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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2d2gDZZPhosphotriesterase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2d2gDZZPhosphotriesterase/1.000
2r1nEPLPhosphotriesterase/0.729
1dpmEBPParathion hydrolase3.1.8.10.528
1ltzHBIPhenylalanine-4-hydroxylase1.14.16.10.520
1r5hAO2Methionine aminopeptidase 2/0.489
4d6qPD2Lysine-specific demethylase 4D1.14.110.487
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.486
1kf6HQOFumarate reductase iron-sulfur subunit1.3.5.10.485
1kf6HQOFumarate reductase subunit C/0.485
1kf6HQOFumarate reductase subunit D/0.485
3lg5BTMEpi-isozizaene synthase4.2.3.370.481
4gaaBESLeukotriene A(4) hydrolase/0.481
2xnn430Serine/threonine-protein kinase Nek22.7.11.10.480
2vo4GTB2,4-D inducible glutathione S-transferase/0.478
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.477
1u70MTXDihydrofolate reductase1.5.1.30.477
4a6eASEAcetylserotonin O-methyltransferase2.1.1.40.477
1ry0PG2Aldo-keto reductase family 1 member C3/0.476
3q7fED2Uncharacterized protein/0.476
4n65FMNFMN-dependent NADH-azoreductase 1/0.476
3c6o2S2Protein TRANSPORT INHIBITOR RESPONSE 1/0.475
2ipjFFAAldo-keto reductase family 1 member C2/0.474
3mauEXTPutative sphingosine-1-phosphate lyase/0.474
1xf0ASDAldo-keto reductase family 1 member C3/0.473
2re8GSUGlutamine--tRNA ligase6.1.1.180.472
2z7gEH9Adenosine deaminase3.5.4.40.471
1cqsEQUSteroid Delta-isomerase5.3.3.10.470
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.470
1uhhCZPAequorin-2/0.469
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.468
5c1gGDUHisto-blood group ABO system transferase/0.468
1euyQSIGlutamine--tRNA ligase6.1.1.180.467
1rxjBNIStreptavidin/0.467
1sl9CZHObelin/0.467
1votHUPAcetylcholinesterase3.1.1.70.467
1rvvINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.466
1z5uCMPClass B acid phosphatase/0.466
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.466
3l06SN0N-acetylornithine carbamoyltransferase2.1.3.90.466
4gd9BTNStreptavidin/0.466
1pqc444Oxysterols receptor LXR-beta/0.465
1q1gMTIPurine nucleoside phosphorylase/0.465
2ea4F79Methionine aminopeptidase 2/0.465
4pl9ADPEthylene receptor 1/0.465
3elePLPAminotransferase/0.464
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.463
1w6jR71Lanosterol synthase5.4.99.70.463
2zs9ADPPantothenate kinase2.7.1.330.463
4bfyZVYPantothenate kinase2.7.1.330.463
4n9qFMNFMN-dependent NADH-azoreductase 1/0.463
4omaLCSMethionine gamma-lyase/0.463
1dp2LPBThiosulfate sulfurtransferase/0.462
1lnmDTXBilin-binding protein/0.462
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.462
2x9vTMQPteridine reductase/0.462
2zsbADPPantothenate kinase2.7.1.330.462
3jq7DX2Pteridine reductase, putative/0.462
3x025GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.462
4dya0MFNucleoprotein/0.462
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.462
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.462
1e92HBIPteridine reductase 11.5.1.330.461
1yw7A41Methionine aminopeptidase 2/0.461
2ga2A19Methionine aminopeptidase 2/0.461
2nnqT4BFatty acid-binding protein, adipocyte/0.461
2wkyIBCGlutamate receptor ionotropic, kainate 1/0.461
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.460
1ftlDNQGlutamate receptor 2/0.460
1yw9A84Methionine aminopeptidase 2/0.460
2od7A1RNAD-dependent protein deacetylase HST23.5.10.460
1dtnAPGMandelate racemase/0.459
1lb9DNQGlutamate receptor 2/0.459
3c35KAIGlutamate receptor ionotropic, kainate 1/0.459
3lutNAPVoltage-gated potassium channel subunit beta-2/0.459
4f1yCNIGlutamate receptor 3/0.459
4l0oPLPCystathionine gamma-synthase2.5.1.480.459
2j0sANPEukaryotic initiation factor 4A-III3.6.4.130.458
4g0k0VSGlutathionyl-hydroquinone reductase YqjG1.80.458
4gh10WXQueuine tRNA-ribosyltransferase2.4.2.290.458
4nqgCZHMitrocomin/0.458
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.457
1r5gAO1Methionine aminopeptidase 2/0.457
2xegCI9Glutamate carboxypeptidase 23.4.17.210.457
3bmqAX5Pteridine reductase/0.457
3mauPLRPutative sphingosine-1-phosphate lyase/0.457
4ey6GNTAcetylcholinesterase3.1.1.70.457
4jvlESTEstrogen sulfotransferase2.8.2.40.457
1mlzPLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.456
1w7h3IPMitogen-activated protein kinase 14/0.456
2iejS48Protein farnesyltransferase subunit beta2.5.1.580.456
2rd2QSIGlutamine--tRNA ligase6.1.1.180.456
2vcmM11Isopenicillin N synthase1.21.3.10.456
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.456
4e2yJHZMethyltransferase/0.456
4zmeADNMyosin heavy chain kinase A2.7.11.70.456
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.456
1ej3CZHAequorin-2/0.455
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.455
1towCRZFatty acid-binding protein, adipocyte/0.455
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.455
2bfaCB3Pteridine reductase 11.5.1.330.455
3ghh2NFCD38 molecule/0.455
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.455
3l05SN0N-acetylornithine carbamoyltransferase2.1.3.90.455
4imuH4BNitric oxide synthase, brain1.14.13.390.455
4iyg1HUStrictosidine synthase4.3.3.20.455
1gpnHUBAcetylcholinesterase3.1.1.70.454
2cekN8TAcetylcholinesterase3.1.1.70.454
2tplHPPTyrosine phenol-lyase4.1.99.20.454
3af1GDPPantothenate kinase2.7.1.330.454
3b7dCNIGlutamate receptor 2/0.454
3lfzADPUncharacterized protein MJ1225/0.454
3r6iJMSAldo-keto reductase family 1 member C3/0.454
5cxv0HKMuscarinic acetylcholine receptor M1/0.454
1afeALZProthrombin3.4.21.50.453
2acwUPGGlycosyltransferase/0.453
2yac937Serine/threonine-protein kinase PLK12.7.11.210.453
3e9sTTTReplicase polyprotein 1ab3.4.220.453
3juqAJDPhenazine biosynthesis protein A/B/0.453
1obnASVIsopenicillin N synthase1.21.3.10.452
2bf7HBIPteridine reductase 11.5.1.330.452
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.452
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.452
2p1pIACProtein TRANSPORT INHIBITOR RESPONSE 1/0.452
2qxxTTPdCTP deaminase3.5.4.130.452
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.452
3ba6AN2Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.452
3gg2UGASugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family/0.452
3ptzUDXUDP-glucose 6-dehydrogenase1.1.1.220.452
4bdrKAIGlutamate receptor ionotropic, kainate 2/0.452
4jxxATPGlutamine--tRNA ligase6.1.1.180.452
1dgfNDPCatalase1.11.1.60.451
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
1s36CEIObelin/0.451
2gesCOKPantothenate kinase2.7.1.330.451
2ixkTDOdTDP-4-dehydrorhamnose 3,5-epimerase5.1.3.130.451
2wd8VGFPteridine reductase/0.451
2xejOKDGlutamate carboxypeptidase 23.4.17.210.451
3d2dRENReticuline oxidase1.21.3.30.451
3kzoAN0N-acetylornithine carbamoyltransferase2.1.3.90.451
3lfeZ84Mitogen-activated protein kinase 14/0.451
3njoPYVAbscisic acid receptor PYR1/0.451
3t403RGIndole-3-glycerol phosphate synthase4.1.1.480.451
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.451
4bfsZVSPantothenate kinase2.7.1.330.451
4kq2U5PGlycogen [starch] synthase isoform 22.4.1.110.451
1p0pBCHCholinesterase3.1.1.80.450
1yunATPProbable nicotinate-nucleotide adenylyltransferase2.7.7.180.450
1z8962PAldose reductase1.1.1.210.450
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2geuCOKPantothenate kinase2.7.1.330.450
2nodH4BNitric oxide synthase, inducible1.14.13.390.450
2v34CTN4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.450
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.450
3hv3R49Mitogen-activated protein kinase 14/0.450
3l04SN0N-acetylornithine carbamoyltransferase2.1.3.90.450
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.450
3znrNU9Histone deacetylase 73.5.1.980.450
3zrrPXGSerine-pyruvate aminotransferase (AgxT)/0.450
4a1oAMZBifunctional purine biosynthesis protein PurH2.1.2.30.450
4b5nFMNNAD(P)H:flavin oxidoreductase Sye4/0.450
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.450
4ixd1HVIntegrin alpha-L/0.450
2idvM7GEukaryotic translation initiation factor 4E-1/0.449
4ydqHFGProline--tRNA ligase6.1.1.150.449
1gs3EQUSteroid Delta-isomerase5.3.3.10.448
1lrmHBIPhenylalanine-4-hydroxylase1.14.16.10.448
1ygjRMCPyridoxal kinase2.7.1.350.448
2bo8GDXMannosylglycerate synthase/0.448
2c42TPPPyruvate synthase/0.448
2gzl2AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.448
2pdbZSTAldose reductase1.1.1.210.448
2y67N21UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.448
3c6n2S8Protein TRANSPORT INHIBITOR RESPONSE 1/0.448
4pnmNU1Tankyrase-22.4.2.300.448
1q63AIQQueuine tRNA-ribosyltransferase2.4.2.290.447
1qzzSAMAclacinomycin 10-hydroxylase RdmB4.1.10.447
1umlFR4Adenosine deaminase3.5.4.40.447
1zisINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.447
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.447
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3iktNADRedox-sensing transcriptional repressor Rex/0.447
3qeoLLTDeoxycytidine kinase2.7.1.740.447
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.447
3rpnGTXGlutathione S-transferase kappa 12.5.1.180.447
3zeiAWHO-acetylserine sulfhydrylase/0.447
5cmx0G6Prothrombin3.4.21.50.447
1gt5BZQOdorant-binding protein/0.446
2b8jADNClass B acid phosphatase3.1.3.20.446
3af4GCPPantothenate kinase2.7.1.330.446
3f3y4OABile salt sulfotransferase2.8.2.140.446
3gncQQQGlutaryl-CoA dehydrogenase/0.446
3i5xANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.446
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.446
4b66NAPL-ornithine N(5)-monooxygenase/0.446
4dyp0MSNucleoprotein/0.446
4fa30SLAldo-keto reductase family 1 member C3/0.446
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.446
1pq944BOxysterols receptor LXR-beta/0.445
2tohHBITyrosine 3-monooxygenase1.14.16.20.445
2vqjTFGHistone deacetylase 43.5.1.980.445
2xytTC9Soluble acetylcholine receptor/0.445
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.445
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.445
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.445
4a99MIYTetX family tetracycline inactivation enzyme/0.445
4c717RD3-oxoacyl-ACP synthase/0.445
4dldTZGGlutamate receptor ionotropic, kainate 1/0.445
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.445
4uy6SAHHistidine N-alpha-methyltransferase/0.445
4zs4ATPMyosin heavy chain kinase A2.7.11.70.445
7catNDPCatalase1.11.1.60.445
5dsg0HKMuscarinic acetylcholine receptor M4/0.445
1dgbNDPCatalase1.11.1.60.444
1dghNDPCatalase1.11.1.60.444
1ekoI84Aldose reductase1.1.1.210.444
1q6nP90Tyrosine-protein phosphatase non-receptor type 13.1.3.480.444
1v79FR7Adenosine deaminase3.5.4.40.444
1xidASCXylose isomerase5.3.1.50.444
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.444
2getCOKPantothenate kinase2.7.1.330.444
2wgs1AZGlutamine synthetase6.3.1.20.444
3aezGDPPantothenate kinase2.7.1.330.444
3ghvGHCDihydrofolate reductase1.5.1.30.444
4h7c10HAldo-keto reductase family 1 member C3/0.444
4li61XOTankyrase-12.4.2.300.444
1qxlFR8Adenosine deaminase3.5.4.40.443
2bfmTOPPteridine reductase 11.5.1.330.443
2pdiZSTAldose reductase1.1.1.210.443
2pdn47DAldose reductase1.1.1.210.443
3jq6DX1Pteridine reductase, putative/0.443
3jt6H4BNitric oxide synthase, brain1.14.13.390.443
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.443
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.443
1h22E10Acetylcholinesterase3.1.1.70.442
1nhkCMPNucleoside diphosphate kinase2.7.4.60.442
1tllFMNNitric oxide synthase, brain1.14.13.390.442
1wxyFRKAdenosine deaminase3.5.4.40.442
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2ea2F77Methionine aminopeptidase 2/0.442
2qt0NNRNicotinamide riboside kinase 1/0.442
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2zsaADPPantothenate kinase2.7.1.330.442
3l3rOAGDihydrofolate reductase1.5.1.30.442
3n0hTOPDihydrofolate reductase1.5.1.30.442
3ugrIMNAldo-keto reductase family 1 member C3/0.442
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.442
4b63NAPL-ornithine N(5)-monooxygenase/0.442
4g2wNI0cGMP-specific 3',5'-cyclic phosphodiesterase/0.442
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.442
4hej14DThymidylate kinase/0.442
4kfqKFQGlutamate receptor ionotropic, NMDA 1/0.442
4u140HKMuscarinic acetylcholine receptor M3/0.442
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.441
1u1d181Uridine phosphorylase2.4.2.30.441
1w6rGNTAcetylcholinesterase3.1.1.70.441
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.441
2g1a5HGClass B acid phosphatase3.1.3.20.441
2g7yMO9Cathepsin S3.4.22.270.441
2idoTMPDNA polymerase III subunit epsilon2.7.7.70.441
2on6IMHPurine nucleoside phosphorylase2.4.2.10.441
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
2qjpANJCytochrome b/0.441
2xeiARKGlutamate carboxypeptidase 23.4.17.210.441
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.441
2xysSY9Soluble acetylcholine receptor/0.441
3c36KAIGlutamate receptor ionotropic, kainate 1/0.441
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.441
3dh8B4NUncharacterized protein PA1000/0.441
3nlwH4BNitric oxide synthase, brain1.14.13.390.441
3pahXDEPhenylalanine-4-hydroxylase1.14.16.10.441
4a16H34Acetylcholinesterase3.1.1.70.441
4f1tH52Probable serine/threonine-protein kinase roco42.7.11.10.441
5c1mCLRMu-type opioid receptor/0.441
1afsTES3-alpha-hydroxysteroid dehydrogenase1.1.1.500.440
1fw0KAIGlutamate receptor 2/0.440
1mdlSMNMandelate racemase/0.440
1s2g3D1Nucleoside 2-deoxyribosyltransferase/0.440
1xduSFGAclacinomycin 10-hydroxylase RdmB4.1.10.440
2pdh47DAldose reductase1.1.1.210.440
2qx7NAPEugenol synthase 11.1.1.3180.440
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3cr0809Wee1-like protein kinase2.7.10.20.440
3lthUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.440
3tydXHPDihydropteroate synthase/0.440
3x03ANPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.440
3zv7NHGAcetylcholinesterase3.1.1.70.440
4bj9UHBTankyrase-22.4.2.300.440
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.440
4k88HFGBifunctional glutamate/proline--tRNA ligase6.1.1.150.440
4relKMPGlycosyltransferase/0.440
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
2yczI32Beta-1 adrenergic receptor/0.440