sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1wop | FFO | Aminomethyltransferase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1wop | FFO | Aminomethyltransferase | / | 1.000 | |
| 1woo | THG | Aminomethyltransferase | / | 0.743 | |
| 4kxj | P34 | Nucleoprotein | / | 0.514 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.511 | |
| 1ecb | 5GP | Amidophosphoribosyltransferase | / | 0.508 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.507 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.502 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.501 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.498 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.498 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.498 | |
| 3c1o | NAP | Eugenol synthase | / | 0.497 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.495 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.494 | |
| 3a8i | C2F | Aminomethyltransferase | 2.1.2.10 | 0.493 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.490 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.489 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.487 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.486 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.484 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.484 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.483 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.483 | |
| 4twl | ASC | Dioscorin 5 | / | 0.483 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.482 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.482 | |
| 4ykl | GMP | Aprataxin-like protein | 3 | 0.482 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.481 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.481 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.481 | |
| 1kzi | THG | Thymidylate synthase | / | 0.480 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.480 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.480 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.479 | |
| 3qdz | PRO_ALA_PRO_ARG | Prothrombin | 3.4.21.5 | 0.479 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.478 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.478 | |
| 2hl0 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.477 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.477 | |
| 4lcn | GNG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.477 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.476 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.475 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.475 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.473 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.473 | |
| 4dmg | SAM | Uncharacterized protein | / | 0.473 | |
| 4nhy | PD2 | Prolyl 3-hydroxylase OGFOD1 | 1.14.11 | 0.473 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.473 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.472 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.472 | |
| 2hzq | STR | Apolipoprotein D | / | 0.471 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.471 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.470 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.469 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.469 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.469 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.469 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.468 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.468 | |
| 3hy3 | 10F | 5-formyltetrahydrofolate cyclo-ligase | 6.3.3.2 | 0.468 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.467 | |
| 3bwc | SAM | Spermidine synthase, putative | / | 0.467 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.467 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.467 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.466 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.466 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.466 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.466 | |
| 3eks | CY9 | Actin-5C | / | 0.466 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.466 | |
| 3ox2 | 79X | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.466 | |
| 4gqi | M49 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.466 | |
| 1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.465 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 2x1e | X1E | Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form | 2.3.1.164 | 0.465 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.465 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.465 | |
| 3gx9 | TXD | Morphinone reductase | / | 0.465 | |
| 3lzz | GDP | Uncharacterized protein | / | 0.465 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.465 | |
| 5fli | QUE | Quercetinase QueD | / | 0.465 | |
| 1g0r | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.464 | |
| 1gax | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.464 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 1w7g | MIU | Prothrombin | 3.4.21.5 | 0.464 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.464 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.464 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.464 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.464 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.463 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.463 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 4bb2 | STR | Corticosteroid-binding globulin | / | 0.463 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.463 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.463 | |
| 4g8j | THM | Uridine phosphorylase | / | 0.463 | |
| 4uy6 | SAH | Histidine N-alpha-methyltransferase | / | 0.463 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.462 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.462 | |
| 3zpq | XF5 | Beta-1 adrenergic receptor | / | 0.462 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.462 | |
| 5d4u | SAM | Uncharacterized protein MJ0489 | / | 0.462 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.462 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.461 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.461 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.461 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.461 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.461 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.460 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.460 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.460 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.460 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.460 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.460 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.460 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.460 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.460 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.460 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.460 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4wct | FAD | Fructosyl amine:oxygen oxidoreductase | / | 0.460 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.460 | |
| 1g2v | TTP | Glucose-1-phosphate thymidylyltransferase | / | 0.459 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.459 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.459 | |
| 2pid | YSA | Tyrosine--tRNA ligase, mitochondrial | 6.1.1.1 | 0.459 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.459 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.459 | |
| 3ccc | 7AC | Dipeptidyl peptidase 4 | / | 0.459 | |
| 4ech | FAD | Polyamine oxidase FMS1 | / | 0.459 | |
| 1e64 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.458 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.458 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4zhi | ADP | Kinesin-like protein KIF11 | / | 0.458 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.457 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.457 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.457 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.456 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.456 | |
| 2obx | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | 2.5.1.78 | 0.456 | |
| 2op1 | 8PC | Enoyl-ACP reductase | / | 0.456 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.456 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.456 | |
| 3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.456 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 4gcm | NAP | Thioredoxin reductase | 1.8.1.9 | 0.456 | |
| 1ny2 | ARG_PRO_PRO_GLY | Prothrombin | 3.4.21.5 | 0.455 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.455 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.455 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.455 | |
| 2ibw | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.455 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.455 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.454 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.454 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.454 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2hwu | URI | Uridine phosphorylase | 2.4.2.3 | 0.454 | |
| 2xjc | 5GP | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.454 | |
| 3e6e | DCS | Alanine racemase | / | 0.454 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.454 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.454 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.454 | |
| 1e6z | NGO | Chitinase | / | 0.453 | |
| 1n2v | BDI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.453 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.453 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.453 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.453 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.453 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.453 | |
| 4a16 | H34 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 4aws | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.453 | |
| 4to2 | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.453 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.452 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1pg0 | MOD | Methionine--tRNA ligase | 6.1.1.10 | 0.452 | |
| 2e8w | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.452 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.452 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.452 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.452 | |
| 3ts1 | TYA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.452 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.452 | |
| 4gg1 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.452 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.452 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.452 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.452 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.451 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.451 | |
| 1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.451 | |
| 2vqz | MGT | Polymerase basic protein 2 | / | 0.451 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3fpk | FAD | Ferredoxin-NADP reductase | / | 0.451 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.451 | |
| 3juq | AKD | Phenazine biosynthesis protein A/B | / | 0.451 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.451 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.451 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 4qfz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.451 | |
| 4xxv | NAD | 3-isopropylmalate dehydrogenase | / | 0.451 | |
| 1acj | THA | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2qmz | LDP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.450 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.450 | |
| 4rxp | DTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.450 | |
| 5je4 | SAH | Methyl transferase | / | 0.450 | |
| 1eqa | MG7 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase | 2.1.1.57 | 0.449 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.449 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.449 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1p4a | PCP | Pur operon repressor | / | 0.449 | |
| 1xpq | FAD | Polyamine oxidase FMS1 | / | 0.449 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.449 | |
| 2xvv | 9DN | Serum albumin | / | 0.449 | |
| 3c4h | DRL | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.449 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.449 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.449 | |
| 4fl0 | PLP | Aminotransferase ALD1, chloroplastic | 2.6.1 | 0.449 | |
| 4hxx | 1AY | Methionine aminopeptidase 1 | / | 0.449 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.449 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.448 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.448 | |
| 1x31 | FMN | Subunit alpha of sarocosine oxidase | / | 0.448 | |
| 1x31 | FMN | Subunit beta of sarcosine oxidase | / | 0.448 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.448 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3bi2 | FAD | Polyamine oxidase FMS1 | / | 0.448 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.448 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.448 | |
| 3g0g | RUM | Dipeptidyl peptidase 4 | / | 0.448 | |
| 3lzx | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.448 | |
| 3rgz | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.448 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4iks | TFD | Methionine aminopeptidase 1 | / | 0.448 | |
| 4rr9 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.448 | |
| 5flj | QUE | Quercetinase QueD | / | 0.448 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.447 | |
| 1ij8 | BNI | Avidin | / | 0.447 | |
| 1ja0 | FAD | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 1kwc | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.447 | |
| 1m9h | NAD | 2,5-diketo-D-gluconic acid reductase A | 1.1.1.346 | 0.447 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2qqf | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.447 | |
| 2y01 | Y00 | Beta-1 adrenergic receptor | / | 0.447 | |
| 3hgg | CHD | CmeR | / | 0.447 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.447 | |
| 3zho | FMN | NAD(P)H dehydrogenase (quinone) | / | 0.447 | |
| 4c35 | NU3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.447 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.447 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 5dw5 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.447 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.446 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.446 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.446 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.446 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.446 | |
| 2vqb | NAP | Putative flavin-containing monooxygenase | / | 0.446 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.446 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.446 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.446 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.446 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.446 | |
| 4jbs | P52 | Endoplasmic reticulum aminopeptidase 2 | 3.4.11 | 0.446 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.446 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.445 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.445 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.445 | |
| 1k02 | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.445 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.445 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.445 | |
| 2a3b | CFF | Endochitinase B1 | 3.2.1.14 | 0.445 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.445 | |
| 3arv | SAU | Chitinase A | / | 0.445 | |
| 3imx | B84 | Glucokinase | 2.7.1.2 | 0.445 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4d96 | 5PA | D-cysteine desulfhydrase | / | 0.445 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.445 | |
| 4nv1 | TYD | Formyl transferase | / | 0.445 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.445 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.445 | |
| 1ahg | TYR_PLP | Aspartate aminotransferase | 2.6.1.1 | 0.444 | |
| 1akb | PPD | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.444 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
| 1krh | FAD | Benzoate 1,2-dioxygenase electron transfer component | 1.18.1.3 | 0.444 | |
| 1rfu | PLP | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 1szc | CNA | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.444 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.444 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.444 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.444 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.444 | |
| 2ft0 | ACO | dTDP-fucosamine acetyltransferase | / | 0.444 | |
| 2o6h | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | 2.5.1.78 | 0.444 | |
| 2pbz | ATP | Uncharacterized protein | / | 0.444 | |
| 2pgt | GPR | Glutathione S-transferase P | 2.5.1.18 | 0.444 | |
| 2q93 | B21 | Methionine aminopeptidase | / | 0.444 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.444 | |
| 3e30 | ED4 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 3fu5 | 492 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.444 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.444 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4iil | RBF | Membrane lipoprotein TpN38(b) | / | 0.444 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 4rrg | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.444 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 4xt8 | TMQ | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.444 | |
| 1e62 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.443 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.443 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.443 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.443 | |
| 2onf | COA | Uncharacterized protein | / | 0.443 | |
| 2v7u | SAM | 5'-fluoro-5'-deoxy-adenosine synthase | / | 0.443 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.443 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.443 | |
| 3haz | FAD | Bifunctional protein PutA | / | 0.443 | |
| 3kmx | G00 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.443 | |
| 3uaz | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.443 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.443 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.443 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.443 | |
| 4rhe | FMN | Flavin prenyltransferase UbiX | / | 0.443 | |
| 1lgt | BP3 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.442 | |
| 1pfy | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.442 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.442 | |
| 1vrq | FON | Subunit alpha of sarocosine oxidase | / | 0.442 | |
| 2nm2 | NEU | Dihydroneopterin aldolase | / | 0.442 | |
| 3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.442 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.442 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.442 | |
| 3t6i | NC9 | Endothiapepsin | 3.4.23.22 | 0.442 | |
| 3tfy | MET_LEU_GLY_PRO | N-alpha-acetyltransferase 50 | 2.3.1 | 0.442 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.442 | |
| 3wqt | ANP | Cell division protein FtsA | / | 0.442 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.442 | |
| 4ikt | TFV | Methionine aminopeptidase 1 | / | 0.442 | |
| 5dep | UD1 | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase | / | 0.442 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.441 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.441 | |
| 1wua | AP8 | Actin, alpha skeletal muscle | / | 0.441 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 1ych | FMN | Nitric oxide reductase | 1 | 0.441 | |
| 2avx | HTF | Regulatory protein SdiA | / | 0.441 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.441 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.441 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2xvw | 9NR | Serum albumin | / | 0.441 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.441 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.441 | |
| 3gey | P34 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.441 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.441 | |
| 3ox3 | 4X4 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.441 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.441 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.441 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 4qoh | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.441 | |
| 5je3 | SAH | Methyl transferase | / | 0.441 | |
| 1bwk | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.440 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.440 | |
| 1h85 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.440 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 1zha | PEP | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.440 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 3btj | DEQ | HTH-type transcriptional regulator QacR | / | 0.440 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.440 | |
| 3dhk | 23U | Prothrombin | 3.4.21.5 | 0.440 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3gf4 | U5P | UDP-galactopyranose mutase | 5.4.99.9 | 0.440 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 3gxf | IFM | Glucosylceramidase | 3.2.1.45 | 0.440 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.440 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3p17 | 99P | Prothrombin | 3.4.21.5 | 0.440 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3vri | 1KX | HLA class I histocompatibility antigen, B-57 alpha chain | / | 0.440 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.440 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4bjc | RPB | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.440 | |
| 4isg | 1FY | Glucokinase | 2.7.1.2 | 0.440 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.440 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.440 | |
| 4nbj | D3Y | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.440 | |
| 4utl | FNR | Xenobiotic reductase | / | 0.440 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.440 | |
| 5erm | 210 | Fusicoccadiene synthase | 4.2.3.43 | 0.440 |