sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4f86 | SFG | Geranyl diphosphate 2-C-methyltransferase | 2.1.1.255 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4f86 | SFG | Geranyl diphosphate 2-C-methyltransferase | 2.1.1.255 | 1.000 | |
| 2fk8 | SAM | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.522 | |
| 1kph | SAH | Cyclopropane mycolic acid synthase 1 | 2.1.1.79 | 0.518 | |
| 3vc1 | SAH | Geranyl diphosphate 2-C-methyltransferase | 2.1.1.255 | 0.512 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.509 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.506 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.504 | |
| 3ha7 | B32 | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.504 | |
| 4fgz | SAH | Phosphoethanolamine N-methyltransferase | / | 0.502 | |
| 1osv | CHC | Bile acid receptor | / | 0.493 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.493 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.493 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.491 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.491 | |
| 3kpj | SAH | Phenylethanolamine N-methyltransferase | 2.1.1.28 | 0.491 | |
| 4pzt | SOP | Histone acetyltransferase p300 | / | 0.490 | |
| 3bus | SAH | Demethylrebeccamycin-D-glucose O-methyltransferase | / | 0.489 | |
| 3vc2 | SAH | Geranyl diphosphate 2-C-methyltransferase | 2.1.1.255 | 0.489 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.488 | |
| 2ob0 | ACO | N-alpha-acetyltransferase 50 | / | 0.487 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.487 | |
| 2fhk | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.486 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.486 | |
| 5dp2 | NAP | CurF | / | 0.486 | |
| 3biy | 01K | Histone acetyltransferase p300 | / | 0.484 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.482 | |
| 3go4 | SAH | Uncharacterized protein | / | 0.482 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.481 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.481 | |
| 5dbg | NAD | Iridoid synthase | 1.3.1.99 | 0.481 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.480 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.480 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.480 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.480 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.479 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.477 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.477 | |
| 2ol4 | JPN | Enoyl-ACP reductase | / | 0.476 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.476 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.475 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.475 | |
| 4li8 | 1XQ | Tankyrase-1 | 2.4.2.30 | 0.475 | |
| 4obw | SAM | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | / | 0.475 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.474 | |
| 3eku | CY9 | Actin-5C | / | 0.474 | |
| 3ha3 | SAH | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.474 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.473 | |
| 4k5f | Q14 | Nitric oxide synthase, brain | 1.14.13.39 | 0.473 | |
| 5f2k | SAH | Uncharacterized protein | / | 0.473 | |
| 2bzg | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.472 | |
| 2q4w | FAD | Cytokinin dehydrogenase 7 | 1.5.99.12 | 0.472 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.472 | |
| 3otq | MZL | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.472 | |
| 3uj7 | SAM | Phosphoethanolamine N-methyltransferase | / | 0.472 | |
| 4fgr | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.472 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.471 | |
| 3int | FDA | UDP-galactopyranose mutase | 5.4.99.9 | 0.471 | |
| 4pzr | COA | Histone acetyltransferase p300 | / | 0.471 | |
| 1aj8 | COA | Citrate synthase | / | 0.470 | |
| 2v6g | NAP | 3-oxo-Delta(4,5)-steroid 5-beta-reductase | / | 0.470 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.470 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.470 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.469 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.469 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.469 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.469 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.469 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.469 | |
| 3p3e | 3P3 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.468 | |
| 4k5e | 1Q7 | Nitric oxide synthase, brain | 1.14.13.39 | 0.468 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.468 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.467 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.467 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.467 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3u1y | 03I | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.466 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.466 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.466 | |
| 5ahs | FAD | Acyl-CoA dehydrogenase | / | 0.466 | |
| 2oxi | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.465 | |
| 3dvl | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.465 | |
| 3jx3 | JI5 | Nitric oxide synthase, brain | 1.14.13.39 | 0.465 | |
| 4pmj | NAP | Putative oxidoreductase | / | 0.465 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.465 | |
| 1vrq | FMN | Subunit alpha of sarocosine oxidase | / | 0.464 | |
| 1vrq | FMN | Subunit beta of sarcosine oxidase | / | 0.464 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.464 | |
| 2wes | FAD | Tryptophan 5-halogenase | / | 0.464 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.464 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 3e68 | AT6 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.464 | |
| 3k7t | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.464 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.464 | |
| 4imp | NDP | Polyketide synthase extender modules 3-4 | / | 0.464 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.464 | |
| 4olf | HFG | Proline--tRNA ligase | 6.1.1.15 | 0.464 | |
| 5dbf | NDP | Iridoid synthase | 1.3.1.99 | 0.464 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.463 | |
| 3gyi | FAD | Cholesterol oxidase | 1.1.3.6 | 0.463 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.463 | |
| 3ryw | K9H | Farnesyl pyrophosphate synthase, putative | / | 0.463 | |
| 3ukl | FAD | UDP-galactopyranose mutase | / | 0.463 | |
| 4g67 | SAH | Uncharacterized ACR, COG1565 superfamily | / | 0.463 | |
| 1cjw | COT | Serotonin N-acetyltransferase | / | 0.462 | |
| 1egd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.462 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 1gsf | EAA | Glutathione S-transferase A1 | 2.5.1.18 | 0.462 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.462 | |
| 1nkz | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.462 | |
| 1nkz | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.462 | |
| 1tys | DHF | Thymidylate synthase | / | 0.462 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 2vce | U2F | UDP-glycosyltransferase 72B1 | / | 0.462 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.462 | |
| 3uce | NDP | Dehydrogenase | / | 0.462 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.462 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.462 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.461 | |
| 1yf3 | SAH | DNA adenine methylase | / | 0.461 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.461 | |
| 3uj8 | SFG | Phosphoethanolamine N-methyltransferase | / | 0.461 | |
| 4imu | 1ET | Nitric oxide synthase, brain | 1.14.13.39 | 0.461 | |
| 5emh | NAP | Iridoid synthase | 1.3.1.99 | 0.461 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.460 | |
| 1ppj | ANY | Cytochrome b | / | 0.460 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.460 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.460 | |
| 3tlj | SAH | Uncharacterized protein | / | 0.460 | |
| 3tm4 | SAM | Uncharacterized protein | / | 0.460 | |
| 4eb4 | D16 | Thymidylate synthase | 2.1.1.45 | 0.460 | |
| 4r6x | SAH | Phosphoethanolamine N-methyltransferase | / | 0.460 | |
| 5doz | NDP | JamJ | / | 0.460 | |
| 1hf3 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.459 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.459 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.459 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.459 | |
| 4irn | FAD | AnaB | / | 0.459 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.459 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.458 | |
| 1kev | NDP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.458 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.458 | |
| 1c3e | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.457 | |
| 1qw5 | 14W | Nitric oxide synthase, inducible | 1.14.13.39 | 0.457 | |
| 1s5k | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.457 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.457 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.457 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.457 | |
| 2vqb | NAP | Putative flavin-containing monooxygenase | / | 0.457 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.457 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.457 | |
| 3wbw | NDP | Putative 2,5-diketo-D-gluconic acid reductase | / | 0.457 | |
| 4cjp | 4D2 | Integrase | / | 0.457 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.457 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.457 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.457 | |
| 5kjc | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.457 | |
| 1f0x | FAD | D-lactate dehydrogenase | 1.1.1.28 | 0.456 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.456 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.456 | |
| 1ptj | NAP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.456 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2i62 | SAH | Nicotinamide N-methyltransferase | 2.1.1.1 | 0.456 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.456 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.456 | |
| 3o2x | 3O2 | Collagenase 3 | 3.4.24 | 0.456 | |
| 4c4o | NAD | SADH | / | 0.456 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.456 | |
| 4isk | 1JY | Thymidylate synthase | / | 0.456 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.456 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.455 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.455 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.455 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.455 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.455 | |
| 3mkh | FAD | Nitroalkane oxidase | / | 0.455 | |
| 3nlr | JRS | Nitric oxide synthase, brain | 1.14.13.39 | 0.455 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.455 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.455 | |
| 4d04 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.455 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.455 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.455 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1s60 | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.454 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.454 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2eix | FAD | NADH-cytochrome b5 reductase | / | 0.454 | |
| 2j4z | 626 | Aurora kinase A | 2.7.11.1 | 0.454 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.454 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.454 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 3stw | 2TD | Methylketone synthase I | / | 0.454 | |
| 3tp0 | FO5 | HTH-type transcriptional regulator EthR | / | 0.454 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.454 | |
| 4pne | SAH | Methyltransferase-like protein | / | 0.454 | |
| 4xxv | NAD | 3-isopropylmalate dehydrogenase | / | 0.454 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.454 | |
| 1f4e | TPR | Thymidylate synthase | / | 0.453 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.453 | |
| 2fzm | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.453 | |
| 2xvh | NAP | Putative flavin-containing monooxygenase | / | 0.453 | |
| 2yyy | NAP | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.59 | 0.453 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.453 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.453 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.453 | |
| 3nn6 | FB0 | 6-hydroxy-L-nicotine oxidase | / | 0.453 | |
| 3pfd | FDA | Acyl-CoA dehydrogenase FadE25 | / | 0.453 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.453 | |
| 5dcy | NAP | Iridoid synthase | 1.3.1.99 | 0.453 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.452 | |
| 1tl7 | ONM | Adenylate cyclase type 2 | / | 0.452 | |
| 1tl7 | ONM | Adenylate cyclase type 5 | / | 0.452 | |
| 3n5y | XFL | Nitric oxide synthase, brain | 1.14.13.39 | 0.452 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.452 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.452 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.452 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.452 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.451 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2bx8 | AZQ | Serum albumin | / | 0.451 | |
| 2wuu | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 2ylw | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.451 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.451 | |
| 3ufw | HW0 | Nitric oxide synthase, brain | 1.14.13.39 | 0.451 | |
| 4cgj | NZL | Integrase | / | 0.451 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.451 | |
| 4hh4 | SAH | CcbJ | / | 0.451 | |
| 1iep | STI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.450 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.450 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.450 | |
| 2igy | A2T | Plasmepsin 2 | / | 0.450 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.450 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.450 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.450 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.450 | |
| 4jsi | Q05 | Nitric oxide synthase, brain | 1.14.13.39 | 0.450 | |
| 4pyt | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.450 | |
| 4u8j | FDA | UDP-galactopyranose mutase | / | 0.450 | |
| 4u8m | FDA | UDP-galactopyranose mutase | / | 0.450 | |
| 1b8s | FAD | Cholesterol oxidase | 1.1.3.6 | 0.449 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.449 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.449 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.449 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.449 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.449 | |
| 3qd0 | 3Q4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 3tfp | 03L | Dehydrosqualene synthase | / | 0.449 | |
| 3ufr | H5W | Nitric oxide synthase, brain | 1.14.13.39 | 0.449 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.449 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.449 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 4hx5 | 19V | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 4iv0 | SAM | Phosphoethanolamine N-methyltransferase, putative | / | 0.449 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.449 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.449 | |
| 4rv9 | SAH | D-mycarose 3-C-methyltransferase | / | 0.449 | |
| 5af7 | FAD | Acyl-CoA dehydrogenase | / | 0.449 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.448 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.448 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.448 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 2fsv | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.448 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.448 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3eks | CY9 | Actin-5C | / | 0.448 | |
| 3m0o | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.448 | |
| 3rqk | X2C | Nitric oxide synthase, brain | 1.14.13.39 | 0.448 | |
| 3syi | FAD | Sulfide-quinone reductase | / | 0.448 | |
| 3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.448 | |
| 3up3 | XCA | aceDAF-12 | / | 0.448 | |
| 4fid | GDP | G protein alpha subunit, putative | / | 0.448 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 4imw | 1EV | Nitric oxide synthase, brain | 1.14.13.39 | 0.448 | |
| 4j54 | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4nu5 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.448 | |
| 5cdt | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.448 | |
| 1kif | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.447 | |
| 1p6j | DP9 | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
| 2gtm | LID | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.447 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 2rm2 | W43 | Genome polyprotein | / | 0.447 | |
| 3ama | SKE | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 3eey | SAM | rRNA methylase | / | 0.447 | |
| 3fcj | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.447 | |
| 3mqg | ACO | Lipopolysaccharides biosynthesis acetyltransferase | / | 0.447 | |
| 3o3n | IRC | (R)-2-hydroxyisocaproyl-CoA dehydratase alpha subunit | / | 0.447 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 3ukk | FAD | UDP-galactopyranose mutase | / | 0.447 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.447 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.447 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.447 | |
| 5dro | ZH2 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.447 | |
| 5je2 | SAH | Methyl transferase | / | 0.447 | |
| 1e6e | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.446 | |
| 1het | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1pz0 | NAP | Protein IolS | 1.1.1 | 0.446 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2bi7 | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.446 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.446 | |
| 2fhj | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.446 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.446 | |
| 2gpj | FAD | Siderophore-interacting protein | / | 0.446 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.446 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.446 | |
| 3a7r | LAQ | Lipoate-protein ligase A | 6.3.1.20 | 0.446 | |
| 3bgi | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.446 | |
| 3jx2 | JI4 | Nitric oxide synthase, brain | 1.14.13.39 | 0.446 | |
| 3mdd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.446 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.446 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.446 | |
| 3utf | FDA | UDP-galactopyranose mutase | / | 0.446 | |
| 4d03 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.446 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.446 | |
| 4jsf | QJ4 | Nitric oxide synthase, brain | 1.14.13.39 | 0.446 | |
| 4xnh | ACO | N-terminal acetyltransferase A complex subunit NAT5 | 2.3.1 | 0.446 | |
| 5i39 | FAD | L-amino acid deaminase | / | 0.446 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.446 | |
| 4z9g | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.446 | |
| 1ffu | FAD | Carbon monoxide dehydrogenase medium chain | / | 0.445 | |
| 1heu | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.445 | |
| 1zzq | DP9 | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.445 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.445 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.445 | |
| 3gyj | FAD | Cholesterol oxidase | 1.1.3.6 | 0.445 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.445 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.445 | |
| 4z44 | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.445 | |
| 5hsa | FAS | Alcohol oxidase 1 | 1.1.3.13 | 0.445 | |
| 5je3 | SAH | Methyl transferase | / | 0.445 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.445 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.444 | |
| 1f8s | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.444 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 1kqo | DND | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.444 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.444 | |
| 2ft0 | ACO | dTDP-fucosamine acetyltransferase | / | 0.444 | |
| 2go4 | TUX | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.444 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.444 | |
| 2wzw | FMN | Nitroreductase NfnB | / | 0.444 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3h7u | NAP | NADPH-dependent aldo-keto reductase, chloroplastic | / | 0.444 | |
| 3ies | M24 | Luciferin 4-monooxygenase | 1.13.12.7 | 0.444 | |
| 3n65 | XFJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.444 | |
| 3q33 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.444 | |
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 | 0.444 | |
| 4bhw | 01K | Histone acetyltransferase p300 | / | 0.444 | |
| 4oth | DRN | Serine/threonine-protein kinase N1 | / | 0.444 | |
| 5a3b | APR | SIR2 family protein | / | 0.444 | |
| 5p2p | DHG | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.444 | |
| 1cs4 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.443 | |
| 1d0m | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.443 | |
| 1ijh | FAD | Cholesterol oxidase | 1.1.3.6 | 0.443 | |
| 1xny | 191 | Propionyl-CoA carboxylase complex B subunit | / | 0.443 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.443 | |
| 2du8 | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.443 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3icr | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.443 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.443 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3rf7 | NAD | Iron-containing alcohol dehydrogenase | / | 0.443 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.443 | |
| 3v5l | 0G1 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.443 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.443 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4e0i | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.443 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.443 | |
| 4qbj | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.443 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.443 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.442 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.442 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.442 | |
| 1u33 | LM2 | Pancreatic alpha-amylase | / | 0.442 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.442 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.442 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 2hej | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.442 | |
| 2qcu | FAD | Aerobic glycerol-3-phosphate dehydrogenase | 1.1.5.3 | 0.442 | |
| 2vqb | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2wo9 | 068 | Macrophage metalloelastase | 3.4.24.65 | 0.442 | |
| 2ylr | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.442 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.442 | |
| 3m13 | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.442 | |
| 3nlv | 3XA | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.442 | |
| 3sju | NDP | Keto reductase | / | 0.442 | |
| 3ufs | HW6 | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.442 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.442 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.442 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.442 | |
| 4fdp | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.442 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.442 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.442 | |
| 4i5h | G17 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 4id7 | 1G0 | Activated CDC42 kinase 1 | / | 0.442 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 4k5d | 1Q6 | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 4kto | FAD | Putative isovaleryl-CoA dehydrogenase protein | / | 0.442 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.442 | |
| 4u8o | FDA | UDP-galactopyranose mutase | / | 0.442 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.441 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.441 | |
| 1sez | FAD | Protoporphyrinogen oxidase, mitochondrial | 1.3.3.4 | 0.441 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.441 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.441 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.441 | |
| 3cnj | FAD | Cholesterol oxidase | 1.1.3.6 | 0.441 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.441 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.441 | |
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.441 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.441 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.441 | |
| 3ukf | FDA | UDP-galactopyranose mutase | / | 0.441 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.441 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.441 | |
| 4phl | PIL | Phosphodiesterase | / | 0.441 | |
| 4tnx | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.441 | |
| 4u8l | FDA | UDP-galactopyranose mutase | / | 0.441 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.441 | |
| 4xwr | FAD | Cholesterol oxidase | 1.1.3.6 | 0.441 | |
| 1e1k | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.440 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.440 | |
| 1ndy | FR3 | Adenosine deaminase | 3.5.4.4 | 0.440 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.440 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 2hzi | JIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.440 | |
| 2qtr | NXX | Probable nicotinate-nucleotide adenylyltransferase | / | 0.440 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3mte | SAM | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.440 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.440 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.440 | |
| 4jsh | Q15 | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 4msg | 2C6 | Tankyrase-1 | 2.4.2.30 | 0.440 | |
| 4nec | SAH | Putative SAM-dependent methyltransferase | / | 0.440 | |
| 4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.440 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.440 | |
| 4u8n | FDA | UDP-galactopyranose mutase | / | 0.440 | |
| 4xxg | FAD | Cholesterol oxidase | 1.1.3.6 | 0.440 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.440 | |
| 5a8e | XTK | Beta-1 adrenergic receptor | / | 0.440 |