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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1px0RPNHalohydrin dehalogenase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
1px0RPNHalohydrin dehalogenase/1.000
1zmtRNOHalohydrin dehalogenase/0.633
4bjbP34Tankyrase-22.4.2.300.515
3c3xNAPEugenol synthase 11.1.1.3180.514
2qryTPSThiamine-binding periplasmic protein/0.510
4jtqFLPAldo-keto reductase family 1 member C2/0.505
3rviRVIBeta-secretase 13.4.23.460.502
3qakUKAAdenosine receptor A2a/0.502
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.501
4jtrIZPAldo-keto reductase family 1 member C2/0.498
3sfh1DIHistone deacetylase 83.5.1.980.497
1xf0ASDAldo-keto reductase family 1 member C3/0.496
1h36R88Squalene--hopene cyclase4.2.1.1290.495
1w6jR71Lanosterol synthase5.4.99.70.495
1ihiIU5Aldo-keto reductase family 1 member C2/0.493
1m9nAMZBifunctional purine biosynthesis protein PURH2.1.2.30.493
4pnmNU1Tankyrase-22.4.2.300.492
3rtnRTNBeta-secretase 13.4.23.460.491
2a3bCFFEndochitinase B13.2.1.140.488
1mlzPLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.487
3nu03TUDihydrofolate reductase1.5.1.30.487
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.486
1pd9CO4Dihydrofolate reductase1.5.1.30.485
2gs9SAHUncharacterized protein/0.485
1ry0PG2Aldo-keto reductase family 1 member C3/0.483
2uuj896Prothrombin3.4.21.50.483
1nm6L86Prothrombin3.4.21.50.482
3wqmB29Diterpene synthase3.1.7.80.482
1o6qR17Squalene--hopene cyclase4.2.1.1290.481
3q7fED2Uncharacterized protein/0.480
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.479
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.479
4u163C0Muscarinic acetylcholine receptor M3/0.479
1t7o152Carnitine O-acetyltransferase2.3.1.70.478
2ea4F79Methionine aminopeptidase 2/0.478
2zc922UProthrombin3.4.21.50.478
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.478
1e66HUXAcetylcholinesterase3.1.1.70.477
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.477
3r6iJMSAldo-keto reductase family 1 member C3/0.477
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.477
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.477
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.477
4jq3ZOMAldo-keto reductase family 1 member C2/0.477
3ojgHL4Phosphotriesterase/0.476
3ufl508Beta-secretase 13.4.23.460.476
4l321VFTankyrase-22.4.2.300.476
4m4821BSodium-dependent dopamine transporter/0.476
1d3pBT3Prothrombin3.4.21.50.475
1qtiGNTAcetylcholinesterase3.1.1.70.475
2jf0HBPAcetylcholinesterase3.1.1.70.475
2rds1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.475
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.475
3f3y4OABile salt sulfotransferase2.8.2.140.475
3h3qH13Collagen type IV alpha-3-binding protein/0.475
1d3dBZTProthrombin3.4.21.50.474
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.474
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.474
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
3zv7NHGAcetylcholinesterase3.1.1.70.474
4b68FADL-ornithine N(5)-monooxygenase/0.474
4u140HKMuscarinic acetylcholine receptor M3/0.474
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.473
3rsv3RSBeta-secretase 13.4.23.460.473
3zkuHCVIsopenicillin N synthase1.21.3.10.473
4fhd0TTSpore photoproduct lyase/0.473
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.472
2xi4AFTAcetylcholinesterase3.1.1.70.472
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.472
1kquBR4Phospholipase A2, membrane associated/0.471
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
2zdv37UProthrombin3.4.21.50.471
2zgx29UProthrombin3.4.21.50.471
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.471
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.471
3tqxPLP2-amino-3-ketobutyrate coenzyme A ligase/0.471
4ixt1H1Halohydrin dehalogenase/0.471
1s36CEIObelin/0.470
2bjsACVIsopenicillin N synthase1.21.3.10.470
2c2bSAMThreonine synthase 1, chloroplastic4.2.3.10.470
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.470
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.470
3zj0ACOPutative acetyltransferase OgpAT/0.470
3nyaJTZBeta-2 adrenergic receptor/0.470
1qoqIGPTryptophan synthase alpha chain/0.469
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.469
2bdyUNBProthrombin3.4.21.50.469
2hq9FADMll6688 protein/0.469
3qwc98PProthrombin3.4.21.50.469
4j0p1H8Beta-secretase 13.4.23.460.469
1yw7A41Methionine aminopeptidase 2/0.468
2wgs1AZGlutamine synthetase6.3.1.20.468
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.468
4nv14TGFormyl transferase/0.468
4tjy3GNTankyrase-22.4.2.300.468
1fmjRTLRetinol dehydratase/0.467
1gky5GPGuanylate kinase2.7.4.80.467
1kmvLIIDihydrofolate reductase1.5.1.30.467
1zgbA1EAcetylcholinesterase3.1.1.70.467
2pksG44Prothrombin3.4.21.50.467
1afeALZProthrombin3.4.21.50.466
1icsFMN12-oxophytodienoate reductase 11.3.1.420.466
1kf6HQOFumarate reductase iron-sulfur subunit1.3.5.10.466
1kf6HQOFumarate reductase subunit C/0.466
1kf6HQOFumarate reductase subunit D/0.466
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.466
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.466
2wu4HBPAcetylcholinesterase3.1.1.70.466
2xujTZ5Acetylcholinesterase3.1.1.70.466
3h0bB35Beta-secretase 13.4.23.460.466
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.466
4jq1NPSAldo-keto reductase family 1 member C2/0.466
4k4eK4ETankyrase-12.4.2.300.466
5ab6CAANonspecific lipid-transfer protein, putative/0.466
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.465
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.465
2fzdTOLAldose reductase1.1.1.210.465
2fzjDH3Dihydrofolate reductase1.5.1.30.465
2j7cIDEBeta-glucosidase A3.2.1.210.465
2ydd2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.465
3gncQQQGlutaryl-CoA dehydrogenase/0.465
3iu9T07Methionine aminopeptidase 2/0.465
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.465
3uonQNBMuscarinic acetylcholine receptor M2/0.465
3biz61EWee1-like protein kinase2.7.10.20.464
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.464
3cuiX4SExoglucanase/xylanase3.2.1.910.464
3hf8ML0Tryptophan 5-hydroxylase 11.14.16.40.464
1ypmRA4Prothrombin3.4.21.50.463
1zgcA2EAcetylcholinesterase3.1.1.70.463
1zuaTOLAldo-keto reductase family 1 member B101.1.10.463
2q153MRBeta-secretase 13.4.23.460.463
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.463
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.463
3vf60H6Glucokinase2.7.1.20.463
4cthRDFNeprilysin/0.463
4dbs0HVAldo-keto reductase family 1 member C3/0.463
4phlPILPhosphodiesterase/0.463
1odcA8BAcetylcholinesterase3.1.1.70.462
1u08PLPMethionine aminotransferase/0.462
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.462
2xuqTZ4Acetylcholinesterase3.1.1.70.462
3fr5I4AFatty acid-binding protein, adipocyte/0.462
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
4e2yJHZMethyltransferase/0.462
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.462
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.461
1lnmDTXBilin-binding protein/0.461
3gyf51PDihydrofolate reductase1.5.1.30.461
3nmpPYVAbscisic acid receptor PYL2/0.461
3pg3DG7Mitogen-activated protein kinase 14/0.461
4arbC57Acetylcholinesterase3.1.1.70.461
4jpc1M6Beta-secretase 13.4.23.460.461
4m6kFOLDihydrofolate reductase1.5.1.30.461
1h22E10Acetylcholinesterase3.1.1.70.460
1icqOPD12-oxophytodienoate reductase 11.3.1.420.460
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.460
3rl35GPMetallophosphoesterase MPPED23.10.460
3rthRTHBeta-secretase 13.4.23.460.460
4acuQN7Beta-secretase 13.4.23.460.460
1vzqSHYProthrombin3.4.21.50.459
1x8b824Wee1-like protein kinase2.7.10.20.459
1yw9A84Methionine aminopeptidase 2/0.459
2aovC2MHistamine N-methyltransferase2.1.1.80.459
2ed4FAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.459
2qw8NAPEugenol synthase 11.1.1.3180.459
3arpDEQChitinase A/0.459
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.459
4n3l2FNProthrombin3.4.21.50.459
4tmcFMNOld yellow enzyme/0.459
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.458
1z8962PAldose reductase1.1.1.210.458
2aj4ANPGalactokinase2.7.1.60.458
2hxzH7JCathepsin S3.4.22.270.458
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.458
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
4e0u0MVCyclic dipeptide N-prenyltransferase/0.458
4hmn16JAldo-keto reductase family 1 member C3/0.458
4kxjP34Nucleoprotein/0.458
4li61XOTankyrase-12.4.2.300.458
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.457
1w4lGL8Acetylcholinesterase3.1.1.70.457
2fz8ZSTAldose reductase1.1.1.210.457
2xuoTZ4Acetylcholinesterase3.1.1.70.457
2zsdCOAPantothenate kinase2.7.1.330.457
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.457
3klbFMNUncharacterized protein/0.457
3p9tTCLRepressor/0.457
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.457
4hknLU2Tankyrase-22.4.2.300.457
4hlm16STankyrase-22.4.2.300.457
4u150HKMuscarinic acetylcholine receptor M3/0.457
1fmlRTLRetinol dehydratase/0.456
1votHUPAcetylcholinesterase3.1.1.70.456
2ejzSAHDiphthine synthase/0.456
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.456
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.456
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.456
3fhxPLPPyridoxal kinase2.7.1.350.456
4bftZVTPantothenate kinase2.7.1.330.456
4dvi2IWTankyrase-12.4.2.300.456
4ey6GNTAcetylcholinesterase3.1.1.70.456
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.456
1ry8RUTAldo-keto reductase family 1 member C3/0.455
1s3vTQDDihydrofolate reductase1.5.1.30.455
1wm1PTBProline iminopeptidase3.4.11.50.455
2dv0ZSTAldose reductase1.1.1.210.455
2gyuHI6Acetylcholinesterase3.1.1.70.455
2zg050UProthrombin3.4.21.50.455
3aezGDPPantothenate kinase2.7.1.330.455
3dz6M8ES-adenosylmethionine decarboxylase proenzyme4.1.1.500.455
3eon341Glutaryl-CoA dehydrogenase/0.455
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
4a39GEMUncharacterized protein/0.455
4rh10TTSpore photoproduct lyase/0.455
1odnAPVIsopenicillin N synthase1.21.3.10.454
1vhzAPRADP compounds hydrolase NudE3.6.10.454
2a2cADPN-acetylgalactosamine kinase2.7.1.1570.454
2cn0F25Prothrombin3.4.21.50.454
2v3hI25Prothrombin3.4.21.50.454
2xupTZ5Acetylcholinesterase3.1.1.70.454
2zhf49UProthrombin3.4.21.50.454
3t0iSAHPutative methyltransferase/0.454
4djv0KMBeta-secretase 13.4.23.460.454
1digL37C-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.453
1j0b5PAPutative 1-aminocyclopropane-1-carboxylate deaminase3.5.99.70.453
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.453
2wjoQUDBeta-secretase 13.4.23.460.453
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3ndjJHZMethyltransferase/0.453
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.453
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.453
1hfrMOTDihydrofolate reductase1.5.1.30.452
1lkeDOGBilin-binding protein/0.452
1mvtDTMDihydrofolate reductase1.5.1.30.452
1u70MTXDihydrofolate reductase1.5.1.30.452
2gevCOKPantothenate kinase2.7.1.330.452
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.452
2q3eUPGUDP-glucose 6-dehydrogenase1.1.1.220.452
2qcxPF1Aminopyrimidine aminohydrolase/0.452
2vt4P32Beta-1 adrenergic receptor/0.452
3gkiCLRNiemann-Pick C1 protein/0.452
3l5eBDWBeta-secretase 13.4.23.460.452
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.452
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.452
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.452
4b0532DBeta-secretase 13.4.23.460.452
4b68NAPL-ornithine N(5)-monooxygenase/0.452
4bfzZVZPantothenate kinase2.7.1.330.452
4j0t6T9Beta-secretase 13.4.23.460.452
5d6lCAUBeta-2 adrenergic receptor/0.452
1dr3TAPDihydrofolate reductase1.5.1.30.451
1ekoI84Aldose reductase1.1.1.210.451
1g3mPCQEstrogen sulfotransferase2.8.2.40.451
1s3uTQDDihydrofolate reductase1.5.1.30.451
1sreHABStreptavidin/0.451
1srjNABStreptavidin/0.451
2b1i93ABifunctional purine biosynthesis protein PURH2.1.2.30.451
2cbqTH2Neocarzinostatin/0.451
2vrjNCWBeta-glucosidase A3.2.1.210.451
2xuhTZ4Acetylcholinesterase3.1.1.70.451
2zhq27UProthrombin3.4.21.50.451
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.451
3ghsLDTAldose reductase1.1.1.210.451
3p2vDOYAldose reductase1.1.1.210.451
3pahXDEPhenylalanine-4-hydroxylase1.14.16.10.451
3qm4PN0Cytochrome P450 2D6/0.451
4dbw511Aldo-keto reductase family 1 member C3/0.451
2y0468HBeta-1 adrenergic receptor/0.451
1ex75GPGuanylate kinase2.7.4.80.450
1h35R01Squalene--hopene cyclase4.2.1.1290.450
1ohkCOPDihydrofolate reductase1.5.1.30.450
1q83TZ5Acetylcholinesterase3.1.1.70.450
1rxjBNIStreptavidin/0.450
2rc6NAPFerredoxin--NADP reductase/0.450
2vdmAGGIntegrin alpha-IIb/0.450
2vdmAGGIntegrin beta-3/0.450
2weaPP6Penicillopepsin-13.4.23.200.450
2znk31UProthrombin3.4.21.50.450
3biu10UProthrombin3.4.21.50.450
3ghwGHWDihydrofolate reductase1.5.1.30.450
3n0tOPYDipeptidyl peptidase 23.4.14.20.450
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.450
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.450
4b67NAPL-ornithine N(5)-monooxygenase/0.450
4bmzMTAAminodeoxyfutalosine nucleosidase/0.450
4fam0SZAldo-keto reductase family 1 member C3/0.450
5jqhCAUBeta-2 adrenergic receptor/0.450
1gj5130Prothrombin3.4.21.50.449
1yciNDFHypoxia-inducible factor 1-alpha inhibitor1.14.11.300.449
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.449
2xlpNAPPutative flavin-containing monooxygenase/0.449
2y035FWBeta-1 adrenergic receptor/0.449
2zhw12UProthrombin3.4.21.50.449
3jqcJU2Pteridine reductase, putative/0.449
3rtmRTMBeta-secretase 13.4.23.460.449
3sfy3FYUncharacterized protein/0.449
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.449
3v0m5GWHisto-blood group ABO system transferase/0.449
4j1k1HGBeta-secretase 13.4.23.460.449
4jpe1M7Beta-secretase 13.4.23.460.449
1b2lNDCAlcohol dehydrogenase1.1.1.10.448
1frbZSTAldose reductase-related protein 2/0.448
1kmsLIHDihydrofolate reductase1.5.1.30.448
1ohjCOPDihydrofolate reductase1.5.1.30.448
1x1bSAHC-20 methyltransferase/0.448
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2nnqT4BFatty acid-binding protein, adipocyte/0.448
2q92B23Methionine aminopeptidase/0.448
2z2w770Wee1-like protein kinase2.7.10.20.448
3cr0809Wee1-like protein kinase2.7.10.20.448
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3lfeZ84Mitogen-activated protein kinase 14/0.448
3nn6HNK6-hydroxy-L-nicotine oxidase/0.448
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.448
4b66NAPL-ornithine N(5)-monooxygenase/0.448
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.448
4bus32FTankyrase-22.4.2.300.448
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.448
4e2zJHZMethyltransferase/0.448
4h3i10VBeta-secretase 13.4.23.460.448
4jq2SUZAldo-keto reductase family 1 member C2/0.448
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.448
1ae8AZLProthrombin3.4.21.50.447
1cbrREACellular retinoic acid-binding protein 1/0.447
1s1rNAPAldo-keto reductase family 1 member C3/0.447
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
1yplRA8Prothrombin3.4.21.50.447
2cekN8TAcetylcholinesterase3.1.1.70.447
2uuk897Prothrombin3.4.21.50.447
2w3mFOLDihydrofolate reductase1.5.1.30.447
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.447
4gtt7TQGeranylgeranyl transferase type-2 subunit beta2.5.1.600.447
4h6uACOAlpha-tubulin N-acetyltransferase 1/0.447
4j1e1HMBeta-secretase 13.4.23.460.447
4y1bNAPAntE/0.447
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.446
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.446
1ieiZESAldose reductase1.1.1.210.446
1jf2CZHObelin/0.446
1t4v14AProthrombin3.4.21.50.446
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.446
1x8lOXRRetinol dehydratase/0.446
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1zosMTM5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/0.446
2h55DZ8Heat shock protein HSP 90-alpha/0.446
2oliIOPBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.446
2y99NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.446
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.446
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3h0vM2TS-adenosylmethionine decarboxylase proenzyme4.1.1.500.446
4a7yNHFAldos-2-ulose dehydratase/0.446
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.446
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.446
4kfqKFQGlutamate receptor ionotropic, NMDA 1/0.446
4yfy0FXVioF/0.446
5p2pDHGPhospholipase A2, major isoenzyme3.1.1.40.446
5pahLDPPhenylalanine-4-hydroxylase1.14.16.10.446
1fxvPNNPenicillin G acylase3.5.1.110.445
1lelBH7Avidin/0.445
1o2g696Prothrombin3.4.21.50.445
1oytFSNProthrombin3.4.21.50.445
1rkwPNTHTH-type transcriptional regulator QacR/0.445
1w6rGNTAcetylcholinesterase3.1.1.70.445
2d06ESTSulfotransferase 1A12.8.2.10.445
2hwuURIUridine phosphorylase2.4.2.30.445
3e4aQIXInsulin-degrading enzyme3.4.24.560.445
3exfTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.445
3exfTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.445
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.445
3vv8B02Beta-secretase 13.4.23.460.445
4g67SAHUncharacterized ACR, COG1565 superfamily/0.445
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.445
4kn0MTXFolate receptor beta/0.445
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.445
1ddtAPUDiphtheria toxin/0.444
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.444
1nenDNTSuccinate dehydrogenase iron-sulfur subunit1.3.5.10.444
1nenDNTSuccinate dehydrogenase cytochrome b556 subunit/0.444
1r58AO5Methionine aminopeptidase 2/0.444
1u65CP0Acetylcholinesterase3.1.1.70.444
2a4xBLMMitomycin-binding protein/0.444
2pdlTOLAldose reductase1.1.1.210.444
2vqqTFGHistone deacetylase 43.5.1.980.444
2zfq45UProthrombin3.4.21.50.444
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.444
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.444
3k47D09Dihydrofolate reductase1.5.1.30.444
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.444
4ey7E20Acetylcholinesterase3.1.1.70.444
4gekGEKCarboxy-S-adenosyl-L-methionine synthase/0.444
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.444
5hynSAHHistone-lysine N-methyltransferase EZH22.1.1.430.444
1hp0AD3IAG-nucleoside hydrolase/0.443
1pj7FFODimethylglycine oxidase1.5.3.100.443
1y52BTNAvidin-related protein 4/5/0.443
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.443
2h7jH7JCathepsin S3.4.22.270.443
3gkjHC3Niemann-Pick C1 protein/0.443
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3px2T3QdTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase2.1.1.2350.443
3t0kDCQSulfide-quinone reductase/0.443
4c3yANB3-ketosteroid dehydrogenase/0.443
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4hlf15ZTankyrase-22.4.2.300.443
4uugPXGBranched-chain amino acid aminotransferase, putative/0.443
4x9dU5PUncharacterized protein MJ1435/0.443
5f59SAHHistone-lysine N-methyltransferase 2C2.1.1.430.443
1c7oPPGHemolysin/0.442
1ej3CZHAequorin-2/0.442
1qipGNBLactoylglutathione lyase4.4.1.50.442
1w76GNTAcetylcholinesterase3.1.1.70.442
2gesCOKPantothenate kinase2.7.1.330.442
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.442
2vuuNAPNitrogen metabolite repression protein nmrA/0.442
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.442
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.442
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.442
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.442
3gcq1BUMitogen-activated protein kinase 14/0.442
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.442
3nhpHGZRibosyldihydronicotinamide dehydrogenase [quinone]/0.442
3p62FMNPentaerythritol tetranitrate reductase/0.442
3rqwACHGamma-aminobutyric-acid receptor subunit beta-1/0.442
3wtjTH4Acetylcholine-binding protein/0.442
3wznBTNStreptavidin/0.442
3zj6VM2Raucaffricine-O-beta-D-glucosidase3.2.1.1250.442
4dch4DCGlucokinase2.7.1.20.442
4djw0KPBeta-secretase 13.4.23.460.442
4g8bHL6Alpha/beta hydrolase fold protein/0.442
4kmzFOLFolate receptor beta/0.442
4msg2C6Tankyrase-12.4.2.300.442
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.442
5ab7MLCNonspecific lipid-transfer protein, putative/0.442
5d7qAR6NAD-dependent protein deacetylase sirtuin-23.5.10.442
1m9hNAD2,5-diketo-D-gluconic acid reductase A1.1.1.3460.441
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.441
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
1zq5E04Aldo-keto reductase family 1 member C3/0.441
2d2gDZZPhosphotriesterase/0.441
2gqaFMNNADH:flavin oxidoreductase Sye1/0.441
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.441
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3eq02TSProthrombin3.4.21.50.441
3ug8IMNAldo-keto reductase family 1 member C3/0.441
3vg9ZMAAdenosine receptor A2a/0.441
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.441
4bjcRPBTankyrase-22.4.2.300.441
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.441
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.441
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.441
4e32DWNMethyltransferase/0.441
4jq4IMNAldo-keto reductase family 1 member C2/0.441
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441
5d7oAR6NAD-dependent protein deacetylase sirtuin-23.5.10.441
1dx6GNTAcetylcholinesterase3.1.1.70.440
1eirBPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.440
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.440
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.440
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.440
1sb1165Prothrombin3.4.21.50.440
1xnzFCDMethionine aminopeptidase/0.440
1zrb062Prothrombin3.4.21.50.440
2cbrA80Cellular retinoic acid-binding protein 1/0.440
2o6hINI6,7-dimethyl-8-ribityllumazine synthase 12.5.1.780.440
2v57PRLTetR family transcriptional regulator/0.440
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.440
3hfbML4Tryptophan 5-hydroxylase 11.14.16.40.440
3r8hZOMAldo-keto reductase family 1 member C3/0.440
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.440
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3wthIM4Acetylcholine-binding protein/0.440
3zj7C1KStrictosidine-O-beta-D-glucosidase3.2.1.1050.440
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4j7hTRHPCZA361.3/0.440
4l8vNAPInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.440
4xt8TMQPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc/0.440
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.440