sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2euh | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.9 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2euh | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.9 | 1.000 | |
| 2qe0 | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.9 | 0.656 | |
| 2esd | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.9 | 0.623 | |
| 3rhh | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.581 | |
| 1qi1 | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.9 | 0.572 | |
| 4nmk | NAP | Aldehyde dehydrogenase | / | 0.535 | |
| 4zvy | NAD | Alpha-aminoadipic semialdehyde dehydrogenase | 1.2.1.31 | 0.526 | |
| 4zuk | NAD | Alpha-aminoadipic semialdehyde dehydrogenase | 1.2.1.31 | 0.521 | |
| 3b4w | NAD | Aldehyde dehydrogenase family protein | / | 0.509 | |
| 4l8u | 9AZ | Serum albumin | / | 0.503 | |
| 1bpw | NAD | Betaine aldehyde dehydrogenase | 1.2.1.8 | 0.498 | |
| 3rhd | NAP | Lactaldehyde dehydrogenase | 1.2.1.22 | 0.497 | |
| 2xdr | NDP | NAD/NADP-dependent betaine aldehyde dehydrogenase | / | 0.494 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.492 | |
| 1uxn | NAP | NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.491 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.489 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.488 | |
| 1uxt | NAD | NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.487 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.487 | |
| 2o2q | NAP | Cytosolic 10-formyltetrahydrofolate dehydrogenase | 1.5.1.6 | 0.487 | |
| 4i3v | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.486 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.485 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.483 | |
| 3gob | HXX | DdmC | / | 0.482 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.481 | |
| 3zqa | NDP | NAD/NADP-dependent betaine aldehyde dehydrogenase | / | 0.479 | |
| 4neu | Q1A | Receptor-interacting serine/threonine-protein kinase 1 | 2.7.11.1 | 0.479 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.477 | |
| 2wme | NAP | NAD/NADP-dependent betaine aldehyde dehydrogenase | / | 0.476 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.476 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.474 | |
| 4fr8 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.474 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.473 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.473 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.472 | |
| 3rho | NAP | Cytosolic 10-formyltetrahydrofolate dehydrogenase | 1.5.1.6 | 0.472 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.471 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.471 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.471 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.470 | |
| 4b4o | NDP | Epimerase family protein SDR39U1 | / | 0.469 | |
| 2gtk | 208 | Peroxisome proliferator-activated receptor gamma | / | 0.468 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.468 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.468 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.467 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.467 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.466 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.466 | |
| 3cop | ADP | Glycogen synthase | 2.4.1.21 | 0.466 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.465 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.465 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 2wmq | ZYQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.464 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.464 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.464 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.464 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.463 | |
| 1jut | LYD | Thymidylate synthase | / | 0.463 | |
| 2w8r | ADP | Succinate-semialdehyde dehydrogenase, mitochondrial | 1.2.1.24 | 0.463 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.462 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.462 | |
| 2vht | ATP | NTPase P4 | / | 0.462 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.462 | |
| 4g16 | 0VM | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.462 | |
| 4ydu | ADP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.462 | |
| 1eyy | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.461 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 2p15 | EZT | Estrogen receptor | / | 0.461 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.461 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.460 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 3e7i | B2 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.460 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.460 | |
| 4xiv | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.460 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.459 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.459 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.459 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.459 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.459 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 2wpx | ACO | Orf14 | / | 0.458 | |
| 3o15 | 3NM | Thiamine-phosphate synthase | / | 0.458 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.458 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.458 | |
| 4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.458 | |
| 1i2l | DCS | Aminodeoxychorismate lyase | 4.1.3.38 | 0.457 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.457 | |
| 2j07 | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.457 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 4fic | 0UL | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.457 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.457 | |
| 4v12 | POG | MaoC like domain protein | / | 0.457 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.456 | |
| 1mei | MOA | Inosine-5'-monophosphate dehydrogenase | / | 0.456 | |
| 1qvr | ANP | Chaperone protein ClpB | / | 0.456 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.456 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.456 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.456 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.456 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.456 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.455 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.455 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.455 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.455 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.455 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.455 | |
| 5a3b | APR | SIR2 family protein | / | 0.455 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.454 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.454 | |
| 1tw4 | CHD | Fatty acid-binding protein, liver | / | 0.454 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 2bxi | AZQ | Serum albumin | / | 0.454 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2x0e | TYD | WsaF | / | 0.454 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.454 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 3haz | NAD | Bifunctional protein PutA | / | 0.454 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.454 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.453 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.453 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.453 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3ncg | BK1 | Calmodulin-domain protein kinase 1, putative | / | 0.453 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 3umv | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.453 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.453 | |
| 5fkl | TDC | Tetracycline repressor protein class D | / | 0.453 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.452 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.452 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 2qoc | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 2xvq | 9DS | Serum albumin | / | 0.452 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.452 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.452 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3eql | MXP | DNA-directed RNA polymerase subunit beta | / | 0.452 | |
| 3eql | MXP | DNA-directed RNA polymerase subunit beta' | / | 0.452 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.452 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.452 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.452 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.452 | |
| 4j4b | NAI | Uncharacterized protein | / | 0.452 | |
| 4otw | DB8 | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.452 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1okz | UCN | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.451 | |
| 1pag | FMP | Antiviral protein I | 3.2.2.22 | 0.451 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.451 | |
| 1wuu | ANP | Galactokinase | 2.7.1.6 | 0.451 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 2w4i | VGA | Glutamate racemase | / | 0.451 | |
| 3eem | 53V | Uncharacterized protein | / | 0.451 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.451 | |
| 3mte | SAM | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.451 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.451 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.451 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.451 | |
| 5a3c | NAD | SIR2 family protein | / | 0.451 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.451 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.451 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.450 | |
| 1jx0 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.450 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 1uum | AFI | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.450 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.450 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.450 | |
| 2izs | BRQ | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.450 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.450 | |
| 2ywv | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | / | 0.450 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.450 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.450 | |
| 3mfr | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.450 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.450 | |
| 3zuy | TCH | Transporter | / | 0.450 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.450 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.450 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.450 | |
| 5d3f | FSC | 14-3-3 protein zeta/delta | / | 0.450 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.449 | |
| 1khr | VIR | Streptogramin A acetyltransferase | 2.3.1 | 0.449 | |
| 1s3z | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.449 | |
| 2cd8 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.449 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.449 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.449 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 4bdh | WVI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.449 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 4zm3 | PLP | Aminotransferase | / | 0.449 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1q3w | ATU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.448 | |
| 2gek | GDP | Phosphatidyl-myo-inositol mannosyltransferase | 2.4.1.57 | 0.448 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.448 | |
| 2onm | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.448 | |
| 2oor | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.448 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.448 | |
| 3cgo | JNO | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.448 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.448 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.448 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.448 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.448 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.448 | |
| 3vgl | ANP | Glucokinase | / | 0.448 | |
| 3zsi | 52P | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 4aic | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.448 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.448 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4feh | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.448 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.448 | |
| 4gu9 | 4GU | Focal adhesion kinase 1 | 2.7.10.2 | 0.448 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.448 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 1i3m | UD1 | UDP-glucose 4-epimerase | / | 0.447 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 1sqv | UHD | Cytochrome b | / | 0.447 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.447 | |
| 2ejz | SAH | Diphthine synthase | / | 0.447 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.447 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.447 | |
| 2wle | COA | Polysialic acid O-acetyltransferase | / | 0.447 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.447 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.447 | |
| 3ac3 | KSH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.447 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.447 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.447 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 3m8p | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.447 | |
| 3pt6 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.447 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.447 | |
| 4cs0 | ACO | PanD regulatory factor | / | 0.447 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.447 | |
| 4i0r | 1B4 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.447 | |
| 4ihi | NAD | Probable pyrroline-5-carboxylate dehydrogenase RocA | / | 0.447 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 4pd6 | URI | Nucleoside permease | / | 0.447 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.446 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.446 | |
| 1l4g | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.446 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.446 | |
| 2bxo | OPB | Serum albumin | / | 0.446 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.446 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.446 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.446 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.446 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.446 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.446 | |
| 3e6o | A55 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.446 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.446 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.446 | |
| 4bva | T3 | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.446 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.446 | |
| 4u2l | SFD | Cholesterol oxidase | 1.1.3.6 | 0.446 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 5kgj | ACO | Predicted acetyltransferase | / | 0.446 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.445 | |
| 1bi9 | NAD | Retinal dehydrogenase 2 | / | 0.445 | |
| 1ep4 | S11 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 1qcf | PP1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.445 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.445 | |
| 1zz2 | B11 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 2hen | ADP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.445 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.445 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 3iw7 | IPK | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3lu6 | IMX | Serum albumin | / | 0.445 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.445 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4eer | FMN | Phototropin-2 | 2.7.11.1 | 0.445 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.445 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.445 | |
| 5kje | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 4k5y | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.445 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.444 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.444 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.444 | |
| 2bfy | H1N | Aurora kinase B-A | 2.7.11.1 | 0.444 | |
| 2czf | XMP | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.444 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.444 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.444 | |
| 3ras | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.444 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.444 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.444 | |
| 3vs3 | VSE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.444 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.444 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.444 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.444 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.444 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.443 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.443 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.443 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.443 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.443 | |
| 2uzf | CAA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.443 | |
| 2wmw | ZYW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2wti | WTI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.443 | |
| 3cjf | SAV | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.443 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.443 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.443 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.443 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.443 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.443 | |
| 4iah | 1DX | Alr2278 protein | / | 0.443 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.443 | |
| 4jxr | ACO | Acetyltransferase | / | 0.443 | |
| 4qmw | KS1 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.443 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.443 | |
| 5dr9 | SKE | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.442 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.442 | |
| 1wzi | NDP | Malate dehydrogenase | / | 0.442 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2eq7 | NAD | Dihydrolipoyl dehydrogenase | / | 0.442 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2imp | NAI | Lactaldehyde dehydrogenase | 1.2.1.22 | 0.442 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.442 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.442 | |
| 3owj | 1EL | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3tdl | 11D | Serum albumin | / | 0.442 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.442 | |
| 4fob | 0US | ALK tyrosine kinase receptor | 2.7.10.1 | 0.442 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4kgm | ATP | Uncharacterized protein | / | 0.442 | |
| 4uga | Q05 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.442 | |
| 4xr9 | NAD | CalS8 | / | 0.442 | |
| 4xxg | FAD | Cholesterol oxidase | 1.1.3.6 | 0.442 | |
| 5bsf | NAD | Pyrroline-5-carboxylate reductase | / | 0.442 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.441 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 2bxf | DZP | Serum albumin | / | 0.441 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.441 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.441 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.441 | |
| 2pzi | AXX | Serine/threonine-protein kinase PknG | 2.7.11.1 | 0.441 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.441 | |
| 2yix | YIX | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.441 | |
| 3meg | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.441 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.441 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.441 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.441 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.441 | |
| 4e2b | FMN | Dehydrogenase | / | 0.441 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.441 | |
| 4jlo | ADP | Adenylate kinase | / | 0.441 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.441 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.441 | |
| 4wq5 | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.441 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.441 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.441 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1zdw | FLV | Prenyltransferase | / | 0.440 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.440 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 2c3i | IYZ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 2dt5 | NAD | Redox-sensing transcriptional repressor Rex | / | 0.440 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.440 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.440 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2p54 | 735 | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
| 2pun | ACP | Methylthioribose kinase | 2.7.1.100 | 0.440 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.440 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.440 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.440 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.440 | |
| 2zm1 | KSF | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.440 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.440 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.440 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.440 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.440 | |
| 3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.440 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.440 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 4mgi | CMP | Rap guanine nucleotide exchange factor 4 | / | 0.440 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.440 | |
| 4ztv | TA7 | Anthranilate phosphoribosyltransferase | / | 0.440 | |
| 5auu | LU2 | Death-associated protein kinase 1 | 2.7.11.1 | 0.440 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.440 |