sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4pzd | NAD | 3-Hydroxyacyl-CoA dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4pzd | NAD | 3-Hydroxyacyl-CoA dehydrogenase | / | 1.000 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.561 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.546 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.537 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.530 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.520 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.511 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.500 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.495 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.488 | |
| 1c6y | MK1 | Protease | / | 0.487 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.482 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.480 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.479 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.479 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.479 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.478 | |
| 5a3b | APR | SIR2 family protein | / | 0.478 | |
| 1t7i | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.476 | |
| 3ggu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.476 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.476 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.476 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.475 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.475 | |
| 3zuy | TCH | Transporter | / | 0.475 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.475 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.474 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.474 | |
| 4n9i | PCG | Catabolite expression activator | / | 0.474 | |
| 4njv | RIT | Protease | / | 0.473 | |
| 1mrw | K57 | Gag-Pol polyprotein | 3.4.23.16 | 0.471 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.470 | |
| 3bgb | LJG | Gag-Pol polyprotein | 3.4.23.16 | 0.470 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.469 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.469 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.469 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.469 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.468 | |
| 2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.468 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.468 | |
| 5a3c | NAD | SIR2 family protein | / | 0.468 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.467 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.467 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.467 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.467 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.466 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.466 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.466 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.466 | |
| 3gob | HXX | DdmC | / | 0.466 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.466 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.465 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.465 | |
| 3jvw | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.465 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.465 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
| 3eky | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.464 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.463 | |
| 1nqa | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.463 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.463 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.463 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.462 | |
| 3el1 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.462 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.461 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.461 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.461 | |
| 2pk6 | O33 | V-1 protease | / | 0.461 | |
| 3ids | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.461 | |
| 3lzu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.460 | |
| 1g35 | AHF | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 1p31 | EPU | UDP-N-acetylmuramate--L-alanine ligase | 6.3.2.8 | 0.460 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.460 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.460 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.460 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.460 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.459 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.459 | |
| 2fdd | 385 | Pol protein | / | 0.459 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.459 | |
| 3dcr | KVS | Protease | / | 0.459 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.459 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.459 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.459 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.459 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.458 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.458 | |
| 1msm | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 2f3k | RO1 | Protease | / | 0.458 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.458 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.458 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.458 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1hon | GNH | Adenylosuccinate synthetase | / | 0.457 | |
| 1npa | 3NH | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 1npw | LGZ | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.457 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.457 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.457 | |
| 3kfn | 3TL | Gag-Pol polyprotein | / | 0.457 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.457 | |
| 4kug | NAD | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.457 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.457 | |
| 1a9m | U0E | Gag-Pol polyprotein | / | 0.456 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.456 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.456 | |
| 2aqu | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.456 | |
| 3nu4 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.456 | |
| 3ucb | 017 | Gag-Pol polyprotein | / | 0.456 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.456 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.456 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.456 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.456 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.455 | |
| 2itn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.455 | |
| 2j4z | 626 | Aurora kinase A | 2.7.11.1 | 0.455 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.455 | |
| 3el9 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3r5z | F42 | Uncharacterized protein | / | 0.455 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 1c6z | ROC | Protease | / | 0.454 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.454 | |
| 2q5k | AB1 | Protease | / | 0.454 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.454 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.454 | |
| 3pwr | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3sm2 | 478 | Putative gag-pro-pol polyprotein | / | 0.454 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.454 | |
| 3w0s | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.454 | |
| 4l4x | NDP | AmphI | / | 0.454 | |
| 4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.454 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.453 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.453 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.453 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.453 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.453 | |
| 3ekp | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3fx5 | KNI | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3lit | E15 | Protease | / | 0.453 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.453 | |
| 3vfa | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.453 | |
| 1dbv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.452 | |
| 1tcx | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 2cen | 4AH | Protease | / | 0.452 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.452 | |
| 2qhc | AB1 | Protease | / | 0.452 | |
| 2r5p | MK1 | Gag-Pol polyprotein | / | 0.452 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.452 | |
| 3gga | GGW | Gag-Pol polyprotein | / | 0.452 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.452 | |
| 3mjh | GTP | Ras-related protein Rab-5A | / | 0.452 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.452 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.452 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.452 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.451 | |
| 1c70 | L75 | Protease | / | 0.451 | |
| 1d4j | MSC | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.451 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.451 | |
| 2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 2y3r | TIR | TamL | / | 0.451 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.451 | |
| 3kfr | 3TL | Gag-Pol polyprotein | / | 0.451 | |
| 3liv | E16 | Protease | / | 0.451 | |
| 3oev | 3OE | Proteasome subunit beta type-5 | 3.4.25.1 | 0.451 | |
| 3oev | 3OE | Proteasome subunit beta type-6 | 3.4.25.1 | 0.451 | |
| 3zpu | M8B | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.451 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.450 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.450 | |
| 1ec3 | MS3 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2bpy | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.450 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.450 | |
| 3pgq | GY3 | Acetyl-CoA carboxylase | / | 0.450 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.450 | |
| 3u9e | COA | Lmo1369 protein | / | 0.450 | |
| 3vvp | BNU | Uncharacterized protein | / | 0.450 | |
| 4ccq | FAD | Thioredoxin reductase | / | 0.450 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.450 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.450 | |
| 4u7w | NDP | MxaA | / | 0.450 | |
| 1bdm | NAX | Malate dehydrogenase | / | 0.449 | |
| 1p0h | COA | Mycothiol acetyltransferase | 2.3.1.189 | 0.449 | |
| 2bb9 | AKC | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.449 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.449 | |
| 2p3c | 3TL | Protease | / | 0.449 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 2qnn | QN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.449 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.449 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.449 | |
| 3mje | NDP | AmphB | / | 0.449 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.449 | |
| 4dqb | 017 | Gag-Pol polyprotein | / | 0.449 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.449 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.449 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.449 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.449 | |
| 1hsg | MK1 | Gag-Pol polyprotein | / | 0.448 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.448 | |
| 1jld | 0PP | Gag-Pol polyprotein | / | 0.448 | |
| 1zsf | 0ZS | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2gtn | LIE | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 2hux | SAH | Diphthine synthase | / | 0.448 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.448 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.448 | |
| 2rgh | FAD | Alpha-Glycerophosphate Oxidase | / | 0.448 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.448 | |
| 3d1y | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3jw2 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.448 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.448 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.448 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.448 | |
| 4kxl | 6C6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.448 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.448 | |
| 5a01 | 12V | O-glycosyltransferase | / | 0.448 | |
| 1ajv | NMB | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1fg6 | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1hii | C20 | Gag-Pol polyprotein | / | 0.447 | |
| 1jsc | TPP | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.447 | |
| 1npv | L27 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1qbu | 846 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.447 | |
| 1ywg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.447 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.447 | |
| 2q63 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.447 | |
| 2upj | U02 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.447 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.447 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.447 | |
| 3nu6 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.447 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.447 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.447 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.447 | |
| 4kwh | NAP | Reductase homolog | / | 0.447 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 1ebw | BEI | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.446 | |
| 1u8f | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.446 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.446 | |
| 2avv | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 2e16 | SAH | Diphthine synthase | / | 0.446 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.446 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 2fde | 385 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.446 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.446 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 2qi7 | MZ9 | Gag-Pol polyprotein | / | 0.446 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.446 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.446 | |
| 3i7e | DJR | Gag-Pol polyprotein | / | 0.446 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.446 | |
| 3ogq | AB1 | Pol polyprotein | / | 0.446 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.446 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4heg | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.446 | |
| 4q1w | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.446 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.446 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.446 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.445 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 1gqt | ACP | Ribokinase | / | 0.445 | |
| 1ida | 0PO | Gag-Pol polyprotein | 3.4.23.47 | 0.445 | |
| 1idb | 0DO | Gag-Pol polyprotein | / | 0.445 | |
| 1rl8 | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1udc | UFM | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.445 | |
| 2ard | FDA | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.445 | |
| 2f3m | GTD | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.445 | |
| 2p2x | SAH | Diphthine synthase | / | 0.445 | |
| 2q64 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.445 | |
| 2wkz | 5AH | Gag-Pol polyprotein | / | 0.445 | |
| 2y8l | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.445 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.445 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.445 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.445 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.445 | |
| 4awi | AQ2 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.445 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.445 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.445 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.445 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 1rm4 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.444 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.444 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.444 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.444 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.444 | |
| 2idw | 017 | Protease | / | 0.444 | |
| 2xye | CXG | Gag-Pol polyprotein | / | 0.444 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.444 | |
| 3cyx | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3icr | FAD | Coenzyme A disulfide reductase | / | 0.444 | |
| 3o9a | K14 | Pol polyprotein | / | 0.444 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.444 | |
| 3ttp | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.444 | |
| 4dqh | 017 | Gag-Pol polyprotein | / | 0.444 | |
| 4kto | FAD | Putative isovaleryl-CoA dehydrogenase protein | / | 0.444 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.444 | |
| 1ec2 | BEJ | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1hpx | KNI | Gag-Pol polyprotein | / | 0.443 | |
| 1izh | Q50 | Protease | / | 0.443 | |
| 1m2r | MNY | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.443 | |
| 1sbg | IM1 | Gag-Pol polyprotein | / | 0.443 | |
| 1t7k | BH0 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.443 | |
| 2b9w | FAD | Putative aminooxidase | / | 0.443 | |
| 2i4u | DJR | Protease | / | 0.443 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.443 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.443 | |
| 2pk5 | 075 | Protease | / | 0.443 | |
| 2uy0 | HV1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3i2l | 2NC | Protease | / | 0.443 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.443 | |
| 3s54 | 017 | Protease | / | 0.443 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.443 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.443 | |
| 4hdb | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.443 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.443 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.443 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.443 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.442 | |
| 1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1soz | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.442 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.442 | |
| 1vij | BAY | Gag-Pol polyprotein | / | 0.442 | |
| 1wbk | 568 | Pol protein | / | 0.442 | |
| 1z1r | HBH | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.442 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.442 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.442 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.442 | |
| 3cmc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.442 | |
| 3d1z | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3dck | KVI | Protease | / | 0.442 | |
| 3el4 | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3kdc | JZP | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.442 | |
| 3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.442 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.442 | |
| 4djq | M86 | Pol polyprotein | / | 0.442 | |
| 4dqe | 017 | Gag-Pol polyprotein | / | 0.442 | |
| 4fi1 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4qi4 | FAD | Cellobiose dehydrogenase | / | 0.442 | |
| 5dr6 | SKE | Aurora kinase A | 2.7.11.1 | 0.442 | |
| 1bdq | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1c6x | 3IN | Protease | / | 0.441 | |
| 1d4h | BEH | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1fgc | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1hpo | UNI | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.441 | |
| 1ivq | 0PX | Gag-Pol polyprotein | / | 0.441 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.441 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 1qxs | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.441 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.441 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1v59 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.441 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.441 | |
| 1yon | A2R | 2-dehydropantoate 2-reductase | 1.1.1.169 | 0.441 | |
| 2c6h | PXI | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.441 | |
| 2i9p | NAD | 3-hydroxyisobutyrate dehydrogenase, mitochondrial | 1.1.1.31 | 0.441 | |
| 2j0j | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.441 | |
| 2pch | SAH | Diphthine synthase | / | 0.441 | |
| 2r3w | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3beg | ANP | SRSF protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3cgf | JNF | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.441 | |
| 3d1x | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.441 | |
| 3ndu | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.441 | |
| 4c57 | FEF | Cyclin-G-associated kinase | 2.7.11.1 | 0.441 | |
| 4hla | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4qgi | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1ajx | AH1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1ghe | ACO | Acetyltransferase | 2.3.1 | 0.440 | |
| 1gyp | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.440 | |
| 1mui | AB1 | Protease | / | 0.440 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.440 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.440 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.440 | |
| 2e08 | SAH | Diphthine synthase | / | 0.440 | |
| 2hb3 | GRL | Protease | / | 0.440 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.440 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.440 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.440 | |
| 3kdd | JZQ | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3mk6 | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.440 | |
| 3ndx | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3so9 | 017 | Pol protein | / | 0.440 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.440 | |
| 4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.440 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.440 | |
| 4fr4 | STU | Serine/threonine-protein kinase 32A | 2.7.11.1 | 0.440 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.440 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.440 | |
| 4ye3 | G04 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.440 |