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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1nenDNTSuccinate dehydrogenase iron-sulfur subunit1.3.5.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1nenDNTSuccinate dehydrogenase iron-sulfur subunit1.3.5.11.000
1nenDNTSuccinate dehydrogenase cytochrome b556 subunit/1.000
2wu5CBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.555
2wu5CBESuccinate dehydrogenase cytochrome b556 subunit/0.555
2wdqCBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.535
2wdqCBESuccinate dehydrogenase cytochrome b556 subunit/0.535
2bjsACVIsopenicillin N synthase1.21.3.10.499
1crbRTLRetinol-binding protein 1/0.495
2zbaZBATrichothecene 3-O-acetyltransferase/0.494
1g28FMNPHY3/0.493
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.493
4u0mGTPCyclic GMP-AMP synthase/0.490
1wxyFRKAdenosine deaminase3.5.4.40.488
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.488
3negPYVAbscisic acid receptor PYL1/0.488
4ytnFD8Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial/0.487
4ytnFD8Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial/0.487
4ytnFD8Succinate dehydrogenase cytochrome b560/0.487
2xvw9NRSerum albumin/0.486
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.485
3pd4A3GThreonine--tRNA ligase6.1.1.30.485
1ykdCMPAdenylate cyclase/0.483
2xvv9DNSerum albumin/0.483
4ia3BIVVitamin D3 receptor A/0.483
2hcdBIVVitamin D3 receptor A/0.482
4iarERM5-hydroxytryptamine receptor 1B/0.480
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.479
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.479
4ia1BIVVitamin D3 receptor A/0.479
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.478
2ociTYCValacyclovir hydrolase3.10.478
3lfcZ86Mitogen-activated protein kinase 14/0.478
4g2i0VQVitamin D3 receptor/0.478
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.477
1diuBDMDihydrofolate reductase1.5.1.30.476
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.476
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.476
4l0qNADAlcohol dehydrogenase class-3/0.476
5efwFMNNPH1-1/0.476
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.475
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.475
1hb1OCVIsopenicillin N synthase1.21.3.10.474
2aj4ANPGalactokinase2.7.1.60.474
2wu2CBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.474
2wu2CBESuccinate dehydrogenase cytochrome b556 subunit/0.474
1dgfNDPCatalase1.11.1.60.473
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.473
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.473
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.473
3nmpPYVAbscisic acid receptor PYL2/0.473
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.473
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.472
4fvrATPTyrosine-protein kinase JAK2/0.472
4z44FADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.472
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.471
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.471
3qlrQLRDihydrofolate reductase1.5.1.30.471
3zqtTESAndrogen receptor/0.471
1j91TBSCasein kinase II subunit alpha2.7.11.10.470
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.470
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.470
4a83DXCMajor pollen allergen Bet v 1-A/0.470
4g2h0VQVitamin D3 receptor A/0.470
4j7xSASSepiapterin reductase1.1.1.1530.470
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.469
2fzeAPRAlcohol dehydrogenase class-31.1.1.10.469
5agyGTBTau class glutathione S-transferase/0.469
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.468
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.468
4iaq2GM5-hydroxytryptamine receptor 1B/0.468
4jqh1MFAlr2278 protein/0.468
4pnmNU1Tankyrase-22.4.2.300.468
1pd9CO4Dihydrofolate reductase1.5.1.30.467
1rx8FOLDihydrofolate reductase1.5.1.30.467
1vruAAPGag-Pol polyprotein2.7.7.490.467
3nxyD2HDihydrofolate reductase1.5.1.30.467
4ffrATPUncharacterized protein/0.467
4kwhNAPReductase homolog/0.467
1gpeFADGlucose oxidase1.1.3.40.466
2acwUPGGlycosyltransferase/0.466
3nj0PYVAbscisic acid receptor PYL2/0.466
4bewACPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.466
4eiyZMAAdenosine receptor A2a/0.466
4g1z0VPVitamin D3 receptor A/0.466
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.466
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.465
1hquHBYGag-Pol polyprotein2.7.7.490.465
1kmsLIHDihydrofolate reductase1.5.1.30.465
1q4xG24Thyroid hormone receptor beta/0.465
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.465
2xvq9DSSerum albumin/0.465
4g1d0VKVitamin D3 receptor A/0.465
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.465
4rrgA3TThreonine--tRNA ligase6.1.1.30.465
4rw4494Gag-Pol polyprotein2.7.7.490.465
5iqdGNPBifunctional AAC/APH2.3.10.465
1hb3SCVIsopenicillin N synthase1.21.3.10.464
1n0uSO1Elongation factor 2/0.464
1wpgADPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.464
2y6fM9FIsopenicillin N synthase1.21.3.10.464
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.464
3ew2BTNHypothetical conserved protein/0.464
3i2834NBifunctional epoxide hydrolase 23.3.2.100.464
3koo24DBifunctional epoxide hydrolase 23.3.2.100.464
3wthIM4Acetylcholine-binding protein/0.464
4a802ANMajor pollen allergen Bet v 1-A/0.464
4er7AW3Histone-lysine N-methyltransferase, H3 lysine-79 specific2.1.1.430.464
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.464
4ie6UN9Alpha-ketoglutarate-dependent dioxygenase FTO/0.464
4ugaQ05Nitric oxide synthase oxygenase1.14.13.1650.464
5iqbGNPBifunctional AAC/APH2.3.10.464
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.463
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.463
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
1z6tADPApoptotic protease-activating factor 1/0.463
2vttLZDCyclin-dependent kinase 22.7.11.220.463
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.463
3evbSAHGenome polyprotein2.1.1.560.463
4jxhHRCCytohesin-2/0.463
1cbsREACellular retinoic acid-binding protein 2/0.462
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.462
2zl9VDAVitamin D3 receptor/0.462
3m08RARDihydrofolate reductase1.5.1.30.462
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
1i9hBNIStreptavidin/0.461
1o6qR17Squalene--hopene cyclase4.2.1.1290.461
1oc1ASVIsopenicillin N synthase1.21.3.10.461
1qiqACCIsopenicillin N synthase1.21.3.10.461
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.461
2bglNAJSecoisolariciresinol dehydrogenase1.1.1.3310.461
3a0iAJIGlucokinase2.7.1.20.461
3bqdDAYGlucocorticoid receptor/0.461
3h3sH15Collagen type IV alpha-3-binding protein/0.461
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
5iqiGNPBifunctional AAC/APH2.3.10.461
5kgpACOPredicted acetyltransferase/0.461
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
1s4dSAHUroporphyrinogen-III C-methyltransferase2.1.1.1070.460
2fa3ACOHydroxymethylglutaryl-CoA synthase/0.460
2o4rVD5Vitamin D3 receptor/0.460
2rhrEMOPutative ketoacyl reductase1.3.10.460
2rqfJH3Hemolymph juvenile hormone binding protein/0.460
2v1aFMNNPH1-1/0.460
3b9lAZZSerum albumin/0.460
3elySAHMethyltransferase/0.460
3mdmFJZCholesterol 24-hydroxylase/0.460
3s1dZIRCytokinin dehydrogenase 11.5.99.120.460
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
4stdBFSScytalone dehydratase4.2.1.940.460
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.459
1upw444Oxysterols receptor LXR-beta/0.459
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.459
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
3csdEMOPutative ketoacyl reductase1.3.10.459
3ddw055Glycogen phosphorylase, liver form2.4.1.10.459
3phjDHKShikimate dehydrogenase (NADP(+))/0.459
3vt5YI2Vitamin D3 receptor/0.459
3wv9FEGHmd co-occurring protein HcgE/0.459
4aosNAPSteroid monooxygenase/0.459
4l8u9AZSerum albumin/0.459
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.459
5eccNAPDehydrofolate reductase type I/0.459
1eioGCHGastrotropin/0.458
1m78CLZDihydrofolate reductase1.5.1.30.458
1vyrFMNPentaerythritol tetranitrate reductase/0.458
2po7CHDFerrochelatase, mitochondrial4.99.1.10.458
2wueKEK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.458
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.458
3cbsR12Cellular retinoic acid-binding protein 2/0.458
3h23B54Dihydropteroate synthase/0.458
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3vt7VDXVitamin D3 receptor/0.458
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.458
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.458
4eepFMNPhototropin-22.7.11.10.458
4g210VPVitamin D3 receptor A/0.458
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.458
3qakUKAAdenosine receptor A2a/0.458
1cqp803Integrin alpha-L/0.457
1klkPMDDihydrofolate reductase1.5.1.30.457
2g78REACellular retinoic acid-binding protein 2/0.457
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.457
4p68MTXDihydrofolate reductase/0.457
3emlZMAAdenosine receptor A2a/0.457
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.456
1ie8KH1Vitamin D3 receptor/0.456
2bfmTOPPteridine reductase 11.5.1.330.456
3dmjGWEPol protein/0.456
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.456
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.456
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.456
3nmhPYVAbscisic acid receptor PYL2/0.456
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.456
1dr3HBIDihydrofolate reductase1.5.1.30.455
1fmlRTLRetinol dehydratase/0.455
1tvrTB9Gag-Pol polyprotein2.7.7.490.455
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.455
2hasC3OVitamin D3 receptor/0.455
2yejXQKHeat shock protein HSP 90-alpha/0.455
2yejZZ3Heat shock protein HSP 90-alpha/0.455
3f0aACOSpermidine N(1)-acetyltransferase/0.455
3i1y33NBifunctional epoxide hydrolase 23.3.2.100.455
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.455
3nga3NGCasein kinase II subunit alpha2.7.11.10.455
3qlrNDPDihydrofolate reductase1.5.1.30.455
4b8zGDPGDP-L-fucose synthase1.1.1.2710.455
4djaFAD(6-4) photolyase/0.455
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
4h9506UDihydrofolate reductase1.5.1.30.455
4ie0PD2Alpha-ketoglutarate-dependent dioxygenase FTO/0.455
4kko1REGag-Pol polyprotein2.7.7.490.455
4okx198Androgen receptor/0.455
1h36R88Squalene--hopene cyclase4.2.1.1290.454
1rkhVD2Vitamin D3 receptor/0.454
1rszDIHPurine nucleoside phosphorylase2.4.2.10.454
1towCRZFatty acid-binding protein, adipocyte/0.454
2bu9HFVIsopenicillin N synthase1.21.3.10.454
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
2g0gSP0Peroxisome proliferator-activated receptor gamma/0.454
2zlaVDBVitamin D3 receptor/0.454
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.454
3ac1KZITyrosine-protein kinase Lck2.7.10.20.454
3i6qNDPPutative leucoanthocyanidin reductase 1/0.454
3nefPYVAbscisic acid receptor PYL1/0.454
3ns2PYVAbscisic acid receptor PYL2/0.454
3vtbTKAVitamin D3 receptor/0.454
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.454
4g1y0VOVitamin D3 receptor A/0.454
4prvADPDNA gyrase subunit B/0.454
1bcpATPPertussis toxin subunit 4/0.453
1bcpATPPertussis toxin subunit 5/0.453
1cjkFOKAdenylate cyclase type 2/0.453
1cjkFOKAdenylate cyclase type 5/0.453
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.453
1swtBTNStreptavidin/0.453
2wo7ASVIsopenicillin N synthase1.21.3.10.453
3cseN22Uncharacterized protein/0.453
3dolGWIPol protein/0.453
3fp0FP015-O-acetyltransferase/0.453
3ha5SFGHydroxymycolate synthase MmaA42.1.10.453
3pe6ZYHMonoglyceride lipase/0.453
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
4bfzZVZPantothenate kinase2.7.1.330.453
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.453
1a4iNDPC-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.452
1p4mADPRiboflavin kinase2.7.1.260.452
1qv0CZHObelin/0.452
1uyhPU0Heat shock protein HSP 90-alpha/0.452
2ban357Gag-Pol polyprotein2.7.7.490.452
2q7gCCLPyrrolysine--tRNA ligase/0.452
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3l0lHC3Nuclear receptor ROR-gamma/0.452
3nr4PYVAbscisic acid receptor PYL2/0.452
3ntz3TZDihydrofolate reductase1.5.1.30.452
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.452
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.452
4oal245Cytokinin dehydrogenase 4/0.452
4qofFMNRibosyldihydronicotinamide dehydrogenase [quinone]/0.452
1aoeGW3Dihydrofolate reductase1.5.1.30.451
1me6IVSPlasmepsin-23.4.23.390.451
1mrqSTRAldo-keto reductase family 1 member C1/0.451
1uofPNNDeacetoxycephalosporin C synthase1.14.20.10.451
2v58LZJBiotin carboxylase6.3.4.140.451
3a783EVVitamin D3 receptor/0.451
3fgoACPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.451
4h3i10VBeta-secretase 13.4.23.460.451
4ly91YYGlucokinase regulatory protein/0.451
4n1gCEIObelin/0.451
4rrhA3SProbable threonine--tRNA ligase 26.1.1.30.451
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.451
4yaiNAIC alpha-dehydrogenase/0.451
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.451
5iqaGNPBifunctional AAC/APH2.3.10.451
1ia4TQ6Dihydrofolate reductase1.5.1.30.450
1iyzNDPProbable quinone oxidoreductase/0.450
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.450
1s19MC9Vitamin D3 receptor/0.450
2ouzC3DEstrogen receptor/0.450
2w3mFOLDihydrofolate reductase1.5.1.30.450
3cgbCOACoenzyme A disulfide reductase/0.450
3h3r14HCollagen type IV alpha-3-binding protein/0.450
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.450
3o6o94MHeat shock protein 83/0.450
3qlxQLRUncharacterized protein/0.450
4cukNAID-lactate dehydrogenase/0.450
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
4ixeIXEDihydrofolate reductase1.5.1.30.450
4jlj1NMDeoxycytidine kinase2.7.1.740.450
4la7A1OAbscisic acid receptor PYL2/0.450
4o95245Cytokinin dehydrogenase 4/0.450
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.450
1cd2FOLDihydrofolate reductase1.5.1.30.449
1db1VDXVitamin D3 receptor/0.449
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.449
1gky5GPGuanylate kinase2.7.4.80.449
1piwNAPNADP-dependent alcohol dehydrogenase 61.1.1.20.449
1qjfACSIsopenicillin N synthase1.21.3.10.449
1yvfPH7Polyprotein/0.449
2ykiYKIHeat shock protein HSP 90-alpha/0.449
3dds26BGlycogen phosphorylase, liver form2.4.1.10.449
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
3td8D2RDihydrofolate reductase1.5.1.30.449
3tdwGDPGentamicin resistance protein/0.449
3v1mHPK2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase3.7.1.80.449
4g8zTOPDihydrofolate reductase1.5.1.30.449
4h9614QDihydrofolate reductase1.5.1.30.449
4ia7BIVVitamin D3 receptor A/0.449
4j0v1H7Beta-secretase 13.4.23.460.449
4nbjD3YD-tyrosyl-tRNA(Tyr) deacylase/0.449
4o71CPBBromodomain-containing protein 4/0.449
4zj8SUVOrexin receptor type 1/0.449
1g4sTPSThiamine-phosphate synthase/0.448
1nueGDPNucleoside diphosphate kinase B2.7.4.60.448
1nzdUPGDNA beta-glucosyltransferase/0.448
1uzwCDHIsopenicillin N synthase1.21.3.10.448
1xddAAYIntegrin alpha-L/0.448
2amb17HAndrogen receptor/0.448
2rkvZBATrichothecene 3-O-acetyltransferase/0.448
3havATPAminoglycoside phosphotransferase/0.448
3med65BGag-Pol polyprotein2.7.7.490.448
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3nxvD2FDihydrofolate reductase1.5.1.30.448
4ctjSAMGenome polyprotein/0.448
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.448
4kwi1TJReductase homolog/0.448
5iu86DZAdenosine receptor A2a/0.448
1blzACVIsopenicillin N synthase1.21.3.10.447
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.447
1drhNAPDihydrofolate reductase1.5.1.30.447
1ek2CDUBifunctional epoxide hydrolase 2/0.447
1hniAAAGag-Pol polyprotein2.7.7.490.447
1lwxAZDNucleoside diphosphate kinase, cytosolic2.7.4.60.447
1rk3VDXVitamin D3 receptor/0.447
1rx1NAPDihydrofolate reductase1.5.1.30.447
1tl7FOKAdenylate cyclase type 2/0.447
1tl7FOKAdenylate cyclase type 5/0.447
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2npxNADNADH peroxidase1.11.1.10.447
2vbdV10Isopenicillin N synthase1.21.3.10.447
2vcmM11Isopenicillin N synthase1.21.3.10.447
2xlpFADPutative flavin-containing monooxygenase/0.447
2xvhFADPutative flavin-containing monooxygenase/0.447
3drcMTXDihydrofolate reductase1.5.1.30.447
3eigMTXDihydrofolate reductase1.5.1.30.447
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.447
3oimVZ5Carbonic anhydrase 24.2.1.10.447
3pcnDHYProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.447
3pcnDHYProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.447
3pl8FADPyranose 2-oxidase/0.447
3sh25DRDihydrofolate reductase1.5.1.30.447
3w5tLHPVitamin D3 receptor/0.447
4iah1DXAlr2278 protein/0.447
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.447
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.447
4y9lFADAcyl-CoA dehydrogenase family member 11/0.447
5ai5BSUBifunctional epoxide hydrolase 23.1.3.760.447
1dg7WRBDihydrofolate reductase1.5.1.30.446
1dr3TAPDihydrofolate reductase1.5.1.30.446
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1revTB9Gag-Pol polyprotein2.7.7.490.446
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.446
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2iviACWIsopenicillin N synthase1.21.3.10.446
2pivDHTAndrogen receptor/0.446
2rehFADNitroalkane oxidase1.7.3.10.446
2yee2ECHeat shock protein HSP 90-alpha/0.446
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3vt8YI3Vitamin D3 receptor/0.446
4bx7B4FStreptavidin/0.446
4h2nFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.446
4iyg1HUStrictosidine synthase4.3.3.20.446
4lgaA2OAbscisic acid receptor PYL2/0.446
4mv8ACPBiotin carboxylase6.3.4.140.446
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.446
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.446
1drbMTXDihydrofolate reductase1.5.1.30.445
1n5vNOMActVA 6 protein/0.445
1o5rFR9Adenosine deaminase3.5.4.40.445
1obnASVIsopenicillin N synthase1.21.3.10.445
1ppjANYCytochrome b/0.445
1trgCB3Thymidylate synthase/0.445
1upaTPPN(2)-(2-carboxyethyl)arginine synthase/0.445
2bakAQZMitogen-activated protein kinase 14/0.445
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.445
2hc4VDXVitamin D3 receptor A/0.445
2ij7TPFMycocyclosin synthase1.14.21.90.445
2j5sKTAAlr4455 protein/0.445
2jb4A14Isopenicillin N synthase1.21.3.10.445
2pirDHTAndrogen receptor/0.445
2rtiGLLStreptavidin/0.445
2v59LZKBiotin carboxylase6.3.4.140.445
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.445
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
3bc1GNPRas-related protein Rab-27A/0.445
3fhxPLPPyridoxal kinase2.7.1.350.445
3fr5I4AFatty acid-binding protein, adipocyte/0.445
3lu8IQXSerum albumin/0.445
3mknDNBPyrimidine-specific ribonucleoside hydrolase RihB/0.445
3nmnPYVAbscisic acid receptor PYL1/0.445
3oiaA31Camphor 5-monooxygenase1.14.15.10.445
3r6pA8SAbscisic acid receptor PYL10/0.445
3w5rLOAVitamin D3 receptor/0.445
4a9yAQZMitogen-activated protein kinase 14/0.445
4dbzNDPPutative ketoacyl reductase1.3.10.445
4do30LAFatty-acid amide hydrolase 13.5.1.990.445
4hy6FJ1Heat shock protein HSP 90-alpha/0.445
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.445
4nhyPD2Prolyl 3-hydroxylase OGFOD11.14.110.445
4nmcFADBifunctional protein PutA/0.445
4uymVOR14-alpha sterol demethylase Cyp51B/0.445
4zasTYDCalS13/0.445
4zzjCNANAD-dependent protein deacetylase sirtuin-13.5.10.445
4mqt2CUMuscarinic acetylcholine receptor M2/0.445
1ao8MTXDihydrofolate reductase1.5.1.30.444
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
1ezvUQ6Cytochrome b/0.444
1fm4DXCMajor pollen allergen Bet v 1-L/0.444
1gwrESTEstrogen receptor/0.444
1ie9VDXVitamin D3 receptor/0.444
1jtuLYBThymidylate synthase/0.444
1luqBTNStreptavidin/0.444
1o6rR19Squalene--hopene cyclase4.2.1.1290.444
1odnAPVIsopenicillin N synthase1.21.3.10.444
1osvCHCBile acid receptor/0.444
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.444
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.444
2a1oCAMCamphor 5-monooxygenase1.14.15.10.444
2bfpH4BPteridine reductase 11.5.1.330.444
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.444
2fpcSCGStrictosidine synthase4.3.3.20.444
2izhBTNStreptavidin/0.444
2punACPMethylthioribose kinase2.7.1.1000.444
2r0pK2CPutative FAD-monooxygenase/0.444
2w3aTOPDihydrofolate reductase1.5.1.30.444
3aosJH2Hemolymph juvenile hormone binding protein/0.444
3bsyACOUDP-N-acetylbacillosamine N-acetyltransferase2.3.1.2030.444
3c1xCKKHepatocyte growth factor receptor2.7.10.10.444
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3gcq1BUMitogen-activated protein kinase 14/0.444
3h1jSMACytochrome b/0.444
3iaeD7KBenzaldehyde lyase/0.444
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3kjm245Cytokinin dehydrogenase 11.5.99.120.444
3l5dBDVBeta-secretase 13.4.23.460.444
3mnrSD1Heat shock protein HSP 90-alpha/0.444
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.444
4a84DXCMajor pollen allergen Bet v 1-A/0.444
4a8v2ANMajor pollen allergen Bet v 1-J/0.444
4bl5GFBGDP-L-fucose synthase1.1.1.2710.444
4h6pFMNChromate reductase/0.444
4jq4IMNAldo-keto reductase family 1 member C2/0.444
4kf1HT5Aryldialkylphosphatase3.1.8.10.444
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
4q93STLTyrosine--tRNA ligase, cytoplasmic6.1.1.10.444
4x28FDAAcyl-CoA dehydrogenase FadE26/0.444
4x28FDAAcyl-CoA dehydrogenase FadE27/0.444
5dcyNAPIridoid synthase1.3.1.990.444
3sn6P0GBeta-2 adrenergic receptor/0.444
3reyXACAdenosine receptor A2a/0.444
1dljUGAUDP-glucose 6-dehydrogenase/0.443
1e3gR18Androgen receptor/0.443
1mvsDTMDihydrofolate reductase1.5.1.30.443
1rfvADPPyridoxal kinase2.7.1.350.443
2a2cADPN-acetylgalactosamine kinase2.7.1.1570.443
2ag1TPPBenzaldehyde lyase/0.443
2cbsR13Cellular retinoic acid-binding protein 2/0.443
2kceD16Thymidylate synthase/0.443
2pg0FADAcyl-CoA dehydrogenase/0.443
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.443
2vd0D27Hematopoietic prostaglandin D synthase/0.443
3dd0EZLCarbonic anhydrase 24.2.1.10.443
3fr4F8AFatty acid-binding protein, adipocyte/0.443
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.443
3ghvGHCDihydrofolate reductase1.5.1.30.443
3h4vDVPPteridine reductase 11.5.1.330.443
3hk1B64Fatty acid-binding protein, adipocyte/0.443
3ipq965Oxysterols receptor LXR-alpha/0.443
3k47D09Dihydrofolate reductase1.5.1.30.443
3kb0A8SAbscisic acid receptor PYL2/0.443
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
3t3r9PLCytochrome P450 2A61.14.130.443
4fhi0S4Vitamin D3 receptor A/0.443
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.443
4oeaDHTAndrogen receptor/0.443
4qx5CMPcGMP-dependent protein kinase 12.7.11.120.443
5k2cZMAAdenosine receptor A2a/0.443
1ai9NDPDihydrofolate reductase1.5.1.30.442
1bk0ACVIsopenicillin N synthase1.21.3.10.442
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.442
1f28UMPThymidylate synthase2.1.1.450.442
1f4fTP3Thymidylate synthase/0.442
1hpzAAPGag-Pol polyprotein2.7.7.490.442
1kvkATPMevalonate kinase2.7.1.360.442
1stpBTNStreptavidin/0.442
2f3815MAldo-keto reductase family 1 member C3/0.442
2f8lSAMLmo1582 protein/0.442
2f8pCEIObelin/0.442
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.442
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3jrxS1AAcetyl-CoA carboxylase 2/0.442
3qge23EGenome polyprotein2.7.7.480.442
3vt65YIVitamin D3 receptor/0.442
3zkyWT4Isopenicillin N synthase1.21.3.10.442
4f700STCyclin-dependent kinase 82.7.11.220.442
4iui1GQEstrogen receptor/0.442
4kfj1R0Dihydrofolate reductase1.5.1.30.442
4rrrA3TThreonine--tRNA ligase6.1.1.30.442
5k2aZMAAdenosine receptor A2a/0.442
1e26GPBDihydrofolate reductase1.5.1.30.441
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.441
1qknRALEstrogen receptor beta/0.441
1s3yTQTDihydrofolate reductase1.5.1.30.441
1wsvTHHAminomethyltransferase, mitochondrial/0.441
1x7jGENEstrogen receptor beta/0.441
2cjeDUNDUTPase/0.441
2cjpVPREpoxide hydrolase/0.441
2izlIMIStreptavidin/0.441
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2xyuQ9GEphrin type-A receptor 42.7.10.10.441
2y6o1N1Ephrin type-A receptor 42.7.10.10.441
3ewkFADSensory box histidine kinase/response regulator/0.441
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3pn1IVHDNA ligase/0.441
3qm4PN0Cytochrome P450 2D6/0.441
3qw4U5POrotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative/0.441
3rsrN5PRibonucleoside-diphosphate reductase large chain 11.17.4.10.441
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.441
3v4aPK1Androgen receptor/0.441
3zs5SB2Mitogen-activated protein kinase 14/0.441
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4b10NHWGlycylpeptide N-tetradecanoyltransferase/0.441
4fgg0U5Dihydrofolate reductase1.5.1.30.441
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4gukP2GNeuronal calcium sensor 1/0.441
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.441
4l4eCAMCamphor 5-monooxygenase1.14.15.10.441
4mkgAP5Adenylate kinase/0.441
4rriA3TProbable threonine--tRNA ligase 26.1.1.30.441
5cp4CAMCamphor 5-monooxygenase1.14.15.10.441
1dhiMTXDihydrofolate reductase1.5.1.30.440
1jomFFODihydrofolate reductase1.5.1.30.440
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.440
1k5dGNPGTP-binding nuclear protein Ran/0.440
1m79MQ1Dihydrofolate reductase1.5.1.30.440
1qxlFR8Adenosine deaminase3.5.4.40.440
1rkpIBMcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
1u0hFOKAdenylate cyclase type 2/0.440
1u0hFOKAdenylate cyclase type 5/0.440
2l1rSXKTroponin C, slow skeletal and cardiac muscles/0.440
2qpyDHTAndrogen receptor/0.440
2qw8NAPEugenol synthase 11.1.1.3180.440
2rtdBTNStreptavidin/0.440
2wi72KLHeat shock protein HSP 90-alpha/0.440
2xx513NATP-dependent molecular chaperone HSP82/0.440
3evaSAHGenome polyprotein2.1.1.560.440
3l6jZ90Alr2278 protein/0.440
3maaFKPAdenylate cyclase type 2/0.440
3maaFKPAdenylate cyclase type 5/0.440
3nmvPYVAbscisic acid receptor PYL2/0.440
3pd2A3SThreonine--tRNA ligase6.1.1.30.440
3tq8TOPDihydrofolate reductase/0.440
3up0D7SaceDAF-12/0.440
3vjoANPEpidermal growth factor receptor2.7.10.10.440
4eqrCOACoenzyme A disulfide reductase/0.440
4frjDWBBeta-secretase 13.4.23.460.440
4l9q9TPSerum albumin/0.440
4li61XOTankyrase-12.4.2.300.440
4uofDATNucleoside diphosphate kinase/0.440