Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
1y6r | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 |
PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
---|---|---|---|---|---|
1y6r | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 1.000 | |
1zos | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.620 | |
3eei | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.615 | |
1y6q | TDI | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.613 | |
3dp9 | BIG | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.607 | |
4x24 | TDI | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.580 | |
1nc1 | MTH | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.569 | |
4bmz | MTA | Aminodeoxyfutalosine nucleosidase | / | 0.563 | |
4wkb | TDI | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.556 | |
1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.496 | |
3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.495 | |
1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.494 | |
1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.493 | |
1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.492 | |
1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.489 | |
1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.489 | |
3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.489 | |
5agy | GTB | Tau class glutathione S-transferase | / | 0.489 | |
3rl4 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.488 | |
1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.486 | |
1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.486 | |
2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.485 | |
3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.485 | |
4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.484 | |
3qp8 | HL0 | Transcriptional activator, LuxR/UhpA family of regulators | / | 0.483 | |
4fr1 | 0V2 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.483 | |
3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.482 | |
3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
3ox1 | 695 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.481 | |
1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.480 | |
2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.480 | |
3tl1 | JRO | Putative polyketide cyclase | / | 0.478 | |
1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.477 | |
2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.476 | |
2x20 | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.476 | |
3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.476 | |
3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.476 | |
1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
4hsh | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.475 | |
4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.475 | |
1u1c | BAU | Uridine phosphorylase | 2.4.2.3 | 0.474 | |
4zvm | DM2 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.474 | |
1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
2cbq | TH2 | Neocarzinostatin | / | 0.473 | |
3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.473 | |
3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.473 | |
4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
3lq2 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.472 | |
4eh8 | IRG | Mitogen-activated protein kinase 14 | / | 0.472 | |
1q63 | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.471 | |
2qmz | LDP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.471 | |
2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.470 | |
3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.470 | |
3gc4 | AAQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.470 | |
4az0 | S61 | Lysosomal protective protein | 3.4.16.5 | 0.470 | |
4gh1 | 0WX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.470 | |
4ixc | 1JD | Glucokinase | 2.7.1.2 | 0.470 | |
4n1g | CEI | Obelin | / | 0.470 | |
1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.469 | |
1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.469 | |
3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.469 | |
4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.469 | |
4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.468 | |
3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.468 | |
3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
4iwv | 1J9 | Glucokinase | 2.7.1.2 | 0.468 | |
1rxj | BNI | Streptavidin | / | 0.467 | |
1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.467 | |
3acy | 702 | Dehydrosqualene synthase | / | 0.467 | |
3nhl | YTR | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.467 | |
4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
1kdm | DHT | Sex hormone-binding globulin | / | 0.466 | |
1txt | CAA | HMG-CoA synthase | / | 0.466 | |
2bt4 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.466 | |
2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
2z1x | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.466 | |
3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.466 | |
3reo | EUG | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.466 | |
4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
1lhu | EST | Sex hormone-binding globulin | / | 0.465 | |
2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.465 | |
2pot | GUN | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.465 | |
2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.465 | |
3ojg | HL4 | Phosphotriesterase | / | 0.465 | |
3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.465 | |
3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.465 | |
3qp6 | HL6 | Transcriptional activator, LuxR/UhpA family of regulators | / | 0.465 | |
4l8v | NAP | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.465 | |
4psb | GA3 | Cytokinin-specific binding protein | / | 0.465 | |
5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.465 | |
1axw | MTX | Thymidylate synthase | / | 0.464 | |
1ozq | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.464 | |
1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.464 | |
2c92 | TP6 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.464 | |
3dzl | 3OC | Phenazine biosynthesis protein A/B | / | 0.464 | |
3ean | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.464 | |
3ox3 | 4X4 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.464 | |
2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.463 | |
3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.463 | |
3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.463 | |
3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
3juo | AJD | Phenazine biosynthesis protein A/B | / | 0.463 | |
3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.463 | |
3p9t | TCL | Repressor | / | 0.463 | |
1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.462 | |
2cy2 | ACO | Probable acetyltransferase | / | 0.462 | |
2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
2gzl | 2AA | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.462 | |
2hzq | STR | Apolipoprotein D | / | 0.462 | |
1ndy | FR3 | Adenosine deaminase | 3.5.4.4 | 0.461 | |
1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.461 | |
2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
3s41 | S41 | Glucokinase | 2.7.1.2 | 0.461 | |
4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.461 | |
4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.461 | |
4knz | CB3 | Thymidylate synthase | / | 0.461 | |
5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.461 | |
3qak | UKA | Adenosine receptor A2a | / | 0.461 | |
1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.460 | |
3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
4qoh | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.460 | |
4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.460 | |
1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.459 | |
1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.459 | |
1n71 | COA | Aac(6')-Ii protein | / | 0.459 | |
1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.459 | |
3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.459 | |
3njo | PYV | Abscisic acid receptor PYR1 | / | 0.459 | |
4phl | PIL | Phosphodiesterase | / | 0.459 | |
1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.458 | |
2bbq | PFG | Thymidylate synthase | / | 0.458 | |
2x21 | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.458 | |
3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.458 | |
3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
3qwc | 98P | Prothrombin | 3.4.21.5 | 0.458 | |
3up0 | D7S | aceDAF-12 | / | 0.458 | |
4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
4s1h | ADP | Pyridoxal kinase, putative | / | 0.458 | |
5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
1s36 | CEI | Obelin | / | 0.457 | |
2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.457 | |
3n0y | APC | Adenylate cyclase 2 | / | 0.457 | |
4dhy | S41 | Glucokinase | 2.7.1.2 | 0.457 | |
4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
4nbl | 2J6 | Caspase-6 | 3.4.22.59 | 0.457 | |
1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.456 | |
3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
3nx2 | FER | Ferulic acid decarboxylase | / | 0.456 | |
3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.456 | |
4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.456 | |
4fhf | 0TT | Spore photoproduct lyase | / | 0.456 | |
1n2v | BDI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.455 | |
1vhn | FMN | tRNA-dihydrouridine synthase | / | 0.455 | |
1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.455 | |
2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.455 | |
2uza | HTL | Pyruvate synthase | / | 0.455 | |
4gtt | 7TQ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.455 | |
4iw8 | KN3 | Estrogen receptor | / | 0.455 | |
1jdz | FMB | Purine nucleoside phosphorylase | / | 0.454 | |
1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.454 | |
1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.454 | |
3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.454 | |
3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.454 | |
3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.454 | |
4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.454 | |
4gcx | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.454 | |
4hmh | F94 | Tankyrase-2 | 2.4.2.30 | 0.454 | |
5k2a | ZMA | Adenosine receptor A2a | / | 0.454 | |
1gt5 | BZQ | Odorant-binding protein | / | 0.453 | |
1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
1mlz | PLP | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.453 | |
1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.453 | |
1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.453 | |
1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
2uxx | FAJ | Lysine-specific histone demethylase 1A | 1 | 0.453 | |
2yat | EEU | Estrogen receptor | / | 0.453 | |
3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
3n87 | N87 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.453 | |
3nwb | 659 | Catechol O-methyltransferase | 2.1.1.6 | 0.453 | |
3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
4lzw | THM | Uridine phosphorylase | / | 0.453 | |
4y1b | NAP | AntE | / | 0.453 | |
1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.452 | |
1jtq | LY3 | Thymidylate synthase | / | 0.452 | |
1kce | CB3 | Thymidylate synthase | / | 0.452 | |
1q4w | DQU | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.452 | |
1sqb | AZO | Cytochrome b | / | 0.452 | |
1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.452 | |
2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.452 | |
3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.452 | |
3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.452 | |
4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.452 | |
5kf8 | ACO | Predicted acetyltransferase | / | 0.452 | |
1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.451 | |
1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.451 | |
1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.451 | |
3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.451 | |
3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.451 | |
4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
4pzt | SOP | Histone acetyltransferase p300 | / | 0.451 | |
4q8p | CKR | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.451 | |
1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
1y5x | E89 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.450 | |
2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.450 | |
2c3o | TPP | Pyruvate synthase | / | 0.450 | |
2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.450 | |
2vi5 | Y19 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.450 | |
3pqb | VGP | Putative oxidoreductase | / | 0.450 | |
3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
4b4w | 9L9 | Bifunctional protein FolD | / | 0.450 | |
4fsa | 0V3 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.450 | |
4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
1ej3 | CZH | Aequorin-2 | / | 0.449 | |
1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
1z5u | CMP | Class B acid phosphatase | / | 0.449 | |
2d2g | DZZ | Phosphotriesterase | / | 0.449 | |
2vxk | COA | Glucosamine 6-phosphate acetyltransferase, putative | / | 0.449 | |
3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.449 | |
3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.449 | |
3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.449 | |
3nhj | A2Z | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.449 | |
3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.449 | |
3zrb | OR8 | Progesterone receptor | / | 0.449 | |
4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
4dm6 | TTB | Retinoic acid receptor beta | / | 0.449 | |
4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.449 | |
4y0k | NAP | AntE | / | 0.449 | |
1jtu | LYB | Thymidylate synthase | / | 0.448 | |
1y5w | NEZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.448 | |
2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
3chr | 4BS | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.448 | |
3k3i | I46 | Mitogen-activated protein kinase 14 | / | 0.448 | |
3nhp | HGZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.448 | |
3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.448 | |
4fev | PP1 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.448 | |
4hqv | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.448 | |
4hut | ATP | Cob(I)yrinic acid a,c-diamide adenosyltransferase | 2.5.1.17 | 0.448 | |
4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
1jf2 | CZH | Obelin | / | 0.447 | |
1ltz | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.447 | |
1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.447 | |
1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
2c97 | JCL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.447 | |
2jl1 | NAP | Triphenylmethane reductase | / | 0.447 | |
3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.447 | |
3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.447 | |
3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.447 | |
4b4v | L34 | Bifunctional protein FolD | / | 0.447 | |
4eh5 | IRG | Mitogen-activated protein kinase 14 | / | 0.447 | |
4fqs | LYA | Thymidylate synthase ThyA | / | 0.447 | |
4l09 | 1UR | Tankyrase-2 | 2.4.2.30 | 0.447 | |
4zth | GG5 | Mitogen-activated protein kinase 14 | / | 0.447 | |
1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
1p0y | SAH | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.446 | |
1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
1syn | F89 | Thymidylate synthase | / | 0.446 | |
1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.446 | |
1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
2ji9 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.446 | |
2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.446 | |
3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
3uxe | 465 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.446 | |
4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
4j3l | AJ5 | Tankyrase-2 | 2.4.2.30 | 0.446 | |
4jqh | 1MF | Alr2278 protein | / | 0.446 | |
4pl9 | ADP | Ethylene receptor 1 | / | 0.446 | |
5g53 | NEC | Adenosine receptor A2a | / | 0.446 | |
1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.445 | |
1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.445 | |
1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.445 | |
2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.445 | |
3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.445 | |
3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
3v0n | 4GW | Histo-blood group ABO system transferase | / | 0.445 | |
3vt7 | VDX | Vitamin D3 receptor | / | 0.445 | |
4af3 | VX6 | Aurora kinase B | 2.7.11.1 | 0.445 | |
4az3 | S35 | Lysosomal protective protein | 3.4.16.5 | 0.445 | |
4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
4fhd | 0TT | Spore photoproduct lyase | / | 0.445 | |
4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
4rh1 | 0TT | Spore photoproduct lyase | / | 0.445 | |
1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.444 | |
1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
1nqx | RLP | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
1qsn | COA | HAT A1 | / | 0.444 | |
1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
2eju | SAH | tRNA (guanine(26)-N(2))-dimethyltransferase | / | 0.444 | |
3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
4a0s | CO8 | Octenoyl-CoA reductase/carboxylase | / | 0.444 | |
4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.444 | |
4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.444 | |
4ubt | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.444 | |
4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.444 | |
1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.443 | |
1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
2c3p | 1TP | Pyruvate synthase | / | 0.443 | |
2clf | F6F | Tryptophan synthase alpha chain | / | 0.443 | |
2g8n | F83 | Phenylethanolamine N-methyltransferase | 2.1.1.28 | 0.443 | |
3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.443 | |
3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
3q6k | SRO | 43.2 kDa salivary protein | / | 0.443 | |
3vi5 | M4M | Hematopoietic prostaglandin D synthase | / | 0.443 | |
4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.443 | |
4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.443 | |
4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.443 | |
1k4h | APQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.442 | |
2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.442 | |
2on6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.442 | |
2xb8 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.442 | |
3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.442 | |
3nhu | M42 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
3seq | NXX | Glutamine-dependent NAD(+) synthetase | 6.3.5.1 | 0.442 | |
3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
4dsb | A8S | Abscisic acid receptor PYL3 | / | 0.442 | |
4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.442 | |
4hdr | DMD | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | / | 0.442 | |
4hdr | DMD | ArsB | / | 0.442 | |
4y6n | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.442 | |
1e1q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
1fcx | 184 | Retinoic acid receptor gamma | / | 0.441 | |
1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.441 | |
1nce | CB3 | Thymidylate synthase | / | 0.441 | |
1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.441 | |
1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.441 | |
1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.441 | |
1rd4 | L08 | Integrin alpha-L | / | 0.441 | |
1s9d | AFB | Cytohesin-2 | / | 0.441 | |
1s9d | AFB | ADP-ribosylation factor 1 | / | 0.441 | |
2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.441 | |
2c42 | TPP | Pyruvate synthase | / | 0.441 | |
2flh | ZEA | Cytokinin-specific binding protein | / | 0.441 | |
2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.441 | |
2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.441 | |
3b5i | SAH | Indole-3-acetate O-methyltransferase 1 | / | 0.441 | |
3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.441 | |
3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.441 | |
3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
3iej | 599 | Cathepsin S | 3.4.22.27 | 0.441 | |
3sfx | JAN | Uncharacterized protein | / | 0.441 | |
3up3 | XCA | aceDAF-12 | / | 0.441 | |
3vru | YS3 | Vitamin D3 receptor | / | 0.441 | |
4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.441 | |
4h7z | GUN | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.441 | |
4ia1 | BIV | Vitamin D3 receptor A | / | 0.441 | |
4iae | 1DX | Alr2278 protein | / | 0.441 | |
4nbi | D3Y | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.441 | |
4ykl | GMP | Aprataxin-like protein | 3 | 0.441 | |
5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.441 | |
5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.441 | |
3eml | ZMA | Adenosine receptor A2a | / | 0.441 | |
1fvp | FMA | Non-fluorescent flavoprotein | / | 0.440 | |
1jla | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
1nqm | BTN | Streptavidin | / | 0.440 | |
1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
1t0i | FMN | NAD(P)H-dependent FMN reductase LOT6 | / | 0.440 | |
1tgv | 5UD | Uridine phosphorylase | 2.4.2.3 | 0.440 | |
1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.440 | |
1xi2 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
1ybg | TAV | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.440 | |
2b3v | ACO | Diamine acetyltransferase 1 | / | 0.440 | |
2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.440 | |
2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.440 | |
2lzg | 13Q | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.440 | |
2o6h | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | 2.5.1.78 | 0.440 | |
2x9v | TMQ | Pteridine reductase | / | 0.440 | |
2zi6 | 3D1 | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.440 | |
3gey | P34 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.440 | |
3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.440 | |
3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
3kqj | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.440 | |
3nhy | A7B | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
3occ | DIH | Purine nucleoside phosphorylase DeoD-type | / | 0.440 | |
3q2j | CKI | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.440 | |
4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.440 | |
4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.440 |