sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4c67 | L5S | Bromodomain-containing protein 4 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4c67 | L5S | Bromodomain-containing protein 4 | / | 1.000 | |
| 2yel | WSH | Bromodomain-containing protein 4 | / | 0.745 | |
| 4bjx | 73B | Bromodomain-containing protein 4 | / | 0.728 | |
| 4j3i | 1K0 | Bromodomain-containing protein 4 | / | 0.679 | |
| 4lr6 | 1XA | Bromodomain-containing protein 4 | / | 0.675 | |
| 4men | 25K | Bromodomain-containing protein 4 | / | 0.643 | |
| 4hxs | 1A3 | Bromodomain-containing protein 4 | / | 0.639 | |
| 4a9o | A9O | Bromodomain-containing protein 2 | / | 0.633 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.627 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.622 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.613 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.609 | |
| 4lyw | 21Q | Bromodomain-containing protein 4 | / | 0.608 | |
| 4a9l | P9L | Bromodomain-containing protein 4 | / | 0.604 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.603 | |
| 3aqa | BYH | Bromodomain-containing protein 2 | / | 0.601 | |
| 4mr4 | 1K0 | Bromodomain-containing protein 4 | / | 0.599 | |
| 4akn | S5B | Bromodomain-containing protein 2 | / | 0.596 | |
| 4j0s | 1H3 | Bromodomain-containing protein 4 | / | 0.593 | |
| 4j1p | 1K0 | Bromodomain-containing protein 2 | / | 0.593 | |
| 4a9i | P9I | Bromodomain-containing protein 2 | / | 0.592 | |
| 4hxr | 1A4 | Bromodomain-containing protein 4 | / | 0.591 | |
| 4nqm | Y1Z | Bromodomain-containing protein 4 | / | 0.591 | |
| 4mep | 24Y | Bromodomain-containing protein 4 | / | 0.589 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.589 | |
| 4a9n | A9N | Bromodomain-containing protein 2 | / | 0.584 | |
| 4bw1 | S5B | Bromodomain-containing protein 4 | / | 0.583 | |
| 4c66 | H4C | Bromodomain-containing protein 4 | / | 0.582 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.578 | |
| 4flp | JQ1 | Bromodomain testis-specific protein | / | 0.577 | |
| 4hxn | 1A7 | Bromodomain-containing protein 4 | / | 0.577 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.576 | |
| 4lrg | 1XB | Bromodomain-containing protein 4 | / | 0.575 | |
| 5bt5 | 2LO | Bromodomain-containing protein 2 | / | 0.575 | |
| 4py6 | R78 | Bromodomain protein, putative | / | 0.573 | |
| 4mr6 | 1K0 | Bromodomain-containing protein 2 | / | 0.572 | |
| 4meq | 25O | Bromodomain-containing protein 4 | / | 0.571 | |
| 3zyu | 1GH | Bromodomain-containing protein 4 | / | 0.566 | |
| 4f3i | 0S6 | Bromodomain-containing protein 4 | / | 0.564 | |
| 4o74 | R78 | Bromodomain-containing protein 4 | / | 0.563 | |
| 4uyg | 73B | Bromodomain-containing protein 2 | / | 0.562 | |
| 4j0r | 1H2 | Bromodomain-containing protein 4 | / | 0.559 | |
| 4hby | 13F | Bromodomain-containing protein 4 | / | 0.558 | |
| 4ogi | R78 | Bromodomain-containing protein 4 | / | 0.558 | |
| 4hxo | 1A6 | Bromodomain-containing protein 4 | / | 0.556 | |
| 4e96 | 0NS | Bromodomain-containing protein 4 | / | 0.553 | |
| 4meo | 25V | Bromodomain-containing protein 4 | / | 0.553 | |
| 4hbw | 14Z | Bromodomain-containing protein 4 | / | 0.552 | |
| 4bw3 | 9BM | Bromodomain-containing protein 4 | / | 0.550 | |
| 4o78 | SAV | Bromodomain-containing protein 4 | / | 0.550 | |
| 4qzs | JQ1 | Bromodomain-containing protein 4 | / | 0.549 | |
| 4a9e | 3PF | Bromodomain-containing protein 2 | / | 0.547 | |
| 2yem | WSH | Bromodomain-containing protein 4 | / | 0.541 | |
| 4nr5 | 2LL | CREB-binding protein | / | 0.541 | |
| 4mr5 | 1K0 | Bromodomain-containing protein 2 | / | 0.537 | |
| 4gpj | 0Q1 | Bromodomain-containing protein 4 | / | 0.535 | |
| 4cfl | 8DQ | Bromodomain-containing protein 4 | / | 0.533 | |
| 4a9h | TVP | Bromodomain-containing protein 2 | / | 0.528 | |
| 4bw2 | UTH | Bromodomain-containing protein 4 | / | 0.528 | |
| 4alg | 1GH | Bromodomain-containing protein 2 | / | 0.521 | |
| 4nr8 | 2LL | Bromodomain-containing protein 4 | / | 0.521 | |
| 4nyw | 2O3 | CREB-binding protein | / | 0.521 | |
| 4nyv | 15E | CREB-binding protein | / | 0.519 | |
| 5dfc | EAM | Bromodomain-containing protein 2 | / | 0.518 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.515 | |
| 4hxm | 1A8 | Bromodomain-containing protein 4 | / | 0.512 | |
| 4ir5 | IR5 | Bromodomain adjacent to zinc finger domain protein 2B | / | 0.504 | |
| 3svg | ODR | Bromodomain-containing protein 4 | / | 0.499 | |
| 4bw4 | 9B6 | Bromodomain-containing protein 4 | / | 0.495 | |
| 4cfk | LY2 | Bromodomain-containing protein 4 | / | 0.493 | |
| 5ii2 | LU2 | Protein polybromo-1 | / | 0.486 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.485 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.485 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.478 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.478 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3zuy | TCH | Transporter | / | 0.477 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.477 | |
| 1ppj | ANY | Cytochrome b | / | 0.473 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 3eem | 53V | Uncharacterized protein | / | 0.472 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.470 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.470 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.469 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.469 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.469 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.468 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.468 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.468 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.468 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.468 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.467 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.467 | |
| 4fk8 | FAD | Ferredoxin--NADP reductase | / | 0.466 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 2wgj | VGH | Hepatocyte growth factor receptor | 2.7.10.1 | 0.465 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.465 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.464 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 3cgc | COA | Coenzyme A disulfide reductase | / | 0.464 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.464 | |
| 2vnh | FAD | NADPH:ferredoxin reductase | / | 0.463 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.463 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.463 | |
| 4nra | 2LW | Bromodomain adjacent to zinc finger domain protein 2B | / | 0.463 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 1a8p | FAD | Ferredoxin--NADP reductase | / | 0.462 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.462 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.461 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.461 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.461 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.461 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.461 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.460 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.460 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.460 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.460 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.460 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.460 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 2v3w | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.459 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.459 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.459 | |
| 4ix6 | ADP | Uncharacterized protein | / | 0.459 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.459 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.458 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.458 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.458 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.458 | |
| 2ovm | AS0 | Progesterone receptor | / | 0.458 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.458 | |
| 3fz1 | B98 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 3lpb | NVB | Tyrosine-protein kinase JAK2 | / | 0.458 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 2bgi | FAD | NADPH:ferredoxin reductase | / | 0.457 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.457 | |
| 3zhu | TD8 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.457 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.457 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.457 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.456 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.456 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2vnk | FAD | NADPH:ferredoxin reductase | / | 0.456 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.455 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.455 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.455 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.455 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.455 | |
| 4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.455 | |
| 4lfi | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.455 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 2y37 | A54 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.454 | |
| 3crz | FAD | Ferredoxin--NADP+ reductase | / | 0.454 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.454 | |
| 4idv | 13V | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.454 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.453 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2xvw | 9NR | Serum albumin | / | 0.453 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.453 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.453 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.453 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.453 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 3wow | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.453 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.453 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.453 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 2ohv | NHL | Glutamate racemase | / | 0.452 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.452 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.452 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.452 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.452 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.452 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 4mf0 | 29Z | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.452 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.451 | |
| 3cse | N22 | Uncharacterized protein | / | 0.451 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.451 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3mfs | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.451 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.451 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.451 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.451 | |
| 1bif | AGS | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 | 0.450 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.450 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.450 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.450 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.450 | |
| 4h4m | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 4nfh | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.450 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.449 | |
| 1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.449 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.449 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.449 | |
| 3gob | HXX | DdmC | / | 0.449 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 4b4d | FAD | Ferredoxin-NADP reductase | / | 0.449 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.449 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.449 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1khr | VIR | Streptogramin A acetyltransferase | 2.3.1 | 0.448 | |
| 1lco | PPY | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.448 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1r2j | FAD | FkbI | / | 0.448 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.448 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.448 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.448 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.448 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.448 | |
| 3at4 | CCK | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 4b13 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4b1f | KRH | Glutamate racemase | / | 0.448 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.448 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.448 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.448 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 5cvh | ADP | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.447 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.447 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.447 | |
| 2vnj | FAD | NADPH:ferredoxin reductase | / | 0.447 | |
| 2z0y | SAM | Ribosomal RNA small subunit methyltransferase E | / | 0.447 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.447 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.447 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.447 | |
| 5dmz | ADP | Mitotic checkpoint serine/threonine-protein kinase BUB1 | 2.7.11.1 | 0.447 | |
| 5dn3 | ATP | Aurora kinase A | 2.7.11.1 | 0.447 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.446 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.446 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1v79 | FR7 | Adenosine deaminase | 3.5.4.4 | 0.446 | |
| 2jfa | RAL | Estrogen receptor | / | 0.446 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.446 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 3eel | 53T | Uncharacterized protein | / | 0.446 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.446 | |
| 3hko | ANP | Calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands | / | 0.446 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.446 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.446 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.446 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.445 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.445 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.445 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 2xvv | 9DN | Serum albumin | / | 0.445 | |
| 2ywv | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | / | 0.445 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.445 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.445 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.445 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.445 | |
| 4qmy | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.445 | |
| 1fml | RTL | Retinol dehydratase | / | 0.444 | |
| 1yre | COA | Uncharacterized protein | / | 0.444 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.444 | |
| 2fyp | RDE | Endoplasmin | / | 0.444 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 3iqf | E4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.444 | |
| 3pj8 | 404 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4dgo | 0JW | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.444 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.444 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1axw | MTX | Thymidylate synthase | / | 0.443 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 1s1v | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.443 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.443 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.443 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2v7a | 627 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.443 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.443 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.443 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.443 | |
| 3dok | GWJ | Pol protein | / | 0.443 | |
| 3e01 | PZ2 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3eek | 53S | Uncharacterized protein | / | 0.443 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.443 | |
| 3h18 | PMS | Esterase/lipase | / | 0.443 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3pxy | JWS | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3zhs | TD6 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.443 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.443 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4ho8 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.443 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.443 | |
| 4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 5a3c | NAD | SIR2 family protein | / | 0.443 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.443 | |
| 1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.442 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.442 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.442 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.442 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 2bgj | FAD | NADPH:ferredoxin reductase | / | 0.442 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.442 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.442 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.442 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.442 | |
| 3jzf | JZK | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.442 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 3pd2 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.442 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.442 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.442 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.442 | |
| 3zlx | 5EZ | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.442 | |
| 4anm | WUL | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.442 | |
| 4l8u | 9AZ | Serum albumin | / | 0.442 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.442 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.442 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.441 | |
| 1m9k | 7NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.441 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.441 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.441 | |
| 1pxx | DIF | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.441 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 2pvl | P55 | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 2vwz | 7X6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.441 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 3ey9 | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.441 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.441 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.441 | |
| 3lal | KRV | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.441 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 3qfc | FAD | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 4aqc | 88A | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.441 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.441 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.441 | |
| 4yau | FAD | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.440 | |
| 1j7k | ATP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.440 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.440 | |
| 1s3z | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.440 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.440 | |
| 1wlv | COA | Phenylacetic acid degradation protein PaaI | / | 0.440 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.440 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.440 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2kce | D16 | Thymidylate synthase | / | 0.440 | |
| 2w05 | FRT | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2w1f | L0F | Aurora kinase A | 2.7.11.1 | 0.440 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.440 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.440 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.440 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.440 | |
| 4jr7 | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.440 |