sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3sfd | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3sfd | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 1.000 | |
| 3sfe | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.725 | |
| 3aeb | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.611 | |
| 4yxd | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.608 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.518 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.509 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.502 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.498 | |
| 4o5u | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.493 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.492 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.491 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.489 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.487 | |
| 5dbj | FAD | FADH2-dependent halogenase PltA | / | 0.487 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.486 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.484 | |
| 2aqj | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.483 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.483 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 2bl4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.480 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.479 | |
| 2q0l | FAD | Thioredoxin reductase | 1.8.1.9 | 0.479 | |
| 1iy8 | NAD | Levodione reductase | / | 0.477 | |
| 2fre | FMN | NAD(P)H-flavin oxidoreductase | / | 0.477 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.477 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.477 | |
| 1onf | FAD | Glutathione reductase | 1.8.1.7 | 0.476 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.476 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.476 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.476 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.476 | |
| 4cpd | NAD | Alcohol dehydrogenase | / | 0.476 | |
| 4jin | 1L7 | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.476 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.476 | |
| 1e1k | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.474 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.474 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.474 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.474 | |
| 2onm | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.474 | |
| 2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.474 | |
| 1ad3 | NAD | Aldehyde dehydrogenase, dimeric NADP-preferring | / | 0.473 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.473 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.473 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.473 | |
| 3qfc | FAD | NADPH--cytochrome P450 reductase | / | 0.472 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.471 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.471 | |
| 1c0l | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.470 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.470 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.470 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.470 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.470 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.470 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.469 | |
| 1zmd | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.469 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.468 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.467 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.467 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.467 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.466 | |
| 3fpz | AHZ | Thiamine thiazole synthase | / | 0.466 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.466 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.466 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.466 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.465 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.465 | |
| 2ard | FDA | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.465 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.465 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.465 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.464 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.464 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.464 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.464 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.464 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.464 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.463 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.463 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.463 | |
| 2wes | FAD | Tryptophan 5-halogenase | / | 0.463 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.463 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.463 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.463 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.462 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.462 | |
| 2q4w | FAD | Cytokinin dehydrogenase 7 | 1.5.99.12 | 0.462 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 2zzc | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.461 | |
| 3cin | NAD | Myo-inositol-1-phosphate synthase-related protein | / | 0.461 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.461 | |
| 3lb8 | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.461 | |
| 1ef9 | 2CP | Methylmalonyl-CoA decarboxylase | 4.1.1.41 | 0.460 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.460 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.460 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.460 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.460 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.460 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.460 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.459 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.459 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.459 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.459 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.459 | |
| 1il0 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.459 | |
| 2b4y | APR | NAD-dependent protein deacylase sirtuin-5, mitochondrial | / | 0.459 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.459 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.459 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.459 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.459 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.458 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1kev | NDP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.458 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.458 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.458 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.458 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.458 | |
| 2vce | U2F | UDP-glycosyltransferase 72B1 | / | 0.458 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.458 | |
| 3f8d | FAD | NADH oxidase/thioredoxin reductase | / | 0.458 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.458 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.458 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.458 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.458 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.458 | |
| 1u1i | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.457 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.457 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.457 | |
| 2yvj | NAI | Ferredoxin reductase | / | 0.457 | |
| 2z3n | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.457 | |
| 3jsk | AHZ | Thiamine thiazole synthase | / | 0.457 | |
| 3mgd | ACO | Predicted acetyltransferase | / | 0.457 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.457 | |
| 4f3x | NAD | Putative aldehyde dehydrogenase | / | 0.457 | |
| 1gqt | ACP | Ribokinase | / | 0.456 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.456 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.456 | |
| 3iwj | NAD | Aminoaldehyde dehydrogenase | / | 0.456 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.456 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.456 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.456 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.456 | |
| 4btj | ATP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.456 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.456 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.456 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.456 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.456 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.456 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.455 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 2dki | FAD | 3-hydroxybenzoate 4-monooxygenase | 1.14.13.23 | 0.455 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.455 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.455 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.455 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.455 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.455 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.455 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.455 | |
| 4gap | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.455 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.455 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1l2t | ATP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.454 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.454 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.454 | |
| 2aa0 | MTP | Adenosine kinase | 2.7.1.20 | 0.454 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.454 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.454 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.454 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.454 | |
| 4c4o | NAD | SADH | / | 0.454 | |
| 5emh | NAP | Iridoid synthase | 1.3.1.99 | 0.454 | |
| 1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.453 | |
| 2p2x | SAH | Diphthine synthase | / | 0.453 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.453 | |
| 3cge | FAD | Coenzyme A disulfide reductase | / | 0.453 | |
| 3d8x | FAD | Thioredoxin reductase 1 | 1.8.1.9 | 0.453 | |
| 3dzv | ADP | Hydroxyethylthiazole kinase | / | 0.453 | |
| 3nlc | FAD | Uncharacterized protein | / | 0.453 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.453 | |
| 3q70 | RIT | Candidapepsin-2 | 3.4.23.24 | 0.453 | |
| 3qe2 | FAD | NADPH--cytochrome P450 reductase | / | 0.453 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.453 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.453 | |
| 4goj | GNP | ADP-ribosylation factor-like protein 3 | / | 0.453 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.453 | |
| 5eox | ADP | Type 4 fimbrial biogenesis protein PilM | / | 0.453 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.453 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.452 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.452 | |
| 2dsg | SAH | Diphthine synthase | / | 0.452 | |
| 2eud | GCQ | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.452 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.452 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.452 | |
| 2rab | FAD | Glutathione amide reductase | / | 0.452 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.452 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.452 | |
| 4qed | NAP | ElxO | / | 0.452 | |
| 4xfj | ANP | Argininosuccinate synthase | / | 0.452 | |
| 1grb | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.451 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.451 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.451 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.451 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.451 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.451 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.451 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.451 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.451 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.451 | |
| 1hon | GNH | Adenylosuccinate synthetase | / | 0.450 | |
| 1yqx | NAP | Sinapyl alcohol dehydrogenase | / | 0.450 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.450 | |
| 2gv8 | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.450 | |
| 2r6g | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.450 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.450 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.450 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.450 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.450 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.450 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.450 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.450 | |
| 4aos | FAD | Steroid monooxygenase | / | 0.450 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.450 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.450 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.449 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.449 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.449 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1j3j | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 1m76 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.449 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.449 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 2pb5 | SAH | Diphthine synthase | / | 0.449 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.449 | |
| 2xpv | MIY | Tetracycline repressor protein class D | / | 0.449 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.449 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.449 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.449 | |
| 4ap1 | FAD | Steroid monooxygenase | / | 0.449 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.449 | |
| 4gav | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.449 | |
| 4irn | FAD | AnaB | / | 0.449 | |
| 4uir | FAD | Oleate hydratase | 4.2.1.53 | 0.449 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.448 | |
| 1mew | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.448 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.448 | |
| 2gd6 | ACO | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.448 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.448 | |
| 3eld | SFG | Methyltransferase | / | 0.448 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.448 | |
| 4f4q | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.448 | |
| 4h4w | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.448 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.448 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4ozn | ATP | Ammonium transporter | / | 0.448 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.448 | |
| 5dbf | NDP | Iridoid synthase | 1.3.1.99 | 0.448 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.447 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.447 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.447 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.447 | |
| 2gsd | NAD | Formate dehydrogenase | / | 0.447 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.447 | |
| 3djg | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.447 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.447 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.447 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.447 | |
| 4f9f | GDP | Putative glycosyltransferase | / | 0.447 | |
| 4la1 | FAD | Thioredoxin glutathione reductase | / | 0.447 | |
| 4u2t | FAD | Cholesterol oxidase | 1.1.3.6 | 0.447 | |
| 4xr9 | NAD | CalS8 | / | 0.447 | |
| 5c77 | SAH | Protein arginine N-methyltransferase SFM1 | / | 0.447 | |
| 5k5z | ANP | Uncharacterized protein | / | 0.447 | |
| 1f0y | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 1ffu | FAD | Carbon monoxide dehydrogenase medium chain | / | 0.446 | |
| 1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.446 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 1mgo | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.446 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1sny | NAP | LD36273p | / | 0.446 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.446 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.446 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.446 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.446 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.446 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.446 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.446 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.446 | |
| 3iaa | TYD | CalG2 | / | 0.446 | |
| 3pju | C2E | Diguanylate cyclase/phosphodiesterase | / | 0.446 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.446 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.446 | |
| 4qec | NAP | ElxO | / | 0.446 | |
| 5dmh | ADP | 3-oxo-tetronate kinase | / | 0.446 | |
| 1h69 | ARH | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1j3k | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 1khr | VIR | Streptogramin A acetyltransferase | 2.3.1 | 0.445 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.445 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.445 | |
| 2fy5 | SOP | Choline O-acetyltransferase | 2.3.1.6 | 0.445 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.445 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2p5c | SAH | Diphthine synthase | / | 0.445 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.445 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.445 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.445 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.445 | |
| 3mx2 | TTP | Nucleoprotein | / | 0.445 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.445 | |
| 4ijr | NDP | D-arabinose dehydrogenase [NAD(P)+] heavy chain | 1.1.1.117 | 0.445 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.445 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.445 | |
| 4xzm | NAP | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.445 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.445 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.445 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.445 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 1uxj | NAD | Malate dehydrogenase | / | 0.444 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.444 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.444 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.444 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.444 | |
| 2v3a | FAD | Rubredoxin-NAD(+) reductase | 1.18.1.1 | 0.444 | |
| 2xrl | DXT | Tetracycline repressor protein class D | / | 0.444 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.444 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.444 | |
| 3a6q | FMN | FMN-binding protein | / | 0.444 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.444 | |
| 3dgh | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.444 | |
| 3fg2 | FAD | Putative rubredoxin reductase | / | 0.444 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.444 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.444 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.444 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.444 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1t2a | NDP | GDP-mannose 4,6 dehydratase | 4.2.1.47 | 0.443 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.443 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.443 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.443 | |
| 2p2b | PRX | Acetyl-coenzyme A synthetase | / | 0.443 | |
| 2ph6 | 712 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.443 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.443 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.443 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.443 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.443 | |
| 3uce | NDP | Dehydrogenase | / | 0.443 | |
| 4b1h | AR6 | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.443 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.443 | |
| 4dna | FAD | Probable glutathione reductase | / | 0.443 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.443 | |
| 4qi4 | FAD | Cellobiose dehydrogenase | / | 0.443 | |
| 5hy5 | FAD | Tryptophan 6-halogenase | / | 0.443 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.442 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1kif | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.442 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.442 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.442 | |
| 1typ | FAD | Trypanothione reductase | 1.8.1.12 | 0.442 | |
| 1x7d | NAD | Putative ornithine cyclodeaminase | / | 0.442 | |
| 1yre | COA | Uncharacterized protein | / | 0.442 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.442 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.442 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 2emu | SAH | Diphthine synthase | / | 0.442 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.442 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.442 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.442 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 3qw2 | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.442 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.442 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.442 | |
| 4aa4 | QC0 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4iac | ACP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.442 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.442 | |
| 4xye | NAD | Formate dehydrogenase | / | 0.442 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.441 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.441 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.441 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.441 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 2iml | FMN | Uncharacterized protein | / | 0.441 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.441 | |
| 3dh9 | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.441 | |
| 3elu | SAM | Methyltransferase | / | 0.441 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.441 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.441 | |
| 3pm9 | FAD | Putative oxidoreductase | / | 0.441 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4ddh | MS0 | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.441 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.441 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.441 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.441 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.441 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.441 | |
| 4qny | ANP | Mitogen activated protein kinase, putative | / | 0.441 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.441 | |
| 5e7o | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.441 | |
| 1ep3 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.440 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.440 | |
| 1gv0 | NAD | Malate dehydrogenase | / | 0.440 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.440 | |
| 1h7w | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.440 | |
| 1hku | NAD | C-terminal-binding protein 1 | 1.1.1 | 0.440 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.440 | |
| 1ykf | NAP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.440 | |
| 1yqz | FAD | Coenzyme A disulfide reductase | / | 0.440 | |
| 2egs | SAH | Diphthine synthase | / | 0.440 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.440 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.440 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.440 | |
| 2oor | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.440 | |
| 2owu | SAH | Diphthine synthase | / | 0.440 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.440 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.440 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3f8p | NAD | NADH oxidase/thioredoxin reductase | / | 0.440 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 3lxd | FAD | FAD-dependent pyridine nucleotide-disulfide oxidoreductase | / | 0.440 | |
| 3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.440 | |
| 3s87 | ADP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.440 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.440 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.440 | |
| 4nfs | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.440 |