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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4cjp4D2Integrase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4cjp4D2Integrase/1.000
4cefD0TIntegrase/0.704
4cf23GMIntegrase/0.673
4cgjNZLIntegrase/0.651
4cjqVXOIntegrase/0.646
3zswZSWIntegrase/0.640
4ceaZSWIntegrase/0.633
4cjfRVNIntegrase/0.624
3zsrO3NIntegrase/0.621
4cezO3NIntegrase/0.621
4cfc7NVIntegrase/0.616
4cggK5QIntegrase/0.613
4ced9NSIntegrase/0.607
4cj54VWIntegrase/0.607
4ceqQCHIntegrase/0.606
4ck2NVUIntegrase/0.606
4cfaWOPIntegrase/0.604
4ce9O3NIntegrase/0.602
3zt0ZT0Integrase/0.593
4cfbOM3Integrase/0.592
4cifJDXIntegrase/0.592
4cieY7NIntegrase/0.590
4cesNFWIntegrase/0.588
4cf0O5UIntegrase/0.586
4cerVL4Integrase/0.581
3zt3ZT4Integrase/0.580
4cf8V7HIntegrase/0.580
4cigX0PIntegrase/0.579
4cjeQ31Integrase/0.578
4cjuJNSIntegrase/0.578
4cfdS8YIntegrase/0.577
4cjkH39Integrase/0.575
4cj3E4FIntegrase/0.573
4ck3K1TIntegrase/0.573
4ceeB0TIntegrase/0.572
4cgd8P3Integrase/0.572
4cgiNZLIntegrase/0.572
4cj4S3GIntegrase/0.569
3zsvZSVIntegrase/0.567
4cebZSVIntegrase/0.567
4cghLOZIntegrase/0.564
3zsyOM3Integrase/0.557
4ceoG0TIntegrase/0.556
4cec2SSIntegrase/0.555
4cjsL0YIntegrase/0.541
4ck1OM1Integrase/0.540
3zszOM2Integrase/0.539
3zsqO4NIntegrase/0.538
3zt2ZT2Integrase/0.536
3zcmPX3Integrase/0.530
4cjrFYMIntegrase/0.530
4chqCWUIntegrase/0.524
3zt1OM1Integrase/0.523
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.516
4chyC5QIntegrase/0.515
4cf1IY7Integrase/0.511
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.508
3zsxN44Integrase/0.503
1ia1NDPDihydrofolate reductase1.5.1.30.497
1dr3TAPDihydrofolate reductase1.5.1.30.493
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.493
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.492
4y8wSTRSteroid 21-hydroxylase/0.489
5bylGCPBifunctional AAC/APH2.3.10.487
3lqfNADGalactitol dehydrogenase/0.485
2vbdV10Isopenicillin N synthase1.21.3.10.481
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.480
1rx1NAPDihydrofolate reductase1.5.1.30.479
2x6o2TCTetracycline repressor protein class D/0.479
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.477
1ia4TQ6Dihydrofolate reductase1.5.1.30.476
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.476
2pvnP63Casein kinase II subunit alpha2.7.11.10.475
3qlrNDPDihydrofolate reductase1.5.1.30.475
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.474
4dpuAGSMevalonate diphosphate decarboxylase/0.474
1poxFADPyruvate oxidase1.2.3.30.473
1x1cSAHC-20 methyltransferase/0.473
2xf3J01Uncharacterized protein/0.472
3be9P04Casein kinase II subunit alpha2.7.11.10.472
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.472
3flwFLWMitogen-activated protein kinase 14/0.472
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.472
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.471
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.471
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.471
4jx1CAHCamphor 5-monooxygenase1.14.15.10.471
1ahiCHO7-alpha-hydroxysteroid dehydrogenase1.1.1.1590.470
1cqp803Integrin alpha-L/0.470
1drhNAPDihydrofolate reductase1.5.1.30.470
1sxjADPReplication factor C subunit 5/0.470
3bhtMFRCyclin-dependent kinase 22.7.11.220.470
3wleNAD(R)-specific carbonyl reductase/0.470
4rquNADAlcohol dehydrogenase class-P/0.470
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.469
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
5cb3APRO-acetyl-ADP-ribose deacetylase/0.469
2zevB71Geranylgeranyl pyrophosphate synthase/0.468
4an4DUDPutative glycosyl transferase/0.468
4kl9NDPDihydrofolate reductase1.5.1.30.468
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.467
3iaeD7KBenzaldehyde lyase/0.467
4eh9IRGMitogen-activated protein kinase 14/0.467
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.467
4m6jNDPDihydrofolate reductase1.5.1.30.467
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.467
2jb4A14Isopenicillin N synthase1.21.3.10.466
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.466
4q72FADBifunctional protein PutA/0.466
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.466
1c1dNAIPhenylalanine dehydrogenase/0.465
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.465
2c3qGTXGlutathione S-transferase theta-12.5.1.180.465
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.465
3w0c6DSVitamin D3 receptor/0.465
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.465
5cdtNAJAlcohol dehydrogenase E chain1.1.1.10.465
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.464
3gbuATPUncharacterized sugar kinase PH14592.7.10.464
4a83DXCMajor pollen allergen Bet v 1-A/0.464
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.463
4o701QKBromodomain-containing protein 4/0.463
4qe6JN3Bile acid receptor/0.463
1dr2TAPDihydrofolate reductase1.5.1.30.462
2e08SAHDiphthine synthase/0.462
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.462
2lfoGCHFatty acid-binding protein, liver/0.462
3hl7I47Mitogen-activated protein kinase 14/0.462
4dxhNAJAlcohol dehydrogenase E chain1.1.1.10.462
4i4b1CV3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.462
4ure1PSCyclohexanol dehydrogenase/0.462
1ef92CPMethylmalonyl-CoA decarboxylase4.1.1.410.461
1o97FADElectron transfer flavoprotein subunit alpha/0.461
1wwkNAD307aa long hypothetical phosphoglycerate dehydrogenase/0.461
2g8yNADHydroxycarboxylate dehydrogenase B/0.461
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.461
3zh8C58Protein kinase C iota type2.7.11.130.461
4c4oNADSADH/0.461
4gyy12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.461
1zrzBI1Protein kinase C iota type2.7.11.130.460
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.460
2xvw9NRSerum albumin/0.460
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
3lsiFADPyranose 2-oxidase/0.460
4d0lGSPRas-related protein Rab-11A/0.460
4e8yIHAD-beta-D-heptose 7-phosphate kinase/0.460
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.459
1lluNADAlcohol dehydrogenase/0.459
3bv3P39Mitogen-activated protein kinase 14/0.459
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.459
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.459
3zoiM2WIsopenicillin N synthase1.21.3.10.459
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.459
4gl4NAIAlcohol dehydrogenase class-3/0.459
4qerSTLPhospholipase A2 VRV-PL-VIIIa/0.459
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.459
5jlaNADPutative short-chain dehydrogenase/reductase/0.459
1nhhANPDNA mismatch repair protein MutL/0.458
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
1v9aSAHUncharacterized protein/0.458
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
3jpuTY4Transcriptional activator protein LasR/0.458
4bb3KKAIsopenicillin N synthase1.21.3.10.458
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.458
1m78NDPDihydrofolate reductase1.5.1.30.457
1tehNADAlcohol dehydrogenase class-31.1.1.10.457
1uycPU7Heat shock protein HSP 90-alpha/0.457
2w6nOA2Biotin carboxylase6.3.4.140.457
3b9lAZZSerum albumin/0.457
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.457
3flyFLYMitogen-activated protein kinase 14/0.457
3kpzZNEVitamin D3 receptor/0.457
3vf80JETyrosine-protein kinase SYK2.7.10.20.457
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.457
4g3jVNTLanosterol 14-alpha-demethylase/0.457
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.457
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.456
1db48INPhospholipase A2, membrane associated/0.456
1db56INPhospholipase A2, membrane associated/0.456
1fm4DXCMajor pollen allergen Bet v 1-L/0.456
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.456
2bjhFERFeruloyl esterase A3.1.1.730.456
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.456
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.456
3pqbVGPPutative oxidoreductase/0.456
3w4yFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.456
3zdu38RCyclin-dependent kinase-like 32.7.11.220.456
4a84DXCMajor pollen allergen Bet v 1-A/0.456
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.456
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.456
1dkfBMSRetinoic acid receptor alpha/0.455
1fwkADPHomoserine kinase2.7.1.390.455
2c29NAPDihydroflavonol 4-reductase/0.455
2vwx7X4Ephrin type-B receptor 42.7.10.10.455
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.455
3nww3NWMitogen-activated protein kinase 14/0.455
3q5kD1UHeat shock protein 83-1/0.455
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.455
4g2fC07Ephrin type-A receptor 32.7.10.10.455
4irnFADAnaB/0.455
4oztP1AEcdysone receptor, putative/0.455
4wfr2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.455
1ma0NADAlcohol dehydrogenase class-31.1.1.10.454
1mzs6693-oxoacyl-[acyl-carrier-protein] synthase 3/0.454
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.454
2oxiNADAlcohol dehydrogenase E chain1.1.1.10.454
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.454
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.454
3cpsNADGlyceraldehyde-3-phosphate dehydrogenase/0.454
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.454
4i22IREEpidermal growth factor receptor2.7.10.10.454
4kip1R9Mitogen-activated protein kinase 14/0.454
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.454
4mv8ACPBiotin carboxylase6.3.4.140.454
5eccNAPDehydrofolate reductase type I/0.454
1b15NAEAlcohol dehydrogenase1.1.1.10.453
1mp0NADAlcohol dehydrogenase class-31.1.1.10.453
1osvCHCBile acid receptor/0.453
1pjkANPCasein kinase II subunit alpha2.7.11.10.453
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.453
2x06NADL-sulfolactate dehydrogenase/0.453
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.453
3mdmFJZCholesterol 24-hydroxylase/0.453
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.453
5dp2NAPCurF/0.453
1dr5NAPDihydrofolate reductase1.5.1.30.452
1dtpAPUDiphtheria toxin/0.452
1yjqNAP2-dehydropantoate 2-reductase1.1.1.1690.452
2acxANPG protein-coupled receptor kinase 62.7.11.160.452
2j14GNIPeroxisome proliferator-activated receptor delta/0.452
2rbeZMGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
3ixp834Ecdysone receptor/0.452
3nga3NGCasein kinase II subunit alpha2.7.11.10.452
3pe2E1BCasein kinase II subunit alpha2.7.11.10.452
3r5yF42Uncharacterized protein/0.452
3raiX85Cyclin-dependent kinase 22.7.11.220.452
4fv7E94Mitogen-activated protein kinase 12.7.11.240.452
4yt5H4MH(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338/0.452
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.452
1dcyI3NPhospholipase A2, membrane associated/0.451
1gqtACPRibokinase/0.451
1msnJE2Gag-Pol polyprotein3.4.23.160.451
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.451
1z1fSTLResveratrol synthase/0.451
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.451
2vceU2FUDP-glycosyltransferase 72B1/0.451
2w2lNADD-mandelate dehydrogenase/0.451
3fskRO6Mitogen-activated protein kinase 14/0.451
3gobHXXDdmC/0.451
3mg3ECHOrange carotenoid-binding protein/0.451
3p8zSAHGenome polyprotein2.1.1.560.451
3qwbNDPProbable quinone oxidoreductase1.6.5.50.451
4ansVGHALK tyrosine kinase receptor2.7.10.10.451
4f6w0SSCyclin-dependent kinase 82.7.11.220.451
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.451
4p8rNADGlyceraldehyde-3-phosphate dehydrogenase/0.451
1e1lNAPNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.450
1hbvGANGag-Pol polyprotein/0.450
1tqf32PBeta-secretase 13.4.23.460.450
1vjy460TGF-beta receptor type-12.7.11.300.450
1yb5NAPQuinone oxidoreductase1.6.5.50.450
2bu9HFVIsopenicillin N synthase1.21.3.10.450
2cdaNAPGlucose 1-dehydrogenase/0.450
2tpsTPSThiamine-phosphate synthase/0.450
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.450
3t3c017Gag-Pol polyprotein3.4.23.160.450
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.450
3up3XCAaceDAF-12/0.450
4bfzZVZPantothenate kinase2.7.1.330.450
4lb2DM5Serum albumin/0.450
4lva20MNicotinamide phosphoribosyltransferase2.4.2.120.450
4olfHFGProline--tRNA ligase6.1.1.150.450
4pmjNAPPutative oxidoreductase/0.450
4xrgNADHomospermidine synthase2.5.1.440.450
4xzjNADPutative NAD(+)--arginine ADP-ribosyltransferase Vis2.4.2.310.450
4yaiNAIC alpha-dehydrogenase/0.450
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1crbRTLRetinol-binding protein 1/0.449
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.449
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1gd1NADGlyceraldehyde-3-phosphate dehydrogenase/0.449
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1rm5NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.449
1u2yGOXPancreatic alpha-amylase/0.449
1vrwNAIEnoyl-ACP reductase/0.449
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2bxmIMNSerum albumin/0.449
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.449
2cig1DGDihydrofolate reductase1.5.1.30.449
2gtmLIDMitogen-activated protein kinase 14/0.449
2hcdBIVVitamin D3 receptor A/0.449
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.449
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.449
2w3bNDPDihydrofolate reductase1.5.1.30.449
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.449
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.449
2xhd7T9Glutamate receptor 2/0.449
2zjwREFCasein kinase II subunit alpha2.7.11.10.449
3g8eIS1Nicotinamide phosphoribosyltransferase2.4.2.120.449
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.449
3otfCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.449
3qofGDPAtlastin-13.6.50.449
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.449
4qzuRTLRetinol-binding protein 2/0.449
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
1kvoOAPPhospholipase A2, membrane associated/0.448
1m17AQ4Epidermal growth factor receptor2.7.10.10.448
1ppjANYCytochrome b/0.448
1q6s214Tyrosine-protein phosphatase non-receptor type 13.1.3.480.448
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2zfnACOHistone acetyltransferase RTT1092.3.1.480.448
3bv2P38Mitogen-activated protein kinase 14/0.448
3bw4FMNPutative 2-nitropropane dioxygenase/0.448
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.448
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.448
3rj9NADAlcohol dehydrogenase1.1.1.10.448
3vtdTKDVitamin D3 receptor/0.448
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.448
4dbzNDPPutative ketoacyl reductase1.3.10.448
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.448
4nieNBHNuclear receptor ROR-gamma/0.448
4o0mATPCircadian clock protein kinase KaiC2.7.11.10.448
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.448
5e8wSTUTGF-beta receptor type-12.7.11.300.448
1di8DTQCyclin-dependent kinase 22.7.11.220.447
1u8fNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.447
1z6tADPApoptotic protease-activating factor 1/0.447
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.447
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.447
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2pvjP44Casein kinase II subunit alpha2.7.11.10.447
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.447
3maaFKPAdenylate cyclase type 2/0.447
3maaFKPAdenylate cyclase type 5/0.447
3up0D7SaceDAF-12/0.447
3w5p4OAVitamin D3 receptor/0.447
3zkyWT4Isopenicillin N synthase1.21.3.10.447
4bb432WEphrin type-B receptor 42.7.10.10.447
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.447
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
4xq9NADHomospermidine synthase2.5.1.440.447
1gpdNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.446
1kquBR4Phospholipase A2, membrane associated/0.446
1n6lGTPRas-related protein Rab-5A/0.446
1qvnFRIInterleukin-2/0.446
2a94AP0L-lactate dehydrogenase1.1.1.270.446
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.446
2o7pNAPRiboflavin biosynthesis protein RibD/0.446
2ozuACOHistone acetyltransferase KAT6A/0.446
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.446
2pdtFADVivid PAS protein VVD/0.446
2vnaNAPProstaglandin reductase 21.3.1.480.446
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.446
3d84NDPDihydrofolate reductase1.5.1.30.446
3dl0AP5Adenylate kinase/0.446
3mlaJJZProbable nicotinate-nucleotide adenylyltransferase/0.446
3o9gF53Gag-Pol polyprotein/0.446
3p6oETGCamphor 5-monooxygenase1.14.15.10.446
3qu0X40Cyclin-dependent kinase 22.7.11.220.446
3w0aDS5Vitamin D3 receptor/0.446
4aacAAVMitogen-activated protein kinase 14/0.446
4anqVGHALK tyrosine kinase receptor2.7.10.10.446
4ap3FADSteroid monooxygenase/0.446
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.446
4dptAGSMevalonate diphosphate decarboxylase/0.446
4tuvCPZCytochrome P450 1191.140.446
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.446
5h8tRTLRetinol-binding protein 1/0.446
1h1r6CPCyclin-dependent kinase 22.7.11.220.445
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
1jpaANPEphrin type-B receptor 22.7.10.10.445
1levCLIFructose-1,6-bisphosphatase 13.1.3.110.445
1n83CLRNuclear receptor ROR-alpha/0.445
1nhqFADNADH peroxidase1.11.1.10.445
1y0s331Peroxisome proliferator-activated receptor delta/0.445
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.445
2fznFADBifunctional protein PutA1.5.5.20.445
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.445
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.445
2wipP49Cyclin-dependent kinase 22.7.11.220.445
3a25SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase/0.445
3cosNADAlcohol dehydrogenase 41.1.1.10.445
3fp0FP015-O-acetyltransferase/0.445
3jv7NADSecondary alcohol dehydrogenase/0.445
3p7nFMNLight-activated DNA-binding protein EL222/0.445
3qizQI2Botulinum neurotoxin type A3.4.24.690.445
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.445
4cgfUJ6Integrase/0.445
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.445
4nbwNADShort-chain dehydrogenase/reductase SDR/0.445
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.445
5kczNAJAlcohol dehydrogenase E chain1.1.1.10.445
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.444
1kvkATPMevalonate kinase2.7.1.360.444
1ot7CHCBile acid receptor/0.444
1s19MC9Vitamin D3 receptor/0.444
1s7nCOAAcetyl transferase/0.444
1u0hGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.444
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
2eleSAHDiphthine synthase/0.444
2fzmFADBifunctional protein PutA1.5.5.20.444
2imlFMNUncharacterized protein/0.444
2iviACWIsopenicillin N synthase1.21.3.10.444
2w4qCBWProstaglandin reductase 21.3.1.480.444
3dt1P40Mitogen-activated protein kinase 14/0.444
3dxmN24Actin-related protein 3/0.444
3tqaNDPDihydrofolate reductase/0.444
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.444
4anmWULCasein kinase II subunit alpha2.7.11.10.444
4gxs0YSGlutamate receptor 2/0.444
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.444
4l5b1UXDeoxycytidine kinase2.7.1.740.444
4uyf73BBromodomain-containing protein 2/0.444
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.444
5cdgNAJAlcohol dehydrogenase E chain1.1.1.10.444
1kzuRG1Light-harvesting protein B-800/850 alpha chain/0.443
1kzuRG1Light-harvesting protein B-800/850 beta chain/0.443
1qf5RPLAdenylosuccinate synthetase/0.443
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.443
1snyNAPLD36273p/0.443
1u4dDBQActivated CDC42 kinase 1/0.443
1upw444Oxysterols receptor LXR-beta/0.443
2c0cNAPProstaglandin reductase 310.443
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.443
2gtnLIEMitogen-activated protein kinase 14/0.443
2hamC33Vitamin D3 receptor/0.443
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.443
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.443
3d7kD7KBenzaldehyde lyase/0.443
3ddw055Glycogen phosphorylase, liver form2.4.1.10.443
3fklFKLMitogen-activated protein kinase 14/0.443
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3nmpPYVAbscisic acid receptor PYL2/0.443
3p6nDSOCamphor 5-monooxygenase1.14.15.10.443
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.443
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.443
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.443
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4f86SFGGeranyl diphosphate 2-C-methyltransferase2.1.1.2550.443
4fqsLYAThymidylate synthase ThyA/0.443
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.443
4yutFMNFamily 3 adenylate cyclase/0.443
5iubCLRAdenosine receptor A2a/0.443
1agnNADAlcohol dehydrogenase class 4 mu/sigma chain1.1.1.10.442
1ay0TPPTransketolase 12.2.1.10.442
1bwsNDPGDP-L-fucose synthase/0.442
1mrxK57Gag-Pol polyprotein3.4.23.160.442
1nqoNADGlyceraldehyde-3-phosphate dehydrogenase/0.442
1q6t600Tyrosine-protein phosphatase non-receptor type 13.1.3.480.442
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.442
1rfuADPPyridoxal kinase2.7.1.350.442
1uyhPU0Heat shock protein HSP 90-alpha/0.442
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.442
2igoFADPyranose 2-oxidase/0.442
2qo9ANPEphrin type-A receptor 32.7.10.10.442
2r0pK2CPutative FAD-monooxygenase/0.442
2w71L23Biotin carboxylase6.3.4.140.442
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.442
3a62STURibosomal protein S6 kinase beta-12.7.11.10.442
3bg7FADPyranose 2-oxidase/0.442
3da1FADGlycerol-3-phosphate dehydrogenase/0.442
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3iphG11Mitogen-activated protein kinase 14/0.442
3kb6NADD-lactate dehydrogenase/0.442
3kduNKSPeroxisome proliferator-activated receptor alpha/0.442
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3tneRITCandidapepsin-13.4.23.240.442
3ts1TYATyrosine--tRNA ligase6.1.1.10.442
3vt7VDXVitamin D3 receptor/0.442
3w32W32Epidermal growth factor receptor2.7.10.10.442
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.442
4h2nFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.442
4jin1L7RIO-type serine/threonine-protein kinase Rio12.7.11.10.442
4l0qNADAlcohol dehydrogenase class-3/0.442
4mleVO1Glucokinase2.7.1.20.442
4mokFADPyranose 2-oxidase/0.442
5ch7MD1DMSO reductase family type II enzyme, molybdopterin subunit/0.442
5dozNDPJamJ/0.442
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.441
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
1pq944BOxysterols receptor LXR-beta/0.441
1v35NAIEnoyl-ACP reductase/0.441
1y4lSVRBasic phospholipase A2 homolog 2/0.441
1youPFDCollagenase 33.4.240.441
1zeoC01Peroxisome proliferator-activated receptor gamma/0.441
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.441
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.441
2d29FADAcyl-CoA dehydrogenase/0.441
2dxwSAHDiphthine synthase/0.441
2f2sCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.441
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.441
2r3wG3GGag-Pol polyprotein3.4.23.160.441
2xvu9DNSerum albumin/0.441
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3cd57HI3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.441
3d7zGK5Mitogen-activated protein kinase 14/0.441
3gxlQIGTGF-beta receptor type-12.7.11.300.441
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
3n4mCMPcAMP-activated global transcriptional regulator CRP/0.441
3p3zP3ZPutative cytochrome P450/0.441
3zc3NAPFerredoxin--NADP reductase1.18.1.20.441
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.441
4aoxFADSteroid monooxygenase/0.441
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.441
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.441
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4isk1JYThymidylate synthase/0.441
4kin1M8Mitogen-activated protein kinase 14/0.441
4kugNAD3-hydroxybutyryl-CoA dehydrogenase/0.441
4m4922YL-lactate dehydrogenase A chain1.1.1.270.441
4m9aFDAAcyl-CoA dehydrogenase/0.441
4mzuCOAWxcM-like protein/0.441
4riyADPEpidermal growth factor receptor2.7.10.10.441
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1cjkFOKAdenylate cyclase type 2/0.440
1cjkFOKAdenylate cyclase type 5/0.440
1cjtFOKAdenylate cyclase type 2/0.440
1cjtFOKAdenylate cyclase type 5/0.440
1hdoNAPFlavin reductase (NADPH)/0.440
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.440
1pw6FRBInterleukin-2/0.440
1srfMTBStreptavidin/0.440
2b53D23Cyclin-dependent kinase 22.7.11.220.440
2g78REACellular retinoic acid-binding protein 2/0.440
2ghlLIBMitogen-activated protein kinase 14/0.440
2xaaNADSecondary alcohol dehydrogenase/0.440
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.440
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
3ojxFADNADPH--cytochrome P450 reductase/0.440
3owuEQUSteroid Delta-isomerase5.3.3.10.440
3q7dNPXProstaglandin G/H synthase 21.14.99.10.440
3tfp03LDehydrosqualene synthase/0.440
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.440
3uxyNADShort-chain dehydrogenase/reductase SDR/0.440
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.440
4fe60TQGag-Pol polyprotein3.4.23.160.440
4fxy0W2Neurolysin, mitochondrial3.4.24.160.440
4j7dI31E3 ubiquitin-protein ligase Mdm26.3.20.440
4jq3NAPAldo-keto reductase family 1 member C2/0.440
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440
4jx1CAMCamphor 5-monooxygenase1.14.15.10.440
4loqSB4Mitogen-activated protein kinase 14/0.440
4q73FADBifunctional protein PutA/0.440
5iqgGDPBifunctional AAC/APH2.3.10.440
5iqhGNPBifunctional AAC/APH2.3.10.440
5kcpNAJAlcohol dehydrogenase E chain1.1.1.10.440