Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
1px0 | RPN | Halohydrin dehalogenase |
PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
---|---|---|---|---|---|
1px0 | RPN | Halohydrin dehalogenase | / | 1.000 | |
1zmt | RNO | Halohydrin dehalogenase | / | 0.633 | |
4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.515 | |
3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.514 | |
2qry | TPS | Thiamine-binding periplasmic protein | / | 0.510 | |
4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.505 | |
3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.502 | |
3qak | UKA | Adenosine receptor A2a | / | 0.502 | |
3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.501 | |
4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.498 | |
3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.497 | |
1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.496 | |
1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.495 | |
1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.495 | |
1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.493 | |
1m9n | AMZ | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.493 | |
4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.492 | |
3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.491 | |
2a3b | CFF | Endochitinase B1 | 3.2.1.14 | 0.488 | |
1mlz | PLP | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.487 | |
3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.486 | |
1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
2gs9 | SAH | Uncharacterized protein | / | 0.485 | |
1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.483 | |
2uuj | 896 | Prothrombin | 3.4.21.5 | 0.483 | |
1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.482 | |
3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.482 | |
1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.481 | |
3q7f | ED2 | Uncharacterized protein | / | 0.480 | |
3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.479 | |
3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.479 | |
4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.479 | |
1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.478 | |
2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.478 | |
2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.478 | |
3hxf | BD9 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.478 | |
1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.477 | |
3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.477 | |
4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.477 | |
4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.477 | |
4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.477 | |
4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.477 | |
3ojg | HL4 | Phosphotriesterase | / | 0.476 | |
3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.476 | |
4l32 | 1VF | Tankyrase-2 | 2.4.2.30 | 0.476 | |
4m48 | 21B | Sodium-dependent dopamine transporter | / | 0.476 | |
1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.475 | |
1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.475 | |
3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.475 | |
3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.475 | |
3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.475 | |
1d3d | BZT | Prothrombin | 3.4.21.5 | 0.474 | |
1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.474 | |
1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.474 | |
1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.474 | |
3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.474 | |
4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.474 | |
2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.473 | |
3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.473 | |
3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
4fhd | 0TT | Spore photoproduct lyase | / | 0.473 | |
1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.472 | |
2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.472 | |
1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.471 | |
1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
2zdv | 37U | Prothrombin | 3.4.21.5 | 0.471 | |
2zgx | 29U | Prothrombin | 3.4.21.5 | 0.471 | |
3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.471 | |
3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.471 | |
3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.471 | |
4ixt | 1H1 | Halohydrin dehalogenase | / | 0.471 | |
1s36 | CEI | Obelin | / | 0.470 | |
2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
2c2b | SAM | Threonine synthase 1, chloroplastic | 4.2.3.1 | 0.470 | |
2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.470 | |
3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.470 | |
3zj0 | ACO | Putative acetyltransferase OgpAT | / | 0.470 | |
3nya | JTZ | Beta-2 adrenergic receptor | / | 0.470 | |
1qoq | IGP | Tryptophan synthase alpha chain | / | 0.469 | |
1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
2bdy | UNB | Prothrombin | 3.4.21.5 | 0.469 | |
2hq9 | FAD | Mll6688 protein | / | 0.469 | |
3qwc | 98P | Prothrombin | 3.4.21.5 | 0.469 | |
4j0p | 1H8 | Beta-secretase 1 | 3.4.23.46 | 0.469 | |
1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.468 | |
2wgs | 1AZ | Glutamine synthetase | 6.3.1.2 | 0.468 | |
3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.468 | |
4nv1 | 4TG | Formyl transferase | / | 0.468 | |
4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.468 | |
1fmj | RTL | Retinol dehydratase | / | 0.467 | |
1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.467 | |
1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
2pks | G44 | Prothrombin | 3.4.21.5 | 0.467 | |
1afe | ALZ | Prothrombin | 3.4.21.5 | 0.466 | |
1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.466 | |
1kf6 | HQO | Fumarate reductase iron-sulfur subunit | 1.3.5.1 | 0.466 | |
1kf6 | HQO | Fumarate reductase subunit C | / | 0.466 | |
1kf6 | HQO | Fumarate reductase subunit D | / | 0.466 | |
2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.466 | |
2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.466 | |
2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
4jq1 | NPS | Aldo-keto reductase family 1 member C2 | / | 0.466 | |
4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.466 | |
5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.466 | |
2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.465 | |
2f0y | 3MN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.465 | |
2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.465 | |
2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
2j7c | IDE | Beta-glucosidase A | 3.2.1.21 | 0.465 | |
2ydd | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.465 | |
3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.465 | |
3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.465 | |
4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.465 | |
3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.465 | |
3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.464 | |
3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.464 | |
3cui | X4S | Exoglucanase/xylanase | 3.2.1.91 | 0.464 | |
3hf8 | ML0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.464 | |
1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.463 | |
1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.463 | |
2q15 | 3MR | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.463 | |
3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.463 | |
3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.463 | |
4cth | RDF | Neprilysin | / | 0.463 | |
4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
4phl | PIL | Phosphodiesterase | / | 0.463 | |
1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
1u08 | PLP | Methionine aminotransferase | / | 0.462 | |
2rd6 | 78P | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.462 | |
2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.462 | |
3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
4e2y | JHZ | Methyltransferase | / | 0.462 | |
4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.462 | |
1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.461 | |
1lnm | DTX | Bilin-binding protein | / | 0.461 | |
3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.461 | |
3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.461 | |
4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
4jpc | 1M6 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.460 | |
2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.460 | |
3rl3 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.460 | |
3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
1vzq | SHY | Prothrombin | 3.4.21.5 | 0.459 | |
1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.459 | |
1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.459 | |
2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.459 | |
2ed4 | FAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.459 | |
2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.459 | |
3arp | DEQ | Chitinase A | / | 0.459 | |
4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.459 | |
4tmc | FMN | Old yellow enzyme | / | 0.459 | |
1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.458 | |
1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.458 | |
2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.458 | |
2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.458 | |
3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.458 | |
4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.458 | |
4kxj | P34 | Nucleoprotein | / | 0.458 | |
4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.458 | |
1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.457 | |
1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.457 | |
2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.457 | |
3e30 | ED4 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.457 | |
3klb | FMN | Uncharacterized protein | / | 0.457 | |
3p9t | TCL | Repressor | / | 0.457 | |
4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.457 | |
4hkn | LU2 | Tankyrase-2 | 2.4.2.30 | 0.457 | |
4hlm | 16S | Tankyrase-2 | 2.4.2.30 | 0.457 | |
4u15 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.457 | |
1fml | RTL | Retinol dehydratase | / | 0.456 | |
1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
2ejz | SAH | Diphthine synthase | / | 0.456 | |
3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.456 | |
3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.456 | |
4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.456 | |
4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.456 | |
4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.456 | |
1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.455 | |
1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
1wm1 | PTB | Proline iminopeptidase | 3.4.11.5 | 0.455 | |
2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.455 | |
2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.455 | |
3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.455 | |
3dz6 | M8E | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.455 | |
3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.455 | |
3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
4a39 | GEM | Uncharacterized protein | / | 0.455 | |
4rh1 | 0TT | Spore photoproduct lyase | / | 0.455 | |
1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
1vhz | APR | ADP compounds hydrolase NudE | 3.6.1 | 0.454 | |
2a2c | ADP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.454 | |
2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.454 | |
2v3h | I25 | Prothrombin | 3.4.21.5 | 0.454 | |
2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
2zhf | 49U | Prothrombin | 3.4.21.5 | 0.454 | |
3t0i | SAH | Putative methyltransferase | / | 0.454 | |
4djv | 0KM | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
1dig | L37 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.453 | |
1j0b | 5PA | Putative 1-aminocyclopropane-1-carboxylate deaminase | 3.5.99.7 | 0.453 | |
1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.453 | |
2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
3ndj | JHZ | Methyltransferase | / | 0.453 | |
3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.453 | |
4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.453 | |
1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
1lke | DOG | Bilin-binding protein | / | 0.452 | |
1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
1u70 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.452 | |
2iej | S48 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.452 | |
2q3e | UPG | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.452 | |
2qcx | PF1 | Aminopyrimidine aminohydrolase | / | 0.452 | |
2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.452 | |
3gki | CLR | Niemann-Pick C1 protein | / | 0.452 | |
3l5e | BDW | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.452 | |
3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.452 | |
3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.452 | |
4b05 | 32D | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.452 | |
4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.452 | |
4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
5d6l | CAU | Beta-2 adrenergic receptor | / | 0.452 | |
1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
1eko | I84 | Aldose reductase | 1.1.1.21 | 0.451 | |
1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.451 | |
1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
1sre | HAB | Streptavidin | / | 0.451 | |
1srj | NAB | Streptavidin | / | 0.451 | |
2b1i | 93A | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.451 | |
2cbq | TH2 | Neocarzinostatin | / | 0.451 | |
2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.451 | |
2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
2zhq | 27U | Prothrombin | 3.4.21.5 | 0.451 | |
3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.451 | |
3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.451 | |
3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.451 | |
3pah | XDE | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.451 | |
3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.451 | |
4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.451 | |
2y04 | 68H | Beta-1 adrenergic receptor | / | 0.451 | |
1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.450 | |
1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.450 | |
1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
1rxj | BNI | Streptavidin | / | 0.450 | |
2rc6 | NAP | Ferredoxin--NADP reductase | / | 0.450 | |
2vdm | AGG | Integrin alpha-IIb | / | 0.450 | |
2vdm | AGG | Integrin beta-3 | / | 0.450 | |
2wea | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.450 | |
2znk | 31U | Prothrombin | 3.4.21.5 | 0.450 | |
3biu | 10U | Prothrombin | 3.4.21.5 | 0.450 | |
3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
3n0t | OPY | Dipeptidyl peptidase 2 | 3.4.14.2 | 0.450 | |
3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.450 | |
3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.450 | |
4bmz | MTA | Aminodeoxyfutalosine nucleosidase | / | 0.450 | |
4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
5jqh | CAU | Beta-2 adrenergic receptor | / | 0.450 | |
1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.449 | |
1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.449 | |
2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.449 | |
2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.449 | |
2y03 | 5FW | Beta-1 adrenergic receptor | / | 0.449 | |
2zhw | 12U | Prothrombin | 3.4.21.5 | 0.449 | |
3jqc | JU2 | Pteridine reductase, putative | / | 0.449 | |
3rtm | RTM | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
3sfy | 3FY | Uncharacterized protein | / | 0.449 | |
3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
3v0m | 5GW | Histo-blood group ABO system transferase | / | 0.449 | |
4j1k | 1HG | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
4jpe | 1M7 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.448 | |
1frb | ZST | Aldose reductase-related protein 2 | / | 0.448 | |
1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
1x1b | SAH | C-20 methyltransferase | / | 0.448 | |
1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.448 | |
2q92 | B23 | Methionine aminopeptidase | / | 0.448 | |
2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.448 | |
3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.448 | |
3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.448 | |
4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.448 | |
4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
4bus | 32F | Tankyrase-2 | 2.4.2.30 | 0.448 | |
4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.448 | |
4e2z | JHZ | Methyltransferase | / | 0.448 | |
4h3i | 10V | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.448 | |
4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.448 | |
1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.447 | |
1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.447 | |
1s1r | NAP | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.447 | |
2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
2uuk | 897 | Prothrombin | 3.4.21.5 | 0.447 | |
2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
4gtt | 7TQ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.447 | |
4h6u | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.447 | |
4j1e | 1HM | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
4y1b | NAP | AntE | / | 0.447 | |
1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.446 | |
1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.446 | |
1iei | ZES | Aldose reductase | 1.1.1.21 | 0.446 | |
1jf2 | CZH | Obelin | / | 0.446 | |
1t4v | 14A | Prothrombin | 3.4.21.5 | 0.446 | |
1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.446 | |
1x8l | OXR | Retinol dehydratase | / | 0.446 | |
1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
1zos | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.446 | |
2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.446 | |
2oli | IOP | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.446 | |
2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.446 | |
3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
3h0v | M2T | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.446 | |
4a7y | NHF | Aldos-2-ulose dehydratase | / | 0.446 | |
4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.446 | |
4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.446 | |
4yfy | 0FX | VioF | / | 0.446 | |
5p2p | DHG | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.446 | |
5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.446 | |
1fxv | PNN | Penicillin G acylase | 3.5.1.11 | 0.445 | |
1lel | BH7 | Avidin | / | 0.445 | |
1o2g | 696 | Prothrombin | 3.4.21.5 | 0.445 | |
1oyt | FSN | Prothrombin | 3.4.21.5 | 0.445 | |
1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.445 | |
1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.445 | |
2hwu | URI | Uridine phosphorylase | 2.4.2.3 | 0.445 | |
3e4a | QIX | Insulin-degrading enzyme | 3.4.24.56 | 0.445 | |
3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.445 | |
3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.445 | |
3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.445 | |
3vv8 | B02 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
4g67 | SAH | Uncharacterized ACR, COG1565 superfamily | / | 0.445 | |
4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.445 | |
4kn0 | MTX | Folate receptor beta | / | 0.445 | |
4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
1ddt | APU | Diphtheria toxin | / | 0.444 | |
1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.444 | |
1nen | DNT | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.444 | |
1nen | DNT | Succinate dehydrogenase cytochrome b556 subunit | / | 0.444 | |
1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.444 | |
1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
2a4x | BLM | Mitomycin-binding protein | / | 0.444 | |
2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.444 | |
2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.444 | |
2zfq | 45U | Prothrombin | 3.4.21.5 | 0.444 | |
3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.444 | |
3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
4gek | GEK | Carboxy-S-adenosyl-L-methionine synthase | / | 0.444 | |
4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.444 | |
5hyn | SAH | Histone-lysine N-methyltransferase EZH2 | 2.1.1.43 | 0.444 | |
1hp0 | AD3 | IAG-nucleoside hydrolase | / | 0.443 | |
1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.443 | |
1y52 | BTN | Avidin-related protein 4/5 | / | 0.443 | |
2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.443 | |
2h7j | H7J | Cathepsin S | 3.4.22.27 | 0.443 | |
3gkj | HC3 | Niemann-Pick C1 protein | / | 0.443 | |
3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
3px2 | T3Q | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | 2.1.1.235 | 0.443 | |
3t0k | DCQ | Sulfide-quinone reductase | / | 0.443 | |
4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.443 | |
4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
4hlf | 15Z | Tankyrase-2 | 2.4.2.30 | 0.443 | |
4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.443 | |
4x9d | U5P | Uncharacterized protein MJ1435 | / | 0.443 | |
5f59 | SAH | Histone-lysine N-methyltransferase 2C | 2.1.1.43 | 0.443 | |
1c7o | PPG | Hemolysin | / | 0.442 | |
1ej3 | CZH | Aequorin-2 | / | 0.442 | |
1qip | GNB | Lactoylglutathione lyase | 4.4.1.5 | 0.442 | |
1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.442 | |
2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
2vuu | NAP | Nitrogen metabolite repression protein nmrA | / | 0.442 | |
2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.442 | |
3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.442 | |
3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.442 | |
3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.442 | |
3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
3nhp | HGZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
3rqw | ACH | Gamma-aminobutyric-acid receptor subunit beta-1 | / | 0.442 | |
3wtj | TH4 | Acetylcholine-binding protein | / | 0.442 | |
3wzn | BTN | Streptavidin | / | 0.442 | |
3zj6 | VM2 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.442 | |
4dch | 4DC | Glucokinase | 2.7.1.2 | 0.442 | |
4djw | 0KP | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
4g8b | HL6 | Alpha/beta hydrolase fold protein | / | 0.442 | |
4kmz | FOL | Folate receptor beta | / | 0.442 | |
4msg | 2C6 | Tankyrase-1 | 2.4.2.30 | 0.442 | |
4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.442 | |
5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.442 | |
5d7q | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.442 | |
1m9h | NAD | 2,5-diketo-D-gluconic acid reductase A | 1.1.1.346 | 0.441 | |
1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.441 | |
1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
2d2g | DZZ | Phosphotriesterase | / | 0.441 | |
2gqa | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.441 | |
2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.441 | |
3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.441 | |
3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
3vg9 | ZMA | Adenosine receptor A2a | / | 0.441 | |
4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
4bjc | RPB | Tankyrase-2 | 2.4.2.30 | 0.441 | |
4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.441 | |
4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.441 | |
4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.441 | |
4e32 | DWN | Methyltransferase | / | 0.441 | |
4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
5d7o | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.441 | |
1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
1eir | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.440 | |
1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.440 | |
1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.440 | |
1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.440 | |
1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.440 | |
1xnz | FCD | Methionine aminopeptidase | / | 0.440 | |
1zrb | 062 | Prothrombin | 3.4.21.5 | 0.440 | |
2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.440 | |
2o6h | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | 2.5.1.78 | 0.440 | |
2v57 | PRL | TetR family transcriptional regulator | / | 0.440 | |
3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.440 | |
3hfb | ML4 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.440 | |
3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.440 | |
3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
3wth | IM4 | Acetylcholine-binding protein | / | 0.440 | |
3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.440 | |
4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
4j7h | TRH | PCZA361.3 | / | 0.440 | |
4l8v | NAP | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.440 | |
4xt8 | TMQ | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.440 | |
5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.440 |