Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.31.000
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.613
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.606
4h9614QDihydrofolate reductase1.5.1.30.605
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.604
4h9506UDihydrofolate reductase1.5.1.30.597
4ixeIXEDihydrofolate reductase1.5.1.30.591
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.589
1klkPMDDihydrofolate reductase1.5.1.30.586
3qls55VDihydrofolate reductase1.5.1.30.582
4h9753SDihydrofolate reductase1.5.1.30.582
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.576
3k47D09Dihydrofolate reductase1.5.1.30.575
3qlwN22Dihydrofolate reductase1.5.1.30.575
1m78CLZDihydrofolate reductase1.5.1.30.571
3cseN22Uncharacterized protein/0.571
3qlrQLRDihydrofolate reductase1.5.1.30.570
3qly55VUncharacterized protein/0.568
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.567
4kak06UDihydrofolate reductase1.5.1.30.567
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.562
4m6l21VDihydrofolate reductase1.5.1.30.562
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.559
2w3aTOPDihydrofolate reductase1.5.1.30.558
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.557
4kfj1R0Dihydrofolate reductase1.5.1.30.557
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.554
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.554
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.553
2fziDH3Dihydrofolate reductase1.5.1.30.551
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.550
3td8D2RDihydrofolate reductase1.5.1.30.549
1dg5TOPDihydrofolate reductase1.5.1.30.547
1m79MQ1Dihydrofolate reductase1.5.1.30.545
1m7aMQUDihydrofolate reductase1.5.1.30.543
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.543
1ia1TQ3Dihydrofolate reductase1.5.1.30.542
1ia2TQ4Dihydrofolate reductase1.5.1.30.542
1hfpMOTDihydrofolate reductase1.5.1.30.541
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.541
3eem53VUncharacterized protein/0.541
3qlxQLRUncharacterized protein/0.541
1aoeGW3Dihydrofolate reductase1.5.1.30.540
4kd79DRDihydrofolate reductase1.5.1.30.540
3qlzQLZUncharacterized protein/0.536
4kbn25UDihydrofolate reductase1.5.1.30.535
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.534
4h9814QUncharacterized protein/0.534
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.533
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.533
1bozPRDDihydrofolate reductase1.5.1.30.530
4g8zTOPDihydrofolate reductase1.5.1.30.530
3eek53SUncharacterized protein/0.528
4kebFOLDihydrofolate reductase1.5.1.30.528
3eej53RUncharacterized protein/0.526
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.526
1cd2FOLDihydrofolate reductase1.5.1.30.524
3nxtD2EDihydrofolate reductase1.5.1.30.524
1vj3TABDihydrofolate reductase1.5.1.30.523
3sa16DRDihydrofolate reductase/0.520
1rx3MTXDihydrofolate reductase1.5.1.30.519
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.518
3l3rOAGDihydrofolate reductase1.5.1.30.518
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.517
4dphP65Bifunctional dihydrofolate reductase-thymidylate synthase/0.517
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.516
3tq9MTXDihydrofolate reductase/0.515
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.514
1ia3TQ5Dihydrofolate reductase1.5.1.30.512
3nxoD2BDihydrofolate reductase1.5.1.30.512
7dfrFOLDihydrofolate reductase1.5.1.30.511
3nj0PYVAbscisic acid receptor PYL2/0.510
3sgy06WDihydrofolate reductase1.5.1.30.510
2cd2FOLDihydrofolate reductase1.5.1.30.509
4p68MTXDihydrofolate reductase/0.508
2jedLG8Protein kinase C theta type2.7.11.130.507
3sh25DRDihydrofolate reductase1.5.1.30.507
1dyrTOPDihydrofolate reductase1.5.1.30.506
1dg7WRBDihydrofolate reductase1.5.1.30.505
1ia4TQ6Dihydrofolate reductase1.5.1.30.505
1ohjCOPDihydrofolate reductase1.5.1.30.504
3eel53TUncharacterized protein/0.504
3nxvD2FDihydrofolate reductase1.5.1.30.504
3h3sH15Collagen type IV alpha-3-binding protein/0.502
3oafOAGDihydrofolate reductase1.5.1.30.502
3nxrD2DDihydrofolate reductase1.5.1.30.501
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.501
1s3yTQTDihydrofolate reductase1.5.1.30.500
4kne1CYDihydrofolate reductase1.5.1.30.500
2w3vTOPDihydrofolate reductase/0.499
3rg9WRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.498
4x5fFOLDihydrofolate reductase1.5.1.30.496
1dhfFOLDihydrofolate reductase1.5.1.30.495
1qzfFOLBifunctional dihydrofolate reductase-thymidylate synthase/0.495
1dr4HBIDihydrofolate reductase1.5.1.30.492
2fszOHTEstrogen receptor beta/0.492
3eigMTXDihydrofolate reductase1.5.1.30.492
1dr3HBIDihydrofolate reductase1.5.1.30.491
1q5dEPBEpothilone C/D epoxidase1.140.491
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.491
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.491
3dfrMTXDihydrofolate reductase1.5.1.30.491
3ns2PYVAbscisic acid receptor PYL2/0.491
1mvsDTMDihydrofolate reductase1.5.1.30.490
3d80Q22Dihydrofolate reductase1.5.1.30.489
1kmsLIHDihydrofolate reductase1.5.1.30.488
3sai9DRDihydrofolate reductase/0.488
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.488
5cccDDFDihydrofolate reductase1.5.1.30.487
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.486
4g95OAGDihydrofolate reductase1.5.1.30.486
1enpNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.485
2w3mFOLDihydrofolate reductase1.5.1.30.485
4m2xTMQDihydrofolate reductase1.5.1.30.485
4nx6FOLDihydrofolate reductase1.5.1.30.485
1s3wTQTDihydrofolate reductase1.5.1.30.483
1hfrMOTDihydrofolate reductase1.5.1.30.482
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.482
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.482
3nxyD2HDihydrofolate reductase1.5.1.30.482
1og5SWFCytochrome P450 2C9/0.481
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.481
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.480
3s3vTOPDihydrofolate reductase1.5.1.30.480
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.479
3tq8TOPDihydrofolate reductase/0.479
4iui1GQEstrogen receptor/0.479
1ra2FOLDihydrofolate reductase1.5.1.30.478
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.478
2zzaFOLDihydrofolate reductase/0.478
3sa27DRDihydrofolate reductase/0.478
4r20AERCytochrome P450 family 17 polypeptide 2/0.478
1ddsMTXDihydrofolate reductase1.5.1.30.477
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.477
3n0hTOPDihydrofolate reductase1.5.1.30.477
4ej1FOLDihydrofolate reductase1.5.1.30.477
3jwcEKBDihydrofolate reductase/0.476
3lfcZ86Mitogen-activated protein kinase 14/0.476
3ntz3TZDihydrofolate reductase1.5.1.30.476
3cv9VDXVitamin D3 dihydroxylase/0.475
3h3t16HCollagen type IV alpha-3-binding protein/0.475
3qm4PN0Cytochrome P450 2D6/0.475
3tqbFOLDihydrofolate reductase/0.475
4p66MTXDihydrofolate reductase/0.475
1e26GPBDihydrofolate reductase1.5.1.30.474
1e7qNAPGDP-L-fucose synthase/0.473
1rb3MTXDihydrofolate reductase1.5.1.30.473
3antS82Bifunctional epoxide hydrolase 23.3.2.100.473
3i8aN22Dihydrofolate reductase1.5.1.30.473
3nmpPYVAbscisic acid receptor PYL2/0.473
1rx2FOLDihydrofolate reductase1.5.1.30.472
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.472
2cy0NAPShikimate dehydrogenase (NADP(+))/0.472
3r336MEDihydrofolate reductase1.5.1.30.472
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.472
2fzhDH1Dihydrofolate reductase1.5.1.30.471
3gc9B45Mitogen-activated protein kinase 112.7.11.240.471
4hni16WCasein kinase I isoform epsilon2.7.11.10.470
4j26ESTEstrogen receptor beta/0.470
4j6dTESCytochrome P450 monooxygenase/0.470
4x5jFOLDihydrofolate reductase1.5.1.30.470
1s1vTNKGag-Pol polyprotein2.7.7.490.469
3ix9MTXDihydrofolate reductase1.5.1.30.469
4zasTYDCalS13/0.469
1b2lNDCAlcohol dehydrogenase1.1.1.10.468
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.468
2ij7TPFMycocyclosin synthase1.14.21.90.468
2zbaZBATrichothecene 3-O-acetyltransferase/0.468
4ixgIXGDihydrofolate reductase1.5.1.30.468
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.468
1dajMOTDihydrofolate reductase1.5.1.30.467
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
2rqfJH3Hemolymph juvenile hormone binding protein/0.467
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.467
3u8hBHPPhospholipase A2, membrane associated/0.467
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.467
2x7hPFNProstaglandin reductase 310.466
3gyf51PDihydrofolate reductase1.5.1.30.466
3nr4PYVAbscisic acid receptor PYL2/0.466
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.466
4cd2FOLDihydrofolate reductase1.5.1.30.466
4g1z0VPVitamin D3 receptor A/0.466
4gg70J8Hepatocyte growth factor receptor2.7.10.10.466
4j6bPLOCytochrome P450 monooxygenase/0.466
1pd9CO4Dihydrofolate reductase1.5.1.30.465
1u72MTXDihydrofolate reductase1.5.1.30.465
4a4wYFBPeroxisome proliferator-activated receptor gamma/0.465
4mv1ADPBiotin carboxylase6.3.4.140.465
1xp9AIJEstrogen receptor/0.463
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.463
2w6oOA3Biotin carboxylase6.3.4.140.463
3freTOPDihydrofolate reductase1.5.1.30.463
3zkuHCVIsopenicillin N synthase1.21.3.10.463
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
4j6cSTRCytochrome P450 monooxygenase/0.463
4xwtU5PRibonuclease J/0.463
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.462
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.462
4jbtASDCytochrome P450 monooxygenase/0.462
1o5rFR9Adenosine deaminase3.5.4.40.461
1rx7FOLDihydrofolate reductase1.5.1.30.461
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.461
1z6tADPApoptotic protease-activating factor 1/0.461
3jyqNADQuinate/shikimate dehydrogenase (NAD(+))/0.461
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3pm1ETHTH-type transcriptional regulator QacR/0.461
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.461
1d3dBZTProthrombin3.4.21.50.460
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
4cdmFO1Deoxyribodipyrimidine photolyase/0.460
4u0oMTALipoyl synthase 2/0.460
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
1dyiFOLDihydrofolate reductase1.5.1.30.459
1rh3MTXDihydrofolate reductase1.5.1.30.459
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.459
2jn3JN3Fatty acid-binding protein, liver/0.459
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.459
4ixc1JDGlucokinase2.7.1.20.459
4kjjFOLDihydrofolate reductase1.5.1.30.459
4qa1B3NHistone deacetylase 83.5.1.980.459
1d2sDHTSex hormone-binding globulin/0.458
1pkfEPDEpothilone C/D epoxidase1.140.458
2wo7ASVIsopenicillin N synthase1.21.3.10.458
3gobHXXDdmC/0.458
3h3r14HCollagen type IV alpha-3-binding protein/0.458
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.458
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
2cdaNAPGlucose 1-dehydrogenase/0.457
2w3wVG9Dihydrofolate reductase/0.457
3ia4MTXDihydrofolate reductase/0.457
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.457
5cwa0GAAnthranilate synthase component 14.1.3.270.457
1fmjRTLRetinol dehydratase/0.456
1u71MXADihydrofolate reductase1.5.1.30.456
3kpzZNEVitamin D3 receptor/0.456
1ddrMTXDihydrofolate reductase1.5.1.30.455
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3p3zP3ZPutative cytochrome P450/0.455
3ql3FOLDihydrofolate reductase1.5.1.30.455
3s1dZIRCytokinin dehydrogenase 11.5.99.120.455
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.455
1diuBDMDihydrofolate reductase1.5.1.30.454
1dyhDZFDihydrofolate reductase1.5.1.30.454
1s4dSAHUroporphyrinogen-III C-methyltransferase2.1.1.1070.454
1x8lOXRRetinol dehydratase/0.454
2ejzSAHDiphthine synthase/0.454
2p15EZTEstrogen receptor/0.454
2ph5NADHomospermidine synthase/0.454
3frfXCFDihydrofolate reductase1.5.1.30.454
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.454
3vt65YIVitamin D3 receptor/0.454
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
1d3pBT3Prothrombin3.4.21.50.453
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
1jraFADFAD-linked sulfhydryl oxidase ERV21.8.3.20.453
1kmvLIIDihydrofolate reductase1.5.1.30.453
1l2jETCEstrogen receptor beta/0.453
1qknRALEstrogen receptor beta/0.453
1s3vTQDDihydrofolate reductase1.5.1.30.453
1upw444Oxysterols receptor LXR-beta/0.453
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
2giuFBREstrogen receptor beta/0.453
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.453
4ipw1G7Mycocyclosin synthase1.14.21.90.453
4l8u9AZSerum albumin/0.453
4lgaA2OAbscisic acid receptor PYL2/0.453
4qa2SHHHistone deacetylase 83.5.1.980.453
4yaf2AMNADPH--cytochrome P450 reductase/0.453
4zowCLMMultidrug transporter MdfA/0.453
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.453
1fmlRTLRetinol dehydratase/0.452
1s7gNADNAD-dependent protein deacylase 2/0.452
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.452
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3k4551PDihydrofolate reductase1.5.1.30.452
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
3tdl11DSerum albumin/0.452
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.452
4e0u0MVCyclic dipeptide N-prenyltransferase/0.452
4hnc0UTMandelate racemase/0.452
4y9uNAPNADPH--cytochrome P450 reductase/0.452
1nceCB3Thymidylate synthase/0.451
1synF89Thymidylate synthase/0.451
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
2drcMTXDihydrofolate reductase1.5.1.30.451
2vn1FK5Peptidylprolyl isomerase/0.451
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.451
3ezpB3NHistone deacetylase 83.5.1.980.451
3vtdTKDVitamin D3 receptor/0.451
4ict1EDMycocyclosin synthase1.14.21.90.451
4l17DNQGlutamate receptor 2/0.451
2xvv9DNSerum albumin/0.450
3l8sBFFMitogen-activated protein kinase 14/0.450
3s79ASDAromatase1.14.14.140.450
3sqyQ11Dihydrofolate reductase1.5.1.30.450
3vrwYS5Vitamin D3 receptor/0.450
4c9oCAMCytochrome P450/0.450
4dhyS41Glucokinase2.7.1.20.450
4dvq1CACytochrome P450 11B2, mitochondrial1.14.15.40.450
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.450
4iyg1HUStrictosidine synthase4.3.3.20.450
3uzcT4EAdenosine receptor A2a/0.450
1dreMTXDihydrofolate reductase1.5.1.30.449
1nzyBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.449
1oc1ASVIsopenicillin N synthase1.21.3.10.449
1rd7FOLDihydrofolate reductase1.5.1.30.449
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2hcdBIVVitamin D3 receptor A/0.449
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.449
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.449
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.449
3jw5TOPDihydrofolate reductase/0.449
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.449
4bfrJ82Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform2.7.1.1530.449
4fhbFOLDihydrofolate reductase1.5.1.30.449
4wa9AXITyrosine-protein kinase ABL12.7.10.20.449
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.449
1bwsNDPGDP-L-fucose synthase/0.448
1l8qADPChromosomal replication initiator protein DnaA/0.448
1tj0FADBifunctional protein PutA1.5.5.20.448
2uxpCLMHTH-type transcriptional regulator TtgR/0.448
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.448
3is9AC7Gag-Pol polyprotein2.7.7.490.448
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
3sp9IL2Peroxisome proliferator-activated receptor delta/0.448
3w5rLOAVitamin D3 receptor/0.448
3zc3FADFerredoxin--NADP reductase1.18.1.20.448
3zoiM2WIsopenicillin N synthase1.21.3.10.448
4cztCPSCBL-interacting serine/threonine-protein kinase 232.7.11.10.448
4jdaA9SAbscisic acid receptor PYL3/0.448
4xz3COAAcyl-CoA synthetase (NDP forming)/0.448
1drbMTXDihydrofolate reductase1.5.1.30.447
1g2vTTPGlucose-1-phosphate thymidylyltransferase/0.447
1krhFADBenzoate 1,2-dioxygenase electron transfer component1.18.1.30.447
1m13HYFNuclear receptor subfamily 1 group I member 2/0.447
1wbwLI4Mitogen-activated protein kinase 14/0.447
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.447
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
2q66ATPPoly(A) polymerase2.7.7.190.447
2xviFADPutative flavin-containing monooxygenase/0.447
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.447
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3junAJDPhenazine biosynthesis protein A/B/0.447
3pqbVGPPutative oxidoreductase/0.447
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.447
4i13FOLDihydrofolate reductase1.5.1.30.447
1uzwCDHIsopenicillin N synthase1.21.3.10.446
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.446
4c3yANB3-ketosteroid dehydrogenase/0.446
4qjcIXEDihydrofolate reductase1.5.1.30.446
1ao8MTXDihydrofolate reductase1.5.1.30.445
1ludTRRDihydrofolate reductase1.5.1.30.445
1obnASVIsopenicillin N synthase1.21.3.10.445
1txiTX5Vitamin D3 receptor/0.445
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.445
2puiADPMethylthioribose kinase2.7.1.1000.445
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.445
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3gd3FADApoptosis-inducing factor 1, mitochondrial1.1.10.445
3kb0A8SAbscisic acid receptor PYL2/0.445
3vt7VDXVitamin D3 receptor/0.445
4ia7BIVVitamin D3 receptor A/0.445
4lb2DM5Serum albumin/0.445
4o71CPBBromodomain-containing protein 4/0.445
4qa0SHHHistone deacetylase 83.5.1.980.445
1jlcFTCGag-Pol polyprotein2.7.7.490.444
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.444
2izrBRKCasein kinase I isoform gamma-32.7.11.10.444
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
2o4rVD5Vitamin D3 receptor/0.444
2vcmM11Isopenicillin N synthase1.21.3.10.444
3d84NDPDihydrofolate reductase1.5.1.30.444
3koo24DBifunctional epoxide hydrolase 23.3.2.100.444
3l6jZ90Alr2278 protein/0.444
3lu8IQXSerum albumin/0.444
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3nxxNDPDihydrofolate reductase1.5.1.30.444
4bchT7ZCyclin-dependent kinase 92.7.11.220.444
4ia1BIVVitamin D3 receptor A/0.444
4nmbFADBifunctional protein PutA/0.444
4yauFADNADPH--cytochrome P450 reductase/0.444
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1cqp803Integrin alpha-L/0.443
1enzNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1kzjCB3Thymidylate synthase/0.443
1zky689Estrogen receptor/0.443
2agvTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.443
2uxoTACHTH-type transcriptional regulator TtgR/0.443
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.443
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.10.443
3och2MXDihydrofolate reductase1.5.1.30.443
4a83DXCMajor pollen allergen Bet v 1-A/0.443
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.443
4ho8THMGlucose-1-phosphate thymidylyltransferase/0.443
4x5hFOLDihydrofolate reductase1.5.1.30.443
1ie9VDXVitamin D3 receptor/0.442
1l2iETCEstrogen receptor/0.442
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.442
1z1fSTLResveratrol synthase/0.442
2d0kFOLDihydrofolate reductase1.5.1.30.442
2hb8MVDVitamin D3 receptor/0.442
2iviACWIsopenicillin N synthase1.21.3.10.442
2j4kU5PUridylate kinase2.7.4.220.442
2rhrEMOPutative ketoacyl reductase1.3.10.442
2y6fM9FIsopenicillin N synthase1.21.3.10.442
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3drcMTXDihydrofolate reductase1.5.1.30.442
3fywXCFDihydrofolate reductase1.5.1.30.442
3g5hYTTMycocyclosin synthase1.14.21.90.442
3hv3R49Mitogen-activated protein kinase 14/0.442
3jwm5WBDihydrofolate reductase/0.442
3mdmFJZCholesterol 24-hydroxylase/0.442
3p62FMNPentaerythritol tetranitrate reductase/0.442
3sr5Q12Dihydrofolate reductase1.5.1.30.442
3vtcTK3Vitamin D3 receptor/0.442
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.442
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
4bfsZVSPantothenate kinase2.7.1.330.442
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4i1nFOLDihydrofolate reductase1.5.1.30.442
4lhtCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.442
1ek2CDUBifunctional epoxide hydrolase 2/0.441
1kquBR4Phospholipase A2, membrane associated/0.441
1krrACOGalactoside O-acetyltransferase2.3.1.180.441
1ra3MTXDihydrofolate reductase1.5.1.30.441
2jb4A14Isopenicillin N synthase1.21.3.10.441
2xytTC9Soluble acetylcholine receptor/0.441
2z2w770Wee1-like protein kinase2.7.10.20.441
2z97CAMCamphor 5-monooxygenase1.14.15.10.441
3fr5I4AFatty acid-binding protein, adipocyte/0.441
3h1vTK1Glucokinase2.7.1.20.441
3iqzH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.441
3njoPYVAbscisic acid receptor PYR1/0.441
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4elb34RDihydrofolate reductase/0.441
4elg52JDihydrofolate reductase/0.441
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.441
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.441
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.441
4iwv1J9Glucokinase2.7.1.20.441
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.441
4nx7FOLDihydrofolate reductase1.5.1.30.441
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.441
5fs9FADApoptosis-inducing factor 1, mitochondrial1.1.10.441
3pwhZMAAdenosine receptor A2a/0.441
1e1nFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.440
1pq6965Oxysterols receptor LXR-beta/0.440
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.440
1tsdF89Thymidylate synthase/0.440
1xu9CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
2bxqIMNSerum albumin/0.440
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
3br3ETHTH-type transcriptional regulator QacR/0.440
3c1xCKKHepatocyte growth factor receptor2.7.10.10.440
3ddw055Glycogen phosphorylase, liver form2.4.1.10.440
3qlhT27Gag-Pol polyprotein2.7.7.490.440
3zkyWT4Isopenicillin N synthase1.21.3.10.440
4aosNAPSteroid monooxygenase/0.440
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.440
4yswNAIXanthine dehydrogenase/oxidase/0.440
5a65TPPThiamine-triphosphatase3.6.1.280.440
5eccNAPDehydrofolate reductase type I/0.440