sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1zoy | UQ1 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1zoy | UQ1 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 1.000 | |
| 1zoy | UQ1 | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial | / | 1.000 | |
| 2fbw | CBE | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 0.546 | |
| 2fbw | CBE | Succinate dehydrogenase cytochrome b, large subunit | / | 0.546 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.508 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.503 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.492 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.484 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 3dhb | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.476 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.475 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.475 | |
| 2ahc | VNL | Chorismate pyruvate-lyase | / | 0.474 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.473 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.472 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.472 | |
| 1r2j | FAD | FkbI | / | 0.471 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.471 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.471 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.471 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.470 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.470 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.469 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.469 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.469 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.469 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.469 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.468 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.468 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.468 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 4okw | 198 | Androgen receptor | / | 0.468 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.467 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.467 | |
| 3v49 | PK0 | Androgen receptor | / | 0.467 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.466 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.465 | |
| 3b9l | AZZ | Serum albumin | / | 0.465 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.465 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.465 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.464 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.464 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.464 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.464 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.463 | |
| 2bxq | IMN | Serum albumin | / | 0.463 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.462 | |
| 4xvr | GNP | GTPase HRas | / | 0.462 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.461 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.461 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 4m11 | MXM | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.461 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.461 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.460 | |
| 1v4s | MRK | Glucokinase | 2.7.1.2 | 0.460 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.460 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.460 | |
| 2wu5 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.460 | |
| 2wu5 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.460 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.460 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.460 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.459 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.459 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.459 | |
| 4wuc | ANP | DNA gyrase subunit B | / | 0.459 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.458 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.458 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.458 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.458 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.458 | |
| 4okx | 198 | Androgen receptor | / | 0.458 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.457 | |
| 2xvv | 9DN | Serum albumin | / | 0.457 | |
| 4e2b | FMN | Dehydrogenase | / | 0.457 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.457 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.456 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.456 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.456 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.456 | |
| 2bxm | IMN | Serum albumin | / | 0.456 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.456 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.456 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.456 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.456 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.456 | |
| 4jic | FMN | GTN Reductase | / | 0.456 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.456 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.456 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.455 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.455 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.455 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.455 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.455 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.455 | |
| 2wdq | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.455 | |
| 2wdq | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.455 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.455 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.455 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.455 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.455 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.455 | |
| 4ojb | 198 | Androgen receptor | / | 0.455 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.454 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.454 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.454 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.454 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.454 | |
| 3kjm | 245 | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.454 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.453 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.453 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.453 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.453 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.453 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.453 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.453 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.453 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.453 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2op9 | WR1 | Orf1ab polyprotein | / | 0.452 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.452 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.452 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.452 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.452 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.452 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.452 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.452 | |
| 4okb | 198 | Androgen receptor | / | 0.452 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.452 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1ezv | UQ6 | Cytochrome b | / | 0.451 | |
| 1osv | CHC | Bile acid receptor | / | 0.451 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2y3s | TIR | TamL | / | 0.451 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.451 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.451 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.451 | |
| 5a3b | APR | SIR2 family protein | / | 0.451 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 2ejz | SAH | Diphthine synthase | / | 0.450 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.450 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.450 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.450 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.450 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 3zlm | ANP | Adenosine monophosphate-protein transferase NmFic | 2.7.7.n1 | 0.450 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.450 | |
| 4jld | ADP | Adenylate kinase | / | 0.450 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.449 | |
| 1wng | SAH | Diphthine synthase | / | 0.449 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.449 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.449 | |
| 2xvw | 9NR | Serum albumin | / | 0.449 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.449 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.449 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.449 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.449 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.448 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 2cgu | 3A3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2dsg | SAH | Diphthine synthase | / | 0.448 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2wp9 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.448 | |
| 2wp9 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.448 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.448 | |
| 3dol | GWI | Pol protein | / | 0.448 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.448 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.448 | |
| 3v2b | AR6 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.448 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.448 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.448 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.448 | |
| 4xt5 | NAP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.448 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.448 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.447 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.447 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.447 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.447 | |
| 2dxv | SAH | Diphthine synthase | / | 0.447 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.447 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.447 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.447 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.447 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.446 | |
| 1yin | CM3 | Estrogen receptor | / | 0.446 | |
| 2ayp | 43A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.446 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.446 | |
| 2e8h | SAH | Diphthine synthase | / | 0.446 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.446 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.446 | |
| 2x8h | FAD | Thioredoxin glutathione reductase | / | 0.446 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.446 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 4qmw | KS1 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.446 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.446 | |
| 9mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.446 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.445 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.445 | |
| 2ejk | SAH | Diphthine synthase | / | 0.445 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.445 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.445 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.445 | |
| 4hxy | NDP | Plm1 | / | 0.445 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.445 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.445 | |
| 4nvk | 2NY | Peroxidase | / | 0.445 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.445 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.445 | |
| 4ytn | FD8 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | / | 0.445 | |
| 4ytn | FD8 | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | / | 0.445 | |
| 4ytn | FD8 | Succinate dehydrogenase cytochrome b560 | / | 0.445 | |
| 5doz | NDP | JamJ | / | 0.445 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.444 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.444 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.444 | |
| 1uu8 | BI1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.444 | |
| 2e8q | SAH | Diphthine synthase | / | 0.444 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.444 | |
| 2z6j | TUI | 2-nitropropane dioxygenase | / | 0.444 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3eks | CY9 | Actin-5C | / | 0.444 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.444 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.444 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.444 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 4qbj | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.444 | |
| 1dfo | PLG | Serine hydroxymethyltransferase | 2.1.2.1 | 0.443 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.443 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.443 | |
| 1pl6 | 572 | Sorbitol dehydrogenase | 1.1.1.14 | 0.443 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.443 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.443 | |
| 1sxj | AGS | Replication factor C subunit 1 | / | 0.443 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.443 | |
| 1upc | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.443 | |
| 2e15 | SAH | Diphthine synthase | / | 0.443 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.443 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.443 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.443 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3qge | 26F | Genome polyprotein | 2.7.7.48 | 0.443 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.443 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2egb | SAH | Diphthine synthase | / | 0.442 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.442 | |
| 2huv | SAH | Diphthine synthase | / | 0.442 | |
| 2hux | SAH | Diphthine synthase | / | 0.442 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.442 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.442 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.442 | |
| 4jky | ADP | Adenylate kinase | / | 0.442 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.442 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.441 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.441 | |
| 1qrr | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.441 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.441 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.441 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2eka | SAH | Diphthine synthase | / | 0.441 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.441 | |
| 2p2x | SAH | Diphthine synthase | / | 0.441 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.441 | |
| 3cob | ADP | Kinesin heavy chain-like protein | / | 0.441 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.441 | |
| 3dok | GWJ | Pol protein | / | 0.441 | |
| 3eej | 53R | Uncharacterized protein | / | 0.441 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.441 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.441 | |
| 4e2d | FMN | Dehydrogenase | / | 0.441 | |
| 4jl5 | ADP | Adenylate kinase | / | 0.441 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.440 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.440 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.440 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.440 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.440 | |
| 3v4a | PK1 | Androgen receptor | / | 0.440 | |
| 3w3l | RX8 | Toll-like receptor 8 | / | 0.440 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.440 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.440 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.440 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.440 | |
| 4lb2 | DM5 | Serum albumin | / | 0.440 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.440 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 |