sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4c66 | H4C | Bromodomain-containing protein 4 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4c66 | H4C | Bromodomain-containing protein 4 | / | 1.000 | |
| 4f3i | 0S6 | Bromodomain-containing protein 4 | / | 0.726 | |
| 4lrg | 1XB | Bromodomain-containing protein 4 | / | 0.665 | |
| 4j0r | 1H2 | Bromodomain-containing protein 4 | / | 0.645 | |
| 4akn | S5B | Bromodomain-containing protein 2 | / | 0.632 | |
| 4j0s | 1H3 | Bromodomain-containing protein 4 | / | 0.631 | |
| 4hxs | 1A3 | Bromodomain-containing protein 4 | / | 0.628 | |
| 4cfl | 8DQ | Bromodomain-containing protein 4 | / | 0.625 | |
| 4a9o | A9O | Bromodomain-containing protein 2 | / | 0.623 | |
| 4ogi | R78 | Bromodomain-containing protein 4 | / | 0.619 | |
| 4nqm | Y1Z | Bromodomain-containing protein 4 | / | 0.617 | |
| 4bjx | 73B | Bromodomain-containing protein 4 | / | 0.615 | |
| 4o74 | R78 | Bromodomain-containing protein 4 | / | 0.612 | |
| 3aqa | BYH | Bromodomain-containing protein 2 | / | 0.608 | |
| 4bw3 | 9BM | Bromodomain-containing protein 4 | / | 0.607 | |
| 4j3i | 1K0 | Bromodomain-containing protein 4 | / | 0.597 | |
| 4hxn | 1A7 | Bromodomain-containing protein 4 | / | 0.596 | |
| 4qzs | JQ1 | Bromodomain-containing protein 4 | / | 0.595 | |
| 4c67 | L5S | Bromodomain-containing protein 4 | / | 0.594 | |
| 4mr4 | 1K0 | Bromodomain-containing protein 4 | / | 0.593 | |
| 4bw2 | UTH | Bromodomain-containing protein 4 | / | 0.591 | |
| 4a9n | A9N | Bromodomain-containing protein 2 | / | 0.590 | |
| 2yel | WSH | Bromodomain-containing protein 4 | / | 0.585 | |
| 4lyw | 21Q | Bromodomain-containing protein 4 | / | 0.579 | |
| 4men | 25K | Bromodomain-containing protein 4 | / | 0.577 | |
| 4lr6 | 1XA | Bromodomain-containing protein 4 | / | 0.575 | |
| 4mep | 24Y | Bromodomain-containing protein 4 | / | 0.569 | |
| 4bw1 | S5B | Bromodomain-containing protein 4 | / | 0.568 | |
| 4hxr | 1A4 | Bromodomain-containing protein 4 | / | 0.568 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.568 | |
| 4a9l | P9L | Bromodomain-containing protein 4 | / | 0.564 | |
| 4hxo | 1A6 | Bromodomain-containing protein 4 | / | 0.564 | |
| 4flp | JQ1 | Bromodomain testis-specific protein | / | 0.563 | |
| 4meq | 25O | Bromodomain-containing protein 4 | / | 0.563 | |
| 3zyu | 1GH | Bromodomain-containing protein 4 | / | 0.557 | |
| 4uyg | 73B | Bromodomain-containing protein 2 | / | 0.549 | |
| 4mr6 | 1K0 | Bromodomain-containing protein 2 | / | 0.548 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.546 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.543 | |
| 4hby | 13F | Bromodomain-containing protein 4 | / | 0.537 | |
| 4j1p | 1K0 | Bromodomain-containing protein 2 | / | 0.531 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.529 | |
| 2yem | WSH | Bromodomain-containing protein 4 | / | 0.526 | |
| 4alg | 1GH | Bromodomain-containing protein 2 | / | 0.522 | |
| 4py6 | R78 | Bromodomain protein, putative | / | 0.522 | |
| 4hbw | 14Z | Bromodomain-containing protein 4 | / | 0.521 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.517 | |
| 4gpj | 0Q1 | Bromodomain-containing protein 4 | / | 0.515 | |
| 5bt5 | 2LO | Bromodomain-containing protein 2 | / | 0.515 | |
| 4bw4 | 9B6 | Bromodomain-containing protein 4 | / | 0.512 | |
| 4nr5 | 2LL | CREB-binding protein | / | 0.512 | |
| 4meo | 25V | Bromodomain-containing protein 4 | / | 0.511 | |
| 4cfk | LY2 | Bromodomain-containing protein 4 | / | 0.510 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.504 | |
| 4o78 | SAV | Bromodomain-containing protein 4 | / | 0.503 | |
| 4mr5 | 1K0 | Bromodomain-containing protein 2 | / | 0.496 | |
| 4e96 | 0NS | Bromodomain-containing protein 4 | / | 0.494 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.491 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.491 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.488 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.483 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.482 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.482 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.480 | |
| 5dfc | EAM | Bromodomain-containing protein 2 | / | 0.480 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.479 | |
| 4ir5 | IR5 | Bromodomain adjacent to zinc finger domain protein 2B | / | 0.479 | |
| 4nra | 2LW | Bromodomain adjacent to zinc finger domain protein 2B | / | 0.479 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.478 | |
| 3svg | ODR | Bromodomain-containing protein 4 | / | 0.478 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.477 | |
| 3b9l | AZZ | Serum albumin | / | 0.475 | |
| 4hxm | 1A8 | Bromodomain-containing protein 4 | / | 0.475 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.473 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.473 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.473 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.472 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.472 | |
| 4k9p | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.472 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.471 | |
| 2xvw | 9NR | Serum albumin | / | 0.471 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.471 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.470 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.469 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.469 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.468 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.467 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.467 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.466 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.466 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.466 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.465 | |
| 2xvv | 9DN | Serum albumin | / | 0.465 | |
| 4pkl | 1GH | Uncharacterized protein | / | 0.465 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 3suf | SUE | Polyprotein | / | 0.464 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.463 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3dle | GFA | Gag-Pol polyprotein | 2.7.7.49 | 0.463 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.462 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.462 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.461 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.461 | |
| 4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.461 | |
| 4nr8 | 2LL | Bromodomain-containing protein 4 | / | 0.461 | |
| 1lik | ADN | Adenosine kinase | 2.7.1.20 | 0.460 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.460 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.460 | |
| 5ej9 | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.460 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.459 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.459 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.459 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.458 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.458 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.458 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.458 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.458 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 3fql | 79Z | Genome polyprotein | 2.7.7.48 | 0.457 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.457 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.457 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.457 | |
| 5ahk | TPP | Acetolactate synthase II, large subunit | / | 0.457 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.456 | |
| 2g1p | SAH | DNA adenine methylase | 2.1.1.72 | 0.456 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.456 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.456 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.455 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.455 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.454 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.454 | |
| 2pan | TDP | Glyoxylate carboligase | 4.1.1.47 | 0.454 | |
| 2wgj | VGH | Hepatocyte growth factor receptor | 2.7.10.1 | 0.454 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.454 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.454 | |
| 3rmf | 20Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.454 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.454 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.454 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1po7 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.453 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.453 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.453 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.453 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.453 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.453 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.453 | |
| 4g2h | 0VQ | Vitamin D3 receptor A | / | 0.453 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.452 | |
| 3c6u | M22 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.452 | |
| 3exn | ACO | Probable acetyltransferase | / | 0.452 | |
| 4feq | 0T8 | Tyrosine-protein kinase receptor TYRO3 | 2.7.10.1 | 0.452 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.452 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.452 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.451 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.451 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.451 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.451 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.451 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.451 | |
| 1fml | RTL | Retinol dehydratase | / | 0.450 | |
| 1ndy | FR3 | Adenosine deaminase | 3.5.4.4 | 0.450 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.450 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.450 | |
| 3ls8 | AJZ | Phosphatidylinositol 3-kinase catalytic subunit type 3 | 2.7.1.137 | 0.450 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.450 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.450 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 4y1b | NAP | AntE | / | 0.450 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.449 | |
| 1g28 | FMN | PHY3 | / | 0.449 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.449 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.449 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.449 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.449 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.449 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.449 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.449 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.448 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.448 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.448 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.448 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.448 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.448 | |
| 3myk | ANP | Myosin-2 heavy chain | / | 0.448 | |
| 3vet | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.448 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.448 | |
| 4aoi | 4K0 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.448 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.448 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.448 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.448 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.447 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.447 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.447 | |
| 3anm | SYD | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.447 | |
| 3i1f | GCP | Translation initiation factor 2 subunit gamma | / | 0.447 | |
| 3owu | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.447 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.447 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.447 | |
| 5csh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 2bxq | IMN | Serum albumin | / | 0.446 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.446 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.446 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.446 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.446 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.446 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.446 | |
| 4nyw | 2O3 | CREB-binding protein | / | 0.446 | |
| 4xf7 | ACP | Carbohydrate/pyrimidine kinase, PfkB family | / | 0.446 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.446 | |
| 5cvh | ADP | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 5kp2 | COA | 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2 | / | 0.446 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.445 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1om1 | IQA | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 1unl | RRC | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.445 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.445 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 3gbk | 2PQ | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.445 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.445 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.445 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.444 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.444 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.444 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.444 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 2af3 | COA | Phosphate acetyltransferase | 2.3.1.8 | 0.444 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.444 | |
| 2vwy | 7X5 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.444 | |
| 2vwz | 7X6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.444 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.444 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.444 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.444 | |
| 3mla | JJZ | Probable nicotinate-nucleotide adenylyltransferase | / | 0.444 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.444 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.444 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.444 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.444 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.444 | |
| 4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.444 | |
| 4pk4 | ADP | Unconventional myosin-VI | / | 0.444 | |
| 4wkq | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 1itz | TPP | Transketolase, chloroplastic | 2.2.1.1 | 0.443 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.443 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2q5q | TPW | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.443 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.443 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.443 | |
| 3e6o | A55 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.443 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.443 | |
| 4bb4 | 32W | Ephrin type-B receptor 4 | 2.7.10.1 | 0.443 | |
| 4bwx | AGS | PAB-dependent poly(A)-specific ribonuclease subunit pan3 | / | 0.443 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.443 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.443 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.443 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.443 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.442 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.442 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 3gob | HXX | DdmC | / | 0.442 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.442 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.442 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.442 | |
| 4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.442 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 1hqu | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1r2j | FAD | FkbI | / | 0.441 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.441 | |
| 1w0k | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.441 | |
| 1w0k | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.441 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.441 | |
| 2cy2 | ACO | Probable acetyltransferase | / | 0.441 | |
| 2fsz | OHT | Estrogen receptor beta | / | 0.441 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.441 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.441 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.441 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.441 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.441 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.441 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.441 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.441 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.440 | |
| 1sn5 | T3 | Transthyretin | / | 0.440 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.440 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.440 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.440 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.440 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.440 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.440 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.440 | |
| 3sfe | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.440 | |
| 3tw6 | ADP | Pyruvate carboxylase | / | 0.440 | |
| 3zc6 | VFC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.440 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.440 | |
| 4ho8 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.440 |