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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1k0l FAD p-hydroxybenzoate hydroxylase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
1k0l FADp-hydroxybenzoate hydroxylase / 1.173
1d7l RFLp-hydroxybenzoate hydroxylase / 0.994
1k0j FADp-hydroxybenzoate hydroxylase / 0.983
1pdh FASp-hydroxybenzoate hydroxylase / 0.966
2qa1 FADPgaE / 0.923
2xdo FADTetX family tetracycline inactivation enzyme / 0.865
4icy FADPgaE / 0.865
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.857
4k2x FADPolyketide oxygenase/hydroxylase / 0.856
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.836
4j2w FADKynurenine 3-monooxygenase / 0.831
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.813
4j33 FADKynurenine 3-monooxygenase / 0.813
4k5r FADOxygenase / 0.813
4j36 FADKynurenine 3-monooxygenase / 0.812
2b9x FADPutative aminooxidase / 0.811
4x4j FADPutative oxygenase / 0.794
4hb9 FADUncharacterized protein / 0.793
2b9y FADPutative aminooxidase / 0.792
4a99 FADTetX family tetracycline inactivation enzyme / 0.792
3cgc FADCoenzyme A disulfide reductase / 0.791
2qa2 FADPolyketide oxygenase CabE / 0.788
3rp8 FADFAD-dependent urate hydroxylase / 0.786
2b9w FADPutative aminooxidase / 0.785
3p9u FADTetX family tetracycline inactivation enzyme / 0.784
4guv FADTetX family tetracycline inactivation enzyme / 0.779
4nzh FADL-ornithine N(5)-monooxygenase / 0.778
2ba9 FADPutative aminooxidase / 0.775
4bk2 FADProbable salicylate monooxygenase / 0.775
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.773
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.773
1geu FADGlutathione reductase 1.8.1.7 0.771
4opd FDAConserved Archaeal protein / 0.770
4opc FDAConserved Archaeal protein / 0.769
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.766
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.766
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.764
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.764
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.764
4jq9 FADDihydrolipoyl dehydrogenase / 0.764
4bjz FADProbable salicylate monooxygenase / 0.763
2eq6 FADDihydrolipoyl dehydrogenase / 0.762
3atq FDAConserved Archaeal protein / 0.762
4j34 FADKynurenine 3-monooxygenase / 0.760
2eq8 FADDihydrolipoyl dehydrogenase / 0.759
4cnk FADL-amino acid oxidase / 0.755
2zbw FADFerredoxin--NADP reductase / 0.754
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.753
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.753
4tm3 FADKtzI / 0.753
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.752
2q7v FADThioredoxin reductase / 0.752
4fwe FADLysine-specific histone demethylase 1B 1 0.749
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.743
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.743
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.743
4b69 FADL-ornithine N(5)-monooxygenase / 0.741
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.740
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.738
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.736
2x3n FADProbable FAD-dependent monooxygenase / 0.735
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.735
4a6n FADTetX family tetracycline inactivation enzyme / 0.735
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.734
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.734
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.733
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.732
2hqm FADGlutathione reductase 1.8.1.7 0.732
2igo FADPyranose 2-oxidase / 0.732
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.732
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.731
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.731
1f8r FADL-amino-acid oxidase 1.4.3.2 0.730
2e1m FADL-glutamate oxidase / 0.729
1yqz FADCoenzyme A disulfide reductase / 0.727
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.727
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.726
4eqx FADCoenzyme A disulfide reductase / 0.726
4gut FADLysine-specific histone demethylase 1B 1 0.726
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.725
4ech FADPolyamine oxidase FMS1 / 0.725
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.725
1nhs FADNADH peroxidase 1.11.1.1 0.724
4cnj FADL-amino acid oxidase / 0.724
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.723
2eq7 FADDihydrolipoyl dehydrogenase / 0.723
1b4v FADCholesterol oxidase 1.1.3.6 0.722
2x8h FADThioredoxin glutathione reductase / 0.722
4tlx FDAKtzI / 0.722
2gqw FADFerredoxin reductase / 0.721
2rgj FADFlavin-containing monooxygenase / 0.721
3lov FADProtoporphyrinogen oxidase / 0.721
3nlc FADUncharacterized protein / 0.721
4opg FDAConserved Archaeal protein / 0.720
3c96 FADFlavin-containing monooxygenase / 0.719
4j57 FADThioredoxin reductase 2 1.8.1.9 0.719
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.718
4c3y FAD3-ketosteroid dehydrogenase / 0.718
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.718
3cge FADCoenzyme A disulfide reductase / 0.717
2yg6 FADPutrescine oxidase / 0.716
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.716
3fmw FADOxygenase / 0.716
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.716
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.716
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.716
4eqs FADCoenzyme A disulfide reductase / 0.716
4opl FDAConserved Archaeal protein / 0.715
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.714
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.714
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.714
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.713
1gxf FADTrypanothione reductase 1.8.1.12 0.712
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.712
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.712
2v6o FADThioredoxin glutathione reductase / 0.711
4gcm FADThioredoxin reductase 1.8.1.9 0.711
1cf3 FADGlucose oxidase 1.1.3.4 0.710
2gr3 FADFerredoxin reductase / 0.710
3cty FADProbable thioredoxin reductase / 0.710
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.709
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.709
2gr0 FADFerredoxin reductase / 0.709
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.709
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.708
3cgb FADCoenzyme A disulfide reductase / 0.708
3r9u FADThioredoxin reductase / 0.708
2x8g FADThioredoxin glutathione reductase / 0.707
3cn8 FADPolyamine oxidase FMS1 / 0.707
4opt FDAConserved Archaeal protein / 0.707
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.707
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.706
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.705
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.704
4jn9 FADDepH / 0.704
1d7y FADFerredoxin reductase / 0.702
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.702
2xve FADPutative flavin-containing monooxygenase / 0.702
3kve FADL-amino-acid oxidase / 0.702
1f8w FADNADH peroxidase 1.11.1.1 0.701
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.701
3cgd FADCoenzyme A disulfide reductase / 0.701
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.701
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.700
1f8s FADL-amino-acid oxidase 1.4.3.2 0.699
1h83 FADPolyamine oxidase 1.5.3.14 0.699
4z2t FAD2-hydroxybiphenyl-3-monooxygenase / 0.699
2rab FADGlutathione amide reductase / 0.698
3f8d FADNADH oxidase/thioredoxin reductase / 0.697
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.696
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.696
3fg2 FADPutative rubredoxin reductase / 0.696
4c3x FAD3-ketosteroid dehydrogenase / 0.696
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.695
1npx FADNADH peroxidase 1.11.1.1 0.695
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.694
3pl8 FADPyranose 2-oxidase / 0.694
1ger FADGlutathione reductase 1.8.1.7 0.693
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.693
1rsg FADPolyamine oxidase FMS1 / 0.693
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.693
3we0 FADLysine 2-monooxygenase / 0.692
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.692
5j60 FADThioredoxin reductase / 0.692
2wba FADTrypanothione reductase 1.8.1.12 0.691
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.690
3t37 FADPyridoxine 4-oxidase / 0.690
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.690
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.689
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.689
3nix FADFlavoprotein/dehydrogenase / 0.689
4dna FADProbable glutathione reductase / 0.689
4nte FADDepH / 0.689
5buk FADFADH2-dependent halogenase / 0.689
3ec7 NADInositol 2-dehydrogenase / 0.688
4eqw FADCoenzyme A disulfide reductase / 0.688
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.687
3ept FDAPutative FAD-monooxygenase / 0.687
1f3p FADFerredoxin reductase / 0.686
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.686
1nhp FADNADH peroxidase 1.11.1.1 0.685
2eq7 NADDihydrolipoyl dehydrogenase / 0.685
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.685
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.684
1zx9 FADMercuric reductase 1.16.1.1 0.684
2bac FADPutative aminooxidase / 0.684
2jae FADL-amino acid oxidase / 0.684
2yqu FADDihydrolipoyl dehydrogenase / 0.684
4j56 FADThioredoxin reductase 2 1.8.1.9 0.684
2xvf FADPutative flavin-containing monooxygenase / 0.683
2npx FADNADH peroxidase 1.11.1.1 0.682
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
4opi FDAConserved Archaeal protein / 0.682
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.682
1gpe FADGlucose oxidase 1.1.3.4 0.681
3lsi FADPyranose 2-oxidase / 0.681
4rsl FADFructosyl peptide oxidase / 0.681
4ynt FDAGlucose oxidase, putative / 0.681
2dw4 FADLysine-specific histone demethylase 1A 1 0.680
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.679
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.679
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.679
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.679
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.678
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.677
4usr FADMonooxygenase / 0.677
1cbo FADCholesterol oxidase 1.1.3.6 0.676
2gvc FADThiol-specific monooxygenase 1.14.13 0.676
2jb2 FADL-amino acid oxidase / 0.676
3bi5 FADPolyamine oxidase FMS1 / 0.676
4b1b FADThioredoxin reductase 1.8.1.9 0.675
1ges FADGlutathione reductase 1.8.1.7 0.674
1nhr FADNADH peroxidase 1.11.1.1 0.674
2hko FADLysine-specific histone demethylase 1A 1 0.674
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.674
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.673
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.672
4mo2 FADUDP-galactopyranose mutase / 0.672
4u8l FDAUDP-galactopyranose mutase / 0.672
2jb1 FADL-amino acid oxidase / 0.671
2vq7 FADPutative flavin-containing monooxygenase / 0.671
2xyo FADTetX family tetracycline inactivation enzyme / 0.671
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.671
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.670
4em4 FADCoenzyme A disulfide reductase / 0.670
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.670
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.669
4bk3 FADProbable salicylate monooxygenase / 0.669
4wct FADFructosyl amine:oxygen oxidoreductase / 0.669
2bab FADPutative aminooxidase / 0.668
2wow FADTrypanothione reductase / 0.668
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.668
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.668
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.667
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.667
2iw5 FADLysine-specific histone demethylase 1A 1 0.667
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.667
2rgh FADAlpha-Glycerophosphate Oxidase / 0.667
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.667
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.667
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.666
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.665
1reo FADL-amino-acid oxidase 1.4.3.2 0.665
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.665
3ict FADCoenzyme A disulfide reductase / 0.665
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.665
4xcx SAHSmall RNA 2'-O-methyltransferase / 0.665
3t2y FADSulfide-quinone reductase / 0.664
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.663
2wsb NADGalactitol dehydrogenase / 0.663
2yg4 FADPutrescine oxidase / 0.663
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.663
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.663
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.662
3atr FDAConserved Archaeal protein / 0.662
3ish FADThioredoxin reductase 1.8.1.9 0.662
1joa FADNADH peroxidase 1.11.1.1 0.661
1nhq FADNADH peroxidase 1.11.1.1 0.661
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.661
3fbs FADOxidoreductase / 0.661
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.661
3ka7 FADPutative oxidoreductase / 0.661
5dbj FADFADH2-dependent halogenase PltA / 0.661
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.660
2xlp FADPutative flavin-containing monooxygenase / 0.660
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.660
4gus FADLysine-specific histone demethylase 1B 1 0.660
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.660
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.659
1qo8 FADFumarate reductase flavoprotein subunit / 0.659
1xpq FADPolyamine oxidase FMS1 / 0.659
3adp NAILambda-crystallin 1.1.1.45 0.659
3d64 NADAdenosylhomocysteinase / 0.659
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.659
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.659
3wsw NADL-lactate dehydrogenase / 0.658
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.658
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.657
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.656
1z6l FADPolyamine oxidase FMS1 / 0.656
3sx2 NADUncharacterized protein / 0.656
3x2f NAIAdenosylhomocysteinase / 0.656
4la1 FADThioredoxin glutathione reductase / 0.656
3ada NADSubunit alpha of sarocosine oxidase / 0.655
3u81 SAHCatechol O-methyltransferase 2.1.1.6 0.655
4em3 FADCoenzyme A disulfide reductase / 0.655
4pyn SAHCatechol O-methyltransferase 2.1.1.6 0.655
1zk7 FADMercuric reductase 1.16.1.1 0.654
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.654
2tpr FADTrypanothione reductase 1.8.1.12 0.654
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.654
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.654
3urh FADDihydrolipoyl dehydrogenase / 0.654
4xbf FADLysine-specific histone demethylase 1A 1 0.654
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.653
1get FADGlutathione reductase 1.8.1.7 0.653
1trb FADThioredoxin reductase 1.8.1.9 0.653
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.652
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.652
4ymg SAMPutative SAM-dependent O-methyltranferase / 0.652
2xls FADPutative flavin-containing monooxygenase / 0.651
2yg3 FADPutrescine oxidase / 0.651
3s55 NADPutative short-chain dehydrogenase/reductase / 0.651
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.651
1bw9 NADPhenylalanine dehydrogenase / 0.650
1c0k FADD-amino-acid oxidase 1.4.3.3 0.650
1h81 FADPolyamine oxidase 1.5.3.14 0.650
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.650
2jk6 FADTrypanothione reductase / 0.650
3wv7 ADPHmd co-occurring protein HcgE / 0.650
4ntc FADThioredoxin reductase gliT / 0.650
5ccx SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.650