sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3n4l | 842 | Beta-secretase 1 | 3.4.23.46 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3n4l | 842 | Beta-secretase 1 | 3.4.23.46 | 1.000 | |
| 4i0j | 842 | Beta-secretase 1 | 3.4.23.46 | 0.667 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.609 | |
| 4ke0 | 1R8 | Beta-secretase 1 | 3.4.23.46 | 0.604 | |
| 3qi1 | C6A | Beta-secretase 1 | 3.4.23.46 | 0.602 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.567 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.553 | |
| 3k5f | AYH | Beta-secretase 1 | 3.4.23.46 | 0.550 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.547 | |
| 2fdp | FRP | Beta-secretase 1 | 3.4.23.46 | 0.546 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.543 | |
| 2f3e | AXQ | Beta-secretase 1 | 3.4.23.46 | 0.542 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.541 | |
| 4lxm | 1YU | Beta-secretase 1 | 3.4.23.46 | 0.540 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.539 | |
| 1w51 | L01 | Beta-secretase 1 | 3.4.23.46 | 0.524 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.524 | |
| 3k5d | XLI | Beta-secretase 1 | 3.4.23.46 | 0.522 | |
| 4l7j | 1W2 | Beta-secretase 1 | 3.4.23.46 | 0.518 | |
| 3ixk | 929 | Beta-secretase 1 | 3.4.23.46 | 0.517 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.517 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.516 | |
| 3vf3 | 0GS | Beta-secretase 1 | 3.4.23.46 | 0.516 | |
| 2p4j | 23I | Beta-secretase 1 | 3.4.23.46 | 0.515 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.515 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.512 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.511 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.510 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.510 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.510 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.509 | |
| 2xfi | XFI | Beta-secretase 1 | 3.4.23.46 | 0.508 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.508 | |
| 4b0q | GMF | Beta-secretase 1 | 3.4.23.46 | 0.508 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.508 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.507 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.507 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.505 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.505 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.505 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.505 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.504 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.504 | |
| 3exo | 5MS | Beta-secretase 1 | 3.4.23.46 | 0.504 | |
| 4j1f | 1HL | Beta-secretase 1 | 3.4.23.46 | 0.504 | |
| 4lc7 | 1WP | Beta-secretase 1 | 3.4.23.46 | 0.503 | |
| 3duy | AFJ | Beta-secretase 1 | 3.4.23.46 | 0.502 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.502 | |
| 4j1k | 1HG | Beta-secretase 1 | 3.4.23.46 | 0.502 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.501 | |
| 2hm1 | LIQ | Beta-secretase 1 | 3.4.23.46 | 0.501 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.501 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.501 | |
| 4dus | 0MP | Beta-secretase 1 | 3.4.23.46 | 0.501 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.498 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.497 | |
| 4b72 | 2FB | Beta-secretase 1 | 3.4.23.46 | 0.496 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.494 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.493 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.493 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.493 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.492 | |
| 1jg0 | DDT | Thymidylate synthase | / | 0.491 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.491 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.491 | |
| 3zlq | 6T9 | Beta-secretase 2 | 3.4.23.45 | 0.491 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.489 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.489 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.489 | |
| 1m9j | CLW | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.488 | |
| 2f3f | AXF | Beta-secretase 1 | 3.4.23.46 | 0.487 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.487 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.487 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.486 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.486 | |
| 3dv1 | AR9 | Beta-secretase 1 | 3.4.23.46 | 0.485 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.485 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.484 | |
| 3i25 | MV7 | Beta-secretase 1 | 3.4.23.46 | 0.484 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.483 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.483 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.483 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.482 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.482 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.482 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.482 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.481 | |
| 4fs4 | H24 | Beta-secretase 1 | 3.4.23.46 | 0.481 | |
| 4h3g | 10Q | Beta-secretase 1 | 3.4.23.46 | 0.481 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.480 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.480 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.480 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.479 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.479 | |
| 4frs | 0V6 | Beta-secretase 1 | 3.4.23.46 | 0.479 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.478 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.478 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 4b00 | I6X | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 4acx | S8Z | Beta-secretase 1 | 3.4.23.46 | 0.477 | |
| 2p8h | MY9 | Beta-secretase 1 | 3.4.23.46 | 0.476 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.475 | |
| 2ph6 | 712 | Beta-secretase 1 | 3.4.23.46 | 0.475 | |
| 3dv5 | BAV | Beta-secretase 1 | 3.4.23.46 | 0.475 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.475 | |
| 4l7g | 1W0 | Beta-secretase 1 | 3.4.23.46 | 0.475 | |
| 2vkm | BSD | Beta-secretase 1 | 3.4.23.46 | 0.474 | |
| 1b5d | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.473 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.473 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.472 | |
| 2qzl | IXS | Beta-secretase 1 | 3.4.23.46 | 0.472 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.472 | |
| 3r2f | PB0 | Beta-secretase 1 | 3.4.23.46 | 0.472 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.472 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.472 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.471 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.471 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.470 | |
| 2vie | VG0 | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.470 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.470 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.470 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.469 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.469 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 3t7x | 4SH | Endothiapepsin | 3.4.23.22 | 0.469 | |
| 4ha5 | 13W | Beta-secretase 1 | 3.4.23.46 | 0.469 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.468 | |
| 2wf1 | ZY1 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.468 | |
| 4azy | 7F3 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 4bek | XK0 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 1eio | GCH | Gastrotropin | / | 0.467 | |
| 1i5e | U5P | Uracil phosphoribosyltransferase | / | 0.467 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.467 | |
| 4h3i | 10V | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 2b8v | 3BN | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.466 | |
| 4djy | 0KR | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.465 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.465 | |
| 2z3n | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.465 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.465 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.464 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.464 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.464 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.464 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 4b70 | WM9 | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.464 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.463 | |
| 2irz | I02 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 2yoj | 8Y6 | Genome polyprotein | 2.7.7.48 | 0.463 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.463 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.463 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.463 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.462 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 2y37 | A54 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.462 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.462 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 2ph8 | 35A | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 3eai | 328 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.461 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.461 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.460 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.460 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 3pw8 | ACO | 1,2-phenylacetyl-CoA epoxidase, subunit A | 1.14.13.149 | 0.460 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.460 | |
| 4dju | 0KK | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.459 | |
| 1m9t | INE | Nitric oxide synthase, inducible | 1.14.13.39 | 0.459 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.459 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 2oah | QIN | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 2onm | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.459 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.459 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.459 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.459 | |
| 4dja | FAD | (6-4) photolyase | / | 0.459 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.459 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.458 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.458 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.458 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.458 | |
| 1l5s | 700 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.457 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.457 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.457 | |
| 3q70 | RIT | Candidapepsin-2 | 3.4.23.24 | 0.457 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.457 | |
| 4b1c | 1B1 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.457 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.457 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.457 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.456 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.456 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.456 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.456 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.456 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.456 | |
| 4b05 | 32D | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.456 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.456 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.455 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.455 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.455 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.455 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.455 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.455 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.455 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.455 | |
| 4yfy | 1YJ | VioF | / | 0.455 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1jdt | MTA | Purine nucleoside phosphorylase | / | 0.454 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.454 | |
| 2djl | FMN | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.454 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.454 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.454 | |
| 3t7q | RB4 | Endothiapepsin | 3.4.23.22 | 0.454 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.454 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.453 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.453 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 3gob | HXX | DdmC | / | 0.453 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.453 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.453 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 5bnw | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.453 | |
| 1b5e | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.452 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.452 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.452 | |
| 4xr9 | NAD | CalS8 | / | 0.452 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.451 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.451 | |
| 2vnm | CM8 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.451 | |
| 3h4l | ANP | DNA mismatch repair protein PMS1 | / | 0.451 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.451 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.451 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.451 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.451 | |
| 4fri | DWA | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.451 | |
| 1gvt | 2ZS | Endothiapepsin | 3.4.23.22 | 0.450 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.450 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.450 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.450 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.450 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.450 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.449 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.449 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.449 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.449 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.449 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.449 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.449 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.449 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.449 | |
| 3axk | NDP | Ribulose bisphosphate carboxylase large chain | 4.1.1.39 | 0.449 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3g6z | A7T | Renin | 3.4.23.15 | 0.449 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 4jpe | 1M7 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.449 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.449 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.448 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.448 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.448 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.448 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.448 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.448 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.448 | |
| 3tpr | 5HA | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3vmm | P0D | Alanine--anticapsin ligase | / | 0.448 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.448 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.448 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.448 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.448 | |
| 2djx | FMN | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.447 | |
| 2g27 | 4LG | Renin | 3.4.23.15 | 0.447 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.447 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.447 | |
| 3ieu | GDP | GTPase Era | / | 0.447 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.447 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.447 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.447 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.447 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.446 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2q9c | GNP | Signal recognition particle receptor FtsY | / | 0.446 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.446 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.446 | |
| 3a3g | DLZ | Lumazine protein | / | 0.446 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.446 | |
| 3t6i | NC9 | Endothiapepsin | 3.4.23.22 | 0.446 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.446 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.446 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.446 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.446 | |
| 4psw | COA | Histone acetyltransferase type B catalytic subunit | / | 0.446 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.445 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.445 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.445 | |
| 3e7i | B2 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.445 | |
| 3lb8 | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.445 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.445 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.445 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.445 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.445 | |
| 4ef4 | C2E | Stimulator of interferon genes protein | / | 0.445 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.445 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.445 | |
| 4j0y | 1H6 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4s0v | SUV | Orexin receptor type 2 | / | 0.445 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.444 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.444 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.444 | |
| 1zap | A70 | Candidapepsin-2 | 3.4.23.24 | 0.444 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.444 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.444 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.444 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 3kmy | D8Y | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3rba | COD | Phosphopantetheine adenylyltransferase | / | 0.444 | |
| 4b78 | KGG | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4ccq | FAD | Thioredoxin reductase | / | 0.444 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 4y1b | NAP | AntE | / | 0.444 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.444 | |
| 5k5z | ANP | Uncharacterized protein | / | 0.444 | |
| 1j78 | VDY | Vitamin D-binding protein | / | 0.443 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.443 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.443 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.443 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.443 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.443 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.443 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.443 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.443 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.443 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.443 | |
| 3zxs | FAD | Deoxyribodipyrimidine photolyase-related protein | / | 0.443 | |
| 4hmx | FMN | Pyridoxamine 5'-phosphate oxidase | / | 0.443 | |
| 4i0f | 1BF | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.443 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.443 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.443 | |
| 4x7v | MIV | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.443 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.443 | |
| 4y3z | F41 | Endothiapepsin | 3.4.23.22 | 0.443 | |
| 5a01 | 12V | O-glycosyltransferase | / | 0.443 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.443 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.442 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1owm | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.442 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.442 | |
| 2e8q | SAH | Diphthine synthase | / | 0.442 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.442 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 2yj4 | ATP | Copper-transporting ATPase | / | 0.442 | |
| 3b04 | OOP | Isopentenyl-diphosphate delta-isomerase | / | 0.442 | |
| 3bnk | FMN | Flavoredoxin | / | 0.442 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.442 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3pbz | F02 | Endothiapepsin | 3.4.23.22 | 0.442 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.442 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.442 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.442 | |
| 4dan | 2FA | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.442 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.442 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.442 | |
| 5ftf | ADP | TPR domain protein | / | 0.442 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.441 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.441 | |
| 2i7n | ACO | Pantothenate kinase 1 | 2.7.1.33 | 0.441 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2qw0 | 34Z | 4-chlorobenzoyl CoA ligase | / | 0.441 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.441 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.441 | |
| 3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.441 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4c4o | NAD | SADH | / | 0.441 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.441 | |
| 4qnw | FMN | Chanoclavine-I aldehyde reductase easA | / | 0.441 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.441 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.441 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 1mbb | EEB | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.440 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.440 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.440 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.440 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.440 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.440 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3ens | ENS | Coagulation factor X | 3.4.21.6 | 0.440 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.440 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.440 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.440 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.440 | |
| 3pfd | FDA | Acyl-CoA dehydrogenase FadE25 | / | 0.440 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.440 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.440 |