sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3hiv | TXN | rRNA N-glycosidase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3hiv | TXN | rRNA N-glycosidase | / | 1.000 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.505 | |
| 5ilw | URI | Ribosome inactivating protein | / | 0.501 | |
| 4mx1 | 1MX | Ricin | 3.2.2.22 | 0.497 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.493 | |
| 2r5n | TPP | Transketolase 1 | / | 0.491 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.489 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.488 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.487 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.487 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.487 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.486 | |
| 4h0v | NAD | Iota toxin component Ia | / | 0.486 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.485 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.484 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.483 | |
| 3o3r | NAP | Aldose reductase-related protein 1 | 1.1.1.21 | 0.483 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.483 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.482 | |
| 2b3v | ACO | Diamine acetyltransferase 1 | / | 0.482 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.482 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.482 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.481 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.481 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.481 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.481 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.479 | |
| 2qw0 | 34Z | 4-chlorobenzoyl CoA ligase | / | 0.479 | |
| 3nh8 | DC2 | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) | 3.5.1.114 | 0.479 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.478 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.477 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.477 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.477 | |
| 1gve | NAP | Aflatoxin B1 aldehyde reductase member 3 | 1 | 0.476 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.475 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.475 | |
| 1qzy | TDE | Methionine aminopeptidase 2 | / | 0.475 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.475 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.475 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.475 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.475 | |
| 1yki | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.474 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.474 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.474 | |
| 3fun | 798 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.474 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.474 | |
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.473 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.473 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.473 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.473 | |
| 1lpc | CMP | Antiviral protein DAP-30 | 3.2.2.22 | 0.472 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 3pfh | T3Q | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | 2.1.1.235 | 0.471 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.471 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.470 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.470 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 1kbj | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.469 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.469 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.469 | |
| 3ntr | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.469 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.468 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.468 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.467 | |
| 1t91 | GTP | Ras-related protein Rab-7a | / | 0.467 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.467 | |
| 5c3a | URM | Histo-blood group ABO system transferase | / | 0.467 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 1qf2 | TI3 | Thermolysin | 3.4.24.27 | 0.466 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.466 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.466 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.465 | |
| 1zdw | FLV | Prenyltransferase | / | 0.465 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.465 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.465 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.465 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.464 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.464 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.464 | |
| 1m9n | AMZ | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.464 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.464 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2x8g | FAD | Thioredoxin glutathione reductase | / | 0.464 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.464 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.464 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 3c8b | ARG_ARG_GLY_ILE_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.463 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.463 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.463 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.462 | |
| 2nm2 | NEU | Dihydroneopterin aldolase | / | 0.462 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.462 | |
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.462 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.462 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.461 | |
| 2evc | FC3 | Methionine aminopeptidase | / | 0.461 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.461 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.461 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.461 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.460 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.460 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.460 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.460 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.460 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.459 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.459 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.459 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.459 | |
| 2x1h | X1H | Prostaglandin reductase 3 | 1 | 0.459 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.459 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.459 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.459 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.459 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.459 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.458 | |
| 2cf8 | ESH | Prothrombin | 3.4.21.5 | 0.458 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.458 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.458 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.458 | |
| 2wzm | NA7 | Uncharacterized oxidoreductase MSMEG_2407/MSMEI_2346 | / | 0.458 | |
| 3go4 | SAH | Uncharacterized protein | / | 0.458 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.458 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.457 | |
| 2j8t | NAP | Aldose reductase | 1.1.1.21 | 0.457 | |
| 2q92 | B23 | Methionine aminopeptidase | / | 0.457 | |
| 2xfy | ACX | Beta-amylase | 3.2.1.2 | 0.457 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.457 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.457 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.457 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.457 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.457 | |
| 4isg | 1FY | Glucokinase | 2.7.1.2 | 0.457 | |
| 4j7g | TRH | PCZA361.3 | / | 0.457 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.457 | |
| 1aka | PLP | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.456 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.456 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.456 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.456 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.456 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.456 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.456 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4n1g | CEI | Obelin | / | 0.456 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.456 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.455 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.455 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.455 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.455 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.455 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.455 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.455 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.455 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.455 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.455 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.455 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.455 | |
| 1ahb | FMP | Ribosome-inactivating protein momordin I | 3.2.2.22 | 0.454 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.454 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.454 | |
| 2oz0 | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.454 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3kmc | 403 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.454 | |
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.454 | |
| 4yp1 | 2BA | Stimulator of interferon genes protein | / | 0.454 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.453 | |
| 1gw2 | FER | Peroxidase C1A | 1.11.1.7 | 0.453 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.453 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.453 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.453 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.453 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.453 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.453 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.453 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.453 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.453 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.453 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.452 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.452 | |
| 1xjq | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 2.7.1.25 | 0.452 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.452 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.452 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.452 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.452 | |
| 3au2 | DGT | DNA polymerase beta family (X family) | / | 0.452 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.452 | |
| 3b9l | AZZ | Serum albumin | / | 0.452 | |
| 3bbp | GTP | Ras-related protein Rab-6A | / | 0.452 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.452 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.452 | |
| 3w3l | RX8 | Toll-like receptor 8 | / | 0.452 | |
| 4rvd | SAM | D-mycarose 3-C-methyltransferase | / | 0.452 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.452 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.451 | |
| 1k5d | GNP | GTP-binding nuclear protein Ran | / | 0.451 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.451 | |
| 1vg8 | GNP | Ras-related protein Rab-7a | / | 0.451 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.451 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.451 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.451 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 3eku | CY9 | Actin-5C | / | 0.451 | |
| 3kkz | SAM | Uncharacterized protein | / | 0.451 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.451 | |
| 3t0i | SAH | Putative methyltransferase | / | 0.451 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.451 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.451 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 4fkz | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.451 | |
| 4fpy | 0V8 | Sialidase B | 3.2.1.18 | 0.451 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.451 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.451 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.450 | |
| 1pfy | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.450 | |
| 1psd | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.450 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.450 | |
| 3lq4 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.450 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.450 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.450 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.450 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.450 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.449 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.449 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.449 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.449 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.449 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.449 | |
| 2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.449 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.449 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.449 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.449 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.449 | |
| 4gsu | DWZ | L,D-transpeptidase 2 | 2.3.2 | 0.449 | |
| 4kxj | P34 | Nucleoprotein | / | 0.449 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 1gox | FMN | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.448 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.448 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.448 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.448 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.448 | |
| 2iu8 | UD1 | UDP-3-O-acylglucosamine N-acyltransferase | 2.3.1 | 0.448 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.448 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.448 | |
| 3c1o | NAP | Eugenol synthase | / | 0.448 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.448 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.448 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.448 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.448 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.448 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 2ejz | SAH | Diphthine synthase | / | 0.447 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.447 | |
| 2hej | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.447 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.447 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.447 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2zzn | SAM | tRNA (guanine(37)-N1)-methyltransferase Trm5b | 2.1.1.228 | 0.447 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.447 | |
| 3vcy | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.447 | |
| 4jic | FMN | GTN Reductase | / | 0.447 | |
| 4y17 | LAE | Transcriptional regulator of ftsQAZ gene cluster | / | 0.447 | |
| 4y6u | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.447 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.446 | |
| 1c7o | PPG | Hemolysin | / | 0.446 | |
| 1og4 | NAI | T-cell ecto-ADP-ribosyltransferase 2 | / | 0.446 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 3ftx | RE2 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.446 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.446 | |
| 3h2n | B62 | Dihydropteroate synthase | / | 0.446 | |
| 3ou2 | SAH | SAM-dependent methyltransferase | / | 0.446 | |
| 3udj | 092 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3w3n | RX8 | Toll-like receptor 8 | / | 0.446 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 5ebu | FMN | Lactate oxidase | / | 0.446 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.445 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 1rp7 | TZD | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.445 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.445 | |
| 2acs | NAP | Aldose reductase | 1.1.1.21 | 0.445 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.445 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.445 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.445 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.445 | |
| 3eo8 | FMN | Putative nitroreductase | / | 0.445 | |
| 3hl4 | CDC | Choline-phosphate cytidylyltransferase A | / | 0.445 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.445 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.445 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.445 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.445 | |
| 4a0r | DTB | Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial | 6.3.3.3 | 0.445 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.445 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.445 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.445 | |
| 5c7h | NDP | Putative oxidoreductase | / | 0.445 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.444 | |
| 1h61 | PDN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.444 | |
| 1sa5 | BMV | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 1ses | AHX | Serine--tRNA ligase | 6.1.1.11 | 0.444 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.444 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.444 | |
| 2pf8 | NDP | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3fu5 | 492 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.444 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.444 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.444 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.444 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1jf0 | CZH | Obelin | / | 0.443 | |
| 1sve | I01 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 1vji | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.443 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.443 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.443 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.443 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.443 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.443 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.443 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 3n19 | FNR | Xenobiotic reductase | / | 0.443 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.443 | |
| 3s1s | SAH | Restriction endonuclease BpuSI | / | 0.443 | |
| 3u8f | FGM | Ribosome inactivating protein | / | 0.443 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.443 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.443 | |
| 4pmj | NAP | Putative oxidoreductase | / | 0.443 | |
| 1icu | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.442 | |
| 1kqf | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.442 | |
| 1qcw | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.442 | |
| 1tkb | N1T | Transketolase 1 | 2.2.1.1 | 0.442 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.442 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2dxi | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.442 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.442 | |
| 2jgb | MGT | Eukaryotic translation initiation factor 4E type 2 | / | 0.442 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.442 | |
| 2x8h | FAD | Thioredoxin glutathione reductase | / | 0.442 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 3e5h | GNP | Ras-related protein Rab-28 | / | 0.442 | |
| 3eks | CY9 | Actin-5C | / | 0.442 | |
| 3f8s | PF2 | Dipeptidyl peptidase 4 | / | 0.442 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.442 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 4e2y | JHZ | Methyltransferase | / | 0.442 | |
| 4o25 | GTP | GTP-binding protein Rheb | / | 0.442 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.442 | |
| 5d4v | YGP | Uncharacterized protein MJ0489 | / | 0.442 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1uxr | NAP | NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.441 | |
| 1vhz | APR | ADP compounds hydrolase NudE | 3.6.1 | 0.441 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.441 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.441 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.441 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.441 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.441 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.441 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3ioe | A7D | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 3muo | ZPR | Prolyl endopeptidase | / | 0.441 | |
| 3n76 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.441 | |
| 3pft | FMN | Flavin reductase | / | 0.441 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.441 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.441 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4bjc | RPB | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4iwn | GEK | Carboxy-S-adenosyl-L-methionine synthase | / | 0.441 | |
| 4kbz | 1QA | Egl nine homolog 1 | / | 0.441 | |
| 4kc4 | WS3 | Histo-blood group ABO system transferase | / | 0.441 | |
| 4oma | LCS | Methionine gamma-lyase | / | 0.441 | |
| 4tmb | FMN | Old yellow enzyme | / | 0.441 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.441 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.441 | |
| 4zgs | NAD | Putative D-lactate dehydrogenase | / | 0.441 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.441 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.440 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1yhn | GTP | Ras-related protein Rab-7a | / | 0.440 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.440 | |
| 2ft0 | ACO | dTDP-fucosamine acetyltransferase | / | 0.440 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.440 | |
| 2iea | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.440 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.440 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.440 | |
| 3bnk | FMN | Flavoredoxin | / | 0.440 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.440 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.440 | |
| 3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.440 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 4hn1 | TYD | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.440 | |
| 4l0o | PLP | Cystathionine gamma-synthase | 2.5.1.48 | 0.440 | |
| 4m99 | ACO | UDP-N-acetylgalactosaminyltransferase | / | 0.440 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.440 | |
| 5hvn | NAD | 3-dehydroquinate synthase | / | 0.440 |