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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1aoeGW3Dihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1aoeGW3Dihydrofolate reductase1.5.1.31.000
1m7aMQUDihydrofolate reductase1.5.1.30.770
1m78CLZDihydrofolate reductase1.5.1.30.694
3qlrQLRDihydrofolate reductase1.5.1.30.680
3qls55VDihydrofolate reductase1.5.1.30.641
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.638
1ia1TQ3Dihydrofolate reductase1.5.1.30.628
3qlwN22Dihydrofolate reductase1.5.1.30.623
3qly55VUncharacterized protein/0.622
3cseN22Uncharacterized protein/0.618
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.618
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.617
1ia2TQ4Dihydrofolate reductase1.5.1.30.615
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.614
4h9614QDihydrofolate reductase1.5.1.30.612
2fziDH3Dihydrofolate reductase1.5.1.30.610
3qlxQLRUncharacterized protein/0.601
1dg5TOPDihydrofolate reductase1.5.1.30.600
4h9753SDihydrofolate reductase1.5.1.30.600
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.598
3eek53SUncharacterized protein/0.598
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.597
4ixeIXEDihydrofolate reductase1.5.1.30.596
1cd2FOLDihydrofolate reductase1.5.1.30.594
2fzhDH1Dihydrofolate reductase1.5.1.30.593
1m79MQ1Dihydrofolate reductase1.5.1.30.588
1rx3MTXDihydrofolate reductase1.5.1.30.586
4ixfIXFDihydrofolate reductase1.5.1.30.586
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.583
1vj3TABDihydrofolate reductase1.5.1.30.580
3eej53RUncharacterized protein/0.577
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.575
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.574
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.574
3qlzQLZUncharacterized protein/0.571
3eem53VUncharacterized protein/0.567
1ly3COGDihydrofolate reductase1.5.1.30.566
4ixgIXGDihydrofolate reductase1.5.1.30.563
1klkPMDDihydrofolate reductase1.5.1.30.562
3cd2MTXDihydrofolate reductase1.5.1.30.561
3td8D2RDihydrofolate reductase1.5.1.30.561
1e26GPBDihydrofolate reductase1.5.1.30.560
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.560
1dajMOTDihydrofolate reductase1.5.1.30.558
4g8zTOPDihydrofolate reductase1.5.1.30.557
4h9506UDihydrofolate reductase1.5.1.30.557
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.556
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.555
2zzaFOLDihydrofolate reductase/0.554
3frfXCFDihydrofolate reductase1.5.1.30.553
4h9814QUncharacterized protein/0.553
4xe606UDihydrofolate reductase1.5.1.30.553
3dfrMTXDihydrofolate reductase1.5.1.30.552
4nx6FOLDihydrofolate reductase1.5.1.30.552
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.547
1hfqMOTDihydrofolate reductase1.5.1.30.546
3eel53TUncharacterized protein/0.545
7dfrFOLDihydrofolate reductase1.5.1.30.545
1ia4TQ6Dihydrofolate reductase1.5.1.30.544
3tq9MTXDihydrofolate reductase/0.543
3ix9MTXDihydrofolate reductase1.5.1.30.540
2cd2FOLDihydrofolate reductase1.5.1.30.537
4x5gFOLDihydrofolate reductase1.5.1.30.537
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.536
3ia4MTXDihydrofolate reductase/0.536
2w3vTOPDihydrofolate reductase/0.534
1ddsMTXDihydrofolate reductase1.5.1.30.533
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.533
4dphP65Bifunctional dihydrofolate reductase-thymidylate synthase/0.533
4m6l21VDihydrofolate reductase1.5.1.30.532
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.530
4nx7FOLDihydrofolate reductase1.5.1.30.530
3sgy06WDihydrofolate reductase1.5.1.30.527
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.523
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.523
4fgh0U6Dihydrofolate reductase1.5.1.30.523
1dg7WRBDihydrofolate reductase1.5.1.30.522
3jwcEKBDihydrofolate reductase/0.522
1ia3TQ5Dihydrofolate reductase1.5.1.30.521
4m2xTMQDihydrofolate reductase1.5.1.30.521
3jw5TOPDihydrofolate reductase/0.520
3sa16DRDihydrofolate reductase/0.520
4cd2FOLDihydrofolate reductase1.5.1.30.520
4p66MTXDihydrofolate reductase/0.520
3jwm5WBDihydrofolate reductase/0.519
3sh25DRDihydrofolate reductase1.5.1.30.519
3ql3FOLDihydrofolate reductase1.5.1.30.518
3tqbFOLDihydrofolate reductase/0.518
3fraI2HDihydrofolate reductase1.5.1.30.517
1bozPRDDihydrofolate reductase1.5.1.30.516
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.516
1re7FOLDihydrofolate reductase1.5.1.30.515
2w3wVG9Dihydrofolate reductase/0.515
2w9gTOPDihydrofolate reductase1.5.1.30.515
4fgg0U5Dihydrofolate reductase1.5.1.30.515
4kjjFOLDihydrofolate reductase1.5.1.30.515
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.513
3dauMTXDihydrofolate reductase1.5.1.30.513
1ddrMTXDihydrofolate reductase1.5.1.30.512
3frdDHFDihydrofolate reductase1.5.1.30.512
1qzfFOLBifunctional dihydrofolate reductase-thymidylate synthase/0.511
3m08RARDihydrofolate reductase1.5.1.30.511
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.511
3vt5YI2Vitamin D3 receptor/0.509
1s3yTQTDihydrofolate reductase1.5.1.30.507
3tq8TOPDihydrofolate reductase/0.507
3srrQ20Dihydrofolate reductase1.5.1.30.506
4kbn25UDihydrofolate reductase1.5.1.30.506
4kd79DRDihydrofolate reductase1.5.1.30.506
4x5fFOLDihydrofolate reductase1.5.1.30.506
1hfpMOTDihydrofolate reductase1.5.1.30.505
3l3rOAGDihydrofolate reductase1.5.1.30.505
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.505
5cccDDFDihydrofolate reductase1.5.1.30.505
3srqQ19Dihydrofolate reductase1.5.1.30.503
1diuBDMDihydrofolate reductase1.5.1.30.502
3oafOAGDihydrofolate reductase1.5.1.30.502
3fy9XCFDihydrofolate reductase1.5.1.30.500
3freTOPDihydrofolate reductase1.5.1.30.499
3fywXCFDihydrofolate reductase1.5.1.30.499
3och2MXDihydrofolate reductase1.5.1.30.499
3fy8XCFDihydrofolate reductase1.5.1.30.498
1df7MTXDihydrofolate reductase1.5.1.30.497
1rx7FOLDihydrofolate reductase1.5.1.30.495
2zbaZBATrichothecene 3-O-acetyltransferase/0.495
3kpzZNEVitamin D3 receptor/0.495
1bk0ACVIsopenicillin N synthase1.21.3.10.494
1draMTXDihydrofolate reductase1.5.1.30.494
1tdrMTXDihydrofolate reductase1.5.1.30.494
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.494
1drbMTXDihydrofolate reductase1.5.1.30.492
2jb4A14Isopenicillin N synthase1.21.3.10.492
2vcmM11Isopenicillin N synthase1.21.3.10.492
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.492
3k47D09Dihydrofolate reductase1.5.1.30.492
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.492
4r20AERCytochrome P450 family 17 polypeptide 2/0.492
1disBDMDihydrofolate reductase1.5.1.30.491
1ek2CDUBifunctional epoxide hydrolase 2/0.491
1ly4COQDihydrofolate reductase1.5.1.30.491
3srwQ27Dihydrofolate reductase1.5.1.30.491
1dreMTXDihydrofolate reductase1.5.1.30.490
2fzjDH3Dihydrofolate reductase1.5.1.30.490
4ia1BIVVitamin D3 receptor A/0.490
4p68MTXDihydrofolate reductase/0.490
2w3aTOPDihydrofolate reductase1.5.1.30.489
2w3mFOLDihydrofolate reductase1.5.1.30.489
3zoiM2WIsopenicillin N synthase1.21.3.10.488
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.487
1hb3SCVIsopenicillin N synthase1.21.3.10.485
2uxoTACHTH-type transcriptional regulator TtgR/0.485
2vbdV10Isopenicillin N synthase1.21.3.10.485
4j6cSTRCytochrome P450 monooxygenase/0.485
3lfcZ86Mitogen-activated protein kinase 14/0.484
1l2jETCEstrogen receptor beta/0.483
1rb3MTXDihydrofolate reductase1.5.1.30.483
4kak06UDihydrofolate reductase1.5.1.30.483
2m56CAMCamphor 5-monooxygenase1.14.15.10.482
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.482
5hi6MTXDihydrofolate reductase/0.482
1kmsLIHDihydrofolate reductase1.5.1.30.481
2qblCAMCamphor 5-monooxygenase1.14.15.10.481
2vn0TDZCytochrome P450 2C8/0.481
2y60M8FIsopenicillin N synthase1.21.3.10.481
3fwgCAMCamphor 5-monooxygenase1.14.15.10.481
3nxrD2DDihydrofolate reductase1.5.1.30.481
2vbpVB1Isopenicillin N synthase1.21.3.10.480
1hb1OCVIsopenicillin N synthase1.21.3.10.479
2jfaRALEstrogen receptor/0.479
2y30SM8Putative repressor SimReg2/0.479
3nxvD2FDihydrofolate reductase1.5.1.30.479
3vt7VDXVitamin D3 receptor/0.479
4ia7BIVVitamin D3 receptor A/0.479
1dz6CAMCamphor 5-monooxygenase1.14.15.10.478
1ie9VDXVitamin D3 receptor/0.478
2iviACWIsopenicillin N synthase1.21.3.10.478
3ghwGHWDihydrofolate reductase1.5.1.30.478
1jolFFODihydrofolate reductase1.5.1.30.477
1uzwCDHIsopenicillin N synthase1.21.3.10.477
2hb7O1CVitamin D3 receptor/0.477
2o4rVD5Vitamin D3 receptor/0.477
4j6dTESCytochrome P450 monooxygenase/0.477
4o281QSNicotinamide phosphoribosyltransferase2.4.2.120.477
1og5SWFCytochrome P450 2C9/0.476
3fwjCAMCamphor 5-monooxygenase1.14.15.10.476
3gyf51PDihydrofolate reductase1.5.1.30.476
3ntz3TZDihydrofolate reductase1.5.1.30.476
1dhjMTXDihydrofolate reductase1.5.1.30.475
1rkhVD2Vitamin D3 receptor/0.475
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.475
2zl9VDAVitamin D3 receptor/0.475
3fyvXCFDihydrofolate reductase1.5.1.30.475
3r336MEDihydrofolate reductase1.5.1.30.475
3s3vTOPDihydrofolate reductase1.5.1.30.475
3sruQ26Dihydrofolate reductase1.5.1.30.475
4g95OAGDihydrofolate reductase1.5.1.30.475
2uxpCLMHTH-type transcriptional regulator TtgR/0.474
3cv9VDXVitamin D3 dihydroxylase/0.474
4ej1FOLDihydrofolate reductase1.5.1.30.474
4m7vRARDihydrofolate reductase/0.474
4rujVDXVitamin D3 receptor A/0.474
1dyrTOPDihydrofolate reductase1.5.1.30.473
2jizANPATP synthase subunit beta, mitochondrial3.6.3.140.473
2zlcVDXVitamin D3 receptor/0.473
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.473
3sai9DRDihydrofolate reductase/0.473
4ele31IDihydrofolate reductase/0.473
4jbtASDCytochrome P450 monooxygenase/0.473
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.472
2fszOHTEstrogen receptor beta/0.472
3drcMTXDihydrofolate reductase1.5.1.30.472
3mdvCL6Cholesterol 24-hydroxylase/0.472
3nxyD2HDihydrofolate reductase1.5.1.30.472
3sa27DRDihydrofolate reductase/0.472
4bb3KKAIsopenicillin N synthase1.21.3.10.472
4ddrMMVDihydrofolate reductase1.5.1.30.472
4enhFVXCholesterol 24-hydroxylase/0.472
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.472
4hni16WCasein kinase I isoform epsilon2.7.11.10.472
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.472
1bzfTMQDihydrofolate reductase1.5.1.30.471
1t88CAMCamphor 5-monooxygenase1.14.15.10.471
1w06W05Isopenicillin N synthase1.21.3.10.471
2feuCAMCamphor 5-monooxygenase1.14.15.10.471
2hb8MVDVitamin D3 receptor/0.471
3l63CAMCamphor 5-monooxygenase1.14.15.10.471
4a9mP9MBromodomain-containing protein 2/0.471
3sqyQ11Dihydrofolate reductase1.5.1.30.470
3srsM23Dihydrofolate reductase1.5.1.30.470
3zkyWT4Isopenicillin N synthase1.21.3.10.470
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.470
4x5iFOLDihydrofolate reductase1.5.1.30.470
4x5jFOLDihydrofolate reductase1.5.1.30.470
1txiTX5Vitamin D3 receptor/0.469
3fwiCAMCamphor 5-monooxygenase1.14.15.10.469
3nxoD2BDihydrofolate reductase1.5.1.30.469
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.469
4kfj1R0Dihydrofolate reductase1.5.1.30.469
4kne1CYDihydrofolate reductase1.5.1.30.469
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.469
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.468
1ohkCOPDihydrofolate reductase1.5.1.30.468
1rx5DDFDihydrofolate reductase1.5.1.30.468
1t86CAMCamphor 5-monooxygenase1.14.15.10.468
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.468
2drcMTXDihydrofolate reductase1.5.1.30.468
3ey9TDPPyruvate dehydrogenase [ubiquinone]1.2.5.10.468
3qyoQ24Dihydrofolate reductase1.5.1.30.468
3vt9YI4Vitamin D3 receptor/0.468
4g1y0VOVitamin D3 receptor A/0.468
1dz4CAMCamphor 5-monooxygenase1.14.15.10.467
1f5fDHTSex hormone-binding globulin/0.467
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
2hamC33Vitamin D3 receptor/0.467
3antS82Bifunctional epoxide hydrolase 23.3.2.100.467
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.467
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
3koo24DBifunctional epoxide hydrolase 23.3.2.100.467
3vt8YI3Vitamin D3 receptor/0.467
4v12POGMaoC like domain protein/0.467
1fm4DXCMajor pollen allergen Bet v 1-L/0.466
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.466
2hasC3OVitamin D3 receptor/0.466
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.466
3wrlCAMCamphor 5-monooxygenase1.14.15.10.466
4g1z0VPVitamin D3 receptor A/0.466
4i1nFOLDihydrofolate reductase1.5.1.30.466
1cjtFOKAdenylate cyclase type 2/0.465
1cjtFOKAdenylate cyclase type 5/0.465
1dr3HBIDihydrofolate reductase1.5.1.30.465
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
1rx2FOLDihydrofolate reductase1.5.1.30.465
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
3wrhCAMCamphor 5-monooxygenase1.14.15.10.465
1fmjRTLRetinol dehydratase/0.464
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.464
2z97CAMCamphor 5-monooxygenase1.14.15.10.464
3a783EVVitamin D3 receptor/0.464
3datMTXDihydrofolate reductase/0.464
3hz137DHeat shock protein HSP 90-alpha/0.464
3nr4PYVAbscisic acid receptor PYL2/0.464
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
1t87CAMCamphor 5-monooxygenase1.14.15.10.463
1tvrTB9Gag-Pol polyprotein2.7.7.490.463
3d80Q22Dihydrofolate reductase1.5.1.30.463
3w0aDS5Vitamin D3 receptor/0.463
4elh53IDihydrofolate reductase/0.463
4ia2BIVVitamin D3 receptor A/0.463
4m6p20RNicotinamide phosphoribosyltransferase2.4.2.120.463
4nieNBHNuclear receptor ROR-gamma/0.463
5k2aZMAAdenosine receptor A2a/0.463
1db1VDXVitamin D3 receptor/0.462
2bj4OHTEstrogen receptor/0.462
2uxhQUEHTH-type transcriptional regulator TtgR/0.462
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.462
4elb34SDihydrofolate reductase/0.462
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.462
4jlj1NMDeoxycytidine kinase2.7.1.740.462
4lb2DM5Serum albumin/0.462
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
1ie8KH1Vitamin D3 receptor/0.461
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.461
3gwfFADCyclohexanone monooxygenase/0.461
3pe6ZYHMonoglyceride lipase/0.461
3w0yDS4Vitamin D3 receptor/0.461
4kebFOLDihydrofolate reductase1.5.1.30.461
4mv1ADPBiotin carboxylase6.3.4.140.461
4q71FADBifunctional protein PutA/0.461
1cjkFOKAdenylate cyclase type 2/0.460
1cjkFOKAdenylate cyclase type 5/0.460
1s0zEB1Vitamin D3 receptor/0.460
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.460
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.460
3ctj320Hepatocyte growth factor receptor2.7.10.10.460
3m7rVDXVitamin D3 receptor/0.460
3vt65YIVitamin D3 receptor/0.460
3w5tLHPVitamin D3 receptor/0.460
4jnm1LJNicotinamide phosphoribosyltransferase2.4.2.120.460
1blzACVIsopenicillin N synthase1.21.3.10.459
1qknRALEstrogen receptor beta/0.459
1rg7MTXDihydrofolate reductase1.5.1.30.459
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
2ph5NADHomospermidine synthase/0.459
2yjxYJXHeat shock protein HSP 90-alpha/0.459
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
3h3sH15Collagen type IV alpha-3-binding protein/0.459
3wrjCAMCamphor 5-monooxygenase1.14.15.10.459
4bbhNHWGlycylpeptide N-tetradecanoyltransferase/0.459
4g1d0VKVitamin D3 receptor A/0.459
4g3rCAMCamphor 5-monooxygenase1.14.15.10.459
4qjcIXEDihydrofolate reductase1.5.1.30.459
1dgfNDPCatalase1.11.1.60.458
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.458
1oc1ASVIsopenicillin N synthase1.21.3.10.458
2d0kFOLDihydrofolate reductase1.5.1.30.458
2e9dB76Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.458
2hc4VDXVitamin D3 receptor A/0.458
2hcdBIVVitamin D3 receptor A/0.458
2hm9TRRDihydrofolate reductase1.5.1.30.458
2w4qCBWProstaglandin reductase 21.3.1.480.458
3b9lAZZSerum albumin/0.458
3rg9WRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.458
4b10NHWGlycylpeptide N-tetradecanoyltransferase/0.458
4elb34RDihydrofolate reductase/0.458
4fhi0S4Vitamin D3 receptor A/0.458
4ia3BIVVitamin D3 receptor A/0.458
4iui1GQEstrogen receptor/0.458
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.458
1culFOKAdenylate cyclase type 2/0.457
1culFOKAdenylate cyclase type 5/0.457
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.457
1rd7FOLDihydrofolate reductase1.5.1.30.457
1rf7DHFDihydrofolate reductase1.5.1.30.457
1t85CAMCamphor 5-monooxygenase1.14.15.10.457
2dhfDZFDihydrofolate reductase1.5.1.30.457
2q70DC8Estrogen receptor/0.457
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.457
3g8eIS1Nicotinamide phosphoribosyltransferase2.4.2.120.457
3nefPYVAbscisic acid receptor PYL1/0.457
3vrtYS2Vitamin D3 receptor/0.457
3vrvYSDVitamin D3 receptor/0.457
4dfrMTXDihydrofolate reductase1.5.1.30.457
4dscA8SAbscisic acid receptor PYL3/0.457
4o95245Cytokinin dehydrogenase 4/0.457
2hw2RFPRifampin ADP-ribosyl transferase/0.456
2jedLG8Protein kinase C theta type2.7.11.130.456
2qboCAMCamphor 5-monooxygenase1.14.15.10.456
2wo7ASVIsopenicillin N synthase1.21.3.10.456
2wpxACOOrf14/0.456
3ns2PYVAbscisic acid receptor PYL2/0.456
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
3vrwYS5Vitamin D3 receptor/0.456
4jr51LSNicotinamide phosphoribosyltransferase2.4.2.120.456
4kfn1QRNicotinamide phosphoribosyltransferase2.4.2.120.456
6cp4CAMCamphor 5-monooxygenase1.14.15.10.456
1jioDEB6-deoxyerythronolide B hydroxylase/0.455
1rx8FOLDihydrofolate reductase1.5.1.30.455
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
1ysx4EBSerum albumin/0.455
2jn3JN3Fatty acid-binding protein, liver/0.455
2wi72KLHeat shock protein HSP 90-alpha/0.455
2zaxCAMCamphor 5-monooxygenase1.14.15.10.455
3csdEMOPutative ketoacyl reductase1.3.10.455
1dhfFOLDihydrofolate reductase1.5.1.30.454
1pq6965Oxysterols receptor LXR-beta/0.454
1rk3VDXVitamin D3 receptor/0.454
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
2b1z17MEstrogen receptor/0.454
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.454
2ze2T27Gag-Pol polyprotein2.7.7.490.454
3hf6LX0Tryptophan 5-hydroxylase 11.14.16.40.454
3wrmCAMCamphor 5-monooxygenase1.14.15.10.454
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4ek1CAMCamphor 5-monooxygenase1.14.15.10.454
4fhbFOLDihydrofolate reductase1.5.1.30.454
4u9vACON-alpha-acetyltransferase 402.3.10.454
5hs1VORLanosterol 14-alpha demethylase/0.454
1cjuFOKAdenylate cyclase type 2/0.453
1cjuFOKAdenylate cyclase type 5/0.453
1hfrMOTDihydrofolate reductase1.5.1.30.453
1mvsDTMDihydrofolate reductase1.5.1.30.453
1qiqACCIsopenicillin N synthase1.21.3.10.453
1yinCM3Estrogen receptor/0.453
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.453
2yncYNCGlycylpeptide N-tetradecanoyltransferase/0.453
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.453
3e5aVX6Aurora kinase A2.7.11.10.453
3vtcTK3Vitamin D3 receptor/0.453
4lvg20ONicotinamide phosphoribosyltransferase2.4.2.120.453
4o761M3Bromodomain-containing protein 4/0.453
1dyiFOLDihydrofolate reductase1.5.1.30.452
1rh3MTXDihydrofolate reductase1.5.1.30.452
1s19MC9Vitamin D3 receptor/0.452
1xddAAYIntegrin alpha-L/0.452
2p15EZTEstrogen receptor/0.452
2w71L23Biotin carboxylase6.3.4.140.452
3atzFMNProstaglandin F2a synthase/0.452
3bejMUFBile acid receptor/0.452
3fwfCAMCamphor 5-monooxygenase1.14.15.10.452
3gi2GHWDihydrofolate reductase1.5.1.30.452
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.452
3w0c6DSVitamin D3 receptor/0.452
4jnc1LFBifunctional epoxide hydrolase 23.1.3.760.452
4nb6444Nuclear receptor ROR-gamma/0.452
4p6wMOFGlucocorticoid receptor/0.452
5k2cZMAAdenosine receptor A2a/0.452
1dyjDDFDihydrofolate reductase1.5.1.30.451
1fmlRTLRetinol dehydratase/0.451
1nbmADPATP synthase subunit beta, mitochondrial3.6.3.140.451
1ohjCOPDihydrofolate reductase1.5.1.30.451
1rkgVD1Vitamin D3 receptor/0.451
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.451
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.451
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.451
2qbnCAMCamphor 5-monooxygenase1.14.15.10.451
3abaFLICytochrome P450/0.451
3njoPYVAbscisic acid receptor PYR1/0.451
3qlhT27Gag-Pol polyprotein2.7.7.490.451
3s79ASDAromatase1.14.14.140.451
3w0jT08Vitamin D3 receptor/0.451
3wbbNAPMeso-diaminopimelate D-dehydrogenase/0.451
3zqtTESAndrogen receptor/0.451
4c68NHWGlycylpeptide N-tetradecanoyltransferase/0.451
4i8vBHFCytochrome P450 1A11.14.14.10.451
4j6bPLOCytochrome P450 monooxygenase/0.451
5irnADPNucleotide binding oligomerization domain containing 2/0.451
1d2sDHTSex hormone-binding globulin/0.450
1dyhDZFDihydrofolate reductase1.5.1.30.450
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
1kl2FONSerine hydroxymethyltransferase/0.450
1nq7ARLNuclear receptor ROR-beta/0.450
1r8qAFBCytohesin-2/0.450
1r8qAFBADP-ribosylation factor 1/0.450
1rt5UC2Gag-Pol polyprotein2.7.7.490.450
1s3uTQDDihydrofolate reductase1.5.1.30.450
1xpcAITEstrogen receptor/0.450
1yrcCAMCamphor 5-monooxygenase1.14.15.10.450
2a1nCAMCamphor 5-monooxygenase1.14.15.10.450
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.450
2zcePYLPyrrolysine--tRNA ligase/0.450
3c15FOKAdenylate cyclase type 2/0.450
3c15FOKAdenylate cyclase type 5/0.450
3i8aN22Dihydrofolate reductase1.5.1.30.450
3p6oETGCamphor 5-monooxygenase1.14.15.10.450
3tmz06XCytochrome P450 2B41.14.14.10.450
4nh82LCHeat shock protein HSP 90-alpha/0.450
3pwhZMAAdenosine receptor A2a/0.450
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1qjfACSIsopenicillin N synthase1.21.3.10.449
1xp9AIJEstrogen receptor/0.449
3m8qDJZGag-Pol polyprotein2.7.7.490.449
3qdd94MHeat shock protein HSP 90-alpha/0.449
3w5rLOAVitamin D3 receptor/0.449
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.449
4jlk1NODeoxycytidine kinase2.7.1.740.449
4jucTPPBenzoylformate decarboxylase4.1.1.70.449
1u72MTXDihydrofolate reductase1.5.1.30.448
2i40BLZCyclin-dependent kinase 22.7.11.220.448
2iyaZIOOleandomycin glycosyltransferase/0.448
2j9gANPBiotin carboxylase6.3.4.140.448
2oaxSNLMineralocorticoid receptor/0.448
2p7zOHTEstrogen-related receptor gamma/0.448
2puiADPMethylthioribose kinase2.7.1.1000.448
2xvw9NRSerum albumin/0.448
2y6fM9FIsopenicillin N synthase1.21.3.10.448
3ezpB3NHistone deacetylase 83.5.1.980.448
3gc9B45Mitogen-activated protein kinase 112.7.11.240.448
3l0lHC3Nuclear receptor ROR-gamma/0.448
3lnbCOAN-acetyltransferase family protein/0.448
3o0iP54Heat shock protein HSP 90-alpha/0.448
3p99LNPLanosterol 14-alpha-demethylase/0.448
3tdl11DSerum albumin/0.448
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
4c2zMYAGlycylpeptide N-tetradecanoyltransferase 1/0.448
4gk2L66Ephrin type-A receptor 32.7.10.10.448
4i13FOLDihydrofolate reductase1.5.1.30.448
4iteTEYVitamin D3 receptor/0.448
4xoqF42Coenzyme F420:L-glutamate ligase/0.448
1bq1CB3Thymidylate synthase/0.447
1c1bGCAGag-Pol polyprotein2.7.7.490.447
1cqp803Integrin alpha-L/0.447
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.447
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2w6qOA5Biotin carboxylase6.3.4.140.447
3eigMTXDihydrofolate reductase1.5.1.30.447
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
4a802ANMajor pollen allergen Bet v 1-A/0.447
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.447
4fhh0U3Vitamin D3 receptor A/0.447
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
1jpaANPEphrin type-B receptor 22.7.10.10.446
1osvCHCBile acid receptor/0.446
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1pd9CO4Dihydrofolate reductase1.5.1.30.446
1rb2FOLDihydrofolate reductase1.5.1.30.446
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.446
3bfb9ODPheromone-binding protein ASP1/0.446
3dhoB2MStreptogramin A acetyltransferase2.3.10.446
4a83DXCMajor pollen allergen Bet v 1-A/0.446
4dvq1CACytochrome P450 11B2, mitochondrial1.14.15.40.446
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.446
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.446
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
4k9yK9YFocal adhesion kinase 12.7.10.20.446
4kfo1QSNicotinamide phosphoribosyltransferase2.4.2.120.446
4mv8ACPBiotin carboxylase6.3.4.140.446
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.446
4wa9AXITyrosine-protein kinase ABL12.7.10.20.446
1bwsNDPGDP-L-fucose synthase/0.445
1dhiMTXDihydrofolate reductase1.5.1.30.445
1kzjCB3Thymidylate synthase/0.445
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.445
1rx6DDFDihydrofolate reductase1.5.1.30.445
1vzdCB3Thymidylate synthase/0.445
2bxqIMNSerum albumin/0.445
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
2pupADPMethylthioribose kinase2.7.1.1000.445
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.445
3lanKBTGag-Pol polyprotein2.7.7.490.445
3nmpPYVAbscisic acid receptor PYL2/0.445
3vt3VDXVitamin D3 receptor/0.445
3w0gW07Vitamin D3 receptor/0.445
4boeCLRJapanin/0.445
4l9kEHFSerum albumin/0.445
4qa0SHHHistone deacetylase 83.5.1.980.445
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.445
1dnpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.444
1x7jGENEstrogen receptor beta/0.444
1x8lOXRRetinol dehydratase/0.444
2cd8PXICytochrome P450 monooxygenase PikC/0.444
2jf9OHTEstrogen receptor/0.444
2npnSAMPutative cobalamin synthesis related protein/0.444
2yk2YJXHeat shock protein HSP 90-alpha/0.444
2ykcYKCHeat shock protein HSP 90-alpha/0.444
2zlaVDBVitamin D3 receptor/0.444
3bfa9ODOdorant binding protein ASP1/0.444
3is9AC7Gag-Pol polyprotein2.7.7.490.444
3nj0PYVAbscisic acid receptor PYL2/0.444
3qj5022Alcohol dehydrogenase class-31.1.1.10.444
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.444
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1jutLYDThymidylate synthase/0.443
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
1yimCM4Estrogen receptor/0.443
3a1l2CCCytochrome P450/0.443
3bgrT27Gag-Pol polyprotein2.7.7.490.443
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.443
3hz142CHeat shock protein HSP 90-alpha/0.443
3i0rRT3Gag-Pol polyprotein2.7.7.490.443
3l8sBFFMitogen-activated protein kinase 14/0.443
3lu8IQXSerum albumin/0.443
3mdmFJZCholesterol 24-hydroxylase/0.443
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.443
3slkNDPPolyketide synthase extender module 2/0.443
3wv9FEGHmd co-occurring protein HcgE/0.443
3zuxTCHTransporter/0.443
4eftEFTHeat shock protein HSP 90-alpha/0.443
4gevCB3Thymidylate synthase/0.443
4kko1REGag-Pol polyprotein2.7.7.490.443
4lva20MNicotinamide phosphoribosyltransferase2.4.2.120.443
4mv3ACPBiotin carboxylase6.3.4.140.443
4r21STRCytochrome P450 family 17 polypeptide 2/0.443
4uyf73BBromodomain-containing protein 2/0.443
1adfTADAlcohol dehydrogenase E chain1.1.1.10.442
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1jomFFODihydrofolate reductase1.5.1.30.442
1rt4UC1Gag-Pol polyprotein2.7.7.490.442
1s9qOHTEstrogen-related receptor gamma/0.442
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.442
1sr7MOFProgesterone receptor/0.442
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
1yrdCAMCamphor 5-monooxygenase1.14.15.10.442
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2ban357Gag-Pol polyprotein2.7.7.490.442
2ewaSB2Mitogen-activated protein kinase 14/0.442
2qe4JJ3Estrogen receptor/0.442
2qk8MTXDihydrofolate reductase/0.442
2ykjYKJHeat shock protein HSP 90-alpha/0.442
3q95ESLEstrogen receptor/0.442
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
4itfTFYVitamin D3 receptor/0.442
4kkyCAMCamphor 5-monooxygenase1.14.15.10.442
4l9q9TPSerum albumin/0.442
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.441
1jraFADFAD-linked sulfhydryl oxidase ERV21.8.3.20.441
1obnASVIsopenicillin N synthase1.21.3.10.441
1ove358Mitogen-activated protein kinase 14/0.441
1p93DEXGlucocorticoid receptor/0.441
1revTB9Gag-Pol polyprotein2.7.7.490.441
1rt7UC4Gag-Pol polyprotein2.7.7.490.441
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.441
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.441
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.441
2po7CHDFerrochelatase, mitochondrial4.99.1.10.441
2q7gCCLPyrrolysine--tRNA ligase/0.441
3c14FOKAdenylate cyclase type 2/0.441
3c14FOKAdenylate cyclase type 5/0.441
3q9zTXQCasein kinase II subunit alpha2.7.11.10.441
3vt45YIVitamin D3 receptor/0.441
3w0iO11Vitamin D3 receptor/0.441
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441
3zc3NAPFerredoxin--NADP reductase1.18.1.20.441
4ap1NAPSteroid monooxygenase/0.441
4e5yNDPGDP-L-fucose synthase1.1.1.2710.441
4ead0NPThymidine phosphorylase2.4.2.40.441
4ejh0QACytochrome P450 2A131.14.14.10.441
4elf35IDihydrofolate reductase/0.441
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4jvmXDIEstrogen sulfotransferase2.8.2.40.441
4l49CAMCamphor 5-monooxygenase1.14.15.10.441
4nc3ERM5-hydroxytryptamine receptor 2B/0.441
3uzaT4GAdenosine receptor A2a/0.441
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
1ju6LYAThymidylate synthase2.1.1.450.440
1m13HYFNuclear receptor subfamily 1 group I member 2/0.440
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1rjkVDZVitamin D3 receptor/0.440
1tkzH16Gag-Pol polyprotein2.7.7.490.440
1tl1H18Gag-Pol polyprotein2.7.7.490.440
1tl3H20Gag-Pol polyprotein2.7.7.490.440
1w1rZEACytokinin dehydrogenase 11.5.99.120.440
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2bf7HBIPteridine reductase 11.5.1.330.440
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.440
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
2wpwACOOrf14/0.440
2x7hPFNProstaglandin reductase 310.440
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3irxUDRGag-Pol polyprotein2.7.7.490.440
3nx4NAPPutative oxidoreductase/0.440
3up3XCAaceDAF-12/0.440
3vruYS3Vitamin D3 receptor/0.440
4a81DXCMajor pollen allergen Bet v 1-A/0.440
4cukNAID-lactate dehydrogenase/0.440
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4mv4ACPBiotin carboxylase6.3.4.140.440
4q0a4OAVitamin D3 receptor A/0.440
4qa1B3NHistone deacetylase 83.5.1.980.440
4ruoBIVVitamin D3 receptor A/0.440
4ubsDIFPentalenic acid synthase1.14.15.110.440
4x5hFOLDihydrofolate reductase1.5.1.30.440