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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1zrzBI1Protein kinase C iota type2.7.11.13

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1zrzBI1Protein kinase C iota type2.7.11.131.000
3zh8C58Protein kinase C iota type2.7.11.130.552
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.550
2vd5BI8Myotonin-protein kinase2.7.11.10.548
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.543
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.539
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.536
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.536
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.535
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.532
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.529
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.527
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.526
2hog710Serine/threonine-protein kinase Chk12.7.11.10.524
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.523
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.521
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.520
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.520
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.518
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.517
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.512
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.512
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.511
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.510
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.509
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.508
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.505
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.505
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.505
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.505
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.504
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.504
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.503
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.503
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.503
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.503
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.502
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.502
4gk3L87Ephrin type-A receptor 32.7.10.10.502
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.501
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.500
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.500
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.500
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.500
3a62STURibosomal protein S6 kinase beta-12.7.11.10.499
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.499
3ibqATPPyridoxal kinase/0.499
4gk2L66Ephrin type-A receptor 32.7.10.10.499
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.498
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.498
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.497
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.497
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.496
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.496
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.496
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.496
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.495
3zewSTUEphrin type-B receptor 42.7.10.10.495
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.494
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.494
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.493
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.493
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.492
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.491
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.490
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.490
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.490
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.490
1jpaANPEphrin type-B receptor 22.7.10.10.489
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.489
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.489
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.489
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.488
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.488
1pjkANPCasein kinase II subunit alpha2.7.11.10.487
3vjoANPEpidermal growth factor receptor2.7.10.10.487
4c62XWWTyrosine-protein kinase JAK2/0.487
2yn8STUEphrin type-B receptor 42.7.10.10.486
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.485
2i40BLZCyclin-dependent kinase 22.7.11.220.485
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.485
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.485
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.485
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.484
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.484
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.483
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.483
1nzdUPGDNA beta-glucosyltransferase/0.482
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.482
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.481
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.481
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.481
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.481
4ure1PSCyclohexanol dehydrogenase/0.481
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.480
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.480
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.480
2acxANPG protein-coupled receptor kinase 62.7.11.160.479
2cchATPCyclin-dependent kinase 22.7.11.220.479
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.479
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.479
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.479
4qnaX11Serine/threonine-protein kinase 242.7.11.10.479
1rx8FOLDihydrofolate reductase1.5.1.30.478
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.478
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.478
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.478
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.478
4fv6E57Mitogen-activated protein kinase 12.7.11.240.478
4fv9E71Mitogen-activated protein kinase 12.7.11.240.478
1pkdUCNCyclin-dependent kinase 22.7.11.220.477
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.477
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.477
2qo9ANPEphrin type-A receptor 32.7.10.10.477
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.477
1tvoFRZMitogen-activated protein kinase 12.7.11.240.476
2ejvNADL-threonine 3-dehydrogenase/0.476
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.476
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.476
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.476
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.476
4riyADPEpidermal growth factor receptor2.7.10.10.476
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.475
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.475
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.475
2po7CHDFerrochelatase, mitochondrial4.99.1.10.474
3pe2E1BCasein kinase II subunit alpha2.7.11.10.474
4a8v2ANMajor pollen allergen Bet v 1-J/0.474
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.474
1bwsNDPGDP-L-fucose synthase/0.473
1r2jFADFkbI/0.473
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.473
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.473
4k28NADShikimate dehydrogenase family protein/0.473
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.473
2izuP01Casein kinase I isoform gamma-32.7.11.10.472
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.472
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.472
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.472
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.471
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.471
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.471
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.471
2hfuMEVMevalonate kinase/0.471
4i231C9Epidermal growth factor receptor2.7.10.10.471
2zbaZBATrichothecene 3-O-acetyltransferase/0.470
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.470
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.470
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.470
1bsvNDPGDP-L-fucose synthase/0.469
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.469
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.469
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.469
2x9dITCTetracycline repressor protein class D/0.469
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.469
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.469
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.469
5a3bAPRSIR2 family protein/0.469
2vwx7X4Ephrin type-B receptor 42.7.10.10.468
3c4xATPRhodopsin kinase/0.468
3il1B5DGlutamate receptor 2/0.468
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.468
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.468
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.468
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.468
1ay0TPPTransketolase 12.2.1.10.467
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.467
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.467
3c15FOKAdenylate cyclase type 2/0.467
3c15FOKAdenylate cyclase type 5/0.467
3tucFPWTyrosine-protein kinase SYK2.7.10.20.467
4aguD15Cyclin-dependent kinase-like 1/0.467
4bcmT7ZCyclin-dependent kinase 22.7.11.220.467
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.467
2rhrEMOPutative ketoacyl reductase1.3.10.466
2vx07X7Ephrin type-B receptor 42.7.10.10.466
3ac1KZITyrosine-protein kinase Lck2.7.10.20.466
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.466
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.466
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.466
1rx8NAPDihydrofolate reductase1.5.1.30.465
2eb3ANPEpidermal growth factor receptor2.7.10.10.465
2ittAEEEpidermal growth factor receptor2.7.10.10.465
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.465
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.465
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.465
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.465
4y93746Tyrosine-protein kinase/0.465
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.464
3d84NDPDihydrofolate reductase1.5.1.30.464
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.464
3triNAPPyrroline-5-carboxylate reductase/0.464
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.464
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.463
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.463
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.463
3csdEMOPutative ketoacyl reductase1.3.10.463
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.462
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.462
4g2fC07Ephrin type-A receptor 32.7.10.10.462
2y6o1N1Ephrin type-A receptor 42.7.10.10.461
3lqfNADGalactitol dehydrogenase/0.461
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.461
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.461
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.461
3zuyTCHTransporter/0.461
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.461
4iva1J5Tyrosine-protein kinase JAK2/0.461
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.461
5e8wSTUTGF-beta receptor type-12.7.11.300.461
1o76CAMCamphor 5-monooxygenase1.14.15.10.460
2izt23DCasein kinase I isoform gamma-32.7.11.10.460
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.460
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.460
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.460
2xvdAS6Ephrin type-B receptor 42.7.10.10.460
2xyuQ9GEphrin type-A receptor 42.7.10.10.460
2znq401Peroxisome proliferator-activated receptor delta/0.460
3gfbNADL-threonine 3-dehydrogenase/0.460
3s1dZIRCytokinin dehydrogenase 11.5.99.120.460
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.460
1hdgNADGlyceraldehyde-3-phosphate dehydrogenase/0.459
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.459
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.459
1rx1NAPDihydrofolate reductase1.5.1.30.459
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.459
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.459
3at4CCKCasein kinase II subunit alpha2.7.11.10.459
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.459
3sheI85MAP kinase-activated protein kinase 32.7.11.10.459
4c58824Cyclin-G-associated kinase2.7.11.10.459
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.459
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.459
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.459
5eccNAPDehydrofolate reductase type I/0.459
1culFOKAdenylate cyclase type 2/0.458
1culFOKAdenylate cyclase type 5/0.458
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.458
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
3fstFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.458
3hx4ANPCalmodulin-domain protein kinase 1/0.458
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.458
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.458
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.458
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.458
4wboANWRhodopsin kinase/0.458
1dr3HBIDihydrofolate reductase1.5.1.30.457
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1tl7FOKAdenylate cyclase type 2/0.457
1tl7FOKAdenylate cyclase type 5/0.457
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.457
2huvSAHDiphthine synthase/0.457
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.457
3bi6396Wee1-like protein kinase2.7.10.20.457
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.457
3wowANPCasein kinase II subunit alpha2.7.11.10.457
1g2vTTPGlucose-1-phosphate thymidylyltransferase/0.456
1meiXMPInosine-5'-monophosphate dehydrogenase/0.456
2in6839Wee1-like protein kinase2.7.10.20.456
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.456
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.456
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.456
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.455
2itnANPEpidermal growth factor receptor2.7.10.10.455
2qoqANPEphrin type-A receptor 32.7.10.10.455
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.455
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.455
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4kl9NDPDihydrofolate reductase1.5.1.30.455
5cshATPCasein kinase II subunit alpha2.7.11.10.455
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.454
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.454
2itvANPEpidermal growth factor receptor2.7.10.10.454
2j0m4STFocal adhesion kinase 12.7.10.20.454
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.454
2rkvZBATrichothecene 3-O-acetyltransferase/0.454
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.454
3frqERYErythromycin resistance repressor protein/0.454
3g70A5TRenin3.4.23.150.454
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.454
3kb1ADPIron-sulfur cluster carrier protein/0.454
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.454
4j97ACPFibroblast growth factor receptor 2/0.454
5a3cNADSIR2 family protein/0.454
1nzfUPGDNA beta-glucosyltransferase/0.453
1vyrFMNPentaerythritol tetranitrate reductase/0.453
2a1oCAMCamphor 5-monooxygenase1.14.15.10.453
2wipP49Cyclin-dependent kinase 22.7.11.220.453
3a1nNADNDP-sugar epimerase/0.453
3fklFKLMitogen-activated protein kinase 14/0.453
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.453
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.453
3q9bB3NAcetylpolyamine amidohydrolase/0.453
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.453
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.453
4gmy0X5Tyrosine-protein kinase JAK2/0.453
4i02CMPcAMP-activated global transcriptional regulator CRP/0.453
4k9oTPPBenzoylformate decarboxylase4.1.1.70.453
1e9hINRCyclin-dependent kinase 22.7.11.220.452
1k6tXN1Gag-Pol polyprotein3.4.23.160.452
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
3t8oATPRhodopsin kinase/0.452
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.452
4qmzB49Serine/threonine-protein kinase 242.7.11.10.452
1j39UPGDNA beta-glucosyltransferase/0.451
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.451
3bqr4RBDeath-associated protein kinase 3/0.451
3f03FMNPentaerythritol tetranitrate reductase/0.451
3i60E86Mitogen-activated protein kinase 12.7.11.240.451
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.451
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.451
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.451
3r0tFU9Casein kinase II subunit alpha2.7.11.10.451
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.451
4qo9627Serine/threonine-protein kinase 242.7.11.10.451
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.451
1h63FMNPentaerythritol tetranitrate reductase/0.450
2jcxNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.450
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.450
3axwTIDCasein kinase II subunit alpha2.7.11.10.450
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.450
4a99FADTetX family tetracycline inactivation enzyme/0.450
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.450
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.450
4i22IREEpidermal growth factor receptor2.7.10.10.450
4ivb1J5Tyrosine-protein kinase JAK1/0.450
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.450
1eioGCHGastrotropin/0.449
1finATPCyclin-dependent kinase 22.7.11.220.449
1pjcNADAlanine dehydrogenase/0.449
1tehNADAlcohol dehydrogenase class-31.1.1.10.449
2wxvWXVCyclin-dependent kinase 22.7.11.220.449
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.449
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.449
3q5kD1UHeat shock protein 83-1/0.449
3tnwF18Cyclin-dependent kinase 22.7.11.220.449
3u9eCOALmo1369 protein/0.449
3w3oROEDihydroorotate dehydrogenase (fumarate)1.3.98.10.449
4dgo0JWCasein kinase II subunit alpha2.7.11.10.449
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.449
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.448
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.448
2mwgFMNBlue-light photoreceptor/0.448
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.448
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.448
3gobHXXDdmC/0.448
3jpuTY4Transcriptional activator protein LasR/0.448
3junAJDPhenazine biosynthesis protein A/B/0.448
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.448
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.448
4fehFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.448
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.448
4l4fCAMCamphor 5-monooxygenase1.14.15.10.448
4q71FADBifunctional protein PutA/0.448
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
2gjlFMNNitronate monooxygenase1.13.12.160.447
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.447
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.447
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.447
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.447
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.447
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.447
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.447
4fv8E63Mitogen-activated protein kinase 12.7.11.240.447
4jia1K3Tyrosine-protein kinase JAK2/0.447
5e92ANPTGF-beta receptor type-22.7.11.300.447
1jioDEB6-deoxyerythronolide B hydroxylase/0.446
2d4vNADIsocitrate dehydrogenase [NADP]/0.446
2dhfDZFDihydrofolate reductase1.5.1.30.446
2el0SAHDiphthine synthase/0.446
2izrBRKCasein kinase I isoform gamma-32.7.11.10.446
2nniMTKCytochrome P450 2C8/0.446
2vwz7X6Ephrin type-B receptor 42.7.10.10.446
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.446
3ih0ANPUncharacterized sugar kinase PH14592.7.10.446
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.446
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.446
4du82P0Mevalonate diphosphate decarboxylase/0.446
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.446
4hvh19RTyrosine-protein kinase JAK32.7.10.20.446
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.446
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.446
4qms1N1Serine/threonine-protein kinase 242.7.11.10.446
5cvhADPCasein kinase II subunit alpha2.7.11.10.446
1f4fTP3Thymidylate synthase/0.445
1ipeNDPTropinone reductase 21.1.1.2360.445
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.445
1u54ACPActivated CDC42 kinase 1/0.445
1vyw292Cyclin-dependent kinase 22.7.11.220.445
2fypRDEEndoplasmin/0.445
2wihP48Cyclin-dependent kinase 22.7.11.220.445
3ctyFADProbable thioredoxin reductase/0.445
3h3cP1EProtein-tyrosine kinase 2-beta2.7.10.20.445
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.445
3igoANPCalmodulin-domain protein kinase 1, putative/0.445
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.445
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.445
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.445
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.445
4c02TAKActivin receptor type-12.7.11.300.445
4eok4SPCyclin-dependent kinase 22.7.11.220.445
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.445
4wkqIREEpidermal growth factor receptor2.7.10.10.445
5jy1NADPutative short-chain dehydrogenase/reductase/0.445
1dr2TAPDihydrofolate reductase1.5.1.30.444
1drhNAPDihydrofolate reductase1.5.1.30.444
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.444
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.444
2dfvNADL-threonine 3-dehydrogenase/0.444
2gjnFMNNitronate monooxygenase1.13.12.160.444
2nq8ZIDEnoyl-ACP reductase/0.444
2qboCAMCamphor 5-monooxygenase1.14.15.10.444
2xa4AZ5Tyrosine-protein kinase JAK2/0.444
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.444
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.444
2zawCAMCamphor 5-monooxygenase1.14.15.10.444
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.444
3dfrMTXDihydrofolate reductase1.5.1.30.444
3drcMTXDihydrofolate reductase1.5.1.30.444
4bcqTJFCyclin-dependent kinase 22.7.11.220.444
4ez50RSCyclin-dependent kinase 62.7.11.220.444
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.444
4gk4L90Ephrin type-A receptor 32.7.10.10.444
4jr7GNPCasein kinase II subunit alpha2.7.11.10.444
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.443
1g5sI17Cyclin-dependent kinase 22.7.11.220.443
1hfqMOTDihydrofolate reductase1.5.1.30.443
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.443
2itpAEEEpidermal growth factor receptor2.7.10.10.443
2ituITQEpidermal growth factor receptor2.7.10.10.443
2oji33AMitogen-activated protein kinase 12.7.11.240.443
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.443
2y3sTIRTamL/0.443
3anmNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.443
3hekBD0Heat shock protein HSP 90-alpha/0.443
3k99PFTHeat shock protein HSP 90-alpha/0.443
3nr4PYVAbscisic acid receptor PYL2/0.443
3p67FMNPentaerythritol tetranitrate reductase/0.443
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.443
3w551FMMitogen-activated protein kinase 12.7.11.240.443
4bb432WEphrin type-B receptor 42.7.10.10.443
4e730NRMitogen-activated protein kinase 82.7.11.240.443
4eu8COASuccinyl-CoA:acetate CoA-transferase/0.443
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.443
4l4eCAMCamphor 5-monooxygenase1.14.15.10.443
4l4xNDPAmphI/0.443
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.443
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.443
5bsfNADPyrroline-5-carboxylate reductase/0.443
3pblETQD(3) dopamine receptor/0.443
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.442
2balPQAMitogen-activated protein kinase 14/0.442
2bxmIMNSerum albumin/0.442
2c475IDCasein kinase I isoform gamma-2/0.442
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.442
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.442
2qblCAMCamphor 5-monooxygenase1.14.15.10.442
2uxpCLMHTH-type transcriptional regulator TtgR/0.442
2x9fX9FEphrin type-B receptor 42.7.10.10.442
2znpK55Peroxisome proliferator-activated receptor delta/0.442
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3ixp834Ecdysone receptor/0.442
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3wmxNADNAD dependent epimerase/dehydratase/0.442
3zdu38RCyclin-dependent kinase-like 32.7.11.220.442
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
5jscFADPutative acyl-CoA dehydrogenase/0.442
1bk0ACVIsopenicillin N synthase1.21.3.10.441
1bxoPP7Penicillopepsin-13.4.23.200.441
1dr3TAPDihydrofolate reductase1.5.1.30.441
1m2qMNXCasein kinase II subunit alpha2.7.11.10.441
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.441
1y0s331Peroxisome proliferator-activated receptor delta/0.441
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.441
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
2itwITQEpidermal growth factor receptor2.7.10.10.441
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.441
3mb601ICasein kinase II subunit alpha2.7.11.10.441
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.441
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.441
4b99R4LMitogen-activated protein kinase 72.7.11.240.441
4fob0USALK tyrosine kinase receptor2.7.10.10.441
4grb0XGCasein kinase II subunit alpha2.7.11.10.441
4h4xFADBiphenyl dioxygenase ferredoxin reductase subunit/0.441
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.441
4ix5ANPUncharacterized protein/0.441
4jqeANPCasein kinase II subunit alpha2.7.11.10.441
4qysPLRTryptophan synthase beta chain 24.2.1.200.441
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.440
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.440
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.440
2d29FADAcyl-CoA dehydrogenase/0.440
2ejjSAHDiphthine synthase/0.440
2huqSAHDiphthine synthase/0.440
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.440
2o0uC0MMitogen-activated protein kinase 102.7.11.240.440
2wi72KLHeat shock protein HSP 90-alpha/0.440
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.440
2x1nX1NCyclin-dependent kinase 22.7.11.220.440
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.440
3dogNNNCyclin-dependent kinase 22.7.11.220.440
3frdDHFDihydrofolate reductase1.5.1.30.440
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.440
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.440
3v2uATPProtein GAL3/0.440
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.440
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4fx360KCyclin-dependent kinase 22.7.11.220.440
4g2rH1LProbable propionyl-CoA carboxylase beta chain 66.4.1.30.440
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.440
4yx6FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.440