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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b1pAIZMitogen-activated protein kinase 102.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2b1pAIZMitogen-activated protein kinase 102.7.11.241.000
2excJNKMitogen-activated protein kinase 102.7.11.240.693
3ttjJBIMitogen-activated protein kinase 102.7.11.240.641
1pmn984Mitogen-activated protein kinase 102.7.11.240.604
2p33J07Mitogen-activated protein kinase 102.7.11.240.586
3eljGS7Mitogen-activated protein kinase 82.7.11.240.581
3ttiKBIMitogen-activated protein kinase 102.7.11.240.562
2o0uC0MMitogen-activated protein kinase 102.7.11.240.561
3fi3JK2Mitogen-activated protein kinase 102.7.11.240.560
5awmANPStress-activated protein kinase JNK2.7.11.240.554
2o2u738Mitogen-activated protein kinase 102.7.11.240.546
2zdt46CMitogen-activated protein kinase 102.7.11.240.542
3cgfJNFMitogen-activated protein kinase 102.7.11.240.530
1pmv537Mitogen-activated protein kinase 102.7.11.240.527
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.524
1jpaANPEphrin type-B receptor 22.7.10.10.516
2xrwANPMitogen-activated protein kinase 82.7.11.240.515
4ux9ANPMitogen-activated protein kinase 82.7.11.240.515
3vquO22Dual specificity protein kinase TTK2.7.12.10.507
3kvxFMYMitogen-activated protein kinase 102.7.11.240.506
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.502
1nvtNAPShikimate dehydrogenase (NADP(+))/0.497
3mtfA3FActivin receptor type-12.7.11.300.497
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.495
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.494
2wotZZGTGF-beta receptor type-12.7.11.300.493
3cgoJNOMitogen-activated protein kinase 102.7.11.240.493
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.493
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.492
1kvtUPGUDP-glucose 4-epimerase5.1.3.20.491
3h86AP5Adenylate kinase/0.491
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.490
2zdu446Mitogen-activated protein kinase 102.7.11.240.489
3vthAPCCarbamoyltransferase/0.489
5e8xSTUTGF-beta receptor type-12.7.11.300.489
3gxlQIGTGF-beta receptor type-12.7.11.300.488
4hnf16WCasein kinase I isoform delta2.7.11.10.488
5e8wSTUTGF-beta receptor type-12.7.11.300.488
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.487
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.487
2qo9ANPEphrin type-A receptor 32.7.10.10.486
4riyADPEpidermal growth factor receptor2.7.10.10.485
2xvdAS6Ephrin type-B receptor 42.7.10.10.484
3mdvCL6Cholesterol 24-hydroxylase/0.484
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.483
2h96893Mitogen-activated protein kinase 82.7.11.240.483
2vx07X7Ephrin type-B receptor 42.7.10.10.483
4wkqIREEpidermal growth factor receptor2.7.10.10.483
4jia1K3Tyrosine-protein kinase JAK2/0.481
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.481
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.480
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.478
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.478
4k33ACPFibroblast growth factor receptor 32.7.10.10.478
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.477
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.477
4dgnLU2Casein kinase II subunit alpha2.7.11.10.477
3oom507Activin receptor type-12.7.11.300.476
1ipeNDPTropinone reductase 21.1.1.2360.475
1udcUFMUDP-glucose 4-epimerase5.1.3.20.475
2vwz7X6Ephrin type-B receptor 42.7.10.10.475
3l8p0CEAngiopoietin-1 receptor2.7.10.10.475
3v3vMYUMitogen-activated protein kinase 82.7.11.240.475
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.475
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.475
4i22IREEpidermal growth factor receptor2.7.10.10.475
4jr7GNPCasein kinase II subunit alpha2.7.11.10.475
5a3cNADSIR2 family protein/0.475
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.474
1kvuUPGUDP-glucose 4-epimerase5.1.3.20.473
1rj6AZMCarbonic anhydrase 144.2.1.10.473
4bgg844Activin receptor type-12.7.11.300.473
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.473
5e92ANPTGF-beta receptor type-22.7.11.300.473
1udaUFGUDP-glucose 4-epimerase5.1.3.20.472
3mvl38PMitogen-activated protein kinase 14/0.472
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.472
3wfjNAD2-dehydropantoate 2-reductase/0.472
1vyrFMNPentaerythritol tetranitrate reductase/0.471
2igoFADPyranose 2-oxidase/0.471
3icrCOACoenzyme A disulfide reductase/0.471
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.471
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.471
2qoqANPEphrin type-A receptor 32.7.10.10.470
2xs0ANPMitogen-activated protein kinase 82.7.11.240.470
3hllI45Mitogen-activated protein kinase 14/0.470
3w18N13Aurora kinase A2.7.11.10.470
4y93746Tyrosine-protein kinase/0.470
2vx17X8Ephrin type-B receptor 42.7.10.10.469
4c4jX21Dual specificity protein kinase TTK2.7.12.10.469
3k5uPFQAurora kinase A2.7.11.10.468
4enhFVXCholesterol 24-hydroxylase/0.468
5drdATPAurora kinase A2.7.11.10.468
1jipKTN6-deoxyerythronolide B hydroxylase/0.467
1y0s331Peroxisome proliferator-activated receptor delta/0.467
2fy4COACholine O-acetyltransferase2.3.1.60.467
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.467
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.467
3gc9B45Mitogen-activated protein kinase 112.7.11.240.467
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.467
4e730NRMitogen-activated protein kinase 82.7.11.240.467
1jnkANPMitogen-activated protein kinase 102.7.11.240.466
1xelUPGUDP-glucose 4-epimerase5.1.3.20.466
2pzpACPFibroblast growth factor receptor 2/0.466
4nr42LKCREB-binding protein/0.466
4wsqKSAAP2-associated protein kinase 12.7.11.10.466
2itnANPEpidermal growth factor receptor2.7.10.10.465
2wqeADPAurora kinase A2.7.11.10.465
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.465
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.465
4gk2L66Ephrin type-A receptor 32.7.10.10.465
4j97ACPFibroblast growth factor receptor 2/0.465
1di8DTQCyclin-dependent kinase 22.7.11.220.464
2hk51BMTyrosine-protein kinase HCK2.7.10.20.464
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.464
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.464
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.464
4o0uADNAurora kinase A2.7.11.10.464
4ocvANPAminoglycoside phosphotransferase/0.464
1udbUFGUDP-glucose 4-epimerase5.1.3.20.463
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.463
3efwAK8Aurora kinase A2.7.11.10.463
3hx4ANPCalmodulin-domain protein kinase 1/0.463
3mpaSB2Mitogen-activated protein kinase 14/0.463
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.463
3vvpBNUUncharacterized protein/0.463
4a6nFADTetX family tetracycline inactivation enzyme/0.463
4gmy0X5Tyrosine-protein kinase JAK2/0.463
4zohFADPutative oxidoreductase FAD-binding subunit/0.463
5cvhADPCasein kinase II subunit alpha2.7.11.10.463
1dawANPCasein kinase II subunit alpha2.7.11.10.462
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.462
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.462
4c4f7CEDual specificity protein kinase TTK2.7.12.10.462
4jboWPHAurora kinase A2.7.11.10.462
4q71FADBifunctional protein PutA/0.462
1nytNAPShikimate dehydrogenase (NADP(+))/0.461
1om1IQACasein kinase II subunit alpha2.7.11.10.461
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.461
2pz5ACPFibroblast growth factor receptor 2/0.461
2q9fC3SCholesterol 24-hydroxylase/0.461
2y6o1N1Ephrin type-A receptor 42.7.10.10.461
3ictCOACoenzyme A disulfide reductase/0.461
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.461
3t2zFADSulfide-quinone reductase/0.461
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.461
4ure1PSCyclohexanol dehydrogenase/0.461
1vjy460TGF-beta receptor type-12.7.11.300.460
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.460
3sm2478Putative gag-pro-pol polyprotein/0.460
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4btjADPTau-tubulin kinase 12.7.11.10.460
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.460
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.460
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.459
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
1u4dDBQActivated CDC42 kinase 1/0.458
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.458
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.458
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.458
2pwlACPFibroblast growth factor receptor 2/0.458
2xa4AZ5Tyrosine-protein kinase JAK2/0.458
3t3c017Gag-Pol polyprotein3.4.23.160.458
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.458
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4nk92K5Fibroblast growth factor receptor 1/0.458
5bsgNAPPyrroline-5-carboxylate reductase/0.458
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
3axwTIDCasein kinase II subunit alpha2.7.11.10.457
3slkNDPPolyketide synthase extender module 2/0.457
3tqhNDPQuinone oxidoreductase/0.457
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.457
4a1zADPKinesin-like protein KIF11/0.457
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.457
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4g2fC07Ephrin type-A receptor 32.7.10.10.457
4j7uNAPSepiapterin reductase1.1.1.1530.457
4q72FADBifunctional protein PutA/0.457
5dn3ATPAurora kinase A2.7.11.10.457
1i44ACPInsulin receptor2.7.10.10.456
1lrjUD1UDP-glucose 4-epimerase5.1.3.20.456
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.456
2itvANPEpidermal growth factor receptor2.7.10.10.456
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.456
2znpK55Peroxisome proliferator-activated receptor delta/0.456
3lqfNADGalactitol dehydrogenase/0.456
3vthAP2Carbamoyltransferase/0.456
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.456
4c02TAKActivin receptor type-12.7.11.300.456
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.456
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.456
5auwQUEDeath-associated protein kinase 12.7.11.10.456
1jioDEB6-deoxyerythronolide B hydroxylase/0.455
1k6tXN1Gag-Pol polyprotein3.4.23.160.455
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.455
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.455
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.455
2qa2FADPolyketide oxygenase CabE/0.455
2vwx7X4Ephrin type-B receptor 42.7.10.10.455
2vwy7X5Ephrin type-B receptor 42.7.10.10.455
2znq401Peroxisome proliferator-activated receptor delta/0.455
3slz3TLPutative gag-pro-pol polyprotein/0.455
3uvqFS8Mitogen-activated protein kinase 14/0.455
3vt7VDXVitamin D3 receptor/0.455
3wmxNADNAD dependent epimerase/dehydratase/0.455
4a32MYAGlycylpeptide N-tetradecanoyltransferase/0.455
4btjATPTau-tubulin kinase 12.7.11.10.455
4eos1ROCyclin-dependent kinase 22.7.11.220.455
2cy0NAPShikimate dehydrogenase (NADP(+))/0.454
2g8yNADHydroxycarboxylate dehydrogenase B/0.454
2ignFADPyranose 2-oxidase/0.454
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.454
2oorNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.454
2py3ACPFibroblast growth factor receptor 2/0.454
2vouFAD2,6-dihydroxypyridine 3-monooxygenase1.14.13.100.454
2w1fL0FAurora kinase A2.7.11.10.454
2x7hPFNProstaglandin reductase 310.454
3hmm855TGF-beta receptor type-12.7.11.300.454
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
3wswNADL-lactate dehydrogenase/0.454
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.454
4g1wG1WMitogen-activated protein kinase 82.7.11.240.454
4hyu1BKMitogen-activated protein kinase 82.7.11.240.454
4jbpYPHAurora kinase A2.7.11.10.454
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.454
4qmpDKISerine/threonine-protein kinase 242.7.11.10.454
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1qr6NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.453
2b7aIZATyrosine-protein kinase JAK2/0.453
2i5bADPPyridoxine kinase/0.453
2ifaFMNUncharacterized protein/0.453
2pvnP63Casein kinase II subunit alpha2.7.11.10.453
2qocANPEphrin type-A receptor 32.7.10.10.453
2wihP48Cyclin-dependent kinase 22.7.11.220.453
2zbaZBATrichothecene 3-O-acetyltransferase/0.453
3be9P04Casein kinase II subunit alpha2.7.11.10.453
3d4pNADL-lactate dehydrogenase 11.1.1.270.453
3gubGUBDeath-associated protein kinase 12.7.11.10.453
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.453
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.453
3v4tUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.453
4c57FEFCyclin-G-associated kinase2.7.11.10.453
1e3eNAIAlcohol dehydrogenase 41.1.1.10.452
1nzdUPGDNA beta-glucosyltransferase/0.452
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.452
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.452
2gjnFMNNitronate monooxygenase1.13.12.160.452
3gu83GUDeath-associated protein kinase 12.7.11.10.452
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.452
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.452
4lfiGNPCasein kinase II subunit alpha2.7.11.10.452
4zcaADPKinesin-like protein KIF11/0.452
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.452
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1gqtACPRibokinase/0.451
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1yb5NAPQuinone oxidoreductase1.6.5.50.451
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.451
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.451
2itzIREEpidermal growth factor receptor2.7.10.10.451
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.451
2wouZZFTGF-beta receptor type-12.7.11.300.451
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.451
3syiFADSulfide-quinone reductase/0.451
4b8zNAPGDP-L-fucose synthase1.1.1.2710.451
4cdmFO1Deoxyribodipyrimidine photolyase/0.451
4ipeANPTNF receptor-associated protein 1/0.451
4yryFADGlutamate synthase, beta subunit/0.451
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.450
1q1rFADPutidaredoxin reductase1.18.1.50.450
1vbiNADMalate/L-lactate dehydrogenase family protein/0.450
2of4979Tyrosine-protein kinase Lck2.7.10.20.450
3d8bADPFidgetin-like protein 13.6.40.450
3t2kFADSulfide-quinone reductase/0.450
3tvuB37Acetyl-CoA carboxylase/0.450
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.450
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.450
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
4kbk1QGCasein kinase I isoform delta2.7.11.10.450
4ryvZEAProtein LlR18A/0.450
1fwkADPHomoserine kinase2.7.1.390.449
2d1cNAPIsocitrate dehydrogenase [NADP]1.1.1.420.449
2henADPEphrin type-B receptor 22.7.10.10.449
2udpUPPUDP-glucose 4-epimerase5.1.3.20.449
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.449
3hyz42CHeat shock protein HSP 90-alpha/0.449
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.449
3sp9IL2Peroxisome proliferator-activated receptor delta/0.449
3zuyTCHTransporter/0.449
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.449
4bb432WEphrin type-B receptor 42.7.10.10.449
4c4h7RODual specificity protein kinase TTK2.7.12.10.449
4elf35IDihydrofolate reductase/0.449
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4fv7E94Mitogen-activated protein kinase 12.7.11.240.449
4g170VNCasein kinase I isoform gamma-32.7.11.10.449
4jbqVX6Aurora kinase A2.7.11.10.449
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.449
4qmlANPSerine/threonine-protein kinase 242.7.11.10.449
2x1nX1NCyclin-dependent kinase 22.7.11.220.448
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.448
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.448
3oriAGSSerine/threonine protein kinase/0.448
3zonIK1Non-receptor tyrosine-protein kinase TYK22.7.10.20.448
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.448
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.448
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.448
4dpmCOAMalonyl-CoA reductase1.2.1.750.448
4e37NDPCatalase1.11.1.60.448
4fv9E71Mitogen-activated protein kinase 12.7.11.240.448
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.448
4q73FADBifunctional protein PutA/0.448
4ubsDIFPentalenic acid synthase1.14.15.110.448
4zseANPEpidermal growth factor receptor2.7.10.10.448
5bsfNADPyrroline-5-carboxylate reductase/0.448
1j39UPGDNA beta-glucosyltransferase/0.447
1m2qMNXCasein kinase II subunit alpha2.7.11.10.447
2ejvNADL-threonine 3-dehydrogenase/0.447
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.447
3cukFADD-amino-acid oxidase1.4.3.30.447
3flsFLSMitogen-activated protein kinase 14/0.447
3kb1ADPIron-sulfur cluster carrier protein/0.447
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.447
3oroAGSSerine/threonine protein kinase/0.447
3rasNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.447
4du82P0Mevalonate diphosphate decarboxylase/0.447
4h3qANPMitogen-activated protein kinase 12.7.11.240.447
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.447
4nka2K7Fibroblast growth factor receptor 1/0.447
4xiwAZMCarbonic anhydrase, alpha type/0.447
5cshATPCasein kinase II subunit alpha2.7.11.10.447
1bxoPP7Penicillopepsin-13.4.23.200.446
1s60COAAminoglycoside N(6')-acetyltransferase type 1/0.446
2j0lANPFocal adhesion kinase 12.7.10.20.446
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.446
2om9AJAPeroxisome proliferator-activated receptor gamma/0.446
3d7kD7KBenzaldehyde lyase/0.446
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3okxSAMS-adenosyl-L-methionine-binding protein RPA0152/0.446
3p3zP3ZPutative cytochrome P450/0.446
4b14NHWGlycylpeptide N-tetradecanoyltransferase/0.446
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.446
4dymIYZActivin receptor type-12.7.11.300.446
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.446
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.446
4n6bCOAUncharacterized protein/0.446
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.446
1zgyBRLPeroxisome proliferator-activated receptor gamma/0.445
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
2izrBRKCasein kinase I isoform gamma-32.7.11.10.445
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.445
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.445
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.445
3ggfGVDSerine/threonine-protein kinase 26/0.445
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.445
3icsADPCoenzyme A disulfide reductase/0.445
3nwq2NCGag-Pol polyprotein3.4.23.160.445
3uyt0CKCasein kinase I isoform delta2.7.11.10.445
3uzp0CKCasein kinase I isoform delta2.7.11.10.445
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.445
4c4g7RODual specificity protein kinase TTK2.7.12.10.445
4dpuAGSMevalonate diphosphate decarboxylase/0.445
4h0xNADIota toxin component Ia/0.445
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.445
1u28NADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.444
1u3cFADCryptochrome-1/0.444
1u54ACPActivated CDC42 kinase 1/0.444
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.444
2ijmATPFocal adhesion kinase 12.7.10.20.444
2x9fX9FEphrin type-B receptor 42.7.10.10.444
3at4CCKCasein kinase II subunit alpha2.7.11.10.444
3clyACPFibroblast growth factor receptor 2/0.444
3fmjFMJMitogen-activated protein kinase 14/0.444
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.444
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.444
4dc0NDPPutative ketoacyl reductase1.3.10.444
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4f650S9Fibroblast growth factor receptor 1/0.444
4o1pANPRibonuclease L/0.444
4wujFMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy/0.444
5jscFADPutative acyl-CoA dehydrogenase/0.444
5l8lADPAurora kinase A2.7.11.10.444
1bwfATFGlycerol kinase/0.443
1lp4ANPCasein kinase II subunit alpha2.7.11.10.443
1m51TSXPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.443
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.443
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1qxoFMNChorismate synthase/0.443
1t88CAMCamphor 5-monooxygenase1.14.15.10.443
2jn3JN3Fatty acid-binding protein, liver/0.443
2np8CC3Aurora kinase A2.7.11.10.443
2rhrEMOPutative ketoacyl reductase1.3.10.443
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.443
2yj5ATPCopper-transporting ATPase/0.443
2ylxFADPhenylacetone monooxygenase1.14.13.920.443
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.443
3crzFADFerredoxin--NADP+ reductase/0.443
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.443
3gwfFADCyclohexanone monooxygenase/0.443
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4a99FADTetX family tetracycline inactivation enzyme/0.443
4dplNAPMalonyl-CoA reductase1.2.1.750.443
4eevL1XHepatocyte growth factor receptor2.7.10.10.443
4jazSTLPeroxisome proliferator-activated receptor gamma/0.443
4l4cCAMCamphor 5-monooxygenase1.14.15.10.443
4yuqKS1Calmodulin-like domain protein kinase/0.443
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.442
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.442
1xkdNAPIsocitrate dehydrogenase [NADP]/0.442
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.442
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.442
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.442
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.442
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.442
3jskAHZThiamine thiazole synthase/0.442
3l9hEMQKinesin-like protein KIF11/0.442
3opdHIEHeat shock protein 83/0.442
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.442
4a28ADPKinesin-like protein KIF11/0.442
4b10NHWGlycylpeptide N-tetradecanoyltransferase/0.442
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.442
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.442
4l9kEHFSerum albumin/0.442
4nbwNADShort-chain dehydrogenase/reductase SDR/0.442
5bp9SAHPutative methyltransferase protein/0.442
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.441
1k6pXN3Gag-Pol polyprotein3.4.23.160.441
1ol5ADPAurora kinase A2.7.11.10.441
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.441
1xe55FEPlasmepsin-23.4.23.390.441
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.441
2etm7PYFocal adhesion kinase 12.7.10.20.441
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.441
2pvyACPFibroblast growth factor receptor 2/0.441
2q59240Peroxisome proliferator-activated receptor gamma/0.441
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.441
2w98P1ZProstaglandin reductase 21.3.1.480.441
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.441
2xneASHAurora kinase A2.7.11.10.441
2yn8STUEphrin type-B receptor 42.7.10.10.441
3mzhCMPCRP-like cAMP-activated global transcriptional regulator/0.441
3p62FMNPentaerythritol tetranitrate reductase/0.441
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.441
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.441
4a61ANPPlasmid segregation protein ParM/0.441
4einNOHThymidylate synthase2.1.1.450.441
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.441
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.441
4jbiNDPAlcohol dehydrogenase (Zinc)/0.441
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.441
5a27MYAGlycylpeptide N-tetradecanoyltransferase/0.441
5a3bAPRSIR2 family protein/0.441
5c41ACPRibokinase/0.441
5fl49FKCarbonic anhydrase 94.2.1.10.441
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.440
1ppjANYCytochrome b/0.440
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
2ittAEEEpidermal growth factor receptor2.7.10.10.440
2v7a627Tyrosine-protein kinase ABL12.7.10.20.440
2y4gTIRTamL/0.440
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.440
3w32W32Epidermal growth factor receptor2.7.10.10.440
4awp99AHeat shock protein HSP 90-alpha/0.440
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
4fkr45KCyclin-dependent kinase 22.7.11.220.440
4gk4L90Ephrin type-A receptor 32.7.10.10.440
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4kl9NDPDihydrofolate reductase1.5.1.30.440
4tuvCPZCytochrome P450 1191.140.440