Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1ifu | FMC | Ricin | 3.2.2.22 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1ifu | FMC | Ricin | 3.2.2.22 | 1.000 | |
| 4lwx | MU2 | Ribosome inactivating protein | / | 0.600 | |
| 1ahb | FMP | Ribosome-inactivating protein momordin I | 3.2.2.22 | 0.561 | |
| 3qji | MGP | Ribosome inactivating protein | / | 0.555 | |
| 4emr | MGP | Ribosome inactivating protein | / | 0.552 | |
| 5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.543 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.540 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.506 | |
| 1lpc | CMP | Antiviral protein DAP-30 | 3.2.2.22 | 0.505 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.501 | |
| 4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.501 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.497 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.496 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.494 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.492 | |
| 3u8f | FGM | Ribosome inactivating protein | / | 0.492 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.491 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.489 | |
| 2wgs | 1AZ | Glutamine synthetase | 6.3.1.2 | 0.488 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.488 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.485 | |
| 3mz9 | BHN | Nickel-binding periplasmic protein | / | 0.485 | |
| 3c0z | SHH | Histone deacetylase 7 | 3.5.1.98 | 0.484 | |
| 4jtp | ASC | Ribosome inactivating protein | / | 0.484 | |
| 3hiv | TXN | rRNA N-glycosidase | / | 0.483 | |
| 1zyd | ATP | eIF-2-alpha kinase GCN2 | / | 0.482 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.480 | |
| 1t13 | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | / | 0.478 | |
| 1w29 | TS1 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.478 | |
| 3c1o | NAP | Eugenol synthase | / | 0.478 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.478 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.478 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.478 | |
| 1w19 | T4P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.477 | |
| 4ikt | TFV | Methionine aminopeptidase 1 | / | 0.477 | |
| 4jbx | SK7 | Thymidine kinase | / | 0.477 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.476 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.476 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.476 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.476 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.475 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.475 | |
| 1czn | FMN | Flavodoxin | / | 0.474 | |
| 3c10 | TSN | Histone deacetylase 7 | 3.5.1.98 | 0.474 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.474 | |
| 3szf | DCQ | Sulfide-quinone reductase | / | 0.474 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.474 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.473 | |
| 1nj6 | A5A | Proline--tRNA ligase | / | 0.473 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.473 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 3hfb | ML4 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.472 | |
| 2hzq | STR | Apolipoprotein D | / | 0.471 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 2vi5 | Y19 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.470 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.470 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.470 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.470 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.469 | |
| 4jvm | XDI | Estrogen sulfotransferase | 2.8.2.4 | 0.469 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.469 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2qxx | TTP | dCTP deaminase | 3.5.4.13 | 0.468 | |
| 2xnm | WGZ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.468 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.468 | |
| 4f79 | P53 | Putative phospho-beta-glucosidase | / | 0.468 | |
| 3hgg | CHD | CmeR | / | 0.467 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.466 | |
| 1n5v | NOM | ActVA 6 protein | / | 0.466 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.466 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.466 | |
| 3b8h | NAD | Exotoxin A | 2.4.2.36 | 0.466 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.466 | |
| 3ko3 | ADP | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.466 | |
| 4eyb | 0WO | Metallo-beta-lactamase type 2 | / | 0.466 | |
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.466 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.466 | |
| 1b2r | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.465 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.465 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.465 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.465 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.465 | |
| 4bjc | RPB | Tankyrase-2 | 2.4.2.30 | 0.465 | |
| 4jq1 | NPS | Aldo-keto reductase family 1 member C2 | / | 0.465 | |
| 1sm4 | FAD | Ferredoxin--NADP reductase | / | 0.464 | |
| 2jgb | MGT | Eukaryotic translation initiation factor 4E type 2 | / | 0.464 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.464 | |
| 3mhp | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.464 | |
| 1px0 | RPN | Halohydrin dehalogenase | / | 0.463 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 3dla | NXX | Glutamine-dependent NAD(+) synthetase | 6.3.5.1 | 0.463 | |
| 3dz6 | M8E | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.463 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.463 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.463 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.463 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.462 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.462 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.462 | |
| 2vq3 | NAP | Metalloreductase STEAP3 | / | 0.462 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.462 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.461 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.461 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.461 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.461 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.461 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3sfx | JAN | Uncharacterized protein | / | 0.461 | |
| 4blc | NDP | Catalase | 1.11.1.6 | 0.461 | |
| 4qtn | NNR | Nicotinamide riboside transporter PnuC | / | 0.461 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.460 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.460 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2zoz | ET | Transcriptional regulator | / | 0.460 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.460 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.460 | |
| 3w3l | RX8 | Toll-like receptor 8 | / | 0.460 | |
| 4cth | RDF | Neprilysin | / | 0.460 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.460 | |
| 4r08 | URI | Toll-like receptor 8 | / | 0.460 | |
| 4rtb | SAM | Putative thiazole biosynthesis protein ThiH | / | 0.460 | |
| 2f59 | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | / | 0.459 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.459 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.459 | |
| 4l8v | NAP | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.459 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.458 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.458 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.458 | |
| 1s36 | CEI | Obelin | / | 0.458 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.458 | |
| 3nh8 | DC2 | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) | 3.5.1.114 | 0.458 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
| 4msg | 2C6 | Tankyrase-1 | 2.4.2.30 | 0.458 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.458 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.457 | |
| 1isj | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.457 | |
| 1kf6 | HQO | Fumarate reductase iron-sulfur subunit | 1.3.5.1 | 0.457 | |
| 1kf6 | HQO | Fumarate reductase subunit C | / | 0.457 | |
| 1kf6 | HQO | Fumarate reductase subunit D | / | 0.457 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.457 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.457 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.457 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.457 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4r07 | URI | Toll-like receptor 8 | / | 0.457 | |
| 5e9e | ANP | Myosin heavy chain kinase A | 2.7.11.7 | 0.457 | |
| 5ilw | URI | Ribosome inactivating protein | / | 0.457 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1ot3 | THM | Deoxynucleoside kinase | / | 0.456 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.456 | |
| 2iej | S48 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.456 | |
| 2r6k | GTX | Glutathione S-transferase A1 | 2.5.1.18 | 0.456 | |
| 2tpl | HPP | Tyrosine phenol-lyase | 4.1.99.2 | 0.456 | |
| 2yat | EEU | Estrogen receptor | / | 0.456 | |
| 3gg2 | UGA | Sugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family | / | 0.456 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.456 | |
| 4khn | XG4 | DNA-directed DNA polymerase | / | 0.456 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.456 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.456 | |
| 5ark | UMP | Ribonuclease 4 | 3.1.27 | 0.456 | |
| 1uk0 | FRM | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.455 | |
| 1w1w | AGS | Structural maintenance of chromosomes protein 1 | / | 0.455 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.455 | |
| 2vdy | HCY | Corticosteroid-binding globulin | / | 0.455 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.455 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.455 | |
| 3p9t | TCL | Repressor | / | 0.455 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 4r5w | XAV | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.455 | |
| 1exa | 394 | Retinoic acid receptor gamma | / | 0.454 | |
| 1go2 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.454 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.454 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.454 | |
| 2d2g | DZZ | Phosphotriesterase | / | 0.454 | |
| 3l7g | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.454 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.454 | |
| 4jhi | EMU | Nodulin-13 | / | 0.454 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1yc2 | APR | NAD-dependent protein deacylase 2 | / | 0.453 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2f2s | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.453 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3h0v | M2T | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.453 | |
| 3ko5 | ADP | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.453 | |
| 3pah | XDE | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.453 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.453 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.453 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.453 | |
| 4mdk | U94 | Ubiquitin-conjugating enzyme E2 R1 | / | 0.453 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.453 | |
| 1cq6 | PY4 | Aspartate aminotransferase | 2.6.1.1 | 0.452 | |
| 1gm8 | SOX | Penicillin G acylase | 3.5.1.11 | 0.452 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.452 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.452 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.452 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.452 | |
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.452 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.452 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.452 | |
| 4xt8 | TMQ | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.452 | |
| 1bx0 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.451 | |
| 1j0b | 5PA | Putative 1-aminocyclopropane-1-carboxylate deaminase | 3.5.99.7 | 0.451 | |
| 1lgt | BP3 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.451 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.451 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3seq | NXX | Glutamine-dependent NAD(+) synthetase | 6.3.5.1 | 0.451 | |
| 4ba5 | PXG | Probable aminotransferase | / | 0.451 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.451 | |
| 4j7g | TRH | PCZA361.3 | / | 0.451 | |
| 4k30 | NLG | N-acetylglutamate synthase, mitochondrial | 2.3.1.1 | 0.451 | |
| 4y6n | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.451 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.450 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.450 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.450 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.450 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3t0k | DCQ | Sulfide-quinone reductase | / | 0.450 | |
| 4cby | KEE | Histone deacetylase 4 | 3.5.1.98 | 0.450 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
| 4wlj | IK2 | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.450 | |
| 4z87 | GDP | Inosine-5'-monophosphate dehydrogenase | / | 0.450 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.449 | |
| 1gaq | FAD | Ferredoxin | / | 0.449 | |
| 1m3q | ANG | N-glycosylase/DNA lyase | 3.2.2 | 0.449 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.449 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.449 | |
| 2pda | TPP | Pyruvate synthase | / | 0.449 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.449 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.449 | |
| 3ebi | BEY | M1 family aminopeptidase | 3.4.11 | 0.449 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.449 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.449 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.449 | |
| 4y9x | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.449 | |
| 5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.449 | |
| 1fkg | SB3 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.448 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1x2e | ATX | Proline iminopeptidase | 3.4.11.5 | 0.448 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 1zhy | CLR | Oxysterol-binding protein homolog 4 | / | 0.448 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 2qt0 | NNR | Nicotinamide riboside kinase 1 | / | 0.448 | |
| 3cv6 | HXS | Aldo-keto reductase family 1 member C21 | / | 0.448 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.448 | |
| 3f8s | PF2 | Dipeptidyl peptidase 4 | / | 0.448 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3q0u | LL3 | HTH-type transcriptional regulator EthR | / | 0.448 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.448 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.448 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.448 | |
| 4to2 | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.448 | |
| 4x9d | U5P | Uncharacterized protein MJ1435 | / | 0.448 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.448 | |
| 1b9i | PXG | 3-amino-5-hydroxybenzoate synthase | 4.2.1.144 | 0.447 | |
| 1dp2 | LPB | Thiosulfate sulfurtransferase | / | 0.447 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.447 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 1s7g | APR | NAD-dependent protein deacylase 2 | / | 0.447 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.447 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.447 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 2xno | ED8 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.447 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.447 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3exn | ACO | Probable acetyltransferase | / | 0.447 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.447 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.447 | |
| 4ug5 | H4B | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.447 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 5fuw | THM | Thymidine kinase, putative | / | 0.447 | |
| 1d7o | TCL | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.446 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.446 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1p4r | 354 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.446 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.446 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1w35 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.446 | |
| 1z5u | CMP | Class B acid phosphatase | / | 0.446 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.446 | |
| 2imk | GTX | AGAP009194-PA | / | 0.446 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.446 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.446 | |
| 2nm2 | NEU | Dihydroneopterin aldolase | / | 0.446 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.446 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.446 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.446 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.446 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3e4a | QIX | Insulin-degrading enzyme | 3.4.24.56 | 0.446 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3lut | NAP | Voltage-gated potassium channel subunit beta-2 | / | 0.446 | |
| 3nt5 | NAI | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.446 | |
| 3v3n | MIY | TetX family tetracycline inactivation enzyme | / | 0.446 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4a33 | PS8 | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4gv8 | DUP | DUTPase | / | 0.446 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.446 | |
| 4jvn | YUG | Estrogen sulfotransferase | 2.8.2.4 | 0.446 | |
| 1dd6 | MCI | Metallo-beta-lactamase type 2 | / | 0.445 | |
| 1i7c | MGB | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.445 | |
| 2evc | FC3 | Methionine aminopeptidase | / | 0.445 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.445 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.445 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3h1q | ATP | Ethanolamine utilization protein EutJ | / | 0.445 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.445 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.445 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4kn0 | MTX | Folate receptor beta | / | 0.445 | |
| 4li8 | 1XQ | Tankyrase-1 | 2.4.2.30 | 0.445 | |
| 4u95 | MIY | Multidrug efflux pump subunit AcrB | / | 0.445 | |
| 1dmw | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.444 | |
| 1ej3 | CZH | Aequorin-2 | / | 0.444 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 1q13 | TES | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.444 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.444 | |
| 1y6r | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.444 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.444 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2h7j | H7J | Cathepsin S | 3.4.22.27 | 0.444 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2xk4 | OL2 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.444 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.444 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.444 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.444 | |
| 3pn1 | IVH | DNA ligase | / | 0.444 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.444 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4boe | CLR | Japanin | / | 0.444 | |
| 4cb4 | MGT | Polymerase basic protein 2 | / | 0.444 | |
| 4dch | 4DC | Glucokinase | 2.7.1.2 | 0.444 | |
| 4fwn | AQP | Propionate kinase | / | 0.444 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.444 | |
| 4nbn | 2J7 | Caspase-6 | 3.4.22.59 | 0.444 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.443 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 1jf2 | CZH | Obelin | / | 0.443 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1po7 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.443 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.443 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.443 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.443 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.443 | |
| 3b78 | NAD | Exotoxin A | 2.4.2.36 | 0.443 | |
| 3c4h | DRL | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.443 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.443 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.443 | |
| 3tg4 | SAM | N-lysine methyltransferase SMYD2 | / | 0.443 | |
| 4g2w | NI0 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.443 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.443 | |
| 4twl | ASC | Dioscorin 5 | / | 0.443 | |
| 4zhi | ADP | Kinesin-like protein KIF11 | / | 0.443 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.442 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.442 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.442 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.442 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.442 | |
| 1qsn | COA | HAT A1 | / | 0.442 | |
| 2v7q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.442 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 3n3a | FMN | Protein NrdI | / | 0.442 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.442 | |
| 3zlm | ANP | Adenosine monophosphate-protein transferase NmFic | 2.7.7.n1 | 0.442 | |
| 3zrb | OR8 | Progesterone receptor | / | 0.442 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.442 | |
| 4ckc | SAH | mRNA-capping enzyme catalytic subunit | 2.1.1.56 | 0.442 | |
| 4dyp | 0MS | Nucleoprotein | / | 0.442 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.442 | |
| 4gh1 | 0WX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.442 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 4pmj | NAP | Putative oxidoreductase | / | 0.442 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1og1 | TAD | T-cell ecto-ADP-ribosyltransferase 2 | / | 0.441 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.441 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.441 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.441 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 2j7d | GI1 | Beta-glucosidase A | 3.2.1.21 | 0.441 | |
| 2opb | F21 | Phenylethanolamine N-methyltransferase | 2.1.1.28 | 0.441 | |
| 2q2z | ADP | Kinesin-like protein KIF11 | / | 0.441 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3c6n | 2S8 | Protein TRANSPORT INHIBITOR RESPONSE 1 | / | 0.441 | |
| 3cvk | N34 | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 3dzj | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.441 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.441 | |
| 3lla | ACP | Myosin heavy chain kinase A | 2.7.11.7 | 0.441 | |
| 3qbw | ADP | Anhydro-N-acetylmuramic acid kinase | / | 0.441 | |
| 4ax8 | SAM | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.441 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.441 | |
| 4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.441 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.441 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.441 | |
| 1bqo | N25 | Stromelysin-1 | 3.4.24.17 | 0.440 | |
| 1e63 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.440 | |
| 1gr1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.440 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.440 | |
| 1lrm | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.440 | |
| 1m67 | BOA | Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal | 1.1.1.8 | 0.440 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.440 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2b35 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2bxq | IMN | Serum albumin | / | 0.440 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.440 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2puc | GUN | HTH-type transcriptional repressor PurR | / | 0.440 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 3bmq | AX5 | Pteridine reductase | / | 0.440 | |
| 3d5w | ADP | Serine/threonine-protein kinase PLK | / | 0.440 | |
| 3dwb | RDF | Endothelin-converting enzyme 1 | 3.4.24.71 | 0.440 | |
| 3gxf | IFM | Glucosylceramidase | 3.2.1.45 | 0.440 | |
| 3iej | 599 | Cathepsin S | 3.4.22.27 | 0.440 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.440 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 4iil | RBF | Membrane lipoprotein TpN38(b) | / | 0.440 | |
| 4uth | FMN | Xenobiotic reductase | / | 0.440 | |
| 5kf2 | ACO | Predicted acetyltransferase | / | 0.440 |