Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ek3 | SAH | Diphthine synthase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2ek3 | SAH | Diphthine synthase | / | 1.000 | |
| 2hut | SAH | Diphthine synthase | / | 0.858 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.829 | |
| 2e15 | SAH | Diphthine synthase | / | 0.820 | |
| 2owk | SAH | Diphthine synthase | / | 0.795 | |
| 2owg | SAH | Diphthine synthase | / | 0.792 | |
| 2p6i | SAH | Diphthine synthase | / | 0.791 | |
| 2eh2 | SAH | Diphthine synthase | / | 0.790 | |
| 2p5c | SAH | Diphthine synthase | / | 0.785 | |
| 2huq | SAH | Diphthine synthase | / | 0.780 | |
| 2dsi | SAH | Diphthine synthase | / | 0.779 | |
| 2p5f | SAH | Diphthine synthase | / | 0.769 | |
| 2p9d | SAH | Diphthine synthase | / | 0.769 | |
| 2pb5 | SAH | Diphthine synthase | / | 0.769 | |
| 2owu | SAH | Diphthine synthase | / | 0.758 | |
| 2dxx | SAH | Diphthine synthase | / | 0.752 | |
| 2e17 | SAH | Diphthine synthase | / | 0.743 | |
| 2e8r | SAH | Diphthine synthase | / | 0.738 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.738 | |
| 2pck | SAH | Diphthine synthase | / | 0.731 | |
| 2huv | SAH | Diphthine synthase | / | 0.729 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.728 | |
| 2eeq | SAH | Diphthine synthase | / | 0.727 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.726 | |
| 2e7r | SAH | Diphthine synthase | / | 0.724 | |
| 2z6r | SAH | Diphthine synthase | / | 0.723 | |
| 2pca | SAH | Diphthine synthase | / | 0.722 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.717 | |
| 2ehl | SAH | Diphthine synthase | / | 0.702 | |
| 2ele | SAH | Diphthine synthase | / | 0.702 | |
| 2p2x | SAH | Diphthine synthase | / | 0.694 | |
| 2emu | SAH | Diphthine synthase | / | 0.684 | |
| 2eni | SAH | Diphthine synthase | / | 0.684 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.682 | |
| 2e4n | SAH | Diphthine synthase | / | 0.681 | |
| 1wng | SAH | Diphthine synthase | / | 0.677 | |
| 2dsh | SAH | Diphthine synthase | / | 0.672 | |
| 2emr | SAH | Diphthine synthase | / | 0.669 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.668 | |
| 2pcg | SAH | Diphthine synthase | / | 0.668 | |
| 2el0 | SAH | Diphthine synthase | / | 0.667 | |
| 2egb | SAH | Diphthine synthase | / | 0.666 | |
| 2e07 | SAH | Diphthine synthase | / | 0.665 | |
| 2egs | SAH | Diphthine synthase | / | 0.665 | |
| 2e08 | SAH | Diphthine synthase | / | 0.663 | |
| 2el3 | SAH | Diphthine synthase | / | 0.661 | |
| 2ejk | SAH | Diphthine synthase | / | 0.657 | |
| 2pci | SAH | Diphthine synthase | / | 0.657 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.656 | |
| 2p6k | SAH | Diphthine synthase | / | 0.656 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.654 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.651 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.650 | |
| 2ejj | SAH | Diphthine synthase | / | 0.648 | |
| 2e8h | SAH | Diphthine synthase | / | 0.644 | |
| 2dxw | SAH | Diphthine synthase | / | 0.640 | |
| 2pch | SAH | Diphthine synthase | / | 0.639 | |
| 1vce | SAH | Diphthine synthase | / | 0.637 | |
| 2eld | SAH | Diphthine synthase | / | 0.636 | |
| 2dxv | SAH | Diphthine synthase | / | 0.627 | |
| 2dek | SAH | Diphthine synthase | / | 0.625 | |
| 2ek4 | SAH | Diphthine synthase | / | 0.624 | |
| 2dsg | SAH | Diphthine synthase | / | 0.621 | |
| 2pcm | SAH | Diphthine synthase | / | 0.621 | |
| 2p6d | SAH | Diphthine synthase | / | 0.616 | |
| 2eka | SAH | Diphthine synthase | / | 0.611 | |
| 2owf | SAH | Diphthine synthase | / | 0.600 | |
| 2e8s | SAH | Diphthine synthase | / | 0.589 | |
| 2hux | SAH | Diphthine synthase | / | 0.581 | |
| 2owv | SAH | Diphthine synthase | / | 0.577 | |
| 2p6l | SAH | Diphthine synthase | / | 0.573 | |
| 2e8q | SAH | Diphthine synthase | / | 0.571 | |
| 2ejz | SAH | Diphthine synthase | / | 0.565 | |
| 2egl | SAH | Diphthine synthase | / | 0.561 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.549 | |
| 2en5 | SAH | Diphthine synthase | / | 0.536 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.534 | |
| 2e16 | SAH | Diphthine synthase | / | 0.532 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.514 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.495 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.494 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.491 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.488 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.486 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.484 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.483 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.483 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.483 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.482 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.480 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.480 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.479 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.477 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.477 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.475 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.474 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.473 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.473 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.473 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.473 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.471 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.469 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.469 | |
| 3v3m | 0EN | Replicase polyprotein 1a | 3.4.19.12 | 0.469 | |
| 4wud | ANP | DNA gyrase subunit B | / | 0.469 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.469 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.468 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.468 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.468 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.468 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.468 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.466 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.466 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.465 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.465 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.465 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.464 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.464 | |
| 2cgv | 3B3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.464 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.464 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.464 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.463 | |
| 1o97 | FAD | Electron transfer flavoprotein subunit alpha | / | 0.463 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.463 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.463 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 4djy | 0KR | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.462 | |
| 1vp6 | CMP | Cyclic nucleotide-gated potassium channel mll3241 | / | 0.462 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.462 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.462 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.462 | |
| 4nwz | FAD | FAD-dependent pyridine nucleotide-disulfide oxidoreductase | / | 0.462 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.461 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.460 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.460 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.460 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3ojx | FAD | NADPH--cytochrome P450 reductase | / | 0.460 | |
| 4ig0 | 1FG | Gag-Pol polyprotein | 2.7.7.49 | 0.460 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.459 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.459 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.459 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.459 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.459 | |
| 5cyo | GDP | Septin-9 | / | 0.459 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.458 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.458 | |
| 2y3s | TIR | TamL | / | 0.458 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 1e1q | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.457 | |
| 1e1q | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.457 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 2b8l | 5HA | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.457 | |
| 3itj | FAD | Thioredoxin reductase 1 | 1.8.1.9 | 0.457 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.457 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.456 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.456 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 3wb2 | YGP | Uncharacterized protein MJ0488 | / | 0.456 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.456 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.455 | |
| 1xl5 | 190 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.455 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.455 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.455 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.455 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.455 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.455 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.455 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.455 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.454 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.454 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.454 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.453 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.453 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.453 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.453 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.453 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.453 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.453 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.453 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.453 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.452 | |
| 1cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.452 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.452 | |
| 1msm | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.452 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.452 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.452 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.452 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.452 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.452 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.452 | |
| 2ym4 | 4YM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.452 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.452 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.452 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 1eio | GCH | Gastrotropin | / | 0.451 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.451 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.451 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.451 | |
| 4l7f | 1V5 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.451 | |
| 1ep3 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.450 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.450 | |
| 1rv1 | IMZ | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.450 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.450 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.450 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.450 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 3oev | 3OE | Proteasome subunit beta type-5 | 3.4.25.1 | 0.450 | |
| 3oev | 3OE | Proteasome subunit beta type-6 | 3.4.25.1 | 0.450 | |
| 3p2e | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.450 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.450 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.450 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.449 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.449 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.449 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.449 | |
| 1zio | AP5 | Adenylate kinase | / | 0.449 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.449 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.449 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.449 | |
| 2q8s | L92 | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.449 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.449 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.449 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.449 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.449 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.449 | |
| 4ohv | ANP | Protein clpf-1 | / | 0.449 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.449 | |
| 4yqf | GDP | Septin-9 | / | 0.449 | |
| 5c77 | SAH | Protein arginine N-methyltransferase SFM1 | / | 0.449 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.448 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.448 | |
| 2op9 | WR1 | Orf1ab polyprotein | / | 0.448 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.448 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.448 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.448 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4dx9 | SER_ALA_VAL_THR | Integrin beta-1 | / | 0.448 | |
| 4dx9 | SER_ALA_VAL_THR | Integrin beta-1-binding protein 1 | / | 0.448 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.448 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.448 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.447 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.447 | |
| 1q12 | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.447 | |
| 2e9o | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.447 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.447 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.447 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.447 | |
| 3so9 | 017 | Pol protein | / | 0.447 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.447 | |
| 4irn | FAD | AnaB | / | 0.447 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.447 | |
| 4l4x | NDP | AmphI | / | 0.447 | |
| 5dp2 | NAP | CurF | / | 0.447 | |
| 1bmf | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.446 | |
| 1bmf | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.446 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.446 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1nyx | DRF | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.446 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.446 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.446 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.446 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.446 | |
| 3u9e | COA | Lmo1369 protein | / | 0.446 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.446 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.445 | |
| 1h8h | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.445 | |
| 1h8h | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.445 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.445 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.445 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.445 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.445 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.445 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.445 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.445 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.445 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.445 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3ut5 | LOC | Tubulin beta chain | / | 0.445 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.445 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.445 | |
| 2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2j07 | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.444 | |
| 2y3r | TRK | TamL | / | 0.444 | |
| 2y3r | TIR | TamL | / | 0.444 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.444 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.444 | |
| 3kga | LX9 | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.444 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.444 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.444 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.444 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.444 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.444 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.444 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.443 | |
| 1i3m | UD1 | UDP-glucose 4-epimerase | / | 0.443 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.443 | |
| 1w0k | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.443 | |
| 1w0k | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.443 | |
| 2fgj | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.443 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.443 | |
| 2xvu | 9DN | Serum albumin | / | 0.443 | |
| 2yj4 | ATP | Copper-transporting ATPase | / | 0.443 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.443 | |
| 3vvp | BNU | Uncharacterized protein | / | 0.443 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.443 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.443 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.442 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.442 | |
| 1xds | DRA | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.442 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.442 | |
| 1z1f | STL | Resveratrol synthase | / | 0.442 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.442 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.442 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.442 | |
| 2dcn | ADP | 2-keto-3-deoxy-gluconate kinase | / | 0.442 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.442 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.442 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.442 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.442 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.442 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.442 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.442 | |
| 3ggf | GVD | Serine/threonine-protein kinase 26 | / | 0.442 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.442 | |
| 3mk6 | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.442 | |
| 3sc1 | 3S1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.442 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.442 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4qec | NAP | ElxO | / | 0.442 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.442 | |
| 1j3k | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 1jkx | 138 | Phosphoribosylglycinamide formyltransferase | / | 0.441 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.441 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.441 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.441 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.441 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 3qfr | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.441 | |
| 4duh | RLI | DNA gyrase subunit B | / | 0.441 | |
| 4jxr | ACO | Acetyltransferase | / | 0.441 | |
| 4nak | PBQ | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic | 2.7.7.60 | 0.441 | |
| 4ohx | ADP | Protein clpf-1 | / | 0.441 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.441 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1ytm | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.440 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2bxm | IMN | Serum albumin | / | 0.440 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.440 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.440 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.440 | |
| 2xy3 | DUP | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.440 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.440 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.440 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.440 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.440 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.440 | |
| 4xr9 | NAD | CalS8 | / | 0.440 |