sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 1.000 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.640 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.630 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.618 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.617 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.611 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.587 | |
| 1iy8 | NAD | Levodione reductase | / | 0.585 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.585 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.582 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.582 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.577 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.573 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.570 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.569 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.568 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.568 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.567 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.567 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.566 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.565 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.564 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.563 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.562 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.562 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.562 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.561 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.560 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.559 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.558 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.557 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.557 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.556 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.551 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.551 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.551 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.550 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.549 | |
| 4kwh | NAP | Reductase homolog | / | 0.549 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.546 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.544 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.543 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.542 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.542 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.542 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.541 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.541 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.541 | |
| 4hxy | NDP | Plm1 | / | 0.537 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.536 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.536 | |
| 1sny | NAP | LD36273p | / | 0.535 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.535 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.534 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.533 | |
| 3mje | NDP | AmphB | / | 0.533 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.532 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.531 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.530 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.530 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.530 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.529 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.529 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.528 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.527 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.527 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.527 | |
| 4l4x | NDP | AmphI | / | 0.527 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.526 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.524 | |
| 4qec | NAP | ElxO | / | 0.524 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.523 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.522 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.521 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.520 | |
| 3sju | NDP | Keto reductase | / | 0.520 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.520 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.519 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.519 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.518 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.518 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.517 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.517 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.517 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.516 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.515 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.515 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.515 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.515 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.513 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.513 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.512 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.511 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.511 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.510 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.510 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.508 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.507 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.507 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.506 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.506 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.506 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.505 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.505 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.504 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.504 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.501 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.500 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.499 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.499 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.499 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.499 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.498 | |
| 5dp2 | NAP | CurF | / | 0.498 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.497 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.496 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.495 | |
| 1nai | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.494 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.494 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.493 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.493 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.493 | |
| 4u7w | NDP | MxaA | / | 0.492 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.490 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.490 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.489 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.487 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.487 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.486 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.486 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.486 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.485 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.484 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.484 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.483 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.482 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.481 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.481 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.481 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.480 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.480 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.480 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.479 | |
| 2x6t | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.479 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.479 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.478 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.478 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.478 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.478 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.478 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.478 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.477 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.475 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.475 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.475 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.475 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.475 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.475 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.475 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.474 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.474 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.474 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.472 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.472 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.471 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.471 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.471 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.471 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.470 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.470 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.470 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.468 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.468 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.468 | |
| 4l8u | 9AZ | Serum albumin | / | 0.468 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.468 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.467 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.467 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.467 | |
| 2pv7 | NAD | T-protein | 1.3.1.12 | 0.467 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.466 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.466 | |
| 2x86 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.466 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.465 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.464 | |
| 1llq | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.464 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.464 | |
| 3ksd | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.464 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.464 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.463 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.463 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.463 | |
| 4dja | FAD | (6-4) photolyase | / | 0.463 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.463 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.463 | |
| 1dbv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.462 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.462 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.462 | |
| 3uqd | ADP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.462 | |
| 4p8r | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.462 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.462 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.461 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.461 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.461 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.461 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.461 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.460 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.460 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.460 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.460 | |
| 3uce | NDP | Dehydrogenase | / | 0.460 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.460 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.460 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.459 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.459 | |
| 4jji | NAD | Alcohol dehydrogenase class-3 | / | 0.459 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.459 | |
| 4y0k | NAP | AntE | / | 0.459 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.458 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.458 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.458 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.458 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.458 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.458 | |
| 5dcy | NAP | Iridoid synthase | 1.3.1.99 | 0.458 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.457 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.457 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.457 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.457 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.457 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.456 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.456 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.456 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.456 | |
| 3muo | ZPR | Prolyl endopeptidase | / | 0.456 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.456 | |
| 4ozn | ATP | Ammonium transporter | / | 0.456 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.456 | |
| 5bt9 | NAP | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.456 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.456 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.455 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.455 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.455 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.455 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.455 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.455 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.455 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.455 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.455 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.455 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.454 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.454 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.454 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.454 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.453 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.453 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.453 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.453 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.453 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.452 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.452 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.452 | |
| 3mk6 | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.452 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.452 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.452 | |
| 4xj4 | 3AT | Cyclic GMP-AMP synthase | / | 0.452 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.451 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.451 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.451 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.451 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.451 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.451 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.451 | |
| 5a3c | NAD | SIR2 family protein | / | 0.451 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.450 | |
| 2voj | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.450 | |
| 3bmo | NAP | Pteridine reductase | / | 0.450 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.450 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.450 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.450 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.450 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.449 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.449 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.449 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.449 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.449 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.448 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.448 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.448 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.448 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.448 | |
| 5ez7 | FAD | Probable FAD-dependent oxidoreductase PA4991 | / | 0.448 | |
| 1hku | NAD | C-terminal-binding protein 1 | 1.1.1 | 0.447 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.447 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.447 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.447 | |
| 4irn | FAD | AnaB | / | 0.447 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.447 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.447 | |
| 1bdm | NAX | Malate dehydrogenase | / | 0.446 | |
| 1h7w | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.446 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.446 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.446 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.446 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.446 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.446 | |
| 2ztu | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.446 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.446 | |
| 3id8 | MRK | Glucokinase | 2.7.1.2 | 0.446 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.446 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.446 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.446 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.446 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.446 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 1npt | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.445 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.445 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.445 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.445 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2pa3 | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.445 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.445 | |
| 4y8v | ADP | Acyl-CoA synthetase (NDP forming) | / | 0.445 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.445 | |
| 1b14 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.444 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.444 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.444 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.444 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.444 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.444 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.444 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.444 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.444 | |
| 4ap1 | FAD | Steroid monooxygenase | / | 0.444 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.444 | |
| 4rls | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.444 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.444 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.444 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1nqo | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 1w73 | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.443 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.443 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.443 | |
| 3utg | FDA | UDP-galactopyranose mutase | / | 0.443 | |
| 3zuy | TCH | Transporter | / | 0.443 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.443 | |
| 4cr8 | NAD | N-acylmannosamine 1-dehydrogenase | 1.1.1.233 | 0.443 | |
| 4hai | I23 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.443 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.443 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.442 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.442 | |
| 1u8f | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.442 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.442 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.442 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.442 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2qn3 | F55 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.442 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.442 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.442 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.442 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 3lu8 | IQX | Serum albumin | / | 0.442 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.442 | |
| 4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.442 | |
| 4l9k | EHF | Serum albumin | / | 0.442 | |
| 4ynt | FDA | Glucose oxidase, putative | / | 0.442 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.441 | |
| 2e20 | B4P | Propionate kinase | / | 0.441 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.441 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.441 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.441 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3gnv | XNZ | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.441 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.441 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.441 | |
| 4jc5 | 1K5 | Stimulator of interferon genes protein | / | 0.441 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.441 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.441 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.441 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.441 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.440 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.440 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.440 | |
| 1tj2 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.440 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.440 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.440 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.440 | |
| 3e8x | NAP | BH1520 protein | / | 0.440 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.440 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4mcb | 21W | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.440 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.440 |