Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.770 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.694 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.680 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.641 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.638 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.628 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.623 | |
| 3qly | 55V | Uncharacterized protein | / | 0.622 | |
| 3cse | N22 | Uncharacterized protein | / | 0.618 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.618 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.617 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.615 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.614 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.612 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.610 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.601 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.600 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.600 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.598 | |
| 3eek | 53S | Uncharacterized protein | / | 0.598 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.597 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.596 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.594 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.593 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.588 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.586 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.586 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.583 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.580 | |
| 3eej | 53R | Uncharacterized protein | / | 0.577 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.575 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.574 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.574 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.571 | |
| 3eem | 53V | Uncharacterized protein | / | 0.567 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.566 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.563 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.562 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.561 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.561 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.560 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.560 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.558 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.557 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.557 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.556 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.555 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.554 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.553 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.553 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.553 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.552 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.552 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.547 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.546 | |
| 3eel | 53T | Uncharacterized protein | / | 0.545 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.545 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.543 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.540 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.536 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.536 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.534 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.533 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.533 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.533 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.530 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.523 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.523 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.522 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.520 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.520 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.520 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.519 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.519 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.518 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.516 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.515 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.513 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.513 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.511 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.511 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.509 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.507 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.505 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.495 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.495 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.494 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.494 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.492 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.492 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.492 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.491 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 1dre | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.490 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.490 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.488 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.487 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.485 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.485 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.484 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.483 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.482 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.482 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.482 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.481 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.481 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.481 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 2jfa | RAL | Estrogen receptor | / | 0.479 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.479 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.479 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.479 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.478 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.478 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.477 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.477 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.477 | |
| 4o28 | 1QS | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.477 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.476 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.476 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.475 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.475 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.474 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.474 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4m7v | RAR | Dihydrofolate reductase | / | 0.474 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.474 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 2jiz | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.473 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.473 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.473 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.473 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.473 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.473 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.472 | |
| 2fsz | OHT | Estrogen receptor beta | / | 0.472 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.472 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.472 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.472 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.472 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.471 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.471 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.471 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.471 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.471 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.469 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.469 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.469 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.469 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.468 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3ey9 | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.468 | |
| 3qyo | Q24 | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.468 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.468 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.467 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.467 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.467 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.467 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.467 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.467 | |
| 4v12 | POG | MaoC like domain protein | / | 0.467 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.466 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.466 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.466 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.466 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.465 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.465 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.464 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.464 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.464 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.464 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.464 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.463 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.463 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.463 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.463 | |
| 4m6p | 20R | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.463 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.463 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.463 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.462 | |
| 2bj4 | OHT | Estrogen receptor | / | 0.462 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.462 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.462 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.462 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.462 | |
| 4lb2 | DM5 | Serum albumin | / | 0.462 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.461 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.461 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.461 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.461 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.461 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.461 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.461 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.460 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.460 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.460 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.460 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.460 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.460 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.460 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.460 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.460 | |
| 4jnm | 1LJ | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.460 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.459 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.459 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.459 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 4bbh | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.459 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 4qjc | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.458 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2d0k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.458 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.458 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.458 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.458 | |
| 3b9l | AZZ | Serum albumin | / | 0.458 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 4b10 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.458 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.458 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.458 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.458 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.458 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.457 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.457 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.457 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2q70 | DC8 | Estrogen receptor | / | 0.457 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.457 | |
| 3g8e | IS1 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.457 | |
| 3nef | PYV | Abscisic acid receptor PYL1 | / | 0.457 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.457 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.457 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.457 | |
| 4o95 | 245 | Cytokinin dehydrogenase 4 | / | 0.457 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.456 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.456 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2wpx | ACO | Orf14 | / | 0.456 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.456 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.456 | |
| 4jr5 | 1LS | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.456 | |
| 4kfn | 1QR | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.456 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.455 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 1ysx | 4EB | Serum albumin | / | 0.455 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.455 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.454 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.454 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 2b1z | 17M | Estrogen receptor | / | 0.454 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.454 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.454 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.454 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4u9v | ACO | N-alpha-acetyltransferase 40 | 2.3.1 | 0.454 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.454 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1yin | CM3 | Estrogen receptor | / | 0.453 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.453 | |
| 2ync | YNC | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.453 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.453 | |
| 4lvg | 20O | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.453 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.453 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1rh3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.452 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.452 | |
| 2p15 | EZT | Estrogen receptor | / | 0.452 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.452 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.452 | |
| 3bej | MUF | Bile acid receptor | / | 0.452 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.452 | |
| 4jnc | 1LF | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.452 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.452 | |
| 4p6w | MOF | Glucocorticoid receptor | / | 0.452 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1fml | RTL | Retinol dehydratase | / | 0.451 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.451 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.451 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.451 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.451 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.451 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3aba | FLI | Cytochrome P450 | / | 0.451 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.451 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.451 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.451 | |
| 3wbb | NAP | Meso-diaminopimelate D-dehydrogenase | / | 0.451 | |
| 3zqt | TES | Androgen receptor | / | 0.451 | |
| 4c68 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.451 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.451 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.451 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.450 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.450 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.450 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.450 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.450 | |
| 1rt5 | UC2 | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1xpc | AIT | Estrogen receptor | / | 0.450 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 2zce | PYL | Pyrrolysine--tRNA ligase | / | 0.450 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.450 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.450 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.450 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1xp9 | AIJ | Estrogen receptor | / | 0.449 | |
| 3m8q | DJZ | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.449 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.449 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 4juc | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.449 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.448 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.448 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.448 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.448 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.448 | |
| 2xvw | 9NR | Serum albumin | / | 0.448 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.448 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.448 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.448 | |
| 3lnb | COA | N-acetyltransferase family protein | / | 0.448 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.448 | |
| 3tdl | 11D | Serum albumin | / | 0.448 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 4c2z | MYA | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.448 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.448 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.448 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.448 | |
| 1bq1 | CB3 | Thymidylate synthase | / | 0.447 | |
| 1c1b | GCA | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.447 | |
| 1xds | DRA | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.447 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.447 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.447 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.446 | |
| 1osv | CHC | Bile acid receptor | / | 0.446 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.446 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.446 | |
| 3dho | B2M | Streptogramin A acetyltransferase | 2.3.1 | 0.446 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.446 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.446 | |
| 4kfo | 1QS | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.446 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.446 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.446 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.445 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.445 | |
| 1lco | PPY | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.445 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1vzd | CB3 | Thymidylate synthase | / | 0.445 | |
| 2bxq | IMN | Serum albumin | / | 0.445 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.445 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.445 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.445 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.445 | |
| 4boe | CLR | Japanin | / | 0.445 | |
| 4l9k | EHF | Serum albumin | / | 0.445 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.445 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.445 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.444 | |
| 1x7j | GEN | Estrogen receptor beta | / | 0.444 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.444 | |
| 2cd8 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.444 | |
| 2jf9 | OHT | Estrogen receptor | / | 0.444 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.444 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.444 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.444 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.444 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.444 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.444 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1jut | LYD | Thymidylate synthase | / | 0.443 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 1yim | CM4 | Estrogen receptor | / | 0.443 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.443 | |
| 3bgr | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.443 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3lu8 | IQX | Serum albumin | / | 0.443 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.443 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.443 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.443 | |
| 3zux | TCH | Transporter | / | 0.443 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.443 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 4lva | 20M | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.443 | |
| 4mv3 | ACP | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.443 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.443 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1rt4 | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.442 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 1sr7 | MOF | Progesterone receptor | / | 0.442 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2ban | 357 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2qe4 | JJ3 | Estrogen receptor | / | 0.442 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.442 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3q95 | ESL | Estrogen receptor | / | 0.442 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.442 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4l9q | 9TP | Serum albumin | / | 0.442 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 1jra | FAD | FAD-linked sulfhydryl oxidase ERV2 | 1.8.3.2 | 0.441 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 1p93 | DEX | Glucocorticoid receptor | / | 0.441 | |
| 1rev | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1rt7 | UC4 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.441 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.441 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 2q7g | CCL | Pyrrolysine--tRNA ligase | / | 0.441 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 3q9z | TXQ | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.441 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.441 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.441 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.441 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.441 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.441 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.441 | |
| 4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4jvm | XDI | Estrogen sulfotransferase | 2.8.2.4 | 0.441 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.441 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.441 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.440 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.440 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.440 | |
| 1tkz | H16 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 1tl1 | H18 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 1tl3 | H20 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 1w1r | ZEA | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.440 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2wpw | ACO | Orf14 | / | 0.440 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.440 | |
| 3dpd | 41A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.440 | |
| 3up3 | XCA | aceDAF-12 | / | 0.440 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.440 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.440 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.440 | |
| 4qa1 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.440 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.440 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 |