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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zz0 FAD Thioredoxin reductase 1, cytoplasmic 1.8.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 1.312
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 1.105
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 1.096
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 1.096
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 1.079
2r9z FADGlutathione amide reductase / 1.074
2rab FADGlutathione amide reductase / 1.054
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 1.033
1ges FADGlutathione reductase 1.8.1.7 1.013
2x8g FADThioredoxin glutathione reductase / 1.013
2x8h FADThioredoxin glutathione reductase / 1.012
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 1.010
4dna FADProbable glutathione reductase / 1.007
2hqm FADGlutathione reductase 1.8.1.7 0.992
4j57 FADThioredoxin reductase 2 1.8.1.9 0.984
2jk6 FADTrypanothione reductase / 0.982
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.980
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.962
1get FADGlutathione reductase 1.8.1.7 0.953
1fec FADTrypanothione reductase 1.8.1.12 0.952
1ger FADGlutathione reductase 1.8.1.7 0.949
2wow FADTrypanothione reductase / 0.946
2v6o FADThioredoxin glutathione reductase / 0.941
2wba FADTrypanothione reductase 1.8.1.12 0.937
4nev FADTrypanothione reductase / 0.937
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.932
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.929
4la1 FADThioredoxin glutathione reductase / 0.929
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.919
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.908
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.908
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.905
1geu FADGlutathione reductase 1.8.1.7 0.904
1feb FADTrypanothione reductase 1.8.1.12 0.900
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.899
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.898
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.896
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.895
2wp5 FADTrypanothione reductase / 0.894
2eq7 FADDihydrolipoyl dehydrogenase / 0.893
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.884
2yqu FADDihydrolipoyl dehydrogenase / 0.877
2tpr FADTrypanothione reductase 1.8.1.12 0.876
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.871
1typ FADTrypanothione reductase 1.8.1.12 0.865
1zx9 FADMercuric reductase 1.16.1.1 0.865
1tyt FADTrypanothione reductase 1.8.1.12 0.862
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.861
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.860
1gxf FADTrypanothione reductase 1.8.1.12 0.859
1bzl FADTrypanothione reductase 1.8.1.12 0.858
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.858
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.858
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.857
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.855
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.852
2w0h FADTrypanothione reductase / 0.850
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.848
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.847
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.847
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.846
4b1b FADThioredoxin reductase 1.8.1.9 0.846
2eq6 FADDihydrolipoyl dehydrogenase / 0.842
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.840
2eq8 FADDihydrolipoyl dehydrogenase / 0.838
1fea FADTrypanothione reductase 1.8.1.12 0.837
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.835
1f8w FADNADH peroxidase 1.11.1.1 0.834
4jq9 FADDihydrolipoyl dehydrogenase / 0.833
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.826
1nhp FADNADH peroxidase 1.11.1.1 0.824
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.823
2eq9 FADDihydrolipoyl dehydrogenase / 0.819
1ijh FADCholesterol oxidase 1.1.3.6 0.815
3urh FADDihydrolipoyl dehydrogenase / 0.815
4xwr FADCholesterol oxidase 1.1.3.6 0.811
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.810
1nhr FADNADH peroxidase 1.11.1.1 0.810
1cbo FADCholesterol oxidase 1.1.3.6 0.807
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.806
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.803
4j56 FADThioredoxin reductase 2 1.8.1.9 0.803
4nte FADDepH / 0.803
4u2t FADCholesterol oxidase 1.1.3.6 0.803
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.800
1mxt FAECholesterol oxidase 1.1.3.6 0.800
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.799
1nhs FADNADH peroxidase 1.11.1.1 0.799
1n1p FADCholesterol oxidase 1.1.3.6 0.795
1n4w FADCholesterol oxidase 1.1.3.6 0.795
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.795
4xxg FADCholesterol oxidase 1.1.3.6 0.795
3cnj FADCholesterol oxidase 1.1.3.6 0.790
3gyi FADCholesterol oxidase 1.1.3.6 0.790
1npx FADNADH peroxidase 1.11.1.1 0.788
4mih FADPyranose 2-oxidase 1.1.3.10 0.788
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.785
4u2s FDACholesterol oxidase 1.1.3.6 0.784
1n4v FADCholesterol oxidase 1.1.3.6 0.783
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.782
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.781
1zk7 FADMercuric reductase 1.16.1.1 0.780
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.779
3lad FADDihydrolipoyl dehydrogenase / 0.779
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.779
4opc FDAConserved Archaeal protein / 0.777
4jn9 FADDepH / 0.775
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.771
1joa FADNADH peroxidase 1.11.1.1 0.770
4j2w FADKynurenine 3-monooxygenase / 0.768
4ntc FADThioredoxin reductase gliT / 0.766
4fwe FADLysine-specific histone demethylase 1B 1 0.762
2npx FADNADH peroxidase 1.11.1.1 0.761
3atr FDAConserved Archaeal protein / 0.761
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.760
2zbw FADFerredoxin--NADP reductase / 0.759
3fbs FADOxidoreductase / 0.758
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.755
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.754
3ict FADCoenzyme A disulfide reductase / 0.753
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.753
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.752
1ojt FADDihydrolipoyl dehydrogenase / 0.752
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.752
3atq FDAConserved Archaeal protein / 0.752
4em4 FADCoenzyme A disulfide reductase / 0.752
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.751
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.748
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.747
3cox FADCholesterol oxidase 1.1.3.6 0.747
4fwf FADLysine-specific histone demethylase 1B 1 0.747
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.744
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.743
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.742
4ntd FADThioredoxin reductase / 0.741
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.740
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.740
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.739
4opu FDAConserved Archaeal protein / 0.739
1onf FADGlutathione reductase 1.8.1.7 0.738
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.738
2bac FADPutative aminooxidase / 0.737
4j34 FADKynurenine 3-monooxygenase / 0.735
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.734
4j33 FADKynurenine 3-monooxygenase / 0.734
4hb9 FADUncharacterized protein / 0.733
4opi FDAConserved Archaeal protein / 0.733
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.733
3qvr FADGlucose oxidase 1.1.3.4 0.732
3ish FADThioredoxin reductase 1.8.1.9 0.730
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.729
4bjz FADProbable salicylate monooxygenase / 0.729
1cf3 FADGlucose oxidase 1.1.3.4 0.728
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.728
3cgc FADCoenzyme A disulfide reductase / 0.728
2whd FADThioredoxin reductase / 0.727
4j31 FADKynurenine 3-monooxygenase / 0.727
1tde FADThioredoxin reductase 1.8.1.9 0.726
4gcm FADThioredoxin reductase 1.8.1.9 0.724
4opl FDAConserved Archaeal protein / 0.723
3ad9 NADSubunit alpha of sarocosine oxidase / 0.722
4eqx FADCoenzyme A disulfide reductase / 0.721
4em3 FADCoenzyme A disulfide reductase / 0.720
4qi7 FADCellobiose dehydrogenase / 0.720
1gal FADGlucose oxidase 1.1.3.4 0.719
2igo FADPyranose 2-oxidase / 0.718
3cgb FADCoenzyme A disulfide reductase / 0.717
2qa1 FADPgaE / 0.715
4bk3 FADProbable salicylate monooxygenase / 0.715
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.715
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.714
2yg4 FADPutrescine oxidase / 0.714
4bk2 FADProbable salicylate monooxygenase / 0.714
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.712
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.712
4opt FDAConserved Archaeal protein / 0.712
2gqf FADUncharacterized protein HI_0933 / 0.710
4cnk FADL-amino acid oxidase / 0.710
5buk FADFADH2-dependent halogenase / 0.710
4cnj FADL-amino acid oxidase / 0.708
3cty FADProbable thioredoxin reductase / 0.707
4cbq FADThioredoxin reductase / 0.707
4eqw FADCoenzyme A disulfide reductase / 0.705
4opg FDAConserved Archaeal protein / 0.705
4ynt FDAGlucose oxidase, putative / 0.705
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.704
2ba9 FADPutative aminooxidase / 0.703
2q7v FADThioredoxin reductase / 0.703
3cgd FADCoenzyme A disulfide reductase / 0.703
4ccq FADThioredoxin reductase / 0.702
2cdu FADNADH oxidase / 0.701
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.701
3d8x FADThioredoxin reductase 1 1.8.1.9 0.700
3itj FADThioredoxin reductase 1 1.8.1.9 0.700
3ept FDAPutative FAD-monooxygenase / 0.699
1d7l RFLp-hydroxybenzoate hydroxylase / 0.698
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.698
3rha FDAPutrescine oxidase / 0.698
3t37 FADPyridoxine 4-oxidase / 0.698
3bg7 FADPyranose 2-oxidase / 0.697
4k2x FADPolyketide oxygenase/hydroxylase / 0.697
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.695
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.695
4up3 FADThioredoxin reductase / 0.695
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.694
1trb FADThioredoxin reductase 1.8.1.9 0.693
2yg3 FADPutrescine oxidase / 0.693
4k5r FADOxygenase / 0.693
4ccr FADThioredoxin reductase / 0.691
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.690
4b66 FADL-ornithine N(5)-monooxygenase / 0.690
4b68 FADL-ornithine N(5)-monooxygenase / 0.690
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.690
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.690
4mok FADPyranose 2-oxidase / 0.689
5dbj FADFADH2-dependent halogenase PltA / 0.689
1q1r FADPutidaredoxin reductase 1.18.1.5 0.688
4rek FADCholesterol oxidase 1.1.3.6 0.688
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.687
2gew FADCholesterol oxidase 1.1.3.6 0.687
2ign FADPyranose 2-oxidase / 0.687
3fg2 FADPutative rubredoxin reductase / 0.687
1gpe FADGlucose oxidase 1.1.3.4 0.686
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.686
3c4a FADProtodeoxyviolaceinate monooxygenase 1 0.685
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.684
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.684
3lsm SFDPyranose 2-oxidase / 0.684
3nlc FADUncharacterized protein / 0.684
4qi5 FADCellobiose dehydrogenase / 0.684
2xdo FADTetX family tetracycline inactivation enzyme / 0.683
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.682
2bab FADPutative aminooxidase / 0.681
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.681
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.680
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.679
3fmw FADOxygenase / 0.679
4a5l FADThioredoxin reductase / 0.679
4aox FADSteroid monooxygenase / 0.679
1xpq FADPolyamine oxidase FMS1 / 0.678
2q0k FADThioredoxin reductase 1.8.1.9 0.678
2xyo FADTetX family tetracycline inactivation enzyme / 0.678
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.678
4a65 FADThioredoxin reductase / 0.678
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.678
3v76 FDAUncharacterized protein / 0.677
2yg6 FADPutrescine oxidase / 0.676
3ics FADCoenzyme A disulfide reductase / 0.675
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.675
5l3d FADLysine-specific histone demethylase 1A 1 0.675
2yg5 FADPutrescine oxidase / 0.674
2yg7 FADPutrescine oxidase / 0.674
3r9u FADThioredoxin reductase / 0.674
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.674
2b9y FADPutative aminooxidase / 0.673
3k4n FADPyranose 2-oxidase / 0.673
4a6n FADTetX family tetracycline inactivation enzyme / 0.673
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.673
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.673
5j60 FADThioredoxin reductase / 0.673
3cnd FADPolyamine oxidase FMS1 / 0.671
4eqs FADCoenzyme A disulfide reductase / 0.671
4jnq FDAThioredoxin reductase / 0.671
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.670
2gr0 FADFerredoxin reductase / 0.670
3lsi FADPyranose 2-oxidase / 0.670
4ylf FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog / 0.670
2b9w FADPutative aminooxidase / 0.669
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.669
3nix FADFlavoprotein/dehydrogenase / 0.669
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.669
4hsu FADLysine-specific histone demethylase 1B 1 0.669
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.668
2x3n FADProbable FAD-dependent monooxygenase / 0.668
3k30 ADPHistamine dehydrogenase / 0.668
3lsh FADPyranose 2-oxidase / 0.668
1kif FADD-amino-acid oxidase 1.4.3.3 0.667
4eqr FADCoenzyme A disulfide reductase / 0.667
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.665
4b69 FADL-ornithine N(5)-monooxygenase / 0.665
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.664
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.664
2gr3 FADFerredoxin reductase / 0.663
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.663
3cge FADCoenzyme A disulfide reductase / 0.662
4fwj FADLysine-specific histone demethylase 1B 1 0.662
4mo2 FDAUDP-galactopyranose mutase / 0.662
1d7y FADFerredoxin reductase / 0.661
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.661
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.661
3qvp FADGlucose oxidase 1.1.3.4 0.660
4c3x FAD3-ketosteroid dehydrogenase / 0.660
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.660
5hsa FASAlcohol oxidase 1 1.1.3.13 0.660
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.659
1yqz FADCoenzyme A disulfide reductase / 0.659
2q0l FADThioredoxin reductase 1.8.1.9 0.659
1cl0 FADThioredoxin reductase 1.8.1.9 0.658
1q1w FADPutidaredoxin reductase 1.18.1.5 0.658
2pr5 FMNBlue-light photoreceptor / 0.658
4xbf FADLysine-specific histone demethylase 1A 1 0.658
3gwf FADCyclohexanone monooxygenase / 0.657
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.657
4gut FADLysine-specific histone demethylase 1B 1 0.656
4u2l SFDCholesterol oxidase 1.1.3.6 0.656
4ysh FADGlycine oxidase / 0.656
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.655
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.655
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.654
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.654
3icr FADCoenzyme A disulfide reductase / 0.654
4gur FADLysine-specific histone demethylase 1B 1 0.654
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.653
3b6d FAECholesterol oxidase 1.1.3.6 0.653
4gus FADLysine-specific histone demethylase 1B 1 0.653
4yry FADGlutamate synthase, beta subunit / 0.653
4fk1 FADPutative thioredoxin reductase / 0.652
4qi4 FADCellobiose dehydrogenase / 0.652
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.651
2uxx FAJLysine-specific histone demethylase 1A 1 0.651
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.650
1k0j FADp-hydroxybenzoate hydroxylase / 0.650
2h94 FADLysine-specific histone demethylase 1A 1 0.650
3k4c FADPyranose 2-oxidase / 0.650