Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2e17 | SAH | Diphthine synthase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2e17 | SAH | Diphthine synthase | / | 1.000 | |
| 2e15 | SAH | Diphthine synthase | / | 0.833 | |
| 2z6r | SAH | Diphthine synthase | / | 0.832 | |
| 2owu | SAH | Diphthine synthase | / | 0.831 | |
| 2eeq | SAH | Diphthine synthase | / | 0.807 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.800 | |
| 2dsi | SAH | Diphthine synthase | / | 0.799 | |
| 2e07 | SAH | Diphthine synthase | / | 0.765 | |
| 2hut | SAH | Diphthine synthase | / | 0.755 | |
| 2owk | SAH | Diphthine synthase | / | 0.746 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.744 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.738 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.738 | |
| 2e4n | SAH | Diphthine synthase | / | 0.735 | |
| 2ek3 | SAH | Diphthine synthase | / | 0.735 | |
| 1wng | SAH | Diphthine synthase | / | 0.726 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.721 | |
| 2emu | SAH | Diphthine synthase | / | 0.717 | |
| 2p6i | SAH | Diphthine synthase | / | 0.714 | |
| 2eh2 | SAH | Diphthine synthase | / | 0.710 | |
| 2huq | SAH | Diphthine synthase | / | 0.702 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.698 | |
| 2huv | SAH | Diphthine synthase | / | 0.694 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.693 | |
| 2el0 | SAH | Diphthine synthase | / | 0.692 | |
| 2p5c | SAH | Diphthine synthase | / | 0.692 | |
| 2dek | SAH | Diphthine synthase | / | 0.691 | |
| 2dsg | SAH | Diphthine synthase | / | 0.680 | |
| 2ejj | SAH | Diphthine synthase | / | 0.680 | |
| 2p5f | SAH | Diphthine synthase | / | 0.680 | |
| 2eni | SAH | Diphthine synthase | / | 0.677 | |
| 2p6l | SAH | Diphthine synthase | / | 0.675 | |
| 2e8r | SAH | Diphthine synthase | / | 0.669 | |
| 2owg | SAH | Diphthine synthase | / | 0.669 | |
| 2p6k | SAH | Diphthine synthase | / | 0.668 | |
| 2emr | SAH | Diphthine synthase | / | 0.667 | |
| 2ehl | SAH | Diphthine synthase | / | 0.663 | |
| 2p9d | SAH | Diphthine synthase | / | 0.663 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.659 | |
| 2pb5 | SAH | Diphthine synthase | / | 0.659 | |
| 2dsh | SAH | Diphthine synthase | / | 0.658 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.656 | |
| 2ejk | SAH | Diphthine synthase | / | 0.655 | |
| 2el3 | SAH | Diphthine synthase | / | 0.652 | |
| 2pca | SAH | Diphthine synthase | / | 0.652 | |
| 2dxx | SAH | Diphthine synthase | / | 0.651 | |
| 2pck | SAH | Diphthine synthase | / | 0.648 | |
| 1vce | SAH | Diphthine synthase | / | 0.646 | |
| 2pci | SAH | Diphthine synthase | / | 0.646 | |
| 2e8h | SAH | Diphthine synthase | / | 0.638 | |
| 2eld | SAH | Diphthine synthase | / | 0.637 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.634 | |
| 2p2x | SAH | Diphthine synthase | / | 0.633 | |
| 2e7r | SAH | Diphthine synthase | / | 0.626 | |
| 2dxw | SAH | Diphthine synthase | / | 0.623 | |
| 2ek4 | SAH | Diphthine synthase | / | 0.622 | |
| 2dxv | SAH | Diphthine synthase | / | 0.621 | |
| 2e16 | SAH | Diphthine synthase | / | 0.619 | |
| 2e08 | SAH | Diphthine synthase | / | 0.615 | |
| 2owv | SAH | Diphthine synthase | / | 0.609 | |
| 2e8s | SAH | Diphthine synthase | / | 0.605 | |
| 2e8q | SAH | Diphthine synthase | / | 0.603 | |
| 2hux | SAH | Diphthine synthase | / | 0.603 | |
| 2egs | SAH | Diphthine synthase | / | 0.601 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.593 | |
| 2p6d | SAH | Diphthine synthase | / | 0.592 | |
| 2ele | SAH | Diphthine synthase | / | 0.590 | |
| 2egb | SAH | Diphthine synthase | / | 0.587 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.586 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.584 | |
| 2pcm | SAH | Diphthine synthase | / | 0.584 | |
| 2ejz | SAH | Diphthine synthase | / | 0.581 | |
| 2owf | SAH | Diphthine synthase | / | 0.571 | |
| 2pcg | SAH | Diphthine synthase | / | 0.570 | |
| 2pch | SAH | Diphthine synthase | / | 0.569 | |
| 2en5 | SAH | Diphthine synthase | / | 0.561 | |
| 2egl | SAH | Diphthine synthase | / | 0.559 | |
| 2eka | SAH | Diphthine synthase | / | 0.557 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.515 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.501 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.500 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.499 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.495 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.491 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.490 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.487 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.486 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.485 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.485 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.485 | |
| 5c77 | SAH | Protein arginine N-methyltransferase SFM1 | / | 0.485 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.484 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.484 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.483 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.483 | |
| 2y3s | TIR | TamL | / | 0.483 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.483 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.481 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.481 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.480 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.480 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.480 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.479 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.478 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.477 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.477 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.477 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.476 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.476 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.476 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.475 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.474 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.473 | |
| 4asu | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.473 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.473 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.472 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.472 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.472 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.471 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.470 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.470 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.469 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.469 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.469 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.468 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.468 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.468 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.468 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.468 | |
| 3zdf | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.467 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.467 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.466 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.466 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.466 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.464 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.464 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.463 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.463 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.463 | |
| 5dp2 | NAP | CurF | / | 0.463 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.462 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.462 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.461 | |
| 2b8l | 5HA | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.461 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.461 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 4xr9 | NAD | CalS8 | / | 0.461 | |
| 1e1q | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.460 | |
| 1e1q | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.460 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.460 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.460 | |
| 1xl5 | 190 | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.460 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.460 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.460 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.460 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.460 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.460 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.460 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.459 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.459 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.459 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.459 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.458 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.458 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.458 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.458 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.458 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.458 | |
| 1vp6 | CMP | Cyclic nucleotide-gated potassium channel mll3241 | / | 0.457 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.457 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.457 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.457 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.457 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.457 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.457 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.457 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.456 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.456 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.456 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.456 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.456 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.456 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.456 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.455 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.455 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.455 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.455 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.455 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.455 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.455 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.454 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.454 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.454 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.454 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.454 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.454 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.454 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.454 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.454 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.453 | |
| 2cgv | 3B3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.453 | |
| 3a3g | DLZ | Lumazine protein | / | 0.453 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.453 | |
| 3omu | IBD | Heat shock protein 83 | / | 0.453 | |
| 3pb3 | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.453 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.453 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.453 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.453 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.452 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.452 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.452 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.452 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.452 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.452 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.452 | |
| 3qpv | ADP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.452 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.452 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.452 | |
| 4qec | NAP | ElxO | / | 0.452 | |
| 4tm3 | FAD | KtzI | / | 0.452 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.452 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.451 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.451 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.451 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.451 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.451 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.451 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.450 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.450 | |
| 1j3k | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.450 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.450 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 2g2z | COZ | Malonyl CoA-acyl carrier protein transacylase | 2.3.1.39 | 0.450 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.450 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.450 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.450 | |
| 3uov | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.450 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.450 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.450 | |
| 4l7f | 1V5 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.450 | |
| 1eio | GCH | Gastrotropin | / | 0.449 | |
| 1h8h | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.449 | |
| 1h8h | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.449 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.449 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.449 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.449 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.449 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.449 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.449 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.449 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.449 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.448 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.448 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.448 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.448 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.448 | |
| 2v7q | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.448 | |
| 2v7q | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.448 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.448 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.448 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.448 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.448 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.448 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.448 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.448 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.447 | |
| 1msm | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.447 | |
| 1w0k | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.447 | |
| 1w0k | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.447 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.447 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.447 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
| 2ym4 | 4YM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 3u9e | COA | Lmo1369 protein | / | 0.447 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.447 | |
| 4irn | FAD | AnaB | / | 0.447 | |
| 4kb9 | G79 | Protease | / | 0.447 | |
| 4ohw | ATP | Protein clpf-1 | / | 0.447 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.447 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.446 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.446 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 1z1f | STL | Resveratrol synthase | / | 0.446 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.446 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.446 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.446 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.446 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.446 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.446 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.446 | |
| 3ilt | TRU | Glutamate receptor 2 | / | 0.446 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 4jl6 | ADP | Adenylate kinase | / | 0.446 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.446 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.445 | |
| 1l2t | ATP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.445 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.445 | |
| 1nlm | UD1 | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | / | 0.445 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.445 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.445 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.445 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.445 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.445 | |
| 2y4g | TIR | TamL | / | 0.445 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.445 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.445 | |
| 3p2e | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.445 | |
| 3sc1 | 3S1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.445 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.444 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.444 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.444 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.444 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.444 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.444 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.444 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4yqf | GDP | Septin-9 | / | 0.444 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.444 | |
| 1gqt | ACP | Ribokinase | / | 0.443 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.443 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.443 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.443 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.443 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.443 | |
| 4l4x | NDP | AmphI | / | 0.443 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.443 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.442 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.442 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.442 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.442 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.442 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.442 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.442 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.442 | |
| 2zrx | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.442 | |
| 3i4b | Z48 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.442 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 3rq6 | APR | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.442 | |
| 3she | I85 | MAP kinase-activated protein kinase 3 | 2.7.11.1 | 0.442 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.442 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.442 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4jl5 | ADP | Adenylate kinase | / | 0.442 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.442 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.441 | |
| 1d4d | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.441 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.441 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.441 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.441 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.441 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.441 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.441 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.441 | |
| 3ivg | FG5 | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.441 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3r95 | ACO | MccE protein | / | 0.441 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.441 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.441 | |
| 4fk8 | FAD | Ferredoxin--NADP reductase | / | 0.441 | |
| 4nak | PBQ | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic | 2.7.7.60 | 0.441 | |
| 4wri | OKA | Okadaic acid binding protein 2-alpha | / | 0.441 | |
| 1bxq | PP8 | Penicillopepsin-1 | 3.4.23.20 | 0.440 | |
| 1cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.440 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.440 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.440 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.440 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.440 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.440 | |
| 3h8b | NSY | Cathepsin L1 | 3.4.22.15 | 0.440 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.440 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.440 | |
| 3tif | ADP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.440 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 3wb2 | YGP | Uncharacterized protein MJ0488 | / | 0.440 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.440 | |
| 4iv6 | FDA | Isovaleryl-CoA dehydrogenase | / | 0.440 | |
| 4oae | CLM | Uncharacterized protein | / | 0.440 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.440 |