Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
2bd0 | BIO | Sepiapterin reductase |
PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
---|---|---|---|---|---|
2bd0 | BIO | Sepiapterin reductase | / | 1.000 | |
2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.538 | |
2vz0 | D64 | Pteridine reductase | / | 0.524 | |
4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.504 | |
4xcz | T3Q | Qdtf | / | 0.501 | |
3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.499 | |
2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.498 | |
3rgz | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.497 | |
2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.493 | |
4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.493 | |
4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.492 | |
1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.488 | |
1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.488 | |
2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.488 | |
3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.488 | |
1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.487 | |
4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.487 | |
4cb6 | 29R | Polymerase basic protein 2 | / | 0.487 | |
4nce | MGT | Polymerase basic protein 2 | / | 0.487 | |
5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
2iu8 | UD1 | UDP-3-O-acylglucosamine N-acyltransferase | 2.3.1 | 0.486 | |
3pke | Y10 | Methionine aminopeptidase 2 | / | 0.486 | |
4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.486 | |
4yfy | 0FX | VioF | / | 0.485 | |
4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.484 | |
2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.483 | |
1u08 | PLP | Methionine aminotransferase | / | 0.482 | |
4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.482 | |
4a33 | PS8 | Glycylpeptide N-tetradecanoyltransferase | / | 0.481 | |
1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.479 | |
1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.479 | |
3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.479 | |
4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.479 | |
1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.478 | |
3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.478 | |
3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.478 | |
4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.478 | |
1mlz | PLP | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.477 | |
1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.477 | |
1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.477 | |
1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.477 | |
2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.477 | |
3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.477 | |
3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.477 | |
4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.477 | |
2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.476 | |
1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.475 | |
3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.475 | |
4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.475 | |
4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.475 | |
1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
1thn | ADP | Anti-sigma F factor | / | 0.474 | |
3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.474 | |
3zj6 | VM2 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.474 | |
4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.474 | |
3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.473 | |
3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.473 | |
4cb7 | 41G | Polymerase basic protein 2 | / | 0.473 | |
1rxj | BNI | Streptavidin | / | 0.472 | |
2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.472 | |
2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.472 | |
1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.471 | |
3dr4 | G4M | GDP-perosamine synthase | / | 0.471 | |
5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.471 | |
2vqz | MGT | Polymerase basic protein 2 | / | 0.470 | |
3lzz | GDP | Uncharacterized protein | / | 0.470 | |
3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.470 | |
4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.469 | |
3gx9 | TXD | Morphinone reductase | / | 0.469 | |
3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.469 | |
4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.469 | |
5fmm | MGT | Polymerase basic protein 2 | / | 0.469 | |
1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.468 | |
1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.468 | |
3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.468 | |
4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
4g09 | 0VD | Histidinol dehydrogenase | / | 0.468 | |
4i10 | 1BS | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.467 | |
3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.467 | |
4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.467 | |
4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.467 | |
4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.467 | |
1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.466 | |
2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.466 | |
3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.466 | |
3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.465 | |
1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.465 | |
3dr7 | GPD | GDP-perosamine synthase | / | 0.465 | |
3e4a | QIX | Insulin-degrading enzyme | 3.4.24.56 | 0.465 | |
4hcy | 0YN | Transketolase | / | 0.465 | |
1uk1 | FRQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.464 | |
2cbq | TH2 | Neocarzinostatin | / | 0.464 | |
2x9v | TMQ | Pteridine reductase | / | 0.464 | |
3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
4kn1 | 04J | Folate receptor beta | / | 0.464 | |
1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.463 | |
2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.463 | |
2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.463 | |
4kdr | SAH | Ubiquinone biosynthesis O-methyltransferase | / | 0.463 | |
5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.463 | |
4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.463 | |
1fwy | UD1 | Bifunctional protein GlmU | / | 0.462 | |
1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.462 | |
1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.462 | |
2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.462 | |
2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.462 | |
2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.462 | |
3af4 | GCP | Pantothenate kinase | 2.7.1.33 | 0.462 | |
3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.462 | |
3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.462 | |
5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.462 | |
1e6z | NGO | Chitinase | / | 0.461 | |
1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.461 | |
1s07 | PLP | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.461 | |
1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.461 | |
2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.461 | |
2gg2 | U12 | Methionine aminopeptidase | / | 0.461 | |
2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.461 | |
2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
4zqc | F6F | Tryptophan synthase alpha chain | / | 0.461 | |
1o2g | 696 | Prothrombin | 3.4.21.5 | 0.460 | |
1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.460 | |
1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.460 | |
2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.460 | |
3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.460 | |
4cb4 | MGT | Polymerase basic protein 2 | / | 0.460 | |
4kmz | FOL | Folate receptor beta | / | 0.460 | |
4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.460 | |
4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.460 | |
5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.460 | |
1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.459 | |
1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.459 | |
2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.459 | |
2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.459 | |
2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.459 | |
2jgb | MGT | Eukaryotic translation initiation factor 4E type 2 | / | 0.459 | |
3e4v | FMN | Uncharacterized protein | / | 0.459 | |
3irh | DTP | HD domain protein | / | 0.459 | |
3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.459 | |
3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.459 | |
4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.459 | |
4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
4phl | PIL | Phosphodiesterase | / | 0.459 | |
2o6h | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | 2.5.1.78 | 0.458 | |
2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.458 | |
3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.458 | |
1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.457 | |
1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.457 | |
1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.457 | |
2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.457 | |
2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.457 | |
3znr | NU9 | Histone deacetylase 7 | 3.5.1.98 | 0.457 | |
4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.457 | |
4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.457 | |
1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.456 | |
1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.456 | |
1n5v | NOM | ActVA 6 protein | / | 0.456 | |
1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.456 | |
1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.456 | |
2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.456 | |
3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.456 | |
3cui | X4S | Exoglucanase/xylanase | 3.2.1.91 | 0.456 | |
3gf4 | U5P | UDP-galactopyranose mutase | 5.4.99.9 | 0.456 | |
3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.456 | |
3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.456 | |
3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.456 | |
3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.456 | |
3szf | DCQ | Sulfide-quinone reductase | / | 0.456 | |
4da5 | 0H7 | Choline kinase alpha | 2.7.1.32 | 0.456 | |
4s1i | PLP | Pyridoxal kinase, putative | / | 0.456 | |
1d3d | BZT | Prothrombin | 3.4.21.5 | 0.455 | |
1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.455 | |
1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
1zz1 | SHH | Histone deacetylase-like amidohydrolase | 3.5.1 | 0.455 | |
2g7y | MO9 | Cathepsin S | 3.4.22.27 | 0.455 | |
2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.455 | |
3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.455 | |
3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
3qkz | NAP | Aldose reductase-related protein 1 | 1.1.1.21 | 0.455 | |
3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.455 | |
4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.455 | |
4gm4 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.455 | |
1aka | PLP | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.454 | |
1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.454 | |
1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.454 | |
1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.454 | |
1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.454 | |
1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.454 | |
2gg3 | U13 | Methionine aminopeptidase | / | 0.454 | |
2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.454 | |
2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.454 | |
3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.454 | |
3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
1dgb | NDP | Catalase | 1.11.1.6 | 0.453 | |
1lnm | DTX | Bilin-binding protein | / | 0.453 | |
1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
2iki | 388 | Aldose reductase | 1.1.1.21 | 0.453 | |
2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.453 | |
2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
3c1o | NAP | Eugenol synthase | / | 0.453 | |
3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
3k31 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
3r7m | SUZ | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.453 | |
4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.453 | |
1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
1s36 | CEI | Obelin | / | 0.452 | |
1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.452 | |
2ejz | SAH | Diphthine synthase | / | 0.452 | |
2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.452 | |
2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.452 | |
3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.452 | |
3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.452 | |
3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
3ntq | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.452 | |
4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
4itx | IN5 | Cystathionine beta-lyase MetC | 4.4.1.8 | 0.452 | |
4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.452 | |
4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.452 | |
6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.452 | |
1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.451 | |
1uhj | CZB | Aequorin-2 | / | 0.451 | |
2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.451 | |
2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.451 | |
3cv6 | HXS | Aldo-keto reductase family 1 member C21 | / | 0.451 | |
3pka | Y02 | Methionine aminopeptidase 2 | / | 0.451 | |
3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
4nv1 | 4TG | Formyl transferase | / | 0.451 | |
1eko | I84 | Aldose reductase | 1.1.1.21 | 0.450 | |
1uhh | CZP | Aequorin-2 | / | 0.450 | |
1vp5 | NAP | Oxidoreductase, aldo/keto reductase family | / | 0.450 | |
1xnz | FCD | Methionine aminopeptidase | / | 0.450 | |
1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.450 | |
2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.450 | |
2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.450 | |
2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.450 | |
3hl0 | NAD | Maleylacetate reductase | / | 0.450 | |
3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.450 | |
3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
4fl0 | PLP | Aminotransferase ALD1, chloroplastic | 2.6.1 | 0.450 | |
4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.450 | |
1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.449 | |
1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.449 | |
1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
1x8l | OXR | Retinol dehydratase | / | 0.449 | |
1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.449 | |
2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.449 | |
2pdw | FID | Aldose reductase | 1.1.1.21 | 0.449 | |
3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.449 | |
3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
3zo7 | K6H | Muconolactone Delta-isomerase | / | 0.449 | |
4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
4bvh | OCZ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.449 | |
4bvh | AR6 | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.449 | |
4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.449 | |
4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
4s1h | ADP | Pyridoxal kinase, putative | / | 0.449 | |
1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
1u2r | SO1 | Elongation factor 2 | / | 0.448 | |
1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.448 | |
1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.448 | |
2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.448 | |
2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.448 | |
2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.448 | |
2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.448 | |
2uuk | 897 | Prothrombin | 3.4.21.5 | 0.448 | |
2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.448 | |
2xeg | CI9 | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.448 | |
3r9f | GSU | MccE protein | / | 0.448 | |
4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
4mm4 | 8PR | Na(+):neurotransmitter symporter (Snf family) | / | 0.448 | |
1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.447 | |
1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.447 | |
1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
1wm1 | PTB | Proline iminopeptidase | 3.4.11.5 | 0.447 | |
2agt | FID | Aldose reductase | 1.1.1.21 | 0.447 | |
2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.447 | |
2bxq | IMN | Serum albumin | / | 0.447 | |
2clf | F6F | Tryptophan synthase alpha chain | / | 0.447 | |
2gg0 | U11 | Methionine aminopeptidase | / | 0.447 | |
2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.447 | |
2x1h | X1H | Prostaglandin reductase 3 | 1 | 0.447 | |
3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.447 | |
3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.447 | |
3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.447 | |
4cb5 | 93G | Polymerase basic protein 2 | / | 0.447 | |
4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.447 | |
4to4 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.447 | |
1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.446 | |
1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
2qjp | ANJ | Cytochrome b | / | 0.446 | |
3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.446 | |
3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
3zov | WZV | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
4a7z | AY9 | Aldos-2-ulose dehydratase | / | 0.446 | |
4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.446 | |
4hrq | AZG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.446 | |
4j7g | TRH | PCZA361.3 | / | 0.446 | |
4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
5dp2 | NAP | CurF | / | 0.446 | |
1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.445 | |
1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.445 | |
1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.445 | |
2ay3 | MPP | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.445 | |
2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
3ght | LDT | Aldose reductase | 1.1.1.21 | 0.445 | |
3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
3len | ZST | Aldose reductase | 1.1.1.21 | 0.445 | |
4aoa | IK2 | Beta-phenylalanine transaminase | 2.6.1 | 0.445 | |
4b66 | FAD | L-ornithine N(5)-monooxygenase | / | 0.445 | |
4bek | XK0 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
4e32 | DWN | Methyltransferase | / | 0.445 | |
4kn2 | LYA | Folate receptor beta | / | 0.445 | |
4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.445 | |
1b2r | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.444 | |
1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.444 | |
1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.444 | |
1x2e | ATX | Proline iminopeptidase | 3.4.11.5 | 0.444 | |
1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.444 | |
2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.444 | |
2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.444 | |
2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
3f8s | PF2 | Dipeptidyl peptidase 4 | / | 0.444 | |
3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.444 | |
3i9j | NFD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | 3.2.2.6 | 0.444 | |
3p9t | TCL | Repressor | / | 0.444 | |
3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.444 | |
3w5u | FAD | Ferredoxin | / | 0.444 | |
4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.444 | |
4hld | 16T | Thymidylate kinase | / | 0.444 | |
4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.444 | |
4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
1bx0 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.443 | |
1dgh | NDP | Catalase | 1.11.1.6 | 0.443 | |
1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.443 | |
1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.443 | |
1sm4 | FAD | Ferredoxin--NADP reductase | / | 0.443 | |
1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.443 | |
1x2b | STX | Proline iminopeptidase | 3.4.11.5 | 0.443 | |
1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.443 | |
2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.443 | |
2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.443 | |
2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.443 | |
3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
3dla | NXX | Glutamine-dependent NAD(+) synthetase | 6.3.5.1 | 0.443 | |
3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.443 | |
3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
3zj0 | ACO | Putative acetyltransferase OgpAT | / | 0.443 | |
4flk | Y10 | Methionine aminopeptidase 1 | / | 0.443 | |
4gr9 | 372 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.443 | |
4j7h | TRH | PCZA361.3 | / | 0.443 | |
4x9d | U5P | Uncharacterized protein MJ1435 | / | 0.443 | |
1jf0 | CZH | Obelin | / | 0.442 | |
1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.442 | |
1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
1s1p | NAP | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.442 | |
2f59 | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | / | 0.442 | |
2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
2hzq | STR | Apolipoprotein D | / | 0.442 | |
2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
3fvu | IAC | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.442 | |
3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.442 | |
3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.442 | |
3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.442 | |
3jq8 | DX3 | Pteridine reductase, putative | / | 0.442 | |
3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
3sxj | SAM | Putative methyltransferase | / | 0.442 | |
3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.442 | |
4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.442 | |
4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.442 | |
4pah | LNR | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.442 | |
3ny9 | JSZ | Beta-2 adrenergic receptor | / | 0.442 | |
1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.441 | |
1po7 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.441 | |
1pr4 | MTP | Purine nucleoside phosphorylase DeoD-type | / | 0.441 | |
1qin | GIP | Lactoylglutathione lyase | 4.4.1.5 | 0.441 | |
1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.441 | |
1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.441 | |
2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
2mji | KTR | Fatty acid-binding protein, intestinal | / | 0.441 | |
2wea | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.441 | |
2zse | ACP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.441 | |
3ele | PLP | Aminotransferase | / | 0.441 | |
3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.441 | |
3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.441 | |
3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.441 | |
3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
3wb5 | 0B4 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
4fal | 0T0 | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.441 | |
4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.441 | |
1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.440 | |
1fml | RTL | Retinol dehydratase | / | 0.440 | |
1j8q | FMN | Flavodoxin | / | 0.440 | |
1map | KET | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.440 | |
1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
1z71 | L17 | Prothrombin | 3.4.21.5 | 0.440 | |
2aot | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.440 | |
2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.440 | |
2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.440 | |
2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.440 | |
2uuo | LK3 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.440 | |
2vqj | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.440 | |
2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
3c1k | T15 | Prothrombin | 3.4.21.5 | 0.440 | |
3g5i | DNB | Pyrimidine-specific ribonucleoside hydrolase RihA | / | 0.440 | |
3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.440 | |
3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.440 | |
4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.440 | |
4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.440 | |
5d7q | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.440 |