sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1srg | MHB | Streptavidin |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1srg | MHB | Streptavidin | / | 1.000 | |
| 4bx7 | B4F | Streptavidin | / | 0.667 | |
| 2izl | IMI | Streptavidin | / | 0.656 | |
| 2rte | BTN | Streptavidin | / | 0.654 | |
| 1srj | NAB | Streptavidin | / | 0.652 | |
| 1sri | DMB | Streptavidin | / | 0.646 | |
| 2rtd | BTN | Streptavidin | / | 0.646 | |
| 3ry2 | BTN | Streptavidin | / | 0.643 | |
| 1sre | HAB | Streptavidin | / | 0.642 | |
| 2izf | BTN | Streptavidin | / | 0.634 | |
| 1srf | MTB | Streptavidin | / | 0.628 | |
| 1i9h | BNI | Streptavidin | / | 0.624 | |
| 2rtg | BTN | Streptavidin | / | 0.623 | |
| 3wzn | BTN | Streptavidin | / | 0.623 | |
| 2rto | IMI | Streptavidin | / | 0.618 | |
| 1mk5 | BTN | Streptavidin | / | 0.617 | |
| 4gda | BTN | Streptavidin | / | 0.614 | |
| 1srh | MOB | Streptavidin | / | 0.612 | |
| 1swt | BTN | Streptavidin | / | 0.612 | |
| 1lcw | SHM | Streptavidin | / | 0.611 | |
| 2rtn | IMI | Streptavidin | / | 0.611 | |
| 1stp | BTN | Streptavidin | / | 0.607 | |
| 4dne | DTB | Streptavidin | / | 0.606 | |
| 1luq | BTN | Streptavidin | / | 0.600 | |
| 2izg | BTN | Streptavidin | / | 0.599 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.595 | |
| 2rtq | IMI | Streptavidin | / | 0.594 | |
| 1df8 | BTN | Streptavidin | / | 0.582 | |
| 2avi | BTN | Avidin | / | 0.582 | |
| 2rtr | IMI | Streptavidin | / | 0.578 | |
| 1lcz | BH7 | Streptavidin | / | 0.575 | |
| 1swn | BTN | Streptavidin | / | 0.572 | |
| 2izh | BTN | Streptavidin | / | 0.571 | |
| 2rtf | BTN | Streptavidin | / | 0.568 | |
| 1avd | BTN | Avidin | / | 0.567 | |
| 1nqm | BTN | Streptavidin | / | 0.565 | |
| 3rdq | DTB | Streptavidin | / | 0.564 | |
| 2y3f | BTN | Streptavidin | / | 0.563 | |
| 1swp | BTQ | Streptavidin | / | 0.561 | |
| 4z28 | BTN | Hoefavidin | / | 0.561 | |
| 2rtp | IMI | Streptavidin | / | 0.560 | |
| 1rxh | BNI | Streptavidin | / | 0.558 | |
| 3wyq | BTN | Streptavidin | / | 0.557 | |
| 2rtm | IMI | Streptavidin | / | 0.552 | |
| 2jgs | BTN | Avidin | / | 0.551 | |
| 4bcs | BTN | Avidin-related protein 4/5 | / | 0.545 | |
| 1swe | BTN | Streptavidin | / | 0.544 | |
| 4gd9 | BTN | Streptavidin | / | 0.543 | |
| 2uz2 | BTN | Avd protein | / | 0.542 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.541 | |
| 1nc9 | IMI | Streptavidin | / | 0.540 | |
| 2izj | BTN | Streptavidin | / | 0.540 | |
| 1n9m | BTN | Streptavidin | / | 0.539 | |
| 1swr | BTN | Streptavidin | / | 0.538 | |
| 2uyw | BTN | Avd protein | / | 0.538 | |
| 2zsc | BTN | Tamavidin2 | / | 0.538 | |
| 1mep | BTN | Streptavidin | / | 0.533 | |
| 2izi | BTN | Streptavidin | / | 0.532 | |
| 1y52 | BTN | Avidin-related protein 4/5 | / | 0.530 | |
| 1swp | BTN | Streptavidin | / | 0.529 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.529 | |
| 2c4i | BTN | Avidin | / | 0.523 | |
| 4bj8 | BTN | Avidin | / | 0.523 | |
| 1ndj | BTN | Streptavidin | / | 0.521 | |
| 1n43 | BTN | Streptavidin | / | 0.516 | |
| 1swd | BTN | Streptavidin | / | 0.505 | |
| 3ew2 | BTN | Hypothetical conserved protein | / | 0.504 | |
| 3arv | SAU | Chitinase A | / | 0.502 | |
| 3t2w | BTN | Avidin/streptavidin | / | 0.501 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.499 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.498 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.496 | |
| 2rtk | GLL | Streptavidin | / | 0.495 | |
| 3wyp | BSO | Streptavidin | / | 0.494 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.493 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.492 | |
| 2rti | GLL | Streptavidin | / | 0.492 | |
| 2a5c | 8DA | Avidin | / | 0.491 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.490 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.488 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.486 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.483 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.483 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.482 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.482 | |
| 2izk | GLL | Streptavidin | / | 0.482 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.482 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.480 | |
| 3vhh | VHH | Avidin | / | 0.480 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.480 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 1nw6 | SFG | Modification methylase RsrI | 2.1.1.72 | 0.476 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.476 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.474 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.474 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.474 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.473 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.473 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.473 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.473 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.473 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.472 | |
| 4dli | IRG | Mitogen-activated protein kinase 14 | / | 0.472 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.470 | |
| 1xp8 | AGS | Protein RecA | / | 0.470 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.470 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.470 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.469 | |
| 3vhi | VHI | Avidin | / | 0.469 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 4yvb | BTN | Streptavidin | / | 0.469 | |
| 1kzi | THG | Thymidylate synthase | / | 0.468 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.468 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.468 | |
| 3up0 | D7S | aceDAF-12 | / | 0.468 | |
| 4aos | FAD | Steroid monooxygenase | / | 0.468 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.468 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.467 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.467 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.467 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.467 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.467 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.466 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.466 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.465 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.465 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.465 | |
| 3vgw | NVZ | Avidin | / | 0.465 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.465 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.464 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 3uk6 | ADP | RuvB-like 2 | 3.6.4.12 | 0.464 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.464 | |
| 1eio | GCH | Gastrotropin | / | 0.463 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.463 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.463 | |
| 3rup | ADP | Biotin carboxylase | 6.3.4.14 | 0.463 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 4mry | CEI | Obelin | / | 0.463 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.463 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.462 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.462 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.462 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.462 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.461 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.461 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.461 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.460 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.460 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.460 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.460 | |
| 2rtl | IMI | Streptavidin | / | 0.460 | |
| 2toh | HBI | Tyrosine 3-monooxygenase | 1.14.16.2 | 0.460 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.460 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.460 | |
| 4rrg | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.460 | |
| 1nw5 | SAM | Modification methylase RsrI | 2.1.1.72 | 0.459 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.459 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.459 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.459 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.459 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.459 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.459 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.459 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.458 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.458 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.458 | |
| 2fbw | CBE | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | 1.3.5.1 | 0.458 | |
| 2fbw | CBE | Succinate dehydrogenase cytochrome b, large subunit | / | 0.458 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.458 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.458 | |
| 1r2j | FAD | FkbI | / | 0.457 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 3dhc | CYK | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.457 | |
| 3iaa | TYD | CalG2 | / | 0.457 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 1ycg | FMN | Nitric oxide reductase | 1 | 0.456 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.456 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.456 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.456 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.456 | |
| 2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.456 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.456 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.456 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.456 | |
| 1o1t | 2NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.455 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.455 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.455 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.455 | |
| 2a2s | GSN | Glutathione S-transferase P | 2.5.1.18 | 0.455 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.455 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.455 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.455 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.455 | |
| 5a01 | 12V | O-glycosyltransferase | / | 0.455 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.454 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.454 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.454 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.454 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.454 | |
| 5dp2 | NAP | CurF | / | 0.454 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.454 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.453 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.453 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.453 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 3bhr | THG | Thymidylate synthase | / | 0.453 | |
| 3bw2 | FMN | Putative 2-nitropropane dioxygenase | / | 0.453 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.453 | |
| 3lq4 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.453 | |
| 3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.453 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.453 | |
| 4rrf | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.453 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.452 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.452 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.452 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.452 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.452 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.452 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.452 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.452 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.452 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.452 | |
| 3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.452 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.452 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.451 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.451 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.451 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.451 | |
| 2ejz | SAH | Diphthine synthase | / | 0.451 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.451 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 3v76 | FDA | Uncharacterized protein | / | 0.451 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.451 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.451 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.451 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.451 | |
| 5dxj | SFG | Histone-arginine methyltransferase CARM1 | / | 0.451 | |
| 5iqd | GNP | Bifunctional AAC/APH | 2.3.1 | 0.451 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.450 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.450 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.450 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.450 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.450 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.450 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.450 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.450 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.450 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.450 | |
| 5cfn | 2BA | Stimulator of interferon genes protein | / | 0.450 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.449 | |
| 1zpr | CB3 | Thymidylate synthase | / | 0.449 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.449 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.449 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 3pah | XDE | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.449 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.449 | |
| 4blc | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.449 | |
| 4plp | NAD | Homospermidine synthase | 2.5.1.44 | 0.449 | |
| 1e2n | RCA | Thymidine kinase | / | 0.448 | |
| 1fml | RTL | Retinol dehydratase | / | 0.448 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.448 | |
| 2q4w | FAD | Cytokinin dehydrogenase 7 | 1.5.99.12 | 0.448 | |
| 2r8o | T5X | Transketolase 1 | / | 0.448 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.448 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3pm9 | FAD | Putative oxidoreductase | / | 0.448 | |
| 3uxv | GUN | NADPH-dependent 7-cyano-7-deazaguanine reductase | / | 0.448 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.448 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.448 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.447 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.447 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.447 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.447 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.447 | |
| 2tsc | CB3 | Thymidylate synthase | / | 0.447 | |
| 2xej | OKD | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.447 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.447 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.447 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.447 | |
| 5d1b | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.447 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.447 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.446 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.446 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1kt7 | RTL | Retinol-binding protein 4 | / | 0.446 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.446 | |
| 1zdw | FLV | Prenyltransferase | / | 0.446 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.446 | |
| 3p3c | 3P3 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.446 | |
| 3tp0 | FO5 | HTH-type transcriptional regulator EthR | / | 0.446 | |
| 4ap1 | FAD | Steroid monooxygenase | / | 0.446 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.446 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.446 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.446 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.446 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.446 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.446 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.445 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.445 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.445 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.445 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.445 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.445 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.445 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.445 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.445 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.445 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.445 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.445 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.445 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.445 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.445 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.445 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.445 | |
| 4c1f | X8Z | Metallo-beta-lactamase type 2 | / | 0.445 | |
| 4l09 | 1UR | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.445 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.445 | |
| 5c3j | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.445 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.445 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.445 | |
| 4lde | P0G | Beta-2 adrenergic receptor | / | 0.445 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1c3e | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.444 | |
| 1cde | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.444 | |
| 1hnj | MLC | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.444 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.444 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.444 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.444 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.444 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.444 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 2ywl | FAD | Thioredoxin reductase related protein | / | 0.444 | |
| 3bl7 | DD1 | m7GpppX diphosphatase | 3.6.1.59 | 0.444 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.444 | |
| 4ayv | 9MQ | Prothrombin | 3.4.21.5 | 0.444 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4hdr | DMD | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | / | 0.444 | |
| 4hdr | DMD | ArsB | / | 0.444 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.444 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.444 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.443 | |
| 1pw1 | HEL | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.443 | |
| 1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.443 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.443 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.443 | |
| 2f0y | 3MN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 2vmy | FFO | Serine hydroxymethyltransferase | / | 0.443 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.443 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4bqu | CLR | Japanin | / | 0.443 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.443 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.443 | |
| 4rts | SAM | DNA adenine methylase | 2.1.1.72 | 0.443 | |
| 5cpm | FNR | NADH:flavin oxidoreductase | / | 0.443 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.442 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.442 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1ypg | UIR | Prothrombin | 3.4.21.5 | 0.442 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.442 | |
| 2iea | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.442 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.442 | |
| 2v2q | NVG | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.442 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.442 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 3n19 | FNR | Xenobiotic reductase | / | 0.442 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4ggz | BTN | Bll1558 protein | / | 0.442 | |
| 5cts | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.442 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.442 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1eyy | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.441 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.441 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 1po7 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.441 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.441 | |
| 1tl7 | ONM | Adenylate cyclase type 2 | / | 0.441 | |
| 1tl7 | ONM | Adenylate cyclase type 5 | / | 0.441 | |
| 1tys | DHF | Thymidylate synthase | / | 0.441 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.441 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.441 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2qta | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.441 | |
| 3cop | ADP | Glycogen synthase | 2.4.1.21 | 0.441 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3rdo | BTN | Streptavidin | / | 0.441 | |
| 3uq9 | TBN | Putative adenosine kinase | / | 0.441 | |
| 4b5o | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.441 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.441 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.441 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.441 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1eq2 | ADQ | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.440 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 1pl6 | 572 | Sorbitol dehydrogenase | 1.1.1.14 | 0.440 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.440 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.440 | |
| 2xfy | ACX | Beta-amylase | 3.2.1.2 | 0.440 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 2zry | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.440 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.440 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 3up3 | XCA | aceDAF-12 | / | 0.440 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.440 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.440 | |
| 4e7r | 0NW | Prothrombin | 3.4.21.5 | 0.440 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4kxj | P34 | Nucleoprotein | / | 0.440 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.440 | |
| 4m6p | 20R | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.440 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.440 |