.471 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.470 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.470 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.470 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.469 | |
| 1dj2 | GDP | Adenylosuccinate synthetase, chloroplastic | / | 0.468 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.468 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.468 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.468 | |
| 4ddh | MS0 | Pantothenate synthetase | 6.3.2.1 | 0.468 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.467 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.466 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.466 | |
| 3w2m | ZRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.466 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.466 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.465 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 4fri | DWA | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 5a3c | NAD | SIR2 family protein | / | 0.465 | |
| 1jmh | UMP | Thymidylate synthase | / | 0.464 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.464 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.464 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.464 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.464 | |
| 3p8z | 36A | Genome polyprotein | 2.1.1.56 | 0.464 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.464 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.463 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.463 | |
| 5a3b | APR | SIR2 family protein | / | 0.463 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.462 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.462 | |
| 3cow | 52H | Pantothenate synthetase | 6.3.2.1 | 0.462 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.462 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.461 | |
| 1qr6 | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.461 | |
| 2iu0 | 203 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.461 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.461 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.461 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.461 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.461 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.460 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.460 | |
| 3hf3 | FMN | Chromate reductase | / | 0.460 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.460 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 3w2n | ROD | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.460 | |
| 3wsw | NAD | L-lactate dehydrogenase | / | 0.460 | |
| 5b0o | ADP | Flagellum-specific ATP synthase | 3.6.3.14 | 0.460 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.459 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.459 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.459 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.459 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.459 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1n2i | PAJ | Pantothenate synthetase | 6.3.2.1 | 0.458 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.458 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.458 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.458 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.458 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.457 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.457 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.457 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.457 | |
| 4b64 | FAD | L-ornithine N(5)-monooxygenase | / | 0.457 | |
| 4dja | FAD | (6-4) photolyase | / | 0.457 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.457 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.456 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.456 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.456 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.456 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.456 | |
| 3a3g | DLZ | Lumazine protein | / | 0.456 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.456 | |
| 3iob | A4D | Pantothenate synthetase | 6.3.2.1 | 0.456 | |
| 3iqg | ASN_TRP_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.456 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.456 | |
| 5cku | FAD | L-ornithine N(5)-monooxygenase | / | 0.456 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.455 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.455 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.455 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.455 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.454 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.454 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.454 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.454 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.454 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.454 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.454 | |
| 1z48 | FMN | NADPH dehydrogenase | / | 0.453 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.452 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.452 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.452 | |
| 2b56 | UTP | RNA editing complex protein MP57 | / | 0.452 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.452 | |
| 3ime | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.452 | |
| 4b72 | 2FB | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4bls | APC | NTPase P4 | / | 0.452 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.452 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.452 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4rvd | SAM | D-mycarose 3-C-methyltransferase | / | 0.452 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.452 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.451 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.451 | |
| 2emr | SAH | Diphthine synthase | / | 0.451 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.451 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3pym | NAD | Glyceraldehyde-3-phosphate dehydrogenase 3 | 1.2.1.12 | 0.451 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.451 | |
| 4fuj | 1U9 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.451 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.451 | |
| 1b5d | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.450 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.450 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.450 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.450 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.450 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.450 | |
| 4fdu | IHS | Putative multiple inositol polyphosphate histidine phosphatase 1 | / | 0.450 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.450 | |
| 1eq2 | ADQ | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.449 | |
| 1nj6 | A5A | Proline--tRNA ligase | / | 0.449 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1rz0 | FAD | Phenol 2-hydroxylase component B | / | 0.449 | |
| 1wn3 | HXC | Phenylacetic acid degradation protein PaaI | / | 0.449 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.449 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.449 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.449 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.449 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.448 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.448 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.448 | |
| 3ty3 | GGG | Homoisocitrate dehydrogenase | 1.1.1.87 | 0.448 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.448 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4l4x | NDP | AmphI | / | 0.448 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.448 | |
| 2abj | PLP | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.447 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.447 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.447 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.447 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.447 | |
| 3rn8 | RN8 | Glutamate receptor 2 | / | 0.447 | |
| 3toz | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.447 | |
| 1gox | FMN | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.446 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.446 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 1w73 | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.446 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.446 | |
| 2ldb | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.446 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.446 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.446 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.446 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.446 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.446 | |
| 3u9e | COA | Lmo1369 protein | / | 0.446 | |
| 4b63 | FAD | L-ornithine N(5)-monooxygenase | / | 0.446 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.446 | |
| 4gtp | 7TP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 1u8f | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.445 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.445 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.445 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.445 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3g7j | GTX | Glutathione transferase GST1-4 | / | 0.445 | |
| 3w1r | MRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.445 | |
| 4f9g | C2E | Stimulator of interferon genes protein | / | 0.445 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.445 | |
| 4umx | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.445 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.445 | |
| 1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2cns | ACO | Ribosomal-protein-alanine acetyltransferase | / | 0.444 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.444 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.444 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.444 | |
| 3muo | ZPR | Prolyl endopeptidase | / | 0.444 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.444 | |
| 4fnc | HMU | G/T mismatch-specific thymine DNA glycosylase | 3.2.2.29 | 0.444 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.444 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.444 | |
| 4yer | ADP | Antibiotic ABC transporter, ATP-binding protein, putative | / | 0.444 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.444 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1c70 | L75 | Protease | / | 0.443 | |
| 1g7u | PEP | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.443 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1w0k | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.443 | |
| 1w0k | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.443 | |
| 1z44 | FMN | NADPH dehydrogenase | / | 0.443 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.443 | |
| 2gz8 | F3F | Orf1a polyprotein | / | 0.443 | |
| 2hux | SAH | Diphthine synthase | / | 0.443 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.443 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.443 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.443 | |
| 1d2h | SAH | Glycine N-methyltransferase | 2.1.1.20 | 0.442 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.442 | |
| 1hwz | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.442 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.442 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.442 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.442 | |
| 4jic | FMN | GTN Reductase | / | 0.442 | |
| 4xfj | ANP | Argininosuccinate synthase | / | 0.442 | |
| 1a5b | IGP | Tryptophan synthase alpha chain | / | 0.441 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.441 | |
| 1hon | GNH | Adenylosuccinate synthetase | / | 0.441 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.441 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.441 | |
| 2ohv | NHL | Glutamate racemase | / | 0.441 | |
| 2pca | SAH | Diphthine synthase | / | 0.441 | |
| 2r8f | AGS | Non-structural protein 2 | 3.6.4 | 0.441 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.441 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 3gst | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.441 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.441 | |
| 3tyv | HI3 | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 4b78 | KGG | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4e2d | FMN | Dehydrogenase | / | 0.441 | |
| 4x3l | MTA | RNA 2'-O ribose methyltransferase | / | 0.441 | |
| 4xsv | CTP | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.441 | |
| 5fi8 | ORO | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.440 | |
| 1i5e | U5P | Uracil phosphoribosyltransferase | / | 0.440 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.440 | |
| 1np7 | FAD | Cryptochrome DASH | / | 0.440 | |
| 2pcm | SAH | Diphthine synthase | / | 0.440 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.440 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.440 | |
| 3r2f | PB0 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.440 | |
| 3zhb | NAP | Putative dehydrogenase | / | 0.440 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 4ein | NOH | Thymidylate synthase | 2.1.1.45 | 0.440 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.440 | |
| 4oug | LP5 | Peptidoglycan recognition protein 1 | / | 0.440 | |
| 4rv9 | SAH | D-mycarose 3-C-methyltransferase | / | 0.440 | |
| 4wso | NAD | Probable nicotinate-nucleotide adenylyltransferase | / | 0.440 | |
| 4xj4 | 3AT | Cyclic GMP-AMP synthase | / | 0.440 | |
| 5c41 | ACP | Ribokinase | / | 0.440 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.440 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 |