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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1q1r FAD Putidaredoxin reductase 1.18.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
1q1r FADPutidaredoxin reductase 1.18.1.5 1.366
1q1w FADPutidaredoxin reductase 1.18.1.5 1.251
3lb8 FADPutidaredoxin reductase 1.18.1.5 1.013
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.918
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.917
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.905
2gqw FADFerredoxin reductase / 0.901
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.901
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.900
2gr1 FADFerredoxin reductase / 0.890
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.882
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.877
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.871
2gr3 FADFerredoxin reductase / 0.870
2yvf FADFerredoxin reductase / 0.870
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.870
1d7y FADFerredoxin reductase / 0.867
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.862
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.856
4yry FADGlutamate synthase, beta subunit / 0.846
2gr0 FADFerredoxin reductase / 0.845
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.842
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.838
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.834
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.831
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.831
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.824
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.822
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.818
3fg2 FADPutative rubredoxin reductase / 0.816
4eqs FADCoenzyme A disulfide reductase / 0.810
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.802
1f3p FADFerredoxin reductase / 0.801
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.799
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.795
2yvj FADFerredoxin reductase / 0.794
4eqw FADCoenzyme A disulfide reductase / 0.790
1zx9 FADMercuric reductase 1.16.1.1 0.786
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.785
4eqx FADCoenzyme A disulfide reductase / 0.781
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.780
4eqr FADCoenzyme A disulfide reductase / 0.779
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.776
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.774
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.774
4nev FADTrypanothione reductase / 0.768
4opl FDAConserved Archaeal protein / 0.766
3cgb FADCoenzyme A disulfide reductase / 0.764
3cgc FADCoenzyme A disulfide reductase / 0.764
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.764
1zk7 FADMercuric reductase 1.16.1.1 0.762
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.762
3ish FADThioredoxin reductase 1.8.1.9 0.761
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.759
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.759
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.756
2wba FADTrypanothione reductase 1.8.1.12 0.755
1feb FADTrypanothione reductase 1.8.1.12 0.751
3atq FDAConserved Archaeal protein / 0.751
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.751
3f8d FADNADH oxidase/thioredoxin reductase / 0.746
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.744
2q7v FADThioredoxin reductase / 0.742
4j33 FADKynurenine 3-monooxygenase / 0.742
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.740
3atr FDAConserved Archaeal protein / 0.740
1fea FADTrypanothione reductase 1.8.1.12 0.738
4em4 FADCoenzyme A disulfide reductase / 0.736
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.735
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.735
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.734
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.734
1f8s FADL-amino-acid oxidase 1.4.3.2 0.733
2eq7 FADDihydrolipoyl dehydrogenase / 0.733
1geu FADGlutathione reductase 1.8.1.7 0.732
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.732
2tpr FADTrypanothione reductase 1.8.1.12 0.732
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.732
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.730
2r9z FADGlutathione amide reductase / 0.728
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.727
3cgd FADCoenzyme A disulfide reductase / 0.726
4j57 FADThioredoxin reductase 2 1.8.1.9 0.726
2jb2 FADL-amino acid oxidase / 0.724
1get FADGlutathione reductase 1.8.1.7 0.723
2wow FADTrypanothione reductase / 0.723
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.723
4b1b FADThioredoxin reductase 1.8.1.9 0.722
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.721
3f8r NAPNADH oxidase/thioredoxin reductase / 0.720
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.719
2yqu FADDihydrolipoyl dehydrogenase / 0.718
2wp5 FADTrypanothione reductase / 0.717
4z24 FADPutative GMC-type oxidoreductase R135 1 0.717
2x8g FADThioredoxin glutathione reductase / 0.715
4mok FADPyranose 2-oxidase / 0.715
3cge FADCoenzyme A disulfide reductase / 0.714
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.713
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.711
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.711
2b9x FADPutative aminooxidase / 0.711
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.711
4cnj FADL-amino acid oxidase / 0.711
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.711
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.710
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.710
4wct FADFructosyl amine:oxygen oxidoreductase / 0.710
4emw FADCoenzyme A disulfide reductase / 0.709
1sez FADProtoporphyrinogen oxidase, mitochondrial 1.3.3.4 0.708
3f8p NADNADH oxidase/thioredoxin reductase / 0.708
1joa FADNADH peroxidase 1.11.1.1 0.707
2x8h FADThioredoxin glutathione reductase / 0.707
1ryi FADGlycine oxidase 1.4.3.19 0.706
1ng4 FADGlycine oxidase 1.4.3.19 0.705
2xdo FADTetX family tetracycline inactivation enzyme / 0.705
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.705
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.705
2hqm FADGlutathione reductase 1.8.1.7 0.704
1tde FADThioredoxin reductase 1.8.1.9 0.703
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.703
4em3 FADCoenzyme A disulfide reductase / 0.703
1tdf FADThioredoxin reductase 1.8.1.9 0.702
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.702
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.702
4cnk FADL-amino acid oxidase / 0.702
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.702
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.701
2qa1 FADPgaE / 0.701
4i58 FADCyclohexylamine Oxidase / 0.701
1fec FADTrypanothione reductase 1.8.1.12 0.700
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.700
3kve FADL-amino-acid oxidase / 0.700
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.700
4x4j FADPutative oxygenase / 0.700
1f8r FADL-amino-acid oxidase 1.4.3.2 0.699
1z6l FADPolyamine oxidase FMS1 / 0.699
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.698
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.698
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.698
2jae FADL-amino acid oxidase / 0.698
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.698
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.697
1kif FADD-amino-acid oxidase 1.4.3.3 0.697
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.697
1ng3 FADGlycine oxidase 1.4.3.19 0.696
2whd FADThioredoxin reductase / 0.696
1reo FADL-amino-acid oxidase 1.4.3.2 0.695
1trb FADThioredoxin reductase 1.8.1.9 0.695
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.695
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.694
4k2x FADPolyketide oxygenase/hydroxylase / 0.692
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.692
1d7l RFLp-hydroxybenzoate hydroxylase / 0.691
3v76 FDAUncharacterized protein / 0.691
2x3n FADProbable FAD-dependent monooxygenase / 0.690
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.689
2jk6 FADTrypanothione reductase / 0.688
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.688
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.687
1nhs FADNADH peroxidase 1.11.1.1 0.687
2jb1 FADL-amino acid oxidase / 0.687
4j2w FADKynurenine 3-monooxygenase / 0.687
4up3 FADThioredoxin reductase / 0.687
1rsg FADPolyamine oxidase FMS1 / 0.686
3fbs FADOxidoreductase / 0.686
3qj4 FADRenalase / 0.686
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.685
2w0h FADTrypanothione reductase / 0.685
4la1 FADThioredoxin glutathione reductase / 0.684
4opi FDAConserved Archaeal protein / 0.684
1nhp FADNADH peroxidase 1.11.1.1 0.683
1nhr FADNADH peroxidase 1.11.1.1 0.683
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.682
2yg4 FADPutrescine oxidase / 0.682
4j36 FADKynurenine 3-monooxygenase / 0.682
1typ FADTrypanothione reductase 1.8.1.12 0.681
4rsl FADFructosyl peptide oxidase / 0.681
1yqz FADCoenzyme A disulfide reductase / 0.680
2ba9 FADPutative aminooxidase / 0.680
4j34 FADKynurenine 3-monooxygenase / 0.680
4k5r FADOxygenase / 0.680
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.679
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.679
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.679
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.679
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.679
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.678
3r9u FADThioredoxin reductase / 0.678
4fk1 FADPutative thioredoxin reductase / 0.678
4opc FDAConserved Archaeal protein / 0.678
4opd FDAConserved Archaeal protein / 0.678
2b9w FADPutative aminooxidase / 0.677
2npx FADNADH peroxidase 1.11.1.1 0.677
3k4n FADPyranose 2-oxidase / 0.677
4jn9 FADDepH / 0.677
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.676
2cdu FADNADH oxidase / 0.676
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.676
3icr FADCoenzyme A disulfide reductase / 0.676
4hb9 FADUncharacterized protein / 0.676
4jq9 FADDihydrolipoyl dehydrogenase / 0.676
3ict FADCoenzyme A disulfide reductase / 0.675
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.675
4ccq FADThioredoxin reductase / 0.675
2v6o FADThioredoxin glutathione reductase / 0.674
4j56 FADThioredoxin reductase 2 1.8.1.9 0.674
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.673
3if9 FADGlycine oxidase 1.4.3.19 0.673
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.673
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.672
3bi5 FADPolyamine oxidase FMS1 / 0.672
3urh FADDihydrolipoyl dehydrogenase / 0.672
1tyt FADTrypanothione reductase 1.8.1.12 0.671
3q9t FAYUncharacterized protein / 0.671
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.670
4gut FADLysine-specific histone demethylase 1B 1 0.670
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.670
1nhq FADNADH peroxidase 1.11.1.1 0.669
1x0p FADTll0078 protein / 0.669
3lad FADDihydrolipoyl dehydrogenase / 0.669
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.668
1f8w FADNADH peroxidase 1.11.1.1 0.668
1ger FADGlutathione reductase 1.8.1.7 0.668
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.668
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.668
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.667
1npx FADNADH peroxidase 1.11.1.1 0.667
3dme FADPutative conserved exported protein / 0.667
3rha FDAPutrescine oxidase / 0.667
3rp8 FADFAD-dependent urate hydroxylase / 0.667
1yy5 FADPolyamine oxidase FMS1 / 0.666
2aqj FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.666
3we0 FADLysine 2-monooxygenase / 0.666
4opg FDAConserved Archaeal protein / 0.666
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.665
3zdn FADMonoamine oxidase N 1.4.3.4 0.665
2rab FADGlutathione amide reductase / 0.664
1knr FADL-aspartate oxidase 1.4.3.16 0.663
3sz0 FADSulfide-quinone reductase / 0.662
4a5l FADThioredoxin reductase / 0.662
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.662
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.661
1qo8 FADFumarate reductase flavoprotein subunit / 0.661
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.661
3bm1 FMNPutative NAD(P)H nitroreductase YdjA / 0.661
3nf4 FADAcyl-CoA dehydrogenase domain-containing protein / 0.661
4a65 FADThioredoxin reductase / 0.661
4a6n FADTetX family tetracycline inactivation enzyme / 0.661
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.661
3cnd FADPolyamine oxidase FMS1 / 0.660
4guu FA9Lysine-specific histone demethylase 1B 1 0.660
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.660
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.660
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.660
5j4e FMNSensory box protein / 0.660
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.659
2rgh FADAlpha-Glycerophosphate Oxidase / 0.659
4bk2 FADProbable salicylate monooxygenase / 0.659
4hsu FADLysine-specific histone demethylase 1B 1 0.659
4rph FADUDP-galactopyranose mutase 5.4.99.9 0.659
2vvl FADMonoamine oxidase N 1.4.3.4 0.658
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.658
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.658
4gus FADLysine-specific histone demethylase 1B 1 0.658
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.657
1b4v FADCholesterol oxidase 1.1.3.6 0.656
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.656
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.656
4tlz FADKtzI / 0.656
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.655
2ar8 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.655
2q0k FADThioredoxin reductase 1.8.1.9 0.655
3k30 ADPHistamine dehydrogenase / 0.655
4cbq FADThioredoxin reductase / 0.655
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.654
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.654
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.654
4ech FADPolyamine oxidase FMS1 / 0.653
1jqi FADShort-chain specific acyl-CoA dehydrogenase, mitochondrial / 0.652
1vrq FMNSubunit alpha of sarocosine oxidase / 0.652
1vrq FMNSubunit beta of sarcosine oxidase / 0.652
2eq7 NADDihydrolipoyl dehydrogenase / 0.652
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.652
4gur FADLysine-specific histone demethylase 1B 1 0.652
1phh FADp-hydroxybenzoate hydroxylase / 0.651
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.651
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.651
4tm4 FDAKtzI / 0.651
4ynt FDAGlucose oxidase, putative / 0.651
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.650
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.650
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.650
2dvl FADAcyl-CoA dehydrogenase / 0.650