sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3zxz | KRW | Hepatocyte growth factor receptor | 2.7.10.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3zxz | KRW | Hepatocyte growth factor receptor | 2.7.10.1 | 1.000 | |
| 3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.726 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.654 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.619 | |
| 4aoi | 4K0 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.607 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.604 | |
| 3zze | 6XP | Hepatocyte growth factor receptor | 2.7.10.1 | 0.596 | |
| 2wgj | VGH | Hepatocyte growth factor receptor | 2.7.10.1 | 0.579 | |
| 4gg5 | 0J3 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.543 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.521 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.515 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.509 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.506 | |
| 3hzt | J60 | Calmodulin-like domain protein kinase isoform 3 | / | 0.493 | |
| 4o4e | ATP | Kinase | / | 0.490 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.487 | |
| 3zbx | 6XE | Hepatocyte growth factor receptor | 2.7.10.1 | 0.486 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.485 | |
| 3vet | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.485 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.484 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.483 | |
| 3psy | RB9 | Endothiapepsin | 3.4.23.22 | 0.482 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.481 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.479 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.478 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.478 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.477 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.476 | |
| 1stc | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.476 | |
| 2uze | C95 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.476 | |
| 3cso | XNI | Genome polyprotein | 2.7.7.48 | 0.476 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.476 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.475 | |
| 4hw2 | 19H | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.475 | |
| 4kb8 | 1QO | Casein kinase I isoform delta | 2.7.11.1 | 0.475 | |
| 3bht | MFR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.474 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.474 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.473 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.473 | |
| 2wkm | PFY | Hepatocyte growth factor receptor | 2.7.10.1 | 0.472 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.471 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.471 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.470 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.470 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.470 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.470 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.469 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.469 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.469 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.468 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.468 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.468 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.468 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.467 | |
| 2vag | V25 | Dual specificity protein kinase CLK1 | 2.7.12.1 | 0.467 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.466 | |
| 2c6t | DT5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.466 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.466 | |
| 3b6p | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.466 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.466 | |
| 4jr7 | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.466 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.465 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.465 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.465 | |
| 2gd2 | CAA | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.464 | |
| 2x3j | ATP | AcsD | / | 0.464 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.464 | |
| 4y3j | HIC | Endothiapepsin | 3.4.23.22 | 0.464 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.463 | |
| 3m42 | HGF | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.463 | |
| 4iwd | 1JC | Hepatocyte growth factor receptor | 2.7.10.1 | 0.463 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.463 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.462 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.462 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.461 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.461 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.461 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.461 | |
| 2xvu | 9DN | Serum albumin | / | 0.460 | |
| 3keu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.460 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.460 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.459 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.459 | |
| 4l8u | 9AZ | Serum albumin | / | 0.459 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.459 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.458 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.458 | |
| 4ih8 | B43 | Calmodulin-domain protein kinase 1 | / | 0.458 | |
| 4j95 | ACP | Fibroblast growth factor receptor 2 | / | 0.458 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.457 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.457 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 3ts1 | TYA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.457 | |
| 4idv | 13V | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.457 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.457 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.456 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.456 | |
| 1zp9 | ATP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.456 | |
| 3gcn | TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.456 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 4czt | CPS | CBL-interacting serine/threonine-protein kinase 23 | 2.7.11.1 | 0.456 | |
| 4f65 | 0S9 | Fibroblast growth factor receptor 1 | / | 0.456 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.456 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.456 | |
| 4o4f | ATP | Kinase | / | 0.456 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.456 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.455 | |
| 1r2j | FAD | FkbI | / | 0.455 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.455 | |
| 2p3b | 3TL | V-1 PROTEASE protein | / | 0.455 | |
| 2p3b | 3TL | V-1 protease | / | 0.455 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.455 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.455 | |
| 2x1n | X1N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.455 | |
| 3c4z | ADP | Rhodopsin kinase | / | 0.455 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 3sw4 | 18K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.455 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 4y3z | F41 | Endothiapepsin | 3.4.23.22 | 0.455 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.455 | |
| 1e81 | M91 | Endothiapepsin | 3.4.23.22 | 0.454 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3fz1 | B98 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.454 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.454 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.453 | |
| 1rw8 | 580 | TGF-beta receptor type-1 | 2.7.11.30 | 0.453 | |
| 2bgi | FAD | NADPH:ferredoxin reductase | / | 0.453 | |
| 2owu | SAH | Diphthine synthase | / | 0.453 | |
| 2wih | P48 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.453 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.453 | |
| 3le6 | 2BZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3pwm | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4dn5 | AGS | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.453 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.453 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.453 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2a5y | ATP | Cell death protein 4 | / | 0.452 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 2jjj | 0QS | Endothiapepsin | 3.4.23.22 | 0.452 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2uzl | C94 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 3mx2 | TTP | Nucleoprotein | / | 0.452 | |
| 3p5p | A3C | Taxadiene synthase | 4.2.3.17 | 0.452 | |
| 3r02 | UNM | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 3r1y | X76 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.452 | |
| 4hgs | 15G | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.452 | |
| 4lfi | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 4tl8 | AGS | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.452 | |
| 4tle | AGS | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.452 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.451 | |
| 1y91 | CT9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.451 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.451 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.451 | |
| 4hyi | 1AO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 4l4x | NDP | AmphI | / | 0.451 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.451 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.451 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.451 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.450 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1od1 | 0QS | Endothiapepsin | 3.4.23.22 | 0.450 | |
| 2euf | LQQ | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.450 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.450 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.450 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.450 | |
| 3eku | CY9 | Actin-5C | / | 0.450 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.450 | |
| 4bwx | AGS | PAB-dependent poly(A)-specific ribonuclease subunit pan3 | / | 0.450 | |
| 4e4m | 0NH | Tyrosine-protein kinase JAK2 | / | 0.450 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.449 | |
| 1fvv | 107 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 1gvv | 0GM | Endothiapepsin | 3.4.23.22 | 0.449 | |
| 1xef | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.449 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.449 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.449 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.449 | |
| 4uyg | 73B | Bromodomain-containing protein 2 | / | 0.449 | |
| 1p2a | 5BN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.448 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.448 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.448 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 4jin | 1L7 | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.448 | |
| 4oth | DRN | Serine/threonine-protein kinase N1 | / | 0.448 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1m2p | HNA | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.447 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.447 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.447 | |
| 3nnu | EDB | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.447 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.447 | |
| 3rm6 | 18Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.447 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.447 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.447 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.447 | |
| 4eiq | KCT | Putative FAD-monooxygenase | / | 0.447 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.447 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.447 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.447 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.447 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1m0b | 0ZQ | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 2c6l | DT4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.446 | |
| 2gcd | STU | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.446 | |
| 2ijg | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.446 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.446 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.446 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.446 | |
| 2xj2 | 985 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 2xyt | TC9 | Soluble acetylcholine receptor | / | 0.446 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.446 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3s1a | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.446 | |
| 4l7f | 1V5 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.446 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.446 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.445 | |
| 1oir | HDY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.445 | |
| 2e15 | SAH | Diphthine synthase | / | 0.445 | |
| 2q15 | 3MR | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 2vtt | LZD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 3i81 | EBI | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.445 | |
| 3prs | RIT | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.445 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.445 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.445 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.445 | |
| 4tld | AGS | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.445 | |
| 4u7w | NDP | MxaA | / | 0.445 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.445 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.445 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.445 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.444 | |
| 1g5s | I17 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.444 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.444 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.444 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.444 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.444 | |
| 3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
| 4l8v | NAP | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.444 | |
| 4n1g | CEI | Obelin | / | 0.444 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.443 | |
| 1j1z | ATP | Argininosuccinate synthase | / | 0.443 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.443 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.443 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2dr3 | ADP | UPF0273 protein PH0284 | / | 0.443 | |
| 2p2x | SAH | Diphthine synthase | / | 0.443 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.443 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3pmy | 41L | Endothiapepsin | 3.4.23.22 | 0.443 | |
| 3rmf | 20Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.443 | |
| 4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.443 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.443 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.443 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.443 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.443 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 1ha3 | MAU | Elongation factor Tu-A | / | 0.442 | |
| 1ppl | 1Z7 | Penicillopepsin-1 | 3.4.23.20 | 0.442 | |
| 1q19 | SSC | Carbapenam-3-carboxylate synthase | 6.3.3.6 | 0.442 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.442 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.442 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.442 | |
| 2fgj | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.442 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.442 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.442 | |
| 2vgo | AD5 | Aurora kinase B-A | 2.7.11.1 | 0.442 | |
| 2vnh | FAD | NADPH:ferredoxin reductase | / | 0.442 | |
| 2vuw | 5ID | Serine/threonine-protein kinase haspin | 2.7.11.1 | 0.442 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.442 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.442 | |
| 4b8m | VX6 | Aurora kinase B-A | 2.7.11.1 | 0.442 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4fv6 | E57 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.442 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.442 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.441 | |
| 1gqt | ACP | Ribokinase | / | 0.441 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.441 | |
| 1j21 | ATP | Argininosuccinate synthase | / | 0.441 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.441 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.441 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.441 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.441 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2ii6 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.441 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.441 | |
| 2nmt | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.441 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.441 | |
| 2rio | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.441 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.441 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.441 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 3ggp | NAD | Prephenate dehydrogenase | / | 0.441 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 3pd3 | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.441 | |
| 3r7y | Z04 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.441 | |
| 4eb4 | D16 | Thymidylate synthase | 2.1.1.45 | 0.441 | |
| 4ek8 | 16K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4fkw | 62K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.441 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.441 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.441 | |
| 4zp0 | DXC | Multidrug transporter MdfA | / | 0.441 | |
| 5cvf | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.441 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.440 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.440 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.440 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.440 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.440 | |
| 3bgc | LJH | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3gnv | XNZ | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 3hl7 | I47 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.440 | |
| 3nsz | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3vcy | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.440 | |
| 4bie | IE6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.440 | |
| 4cfa | WOP | Integrase | / | 0.440 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.440 | |
| 4en4 | ATP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 4fg9 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.440 | |
| 4fks | 46K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4r7i | STI | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.440 | |
| 4req | 5AD | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.440 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.440 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.440 |