sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3egk | M18 | Prothrombin | 3.4.21.5 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3egk | M18 | Prothrombin | 3.4.21.5 | 1.000 | |
| 3dhk | 23U | Prothrombin | 3.4.21.5 | 0.761 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.743 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.691 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.676 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.674 | |
| 3f68 | 91U | Prothrombin | 3.4.21.5 | 0.672 | |
| 2zda | 32U | Prothrombin | 3.4.21.5 | 0.669 | |
| 2znk | 31U | Prothrombin | 3.4.21.5 | 0.665 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.658 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.657 | |
| 2ziq | 26U | Prothrombin | 3.4.21.5 | 0.656 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.650 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.646 | |
| 1ypg | UIR | Prothrombin | 3.4.21.5 | 0.642 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.641 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.640 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.636 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.635 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.635 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.634 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.634 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.633 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.629 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.624 | |
| 2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.624 | |
| 3biv | 11U | Prothrombin | 3.4.21.5 | 0.624 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.623 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.623 | |
| 2jh0 | 701 | Prothrombin | 3.4.21.5 | 0.622 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.622 | |
| 1mu8 | CDB | Prothrombin | 3.4.21.5 | 0.621 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.620 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.619 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.618 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.618 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.615 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.611 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.608 | |
| 1c5n | ESI | Prothrombin | 3.4.21.5 | 0.607 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.607 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.606 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.605 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.604 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.603 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.603 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.603 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.602 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.601 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.599 | |
| 1o0d | 163 | Prothrombin | 3.4.21.5 | 0.598 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.598 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.596 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.593 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.593 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.591 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.591 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.590 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.587 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.583 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.582 | |
| 4ayy | 9MX | Prothrombin | 3.4.21.5 | 0.581 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.578 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.576 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.575 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.575 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.573 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.573 | |
| 1kts | C24 | Prothrombin | 3.4.21.5 | 0.572 | |
| 1ta2 | 176 | Prothrombin | 3.4.21.5 | 0.571 | |
| 1uvs | I11 | Prothrombin | 3.4.21.5 | 0.571 | |
| 7kme | ACE_0BN_CHG_PRR | Prothrombin | 3.4.21.5 | 0.570 | |
| 4loy | 6XS | Prothrombin | 3.4.21.5 | 0.569 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.567 | |
| 2zf0 | 51U | Prothrombin | 3.4.21.5 | 0.567 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.566 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.565 | |
| 4ayv | 9MQ | Prothrombin | 3.4.21.5 | 0.565 | |
| 2gde | SN3 | Prothrombin | 3.4.21.5 | 0.564 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.560 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.559 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.551 | |
| 1ny2 | ARG_PRO_PRO_GLY | Prothrombin | 3.4.21.5 | 0.551 | |
| 1k21 | IGN | Prothrombin | 3.4.21.5 | 0.550 | |
| 1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.550 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.549 | |
| 2zfp | 19U | Prothrombin | 3.4.21.5 | 0.548 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.547 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.547 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.545 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.541 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.540 | |
| 4az2 | 9MU | Prothrombin | 3.4.21.5 | 0.538 | |
| 1vzq | SHY | Prothrombin | 3.4.21.5 | 0.537 | |
| 2cf8 | ESH | Prothrombin | 3.4.21.5 | 0.536 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.536 | |
| 3qto | 10P | Prothrombin | 3.4.21.5 | 0.535 | |
| 3p17 | 99P | Prothrombin | 3.4.21.5 | 0.532 | |
| 1k22 | MEL | Prothrombin | 3.4.21.5 | 0.531 | |
| 4ban | M6S | Prothrombin | 3.4.21.5 | 0.530 | |
| 1w7g | MIU | Prothrombin | 3.4.21.5 | 0.528 | |
| 4e7r | 0NW | Prothrombin | 3.4.21.5 | 0.528 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.525 | |
| 1sl3 | 170 | Prothrombin | 3.4.21.5 | 0.523 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.522 | |
| 2viv | VG2 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.521 | |
| 1ghv | 120 | Prothrombin | 3.4.21.5 | 0.518 | |
| 4bao | MVF | Prothrombin | 3.4.21.5 | 0.518 | |
| 3qtv | 06P | Prothrombin | 3.4.21.5 | 0.517 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.515 | |
| 4fub | 4UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.514 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.512 | |
| 1riw | OSC | Prothrombin | 3.4.21.5 | 0.510 | |
| 3qdz | PRO_ALA_PRO_ARG | Prothrombin | 3.4.21.5 | 0.508 | |
| 4baq | M4Z | Prothrombin | 3.4.21.5 | 0.506 | |
| 2g00 | 4QC | Coagulation factor X | 3.4.21.6 | 0.504 | |
| 3v2u | ATP | Protein GAL3 | / | 0.502 | |
| 4fue | 7UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.501 | |
| 1zsk | 421 | Coagulation factor XI | 3.4.21.27 | 0.499 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.498 | |
| 1owe | 675 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.496 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.496 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.492 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.492 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.491 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.491 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.491 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.488 | |
| 2vqz | MGT | Polymerase basic protein 2 | / | 0.488 | |
| 5dp2 | NAP | CurF | / | 0.487 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.486 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.485 | |
| 4fuf | 8UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.485 | |
| 2uuj | 896 | Prothrombin | 3.4.21.5 | 0.484 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.482 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.482 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.481 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.479 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.477 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.476 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 1wli | FMN | FMN-binding protein | / | 0.475 | |
| 2y5g | FJD | Coagulation factor X | 3.4.21.6 | 0.475 | |
| 3v0x | ANH | Cationic trypsin | 3.4.21.4 | 0.475 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 2bxt | C2D | Prothrombin | 3.4.21.5 | 0.473 | |
| 2q0l | NAP | Thioredoxin reductase | 1.8.1.9 | 0.473 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.473 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.472 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.472 | |
| 1nfy | RTR | Coagulation factor X | 3.4.21.6 | 0.472 | |
| 2fhj | H4Z | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.472 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.472 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.472 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.471 | |
| 2qf2 | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.471 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.471 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.471 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.470 | |
| 3dt2 | GTP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.470 | |
| 4fui | UI3 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.469 | |
| 4rxs | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.468 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.467 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.467 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.466 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.466 | |
| 2fzm | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.466 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.466 | |
| 3tjl | FMN | NADPH dehydrogenase | / | 0.466 | |
| 4xr9 | NAD | CalS8 | / | 0.466 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.465 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 1vja | 7IN | Urokinase-type plasminogen activator | 3.4.21.73 | 0.464 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.464 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.464 | |
| 3n71 | SFG | Histone-lysine N-methyltransferase Smyd1 | / | 0.464 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 5cyo | GDP | Septin-9 | / | 0.464 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.463 | |
| 2p98 | YE7 | Methionine aminopeptidase | / | 0.463 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.463 | |
| 3udq | 09E | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.462 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.462 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.462 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.462 | |
| 4j1t | NAP | NAD(P) transhydrogenase subunit beta | / | 0.462 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.462 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.461 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.461 | |
| 3s8p | SAM | Histone-lysine N-methyltransferase KMT5B | 2.1.1.43 | 0.461 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.460 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.460 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 1nt1 | T76 | Prothrombin | 3.4.21.5 | 0.459 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.459 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.459 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.459 | |
| 4btu | 6XS | Coagulation factor X | 3.4.21.6 | 0.459 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.459 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.458 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.458 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.458 | |
| 4j1e | 1HM | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.458 | |
| 4nv1 | TYD | Formyl transferase | / | 0.458 | |
| 1aa6 | MGD | Formate dehydrogenase H | 1.1.99.33 | 0.457 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.457 | |
| 2g0b | NLT | Long-chain N-acyl amino acid synthase | / | 0.457 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.457 | |
| 2jt2 | C90 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.457 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.457 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.457 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.457 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.457 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.457 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.457 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.457 | |
| 1sqt | UI3 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.456 | |
| 1umk | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.456 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.456 | |
| 3hdy | GDU | UDP-galactopyranose mutase | / | 0.456 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.456 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.456 | |
| 4q36 | CO8 | Uncharacterized protein | / | 0.456 | |
| 1iki | REY | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.455 | |
| 1og4 | NAI | T-cell ecto-ADP-ribosyltransferase 2 | / | 0.455 | |
| 1owk | 303 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.455 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4iji | 99T | Glutathione S-transferase-like protein YibF | / | 0.455 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.454 | |
| 1lv8 | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2qw0 | 34Z | 4-chlorobenzoyl CoA ligase | / | 0.454 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.454 | |
| 3ho9 | N3A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.454 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.454 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.454 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.454 | |
| 4bti | 7R9 | Coagulation factor X | 3.4.21.6 | 0.454 | |
| 1iqe | XMB | Coagulation factor X | 3.4.21.6 | 0.453 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.453 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.453 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1lce | TMF | Thymidylate synthase | / | 0.452 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.452 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.452 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3e6e | DCS | Alanine racemase | / | 0.452 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3wth | IM4 | Acetylcholine-binding protein | / | 0.452 | |
| 4e2y | JHZ | Methyltransferase | / | 0.452 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.452 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.451 | |
| 3mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.451 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.451 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.451 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.451 | |
| 1mma | ADP | Myosin-2 heavy chain | / | 0.450 | |
| 2h21 | SAM | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.450 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2i9k | SAH | Modification methylase HhaI | 2.1.1.37 | 0.450 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.450 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.450 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.450 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 3gf4 | U5P | UDP-galactopyranose mutase | 5.4.99.9 | 0.450 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.450 | |
| 3sor | O58 | Coagulation factor XI | 3.4.21.27 | 0.450 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4bup | SAM | Histone-lysine N-methyltransferase KMT5B | 2.1.1.43 | 0.450 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 4zwe | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.450 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.450 | |
| 1f92 | UKP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.449 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.449 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.449 | |
| 2e1m | FAD | L-glutamate oxidase | / | 0.449 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.449 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.449 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.449 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.449 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.448 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3e8x | NAP | BH1520 protein | / | 0.448 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.448 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.448 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.447 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.447 | |
| 2d81 | RB3 | Poly(3-hydroxybutyrate) depolymerase | / | 0.447 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.447 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.447 | |
| 2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.447 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.447 | |
| 2y8l | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.447 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.447 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.447 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.447 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.447 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.447 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.447 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.447 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.447 | |
| 4wlj | IK2 | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.447 | |
| 1a8r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.446 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 1h69 | ARH | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1iqg | XME | Coagulation factor X | 3.4.21.6 | 0.446 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.446 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.446 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.446 | |
| 3udj | 092 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4brd | ANP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.446 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.446 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.446 | |
| 1c1u | BAI | Prothrombin | 3.4.21.5 | 0.445 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.445 | |
| 1wur | 8DG | GTP cyclohydrolase 1 | / | 0.445 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 2aqb | TL6 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.445 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.445 | |
| 2q93 | B21 | Methionine aminopeptidase | / | 0.445 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.445 | |
| 2y5h | Y5H | Coagulation factor X | 3.4.21.6 | 0.445 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.445 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 4bri | UNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.445 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.445 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.445 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.445 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.445 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.445 | |
| 1ftl | DNQ | Glutamate receptor 2 | / | 0.444 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1m2g | APR | NAD-dependent protein deacylase 1 | / | 0.444 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.444 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 2j4l | UTP | Uridylate kinase | 2.7.4.22 | 0.444 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.444 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.444 | |
| 2y82 | 930 | Coagulation factor X | 3.4.21.6 | 0.444 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.444 | |
| 3zhu | TD8 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.444 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.444 | |
| 4to3 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.444 | |
| 1gmc | PRO_GLY_ALA_TYR | Chymotrypsinogen A | 3.4.21.1 | 0.443 | |
| 1mlv | SAH | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.443 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.443 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.443 | |
| 2hm1 | LIQ | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.443 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.443 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.443 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.443 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.443 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.442 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1rxj | BNI | Streptavidin | / | 0.442 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.442 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.442 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.442 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.442 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.442 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 2ptf | FMN | Uncharacterized protein MTH_863 | / | 0.442 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.442 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.442 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.442 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.442 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.442 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.442 | |
| 4r5w | XAV | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 4zm6 | ACO | N-acetyl-beta-D glucosaminidase | / | 0.442 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.442 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.441 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1nlm | UD1 | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | / | 0.441 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.441 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.441 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.441 | |
| 2gq3 | COA | Malate synthase G | / | 0.441 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2r59 | PH0 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.441 | |
| 2vij | C44 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.441 | |
| 3s5w | NAP | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 3tfy | COA | N-alpha-acetyltransferase 50 | 2.3.1 | 0.441 | |
| 3wag | TYD | Glycosyltransferase | / | 0.441 | |
| 4dpi | 0N1 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.441 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.441 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.441 | |
| 5fmm | MGT | Polymerase basic protein 2 | / | 0.441 | |
| 1c7o | PPG | Hemolysin | / | 0.440 | |
| 1m4i | COA | Aminoglycoside 2'-N-acetyltransferase | 2.3.1 | 0.440 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.440 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.440 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.440 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.440 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.440 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.440 | |
| 4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.440 | |
| 4up3 | FAD | Thioredoxin reductase | / | 0.440 |