sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3vjl | W94 | Dipeptidyl peptidase 4 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3vjl | W94 | Dipeptidyl peptidase 4 | / | 1.000 | |
| 3vjk | M51 | Dipeptidyl peptidase 4 | / | 0.762 | |
| 3qbj | NXZ | Dipeptidyl peptidase 4 | / | 0.636 | |
| 3ccb | B2Y | Dipeptidyl peptidase 4 | / | 0.627 | |
| 3f8s | PF2 | Dipeptidyl peptidase 4 | / | 0.620 | |
| 2aj8 | SC3 | Dipeptidyl peptidase 4 | / | 0.548 | |
| 3opm | LUI | Dipeptidyl peptidase 4 | / | 0.545 | |
| 3ccc | 7AC | Dipeptidyl peptidase 4 | / | 0.530 | |
| 4ffw | 715 | Dipeptidyl peptidase 4 | / | 0.525 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.509 | |
| 2rgu | 356 | Dipeptidyl peptidase 4 | / | 0.505 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.505 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.497 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.495 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.495 | |
| 3g0b | T22 | Dipeptidyl peptidase 4 | / | 0.492 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.492 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.492 | |
| 3g0g | RUM | Dipeptidyl peptidase 4 | / | 0.490 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.490 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.488 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.487 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.486 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.485 | |
| 2oae | AIL | Dipeptidyl peptidase 4 | / | 0.485 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.482 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.482 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.481 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.480 | |
| 3int | FDA | UDP-galactopyranose mutase | 5.4.99.9 | 0.480 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.479 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.479 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.479 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.477 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.477 | |
| 1vhz | APR | ADP compounds hydrolase NudE | 3.6.1 | 0.477 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.477 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.477 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.477 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.477 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.476 | |
| 3g0d | XIH | Dipeptidyl peptidase 4 | / | 0.476 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.476 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.476 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.474 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.474 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.474 | |
| 3d3x | ARG_ILE_MET_GLU_NH2 | Type E botulinum toxin | / | 0.473 | |
| 3o5r | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.473 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.472 | |
| 3udj | 092 | Beta-secretase 1 | 3.4.23.46 | 0.472 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.471 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.471 | |
| 2c6c | 24I | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.470 | |
| 2x91 | LPR | Angiotensin-converting enzyme | 3.4.15.1 | 0.470 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.470 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 4g1f | 0WG | Dipeptidyl peptidase 4 | / | 0.470 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.469 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.469 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.469 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.469 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.468 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.468 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.467 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.467 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.467 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.466 | |
| 1qpl | 587 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.466 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.466 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.466 | |
| 5dld | UD1 | UDP-N-Acetylglucosamine 2-epimerase | / | 0.466 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.465 | |
| 1mbb | EEB | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.465 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.465 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.465 | |
| 2jgb | MGT | Eukaryotic translation initiation factor 4E type 2 | / | 0.465 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.465 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.464 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.464 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.464 | |
| 2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.463 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.463 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.463 | |
| 1j37 | X8Z | Angiotensin-converting enzyme | 3.4.15.1 | 0.462 | |
| 3muo | ZPR | Prolyl endopeptidase | / | 0.462 | |
| 4asu | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.462 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.462 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.461 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.461 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.461 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.461 | |
| 3c8b | ARG_ARG_GLY_ILE_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.461 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.461 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.461 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.460 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.460 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.460 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2fxf | ACO | Diamine acetyltransferase 1 | / | 0.459 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.459 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.459 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.459 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.458 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.458 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.458 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.458 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.458 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.458 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.458 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.457 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.457 | |
| 2wat | COA | Fatty acid synthase subunit alpha | 2.3.1.86 | 0.457 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.457 | |
| 3c8a | ARG_ARG_GLY_LEU_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.457 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.457 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 4coj | CTP | Uncharacterized protein | / | 0.457 | |
| 4jb1 | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.457 | |
| 4qfz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.457 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.456 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.456 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.456 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.456 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.456 | |
| 4lut | DCS | Alanine racemase | / | 0.456 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.456 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.455 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 4drm | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.455 | |
| 4f3x | NAD | Putative aldehyde dehydrogenase | / | 0.455 | |
| 4nv1 | TYD | Formyl transferase | / | 0.455 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.454 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.454 | |
| 2xnv | VU3 | Soluble acetylcholine receptor | / | 0.454 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.454 | |
| 1tiq | COA | Spermidine/spermine N(1)-acetyltransferase | / | 0.453 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.453 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.453 | |
| 2x3j | ATP | AcsD | / | 0.453 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.453 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.452 | |
| 1oxo | IK2 | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.452 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.452 | |
| 3e6e | DCS | Alanine racemase | / | 0.452 | |
| 4aws | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.452 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
| 4x7v | MIV | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.452 | |
| 1zp4 | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.451 | |
| 2anb | 5GP | Guanylate kinase | 2.7.4.8 | 0.451 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.451 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.451 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.451 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.451 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.451 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.451 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.451 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.451 | |
| 4rkd | KET | Aminotransferase | / | 0.451 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.450 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.450 | |
| 1v45 | 3DG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2v7q | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.450 | |
| 2v7q | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.450 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.450 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.450 | |
| 4dya | 0MF | Nucleoprotein | / | 0.450 | |
| 1fkb | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.449 | |
| 1fxu | GU7 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 1iki | REY | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.449 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.449 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.449 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 3hdy | GDU | UDP-galactopyranose mutase | / | 0.449 | |
| 3s2v | 3HU | Glutamate receptor ionotropic, kainate 1 | / | 0.449 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.449 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4bxk | 1IU | Angiotensin-converting enzyme | 3.2.1 | 0.449 | |
| 4de1 | 0J6 | Beta-lactamase | / | 0.449 | |
| 4ikz | AFS | Di-tripeptide ABC transporter (Permease) | / | 0.449 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.448 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.448 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.448 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.448 | |
| 4jic | FMN | GTN Reductase | / | 0.448 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.447 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.447 | |
| 2qs4 | LY5 | Glutamate receptor ionotropic, kainate 1 | / | 0.447 | |
| 2vj6 | VG5 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.447 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.447 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.447 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 4awt | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.447 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.446 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.446 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.446 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.446 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.446 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.446 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.446 | |
| 4c5o | FAD | Putative monooxygenase | / | 0.446 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.446 | |
| 4l7g | 1W0 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.446 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.446 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.445 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.445 | |
| 2ck3 | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.445 | |
| 2ck3 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.445 | |
| 2po3 | T4K | 4-dehydrase | / | 0.445 | |
| 2qjo | NAD | Bifunctional NMN adenylyltransferase/Nudix hydrolase | 2.7.7.1 | 0.445 | |
| 3akz | GSU | Glutamate--tRNA ligase 2 | / | 0.445 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.445 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.445 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.445 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.445 | |
| 3zgz | 84T | Leucine--tRNA ligase | / | 0.445 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.445 | |
| 4ca8 | 3ES | Angiotensin-converting enzyme | 3.4.15.1 | 0.445 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.445 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.445 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.445 | |
| 4rxr | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.445 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.444 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.444 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.444 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 3tjl | FMN | NADPH dehydrogenase | / | 0.444 | |
| 4j7h | TRH | PCZA361.3 | / | 0.444 | |
| 4m2b | UPG | UDP-glucose pyrophosphorylase | / | 0.444 | |
| 4qfy | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 5cfl | C2E | Stimulator of interferon genes protein | / | 0.444 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1umk | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.443 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.443 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.443 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.443 | |
| 2q96 | A18 | Methionine aminopeptidase | / | 0.443 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
| 3kyb | FMN | UDP-galactopyranose mutase | 5.4.99.9 | 0.443 | |
| 4zwe | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.443 | |
| 1ja0 | FMN | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.442 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.442 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.442 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.442 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.442 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.442 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.442 | |
| 3wid | NAP | Glucose 1-dehydrogenase | / | 0.442 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.442 | |
| 3zxi | TYA | Tyrosine--tRNA ligase, mitochondrial | 6.1.1.1 | 0.442 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.442 | |
| 4de3 | DN8 | Beta-lactamase | / | 0.442 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.442 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.442 | |
| 4lay | I63 | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.442 | |
| 1j0d | 5PA | 1-aminocyclopropane-1-carboxylate deaminase | 3.5.99.7 | 0.441 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.441 | |
| 1s1r | NAP | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1v5z | 2HC | Major NAD(P)H-flavin oxidoreductase | 1.6.99 | 0.441 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.441 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.441 | |
| 2gqa | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.441 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.441 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.441 | |
| 4drk | I63 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.441 | |
| 4to1 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.441 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.441 | |
| 1fkh | SBX | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 1fkj | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 2dg4 | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.440 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.440 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.440 | |
| 2xpc | 051 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.440 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 3i5x | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.440 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.440 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.440 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.440 |