sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1v48 | HA1 | Purine nucleoside phosphorylase | 2.4.2.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1v48 | HA1 | Purine nucleoside phosphorylase | 2.4.2.1 | 1.000 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.601 | |
| 1yry | MSG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.589 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.581 | |
| 1fxu | GU7 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.572 | |
| 1lv8 | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.554 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.535 | |
| 1pf7 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.529 | |
| 1v2h | GUN | Purine nucleoside phosphorylase | 2.4.2.1 | 0.528 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.527 | |
| 3k8o | 229 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.523 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.521 | |
| 1b8n | IMG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.518 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.516 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.513 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.511 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.504 | |
| 1a9s | NOS | Purine nucleoside phosphorylase | 2.4.2.1 | 0.502 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.500 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.500 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.499 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.496 | |
| 2vkm | BSD | Beta-secretase 1 | 3.4.23.46 | 0.495 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.494 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.492 | |
| 2on6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.492 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.491 | |
| 2ejz | SAH | Diphthine synthase | / | 0.489 | |
| 3up0 | D7S | aceDAF-12 | / | 0.487 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.486 | |
| 4rel | KMP | Glycosyltransferase | / | 0.486 | |
| 3w2f | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.485 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.484 | |
| 4j7h | TRH | PCZA361.3 | / | 0.484 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.483 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.483 | |
| 1a9p | 9DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.482 | |
| 2p4s | DIH | AGAP005945-PA | / | 0.482 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.482 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.482 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.482 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.481 | |
| 4ttj | FMC | Purine nucleoside phosphorylase DeoD-type | / | 0.481 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.480 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.480 | |
| 5dp2 | NAP | CurF | / | 0.480 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.478 | |
| 4y7c | FMN | NADPH--cytochrome P450 reductase | / | 0.477 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.476 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.475 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.475 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.475 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.474 | |
| 1rct | NOS | Purine nucleoside phosphorylase | 2.4.2.1 | 0.474 | |
| 1zdw | FLV | Prenyltransferase | / | 0.474 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.474 | |
| 2v34 | CTN | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.473 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.473 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.472 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.472 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.471 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.471 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.471 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.470 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.469 | |
| 3f8w | ADN | Purine nucleoside phosphorylase | / | 0.469 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.469 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.469 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.469 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.468 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.467 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.467 | |
| 4ear | IM5 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.467 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 4q4k | FMN | Uncharacterized protein | / | 0.467 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.466 | |
| 3eks | CY9 | Actin-5C | / | 0.466 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.466 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.466 | |
| 4e2x | TYD | Methyltransferase | / | 0.466 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.466 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.466 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.465 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.465 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 1b8o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.464 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.464 | |
| 3v2u | ATP | Protein GAL3 | / | 0.464 | |
| 2wba | FAD | Trypanothione reductase | 1.8.1.12 | 0.463 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.463 | |
| 4e32 | DWN | Methyltransferase | / | 0.463 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.461 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.461 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4k9h | 1QU | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.460 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.460 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3fow | IMH | Purine nucleoside phosphorylase | / | 0.460 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.460 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.460 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.459 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.458 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.458 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.458 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.458 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.458 | |
| 4fco | 0U4 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.458 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
| 4l82 | FMN | Uncharacterized protein | / | 0.458 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4tm0 | NAP | KtzI | / | 0.458 | |
| 1s1r | NAP | Aldo-keto reductase family 1 member C3 | / | 0.457 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.457 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.457 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.457 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.457 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.457 | |
| 4dan | 2FA | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.457 | |
| 4j1e | 1HM | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.457 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.457 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1pke | 2FD | Purine nucleoside phosphorylase DeoD-type | / | 0.456 | |
| 1pr1 | FMB | Purine nucleoside phosphorylase DeoD-type | / | 0.456 | |
| 2f3e | AXQ | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.456 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.455 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.455 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.455 | |
| 3eku | CY9 | Actin-5C | / | 0.455 | |
| 3zks | WZV | Beta-secretase 2 | 3.4.23.45 | 0.455 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.455 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.455 | |
| 4uy6 | SAH | Histidine N-alpha-methyltransferase | / | 0.455 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 2hej | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.454 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 3t0i | SAH | Putative methyltransferase | / | 0.454 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.454 | |
| 1r2j | FAD | FkbI | / | 0.453 | |
| 1yun | ATP | Probable nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.453 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.453 | |
| 2rfi | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.453 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.453 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3nd6 | ATP | Phosphopantetheine adenylyltransferase | / | 0.453 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.453 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.453 | |
| 4y9u | NAP | NADPH--cytochrome P450 reductase | / | 0.453 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.452 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 2qzl | IXS | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.452 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4dpi | 0N1 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.452 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.451 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.451 | |
| 2ft0 | ACO | dTDP-fucosamine acetyltransferase | / | 0.451 | |
| 2v6g | NAP | 3-oxo-Delta(4,5)-steroid 5-beta-reductase | / | 0.451 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.451 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.451 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.451 | |
| 1oya | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.450 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.450 | |
| 3ens | ENS | Coagulation factor X | 3.4.21.6 | 0.450 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.450 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.450 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4phl | PIL | Phosphodiesterase | / | 0.450 | |
| 4yek | THM | Thymidine phosphorylase | / | 0.450 | |
| 1d0m | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.449 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.449 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.449 | |
| 2a3b | CFF | Endochitinase B1 | 3.2.1.14 | 0.449 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.449 | |
| 3bw2 | FMN | Putative 2-nitropropane dioxygenase | / | 0.449 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3exo | 5MS | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3ftx | RE2 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.449 | |
| 3ies | M24 | Luciferin 4-monooxygenase | 1.13.12.7 | 0.449 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.449 | |
| 4ha5 | 13W | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.448 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.448 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.448 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1sa5 | BMV | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.448 | |
| 2gs9 | SAH | Uncharacterized protein | / | 0.448 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.448 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.448 | |
| 3ndj | JHZ | Methyltransferase | / | 0.448 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.448 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1q1g | MTI | Purine nucleoside phosphorylase | / | 0.447 | |
| 2jfh | LK1 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.447 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2rgo | FAD | Alpha-Glycerophosphate Oxidase | / | 0.447 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.447 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.447 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.447 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.447 | |
| 4b6u | M7G | Eukaryotic translation initiation factor 4E type 3 | / | 0.447 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.447 | |
| 4xsd | UMP | Thymidylate synthase | 2.1.1.45 | 0.447 | |
| 1ksz | PGS | Adenylosuccinate synthetase | / | 0.446 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.446 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.446 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.446 | |
| 2hv9 | SFG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.446 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.446 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.446 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.446 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.446 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.446 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.446 | |
| 4frj | DWB | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.446 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.446 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.445 | |
| 1je1 | GMP | Purine nucleoside phosphorylase | / | 0.445 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.445 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.445 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1t0i | FMN | NAD(P)H-dependent FMN reductase LOT6 | / | 0.445 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.445 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.445 | |
| 3f6r | FMN | Flavodoxin | / | 0.445 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.445 | |
| 4to1 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.445 | |
| 4tta | FMC | Purine nucleoside phosphorylase DeoD-type | / | 0.445 | |
| 5czy | SAM | Eukaryotic huntingtin interacting protein B | / | 0.445 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.444 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.444 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1pr0 | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.444 | |
| 1tw4 | CHD | Fatty acid-binding protein, liver | / | 0.444 | |
| 1ve9 | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.444 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.444 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.444 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.444 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3akz | GSU | Glutamate--tRNA ligase 2 | / | 0.444 | |
| 3ha7 | B32 | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.444 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.444 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.444 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4j0z | 1H5 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4l4x | NDP | AmphI | / | 0.444 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.444 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.443 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.443 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.443 | |
| 3gwd | NAP | Cyclohexanone monooxygenase | / | 0.443 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.443 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.443 | |
| 3uaw | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.443 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.443 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.443 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.443 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.443 | |
| 5emh | NAP | Iridoid synthase | 1.3.1.99 | 0.443 | |
| 1c7o | PPG | Hemolysin | / | 0.442 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.442 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.442 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.442 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.442 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.442 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.442 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.442 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.442 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.442 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.442 | |
| 4b70 | WM9 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.442 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.442 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.442 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.442 | |
| 5cho | FAD | Flavin reductase | / | 0.442 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.442 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1j9z | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 1pr6 | XYA | Purine nucleoside phosphorylase DeoD-type | / | 0.441 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.441 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.441 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.441 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.441 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.441 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.441 | |
| 2wez | ZYE | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.441 | |
| 3upr | 1KX | HLA class I histocompatibility antigen, B-57 alpha chain | / | 0.441 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.441 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4dju | 0KK | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4ohw | ATP | Protein clpf-1 | / | 0.441 | |
| 4pmj | NAP | Putative oxidoreductase | / | 0.441 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.440 | |
| 1req | DCA | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.440 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.440 | |
| 2fxf | ACO | Diamine acetyltransferase 1 | / | 0.440 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2vij | C44 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.440 | |
| 2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3aw9 | GDU | NAD-dependent epimerase/dehydratase | / | 0.440 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.440 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.440 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.440 | |
| 3vkj | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.440 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.440 | |
| 4j7g | TRH | PCZA361.3 | / | 0.440 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.440 | |
| 4tyq | AP5 | Adenylate kinase | / | 0.440 | |
| 4y9r | NAP | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 4yal | 2AM | NADPH--cytochrome P450 reductase | / | 0.440 |