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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2potGUNQueuine tRNA-ribosyltransferase2.4.2.29

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2potGUNQueuine tRNA-ribosyltransferase2.4.2.291.000
2bbf344Queuine tRNA-ribosyltransferase2.4.2.290.661
1k4hAPQQueuine tRNA-ribosyltransferase2.4.2.290.628
4fsa0V3Queuine tRNA-ribosyltransferase2.4.2.290.622
1r5yDQUQueuine tRNA-ribosyltransferase2.4.2.290.604
1q4wDQUQueuine tRNA-ribosyltransferase2.4.2.290.603
4fr10V2Queuine tRNA-ribosyltransferase2.4.2.290.592
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.591
1f3eDPZQueuine tRNA-ribosyltransferase2.4.2.290.587
4gg90WWQueuine tRNA-ribosyltransferase2.4.2.290.584
4hshQEIQueuine tRNA-ribosyltransferase2.4.2.290.581
1p0ePRFQueuine tRNA-ribosyltransferase2.4.2.290.579
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.579
4gkt0O1Queuine tRNA-ribosyltransferase2.4.2.290.575
1ozqPRFQueuine tRNA-ribosyltransferase2.4.2.290.562
1y5vNE8Queuine tRNA-ribosyltransferase2.4.2.290.562
1pxgPRFQueuine tRNA-ribosyltransferase2.4.2.290.561
4gh10WXQueuine tRNA-ribosyltransferase2.4.2.290.561
4fps0UXQueuine tRNA-ribosyltransferase2.4.2.290.560
4gh30EVQueuine tRNA-ribosyltransferase2.4.2.290.559
4giy0WYQueuine tRNA-ribosyltransferase2.4.2.290.557
2qzrS79Queuine tRNA-ribosyltransferase2.4.2.290.556
2z1xPRFQueuine tRNA-ribosyltransferase2.4.2.290.553
4q8pCKRQueuine tRNA-ribosyltransferase2.4.2.290.550
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.545
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.541
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.529
4gcxPRFQueuine tRNA-ribosyltransferase2.4.2.290.529
4ej1FOLDihydrofolate reductase1.5.1.30.527
1efzPRFQueuine tRNA-ribosyltransferase2.4.2.290.524
3gc4AAQQueuine tRNA-ribosyltransferase2.4.2.290.521
2pwuGUNQueuine tRNA-ribosyltransferase2.4.2.290.519
4h7zGUNQueuine tRNA-ribosyltransferase2.4.2.290.514
4hqvQEIQueuine tRNA-ribosyltransferase2.4.2.290.514
2z1wBDIQueuine tRNA-ribosyltransferase2.4.2.290.511
1kruIPTGalactoside O-acetyltransferase2.3.1.180.509
1q65BHBQueuine tRNA-ribosyltransferase2.4.2.290.505
3bllBPQQueuine tRNA-ribosyltransferase2.4.2.290.505
1m9k7NINitric oxide synthase, endothelial1.14.13.390.502
3sm0AEKQueuine tRNA-ribosyltransferase2.4.2.290.502
1q66KMBQueuine tRNA-ribosyltransferase2.4.2.290.500
1q63AIQQueuine tRNA-ribosyltransferase2.4.2.290.499
1it7GUNtRNA-guanine(15) transglycosylase2.4.2.480.498
4uqsINENitric oxide synthase oxygenase1.14.13.1650.496
4iarERM5-hydroxytryptamine receptor 1B/0.488
1m9jCLWNitric oxide synthase, endothelial1.14.13.390.486
1zy5ANPeIF-2-alpha kinase GCN2/0.486
1fw0KAIGlutamate receptor 2/0.485
4jshQ15Nitric oxide synthase, brain1.14.13.390.485
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.483
4hfp15UProthrombin3.4.21.50.482
1jdzFMBPurine nucleoside phosphorylase/0.481
4fvz4KJNitric oxide synthase, brain1.14.13.390.480
4b6uM7GEukaryotic translation initiation factor 4E type 3/0.479
3ex8AIFRiboflavin biosynthesis protein RibD1.1.1.1930.478
1e7wMTXPteridine reductase 11.5.1.330.477
1ltzHBIPhenylalanine-4-hydroxylase1.14.16.10.477
3c3ySAHO-methyltransferase/0.477
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.476
3rykTYDdTDP-4-dehydrorhamnose 3,5-epimerase/0.476
4hvxQEIQueuine tRNA-ribosyltransferase2.4.2.290.476
2z7gEH9Adenosine deaminase3.5.4.40.473
2zzcNAPThioredoxin reductase 1, cytoplasmic1.8.1.90.473
1krv147Galactoside O-acetyltransferase2.3.1.180.472
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.472
3ar612DSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.472
3mauEXTPutative sphingosine-1-phosphate lyase/0.472
4l64C2F5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase2.1.1.140.472
1n2vBDIQueuine tRNA-ribosyltransferase2.4.2.290.471
2b8jADNClass B acid phosphatase3.1.3.20.471
3c36KAIGlutamate receptor ionotropic, kainate 1/0.471
3m3z3F5Heat shock cognate 71 kDa protein/0.471
2cdcNAPGlucose 1-dehydrogenase/0.470
3dqrJI2Nitric oxide synthase, brain1.14.13.390.469
4rtbSAMPutative thiazole biosynthesis protein ThiH/0.469
2x94X94Angiotensin-converting enzyme3.4.15.10.468
4h3j10WBeta-secretase 13.4.23.460.468
4lwaQ13Nitric oxide synthase oxygenase1.14.13.1650.468
2bt4CA23-dehydroquinate dehydratase4.2.1.100.467
2i4tUA2Purine nucleoside phosphorylase, putative/0.467
2q0cCTPPoly(A) polymerase, putative/0.467
3axsSFGtRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase/0.467
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.300.467
3nmhPYVAbscisic acid receptor PYL2/0.466
2vrjNCWBeta-glucosidase A3.2.1.210.465
3biz61EWee1-like protein kinase2.7.10.20.465
4jseQJ2Nitric oxide synthase, brain1.14.13.390.465
2bo7GDPMannosylglycerate synthase/0.464
2io6330Wee1-like protein kinase2.7.10.20.464
2o98FSC14-3-3-like protein C/0.464
2oalFADFlavin-dependent tryptophan halogenase RebH1.14.19.90.464
2ytzSAHtRNA (guanine(26)-N(2))-dimethyltransferase/0.464
3c1xCKKHepatocyte growth factor receptor2.7.10.10.464
3uq9TBNPutative adenosine kinase/0.464
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.464
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.464
4gqe6KJNitric oxide synthase, brain1.14.13.390.464
1m8h6NINitric oxide synthase, inducible1.14.13.390.463
3c35KAIGlutamate receptor ionotropic, kainate 1/0.463
3hr4FMNNitric oxide synthase, inducible1.14.13.390.463
2azyCHDPhospholipase A2, major isoenzyme3.1.1.40.462
3nlv3XANitric oxide synthase, brain1.14.13.390.462
4l7g1W0Beta-secretase 13.4.23.460.462
4s1iPLPPyridoxal kinase, putative/0.462
2q0gUPUPoly(A) polymerase, putative/0.461
3axtSAMtRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase/0.461
3cr7PPSAdenylyl-sulfate kinase2.7.1.250.461
3d2dRENReticuline oxidase1.21.3.30.461
4bdrKAIGlutamate receptor ionotropic, kainate 2/0.461
4mmf29QNa(+):neurotransmitter symporter (Snf family)/0.461
4ug5XFKNitric oxide synthase oxygenase1.14.13.1650.461
1rs6DP2Nitric oxide synthase, brain1.14.13.390.460
1zisINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.460
3nlw3XFNitric oxide synthase, brain1.14.13.390.460
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.459
3eah327Nitric oxide synthase, endothelial1.14.13.390.459
3nxrD2DDihydrofolate reductase1.5.1.30.459
3rm8RM8Acidic mammalian chitinase3.2.1.140.459
1kyzFERCaffeic acid 3-O-methyltransferase2.1.1.680.458
3c3eFO12-phospho-L-lactate transferase/0.458
1k9sFM1Purine nucleoside phosphorylase DeoD-type/0.457
1p6jDP9Nitric oxide synthase, brain1.14.13.390.457
3arzI5IChitinase A/0.457
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.457
4ug71EVNitric oxide synthase oxygenase1.14.13.1650.457
5aqzSGVHeat shock 70 kDa protein 1A/0.457
5hvnNAD3-dehydroquinate synthase/0.457
3anlSYC1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.456
3arwCTIChitinase A/0.456
3eanNAPThioredoxin reductase 1, cytoplasmic1.8.1.90.456
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
4u7wNDPMxaA/0.456
1q6nP90Tyrosine-protein phosphatase non-receptor type 13.1.3.480.455
1rx4DDFDihydrofolate reductase1.5.1.30.455
4mmc29JNa(+):neurotransmitter symporter (Snf family)/0.455
1dljUGAUDP-glucose 6-dehydrogenase/0.454
3bldPRFQueuine tRNA-ribosyltransferase2.4.2.290.454
3e7mAT2Nitric oxide synthase, inducible1.14.13.390.454
3roeTHMNAD(P)H-hydrate epimerase5.1.99.60.454
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.454
4l17DNQGlutamate receptor 2/0.454
4ndnSAMS-adenosylmethionine synthase isoform type-22.5.1.60.454
2j7cIDEBeta-glucosidase A3.2.1.210.453
3e6t1A2Nitric oxide synthase, inducible1.14.13.390.453
4gqkADPActin cross-linking toxin VgrG1/0.453
4i13FOLDihydrofolate reductase1.5.1.30.453
1nd52BFProstatic acid phosphatase3.1.3.20.452
3rupADPBiotin carboxylase6.3.4.140.452
1eqbFFOSerine hydroxymethyltransferase2.1.2.10.451
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.451
1r35I58Nitric oxide synthase, inducible1.14.13.390.451
2q0dATPPoly(A) polymerase, putative/0.451
3vaqADNPutative adenosine kinase/0.451
4n3r2GUTankyrase-12.4.2.300.451
5bp7SAHSAM-dependent methyltransferase/0.451
1lb9DNQGlutamate receptor 2/0.450
1qw514WNitric oxide synthase, inducible1.14.13.390.450
3i53SAH2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase/0.450
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.450
4ho6UPGGlucose-1-phosphate thymidylyltransferase/0.450
4jxzATPGlutamine--tRNA ligase6.1.1.180.450
4mm48PRNa(+):neurotransmitter symporter (Snf family)/0.450
1z4iUMP5'(3')-deoxyribonucleotidase, mitochondrial3.1.30.449
3c34KAIGlutamate receptor ionotropic, kainate 1/0.449
5dx8SFGHistone-arginine methyltransferase CARM1/0.449
5ks72BACarnitine transport ATP-binding protein OpuCA3.6.3.320.449
1jdtMTAPurine nucleoside phosphorylase/0.448
1pr1FMBPurine nucleoside phosphorylase DeoD-type/0.448
1u8xNADMaltose-6'-phosphate glucosidase3.2.1.1220.448
1y5wNEZQueuine tRNA-ribosyltransferase2.4.2.290.448
2ea4F79Methionine aminopeptidase 2/0.448
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.448
1kijNOVDNA gyrase subunit B/0.447
1m9rINENitric oxide synthase, endothelial1.14.13.390.447
3aw9GDUNAD-dependent epimerase/dehydratase/0.447
4jsjQJ7Nitric oxide synthase, brain1.14.13.390.447
4lwbQJ8Nitric oxide synthase oxygenase1.14.13.1650.447
4mm9FVXNa(+):neurotransmitter symporter (Snf family)/0.447
4n65FMNFMN-dependent NADH-azoreductase 1/0.447
1jwtBLIProthrombin3.4.21.50.446
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.446
2a4xBLMMitomycin-binding protein/0.446
2ejuSAHtRNA (guanine(26)-N(2))-dimethyltransferase/0.446
3rmeRMEAcidic mammalian chitinase3.2.1.140.446
4h3g10QBeta-secretase 13.4.23.460.446
4kbn25UDihydrofolate reductase1.5.1.30.446
1m9tINENitric oxide synthase, inducible1.14.13.390.445
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.445
2wbgLGSBeta-glucosidase A3.2.1.210.445
3a26MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase/0.445
3eai328Nitric oxide synthase, inducible1.14.13.390.445
4l0oPLPCystathionine gamma-synthase2.5.1.480.445
1mc1PCXCarboxyethyl-arginine beta-lactam-synthase6.3.3.40.444
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.444
2bf4FADNADPH--cytochrome P450 reductase/0.444
2itqITQEpidermal growth factor receptor2.7.10.10.444
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.444
2y0dUGAUDP-glucose dehydrogenase/0.444
2y1xSAHHistone-arginine methyltransferase CARM1/0.444
3jx0JI4Nitric oxide synthase, brain1.14.13.390.444
3nmvPYVAbscisic acid receptor PYL2/0.444
3sglSAMtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC/0.444
4fw05KJNitric oxide synthase, brain1.14.13.390.444
4zqmXMPInosine-5'-monophosphate dehydrogenase/0.444
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
1td2PXLPyridoxal kinase PdxY/0.443
1ygjRMCPyridoxal kinase2.7.1.350.443
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.443
2isc223Purine nucleoside phosphorylase, putative/0.443
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.443
4ugaQ05Nitric oxide synthase oxygenase1.14.13.1650.443
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.443
1o6i0HZChitinase B3.2.1.140.442
1pk92FAPurine nucleoside phosphorylase DeoD-type/0.442
1pke2FDPurine nucleoside phosphorylase DeoD-type/0.442
3e7tB14Nitric oxide synthase, inducible1.14.13.390.442
1o86LPRAngiotensin-converting enzyme3.2.10.441
2j7dGI1Beta-glucosidase A3.2.1.210.441
2q66ATPPoly(A) polymerase2.7.7.190.441
3fzm3GOHeat shock cognate 71 kDa protein/0.441
3g72A6TRenin3.4.23.150.441
3lpgZ78Beta-glucuronidase3.2.1.310.441
3n5yXFLNitric oxide synthase, brain1.14.13.390.441
3nlkJSSNitric oxide synthase, brain1.14.13.390.441
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.441
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.441
4lt63ATPoly(A) polymerase gamma2.7.7.190.441
4m2xTMQDihydrofolate reductase1.5.1.30.441
4yjdFADD-amino-acid oxidase1.4.3.30.441
5dhhDGWNociceptin receptor/0.441
1giqNAIIota toxin component Ia/0.440
1jdvADNPurine nucleoside phosphorylase/0.440
1p33MTXPteridine reductase 11.5.1.330.440
1u22THG5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 12.1.1.140.440
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3b5iSAHIndole-3-acetate O-methyltransferase 1/0.440
3jwsJI4Nitric oxide synthase, brain1.14.13.390.440
3rviRVIBeta-secretase 13.4.23.460.440
3uawADNPurine nucleoside phosphorylase DeoD-type/0.440
4dsjDGTDNA polymerase I/0.440
4e31JHZMethyltransferase/0.440
4f97VDOPutative glycosyltransferase/0.440
4k5fQ14Nitric oxide synthase, brain1.14.13.390.440
4req5ADMethylmalonyl-CoA mutase large subunit5.4.99.20.440
4xp4COCSodium-dependent dopamine transporter/0.440
4z9rNADOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.440
5dx1SFGHistone-arginine methyltransferase CARM1/0.440