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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1k0j FAD p-hydroxybenzoate hydroxylase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
1k0j FADp-hydroxybenzoate hydroxylase / 1.394
1d7l RFLp-hydroxybenzoate hydroxylase / 1.091
1k0l FADp-hydroxybenzoate hydroxylase / 0.983
1pdh FASp-hydroxybenzoate hydroxylase / 0.975
2qa1 FADPgaE / 0.898
4k5r FADOxygenase / 0.890
3rp8 FADFAD-dependent urate hydroxylase / 0.887
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.874
2xdo FADTetX family tetracycline inactivation enzyme / 0.848
4k2x FADPolyketide oxygenase/hydroxylase / 0.827
4j36 FADKynurenine 3-monooxygenase / 0.821
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.819
4j2w FADKynurenine 3-monooxygenase / 0.817
4hb9 FADUncharacterized protein / 0.813
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.804
4icy FADPgaE / 0.804
4j33 FADKynurenine 3-monooxygenase / 0.803
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.796
4j34 FADKynurenine 3-monooxygenase / 0.793
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.793
3fmw FADOxygenase / 0.792
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.789
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.787
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.782
4x4j FADPutative oxygenase / 0.779
4nzh FADL-ornithine N(5)-monooxygenase / 0.776
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.775
1c0k FADD-amino-acid oxidase 1.4.3.3 0.773
2eq8 FADDihydrolipoyl dehydrogenase / 0.772
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.772
4bjz FADProbable salicylate monooxygenase / 0.769
1zx9 FADMercuric reductase 1.16.1.1 0.767
4bk3 FADProbable salicylate monooxygenase / 0.765
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.757
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.756
4bk2 FADProbable salicylate monooxygenase / 0.755
4a99 FADTetX family tetracycline inactivation enzyme / 0.753
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.751
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.750
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.748
4eqs FADCoenzyme A disulfide reductase / 0.746
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.745
4eqr FADCoenzyme A disulfide reductase / 0.745
2rgj FADFlavin-containing monooxygenase / 0.744
2eq6 FADDihydrolipoyl dehydrogenase / 0.742
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.741
2qa2 FADPolyketide oxygenase CabE / 0.740
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.739
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.739
1npx FADNADH peroxidase 1.11.1.1 0.738
3ept FDAPutative FAD-monooxygenase / 0.738
1c0l FADD-amino-acid oxidase 1.4.3.3 0.737
1f8w FADNADH peroxidase 1.11.1.1 0.737
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.737
2v6o FADThioredoxin glutathione reductase / 0.737
2xyo FADTetX family tetracycline inactivation enzyme / 0.737
3atq FDAConserved Archaeal protein / 0.737
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.736
2cdu FADNADH oxidase / 0.734
1nhp FADNADH peroxidase 1.11.1.1 0.733
1nhr FADNADH peroxidase 1.11.1.1 0.732
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.732
1nhs FADNADH peroxidase 1.11.1.1 0.731
1nhq FADNADH peroxidase 1.11.1.1 0.730
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.730
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.729
3atr FDAConserved Archaeal protein / 0.729
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.728
2eq7 FADDihydrolipoyl dehydrogenase / 0.728
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.726
3gsi FADDimethylglycine oxidase 1.5.3.10 0.726
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.725
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.724
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.723
1zk7 FADMercuric reductase 1.16.1.1 0.722
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.722
4b69 FADL-ornithine N(5)-monooxygenase / 0.721
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.721
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.721
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.720
2wba FADTrypanothione reductase 1.8.1.12 0.720
2x8h FADThioredoxin glutathione reductase / 0.720
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.720
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.720
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.720
4opg FDAConserved Archaeal protein / 0.720
4z2t FAD2-hydroxybiphenyl-3-monooxygenase / 0.720
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.719
1phh FADp-hydroxybenzoate hydroxylase / 0.719
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.719
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.719
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.718
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.718
4jq9 FADDihydrolipoyl dehydrogenase / 0.718
3cgc FADCoenzyme A disulfide reductase / 0.717
4i58 FADCyclohexylamine Oxidase / 0.717
4opc FDAConserved Archaeal protein / 0.716
4tm1 FDAKtzI / 0.716
1ryi FADGlycine oxidase 1.4.3.19 0.715
2npx FADNADH peroxidase 1.11.1.1 0.714
3if9 FADGlycine oxidase 1.4.3.19 0.714
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.714
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.713
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.713
2yg6 FADPutrescine oxidase / 0.713
4nte FADDepH / 0.713
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.712
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.712
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.711
3cge FADCoenzyme A disulfide reductase / 0.711
3f8d FADNADH oxidase/thioredoxin reductase / 0.711
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.710
3lad FADDihydrolipoyl dehydrogenase / 0.710
1f3p FADFerredoxin reductase / 0.709
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.709
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.709
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.709
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.708
3ad9 FADSubunit beta of sarcosine oxidase / 0.708
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.708
4opi FDAConserved Archaeal protein / 0.708
2wow FADTrypanothione reductase / 0.707
2x8g FADThioredoxin glutathione reductase / 0.707
2yg5 FADPutrescine oxidase / 0.707
2yqu FADDihydrolipoyl dehydrogenase / 0.707
1yqz FADCoenzyme A disulfide reductase / 0.706
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.706
4ntc FADThioredoxin reductase gliT / 0.706
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.705
3cgb FADCoenzyme A disulfide reductase / 0.705
2q0k FADThioredoxin reductase 1.8.1.9 0.703
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.703
4a6n FADTetX family tetracycline inactivation enzyme / 0.703
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.702
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.702
4em4 FADCoenzyme A disulfide reductase / 0.702
1get FADGlutathione reductase 1.8.1.7 0.701
2eq9 FADDihydrolipoyl dehydrogenase / 0.701
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.701
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.701
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.699
2q7v FADThioredoxin reductase / 0.699
2vvl FADMonoamine oxidase N 1.4.3.4 0.699
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.699
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.698
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.698
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.698
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.697
3fbs FADOxidoreductase / 0.697
4rsl FADFructosyl peptide oxidase / 0.697
2r9z FADGlutathione amide reductase / 0.696
2rab FADGlutathione amide reductase / 0.696
2yg4 FADPutrescine oxidase / 0.696
3ukk FDAUDP-galactopyranose mutase / 0.696
2gr0 FADFerredoxin reductase / 0.695
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.695
3ka7 FADPutative oxidoreductase / 0.695
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.695
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.695
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.694
2wp5 FADTrypanothione reductase / 0.694
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.693
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.693
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.692
3cty FADProbable thioredoxin reductase / 0.692
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.692
3p9u FADTetX family tetracycline inactivation enzyme / 0.692
3urh FADDihydrolipoyl dehydrogenase / 0.692
4j31 FADKynurenine 3-monooxygenase / 0.692
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.692
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.690
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.690
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.690
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.689
1geu FADGlutathione reductase 1.8.1.7 0.689
1ng4 FADGlycine oxidase 1.4.3.19 0.689
2igo FADPyranose 2-oxidase / 0.689
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.689
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.688
2gqw FADFerredoxin reductase / 0.688
1fec FADTrypanothione reductase 1.8.1.12 0.687
4usr FADMonooxygenase / 0.686
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.686
2ba9 FADPutative aminooxidase / 0.685
2iid FADL-amino-acid oxidase 1.4.3.2 0.685
2yg7 FADPutrescine oxidase / 0.685
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.685
3s5w FADL-ornithine N(5)-monooxygenase / 0.685
4nev FADTrypanothione reductase / 0.685
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.684
3r9u FADThioredoxin reductase / 0.684
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.683
3ics FADCoenzyme A disulfide reductase / 0.683
2bab FADPutative aminooxidase / 0.682
1ges FADGlutathione reductase 1.8.1.7 0.681
4emw FADCoenzyme A disulfide reductase / 0.681
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.680
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.680
4ysh FADGlycine oxidase / 0.680
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.679
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.678
2y48 FADLysine-specific histone demethylase 1A 1 0.678
2yg3 FADPutrescine oxidase / 0.678
3lsm SFDPyranose 2-oxidase / 0.678
4a5l FADThioredoxin reductase / 0.678
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.677
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.677
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.677
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.677
3cgd FADCoenzyme A disulfide reductase / 0.677
4jn9 FADDepH / 0.677
1d7y FADFerredoxin reductase / 0.676
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.676
1feb FADTrypanothione reductase 1.8.1.12 0.676
1rsg FADPolyamine oxidase FMS1 / 0.676
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.676
3ict FADCoenzyme A disulfide reductase / 0.676
4gcm FADThioredoxin reductase 1.8.1.9 0.676
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.676
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.676
1gxf FADTrypanothione reductase 1.8.1.12 0.675
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.675
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.675
3bg7 FADPyranose 2-oxidase / 0.674
4a65 FADThioredoxin reductase / 0.674
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.673
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.673
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.672
3icr FADCoenzyme A disulfide reductase / 0.672
4j57 FADThioredoxin reductase 2 1.8.1.9 0.672
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.672
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.671
4em3 FADCoenzyme A disulfide reductase / 0.671
4yac NAIC alpha-dehydrogenase / 0.671
2b9w FADPutative aminooxidase / 0.670
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.670
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.669
4opu FDAConserved Archaeal protein / 0.669
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.668
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.668
4fwe FADLysine-specific histone demethylase 1B 1 0.668
4hnb FMNLOV protein / 0.668
4la1 FADThioredoxin glutathione reductase / 0.668
2hko FADLysine-specific histone demethylase 1A 1 0.667
3ada NADSubunit alpha of sarocosine oxidase / 0.667
3axb FADPutative oxidoreductase / 0.667
3bi2 FADPolyamine oxidase FMS1 / 0.667
3rha FDAPutrescine oxidase / 0.667
1ger FADGlutathione reductase 1.8.1.7 0.666
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.666
2eq7 NADDihydrolipoyl dehydrogenase / 0.666
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.666
1h81 FADPolyamine oxidase 1.5.3.14 0.665
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.665
3fg2 FADPutative rubredoxin reductase / 0.665
3ish FADThioredoxin reductase 1.8.1.9 0.665
4opt FDAConserved Archaeal protein / 0.665
3dme FADPutative conserved exported protein / 0.664
4nec SAHPutative SAM-dependent methyltransferase / 0.664
5dbj FADFADH2-dependent halogenase PltA / 0.663
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.663
1onf FADGlutathione reductase 1.8.1.7 0.662
2b9x FADPutative aminooxidase / 0.661
3nix FADFlavoprotein/dehydrogenase / 0.661
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.661
4gdp FADPolyamine oxidase FMS1 / 0.661
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.660
2xve FADPutative flavin-containing monooxygenase / 0.660
3zdn FADMonoamine oxidase N 1.4.3.4 0.660
4opl FDAConserved Archaeal protein / 0.660
1cl0 FADThioredoxin reductase 1.8.1.9 0.659
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.659
2tpr FADTrypanothione reductase 1.8.1.12 0.659
4ech FADPolyamine oxidase FMS1 / 0.659
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.658
1tde FADThioredoxin reductase 1.8.1.9 0.658
1tdf FADThioredoxin reductase 1.8.1.9 0.658
2bac FADPutative aminooxidase / 0.658
3bi5 FADPolyamine oxidase FMS1 / 0.658
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.658
4gus FADLysine-specific histone demethylase 1B 1 0.658
4x9m FADUncharacterized protein MG039 homolog / 0.658
4x9n FADUncharacterized protein MG039 homolog / 0.658
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.657
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.657
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.657
4cnj FADL-amino acid oxidase / 0.657
1n07 FMNRiboflavin kinase 2.7.1.26 0.656
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.656
2zbw FADFerredoxin--NADP reductase / 0.656
4fwf FADLysine-specific histone demethylase 1B 1 0.656
1kif FADD-amino-acid oxidase 1.4.3.3 0.655
2b9y FADPutative aminooxidase / 0.655
3cnt FADPolyamine oxidase FMS1 / 0.655
3ukf FDAUDP-galactopyranose mutase / 0.655
1reo FADL-amino-acid oxidase 1.4.3.2 0.654
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.654
2q0l FADThioredoxin reductase 1.8.1.9 0.654
2whd FADThioredoxin reductase / 0.654
3mpj FADGlutaryl-CoA dehydrogenase 1.3.99.32 0.654
4eeu FMNPhototropin-2 2.7.11.1 0.654
4gur FADLysine-specific histone demethylase 1B 1 0.654
1qo8 FADFumarate reductase flavoprotein subunit / 0.653
2gr3 FADFerredoxin reductase / 0.653
1tyt FADTrypanothione reductase 1.8.1.12 0.652
2jb1 FADL-amino acid oxidase / 0.652
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.652
1bzl FADTrypanothione reductase 1.8.1.12 0.651
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.651
1tdn FADL-amino-acid oxidase 1.4.3.2 0.651
3ec7 NADInositol 2-dehydrogenase / 0.651
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.650
3cnd FADPolyamine oxidase FMS1 / 0.650
4fk1 FADPutative thioredoxin reductase / 0.650
4rpj FADUDP-galactopyranose mutase 5.4.99.9 0.650