sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1n5v | NOM | ActVA 6 protein |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1n5v | NOM | ActVA 6 protein | / | 1.000 | |
| 1fml | RTL | Retinol dehydratase | / | 0.528 | |
| 1cq8 | PY6 | Aspartate aminotransferase | 2.6.1.1 | 0.518 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.514 | |
| 1n5q | TNC | ActVA 6 protein | / | 0.509 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.508 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.503 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.502 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.502 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.498 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.496 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.496 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.496 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.494 | |
| 1r2j | FAD | FkbI | / | 0.493 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.492 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.490 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.489 | |
| 1cq7 | PY5 | Aspartate aminotransferase | 2.6.1.1 | 0.487 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.487 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.487 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.487 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.487 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.487 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.485 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.481 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.481 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.480 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.480 | |
| 1u0w | STL | Chalcone synthase 2 | 2.3.1.74 | 0.480 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.479 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.478 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.477 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.477 | |
| 1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.476 | |
| 2d3a | ADP | Glutamine synthetase root isozyme 3 | 6.3.1.2 | 0.476 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.476 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.475 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.475 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.475 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.474 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.474 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.474 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.474 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.473 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.473 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.473 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.472 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.472 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.471 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 2ejz | SAH | Diphthine synthase | / | 0.471 | |
| 2qw0 | 34Z | 4-chlorobenzoyl CoA ligase | / | 0.471 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.471 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.470 | |
| 1syn | F89 | Thymidylate synthase | / | 0.470 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.470 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.470 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.470 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.470 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.470 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.469 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.469 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2acw | UPG | Glycosyltransferase | / | 0.468 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.468 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.468 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.468 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.468 | |
| 3imx | B84 | Glucokinase | 2.7.1.2 | 0.467 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.467 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.467 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.466 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.466 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.466 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.466 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.466 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.465 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.465 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.465 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.464 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.464 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.464 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.464 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.464 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.464 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.463 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.463 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.463 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.463 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.463 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.463 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.463 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.463 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.463 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.463 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.462 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.462 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.462 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.462 | |
| 4l8u | 9AZ | Serum albumin | / | 0.462 | |
| 1c7o | PPG | Hemolysin | / | 0.461 | |
| 1ivs | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.461 | |
| 2kce | D16 | Thymidylate synthase | / | 0.461 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.461 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.461 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.461 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.461 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.461 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.461 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.460 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.460 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.460 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.460 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.460 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.460 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.460 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.459 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.459 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.459 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.459 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.459 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 4dan | 2FA | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.459 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.459 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.459 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 1uhj | CZB | Aequorin-2 | / | 0.458 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.458 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.458 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.458 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.458 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.458 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.458 | |
| 4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.458 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.457 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.457 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.457 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.457 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.457 | |
| 4k39 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.457 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.457 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.456 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.456 | |
| 2qc8 | ADP | Glutamine synthetase | 6.3.1.2 | 0.456 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.456 | |
| 3uk6 | ADP | RuvB-like 2 | 3.6.4.12 | 0.456 | |
| 4biw | ANP | Sensor histidine kinase CpxA | / | 0.456 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.455 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.455 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.455 | |
| 2jiz | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.455 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.455 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.455 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.454 | |
| 1jf2 | CZH | Obelin | / | 0.454 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.454 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1rq1 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.454 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.454 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.454 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.454 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.454 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4wso | NAD | Probable nicotinate-nucleotide adenylyltransferase | / | 0.454 | |
| 4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.454 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.453 | |
| 2re8 | GSU | Glutamine--tRNA ligase | 6.1.1.18 | 0.453 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 3arv | SAU | Chitinase A | / | 0.453 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3eku | CY9 | Actin-5C | / | 0.453 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.453 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.453 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.453 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.453 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.453 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.453 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.452 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.452 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.452 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.452 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.452 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.452 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.452 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.452 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.452 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.452 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.452 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 4itm | ATP | Tetraacyldisaccharide 4'-kinase | / | 0.452 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.452 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.451 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.451 | |
| 1el4 | CTZ | Obelin | / | 0.451 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.451 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.451 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.451 | |
| 3jzf | JZK | Biotin carboxylase | 6.3.4.14 | 0.451 | |
| 3nz2 | ACO | Hexapeptide-repeat containing-acetyltransferase | / | 0.451 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.451 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.451 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.451 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.450 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.450 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.450 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.450 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 | 0.450 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.450 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.450 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.450 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.450 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.450 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.450 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.450 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1odj | GMP | Purine nucleoside phosphorylase | / | 0.449 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.449 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.449 | |
| 2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.449 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.449 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 3b9l | AZZ | Serum albumin | / | 0.449 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.449 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.449 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3uko | NAD | Alcohol dehydrogenase class-3 | / | 0.449 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.449 | |
| 4ma6 | 28E | Ara h 8 allergen | / | 0.449 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.449 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.449 | |
| 5cho | FAD | Flavin reductase | / | 0.449 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 1nm5 | NAP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.448 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.448 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.448 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.448 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3ahi | HTL | Probable phosphoketolase | / | 0.448 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.448 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.447 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.447 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.447 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.447 | |
| 1xh7 | R96 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.447 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.447 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.447 | |
| 2pda | TPP | Pyruvate synthase | / | 0.447 | |
| 3cgy | RDC | Virulence sensor histidine kinase PhoQ | 2.7.13.3 | 0.447 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.447 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.447 | |
| 3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.447 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.447 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4lwa | Q13 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.447 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.446 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 1s36 | CEI | Obelin | / | 0.446 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.446 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.446 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 2vz0 | D64 | Pteridine reductase | / | 0.446 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.446 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.446 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.446 | |
| 4m2b | UPG | UDP-glucose pyrophosphorylase | / | 0.446 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.446 | |
| 1lgt | BP3 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.445 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.445 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.445 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.445 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.445 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.445 | |
| 3mla | JJZ | Probable nicotinate-nucleotide adenylyltransferase | / | 0.445 | |
| 3rgz | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.445 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.445 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.445 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.445 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.445 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.445 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 1maq | PGU | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.444 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.444 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.444 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.444 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.444 | |
| 3clx | X22 | E3 ubiquitin-protein ligase XIAP | 6.3.2 | 0.444 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 3gob | HXX | DdmC | / | 0.444 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.444 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4bmo | FMN | Protein NrdI | / | 0.444 | |
| 4h6p | FMN | Chromate reductase | / | 0.444 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.444 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.444 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.443 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.443 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.443 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.443 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.443 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.443 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.443 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3uf6 | COD | Lmo1369 protein | / | 0.443 | |
| 4e2d | FMN | Dehydrogenase | / | 0.443 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.443 | |
| 1g6o | ADP | Cag alpha | / | 0.442 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.442 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.442 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.442 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.442 | |
| 2eix | FAD | NADH-cytochrome b5 reductase | / | 0.442 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.442 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.442 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.442 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.442 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 4guu | FA9 | Lysine-specific histone demethylase 1B | 1 | 0.442 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.442 | |
| 4obw | SAM | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | / | 0.442 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.442 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.442 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.441 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.441 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2g1a | 5HG | Class B acid phosphatase | 3.1.3.2 | 0.441 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.441 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.441 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.441 | |
| 3zhu | TD8 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.441 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4iah | 1DX | Alr2278 protein | / | 0.441 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.441 | |
| 4y9r | FAD | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.441 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.440 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.440 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.440 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.440 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.440 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.440 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.440 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3myt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.440 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3zhv | TDW | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.440 | |
| 4a6e | ASE | Acetylserotonin O-methyltransferase | 2.1.1.4 | 0.440 | |
| 4bqh | 9VU | UDP-N-acetylglucosamine pyrophosphorylase, putative | / | 0.440 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.440 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.440 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.440 | |
| 4qii | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.440 | |
| 4r7u | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.440 | |
| 4xwt | U5P | Ribonuclease J | / | 0.440 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.440 |