sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4cfk | LY2 | Bromodomain-containing protein 4 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4cfk | LY2 | Bromodomain-containing protein 4 | / | 1.000 | |
| 4gpj | 0Q1 | Bromodomain-containing protein 4 | / | 0.617 | |
| 4nr8 | 2LL | Bromodomain-containing protein 4 | / | 0.617 | |
| 4c67 | L5S | Bromodomain-containing protein 4 | / | 0.601 | |
| 4hxr | 1A4 | Bromodomain-containing protein 4 | / | 0.599 | |
| 4hxm | 1A8 | Bromodomain-containing protein 4 | / | 0.598 | |
| 4hbw | 14Z | Bromodomain-containing protein 4 | / | 0.577 | |
| 5bt5 | 2LO | Bromodomain-containing protein 2 | / | 0.562 | |
| 4akn | S5B | Bromodomain-containing protein 2 | / | 0.534 | |
| 4alg | 1GH | Bromodomain-containing protein 2 | / | 0.526 | |
| 4j1p | 1K0 | Bromodomain-containing protein 2 | / | 0.518 | |
| 4mr4 | 1K0 | Bromodomain-containing protein 4 | / | 0.517 | |
| 4cfl | 8DQ | Bromodomain-containing protein 4 | / | 0.516 | |
| 4hxs | 1A3 | Bromodomain-containing protein 4 | / | 0.515 | |
| 4meo | 25V | Bromodomain-containing protein 4 | / | 0.513 | |
| 4meq | 25O | Bromodomain-containing protein 4 | / | 0.511 | |
| 3svg | ODR | Bromodomain-containing protein 4 | / | 0.510 | |
| 4lyw | 21Q | Bromodomain-containing protein 4 | / | 0.508 | |
| 4nqm | Y1Z | Bromodomain-containing protein 4 | / | 0.508 | |
| 4bjx | 73B | Bromodomain-containing protein 4 | / | 0.505 | |
| 4hby | 13F | Bromodomain-containing protein 4 | / | 0.502 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.501 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.501 | |
| 4a9l | P9L | Bromodomain-containing protein 4 | / | 0.500 | |
| 4bw2 | UTH | Bromodomain-containing protein 4 | / | 0.500 | |
| 4lrg | 1XB | Bromodomain-containing protein 4 | / | 0.500 | |
| 4ogi | R78 | Bromodomain-containing protein 4 | / | 0.500 | |
| 4j0s | 1H3 | Bromodomain-containing protein 4 | / | 0.499 | |
| 4bw3 | 9BM | Bromodomain-containing protein 4 | / | 0.498 | |
| 4j0r | 1H2 | Bromodomain-containing protein 4 | / | 0.498 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.497 | |
| 4lr6 | 1XA | Bromodomain-containing protein 4 | / | 0.497 | |
| 4men | 25K | Bromodomain-containing protein 4 | / | 0.497 | |
| 1gvv | 0GM | Endothiapepsin | 3.4.23.22 | 0.495 | |
| 4nyw | 2O3 | CREB-binding protein | / | 0.493 | |
| 4o78 | SAV | Bromodomain-containing protein 4 | / | 0.490 | |
| 4hxn | 1A7 | Bromodomain-containing protein 4 | / | 0.489 | |
| 4y3z | F41 | Endothiapepsin | 3.4.23.22 | 0.488 | |
| 4bw1 | S5B | Bromodomain-containing protein 4 | / | 0.486 | |
| 4c66 | H4C | Bromodomain-containing protein 4 | / | 0.485 | |
| 4ir5 | IR5 | Bromodomain adjacent to zinc finger domain protein 2B | / | 0.485 | |
| 3zyu | 1GH | Bromodomain-containing protein 4 | / | 0.483 | |
| 4mr6 | 1K0 | Bromodomain-containing protein 2 | / | 0.483 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 4py6 | R78 | Bromodomain protein, putative | / | 0.481 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 4uyg | 73B | Bromodomain-containing protein 2 | / | 0.478 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.477 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.477 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.476 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.475 | |
| 3t7x | 4SH | Endothiapepsin | 3.4.23.22 | 0.475 | |
| 4o74 | R78 | Bromodomain-containing protein 4 | / | 0.475 | |
| 2j5b | TYE | Tyrosine--tRNA ligase | 6.1.1.1 | 0.473 | |
| 2rew | REW | Peroxisome proliferator-activated receptor alpha | / | 0.473 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.473 | |
| 3v1y | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic | 1.2.1.12 | 0.473 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.472 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.471 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.471 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 4hxo | 1A6 | Bromodomain-containing protein 4 | / | 0.470 | |
| 4mep | 24Y | Bromodomain-containing protein 4 | / | 0.470 | |
| 4nr5 | 2LL | CREB-binding protein | / | 0.470 | |
| 4ea3 | 0NN | Nociceptin receptor | / | 0.470 | |
| 2lf1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.469 | |
| 3ffi | 3OB | Gag-Pol polyprotein | 2.7.7.49 | 0.469 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.469 | |
| 4l98 | LRG | Peroxisome proliferator-activated receptor gamma | / | 0.469 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.468 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.468 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.468 | |
| 5it1 | 2OH | Putative cytochrome P450 | / | 0.468 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.467 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.467 | |
| 3sii | A1R | Uncharacterized protein | / | 0.467 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.465 | |
| 3ocg | OCG | Mitogen-activated protein kinase 14 | / | 0.465 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.465 | |
| 1gvh | FAD | Flavohemoprotein | / | 0.464 | |
| 3aqa | BYH | Bromodomain-containing protein 2 | / | 0.464 | |
| 4a9o | A9O | Bromodomain-containing protein 2 | / | 0.464 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.464 | |
| 4qzs | JQ1 | Bromodomain-containing protein 4 | / | 0.464 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.463 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.463 | |
| 2eeq | SAH | Diphthine synthase | / | 0.463 | |
| 2gtn | LIE | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 2yem | WSH | Bromodomain-containing protein 4 | / | 0.463 | |
| 3eej | 53R | Uncharacterized protein | / | 0.463 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.463 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.462 | |
| 4flp | JQ1 | Bromodomain testis-specific protein | / | 0.462 | |
| 1vsv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.461 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.461 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2vhx | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.461 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.460 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.460 | |
| 3t37 | FAD | Pyridoxine 4-oxidase | / | 0.460 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.459 | |
| 1ywg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.459 | |
| 2z6i | FMN | 2-nitropropane dioxygenase | / | 0.459 | |
| 4bw4 | 9B6 | Bromodomain-containing protein 4 | / | 0.459 | |
| 2dsh | SAH | Diphthine synthase | / | 0.458 | |
| 1dc6 | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.457 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.457 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.457 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 4z0h | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic | 1.2.1.12 | 0.457 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1yin | CM3 | Estrogen receptor | / | 0.456 | |
| 2jdv | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.456 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.456 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.456 | |
| 4r8h | SP1 | cAMP-activated global transcriptional regulator CRP | / | 0.456 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.456 | |
| 5fs7 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.456 | |
| 1gvt | 2ZS | Endothiapepsin | 3.4.23.22 | 0.455 | |
| 1hqt | NAP | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.455 | |
| 1hqu | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1qrr | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.455 | |
| 2jlc | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.455 | |
| 2y3s | TIR | TamL | / | 0.455 | |
| 3pgi | F41 | Endothiapepsin | 3.4.23.22 | 0.455 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.455 | |
| 4i0t | 1B6 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.455 | |
| 4mr5 | 1K0 | Bromodomain-containing protein 2 | / | 0.455 | |
| 4nyv | 15E | CREB-binding protein | / | 0.455 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.455 | |
| 2ylr | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.454 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.454 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.454 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.454 | |
| 4e96 | 0NS | Bromodomain-containing protein 4 | / | 0.454 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1ihx | SND | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.453 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.453 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.453 | |
| 4f3i | 0S6 | Bromodomain-containing protein 4 | / | 0.453 | |
| 4h4y | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.453 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 1gad | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.452 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.452 | |
| 2yel | WSH | Bromodomain-containing protein 4 | / | 0.452 | |
| 3mtw | M3R | Xaa-Pro dipeptidase, putative | / | 0.452 | |
| 4ozn | ATP | Ammonium transporter | / | 0.452 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.451 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.451 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.451 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.451 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.451 | |
| 4y0k | NAP | AntE | / | 0.451 | |
| 5cdt | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.451 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.450 | |
| 1i3n | UD1 | UDP-glucose 4-epimerase | / | 0.450 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.450 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.450 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.450 | |
| 3gob | HXX | DdmC | / | 0.450 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.450 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.450 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.450 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.450 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.450 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.449 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.449 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.449 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.449 | |
| 3cly | ACP | Fibroblast growth factor receptor 2 | / | 0.449 | |
| 3ids | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.449 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.449 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.449 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4pd6 | URI | Nucleoside permease | / | 0.449 | |
| 5a3b | APR | SIR2 family protein | / | 0.449 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2b4r | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.448 | |
| 3crz | FAD | Ferredoxin--NADP+ reductase | / | 0.448 | |
| 3dg8 | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3nsz | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.448 | |
| 3t7p | 7SP | Endothiapepsin | 3.4.23.22 | 0.448 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.448 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.448 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.448 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.448 | |
| 5kjc | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 1a5b | IGP | Tryptophan synthase alpha chain | / | 0.447 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1szj | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.447 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.447 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.447 | |
| 2gsd | NAD | Formate dehydrogenase | / | 0.447 | |
| 2v00 | V15 | Endothiapepsin | 3.4.23.22 | 0.447 | |
| 2vrb | NAP | Triphenylmethane reductase | / | 0.447 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 3i59 | N6S | CRP-like cAMP-activated global transcriptional regulator | / | 0.447 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.447 | |
| 3wag | TYD | Glycosyltransferase | / | 0.447 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.447 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.447 | |
| 4o63 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.447 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.447 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.446 | |
| 2e7r | SAH | Diphthine synthase | / | 0.446 | |
| 2owk | SAH | Diphthine synthase | / | 0.446 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3stx | BKA | Methylketone synthase I | / | 0.446 | |
| 3uoy | NAP | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.446 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.446 | |
| 4a9e | 3PF | Bromodomain-containing protein 2 | / | 0.446 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.446 | |
| 4lsm | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.446 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.446 | |
| 4oty | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.446 | |
| 5cdt | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 5dfc | EAM | Bromodomain-containing protein 2 | / | 0.446 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1j0x | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.445 | |
| 1mr9 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.445 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3mzi | FMN | Activator of photopigment and puc expression | / | 0.445 | |
| 3pbz | F02 | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 4a9n | A9N | Bromodomain-containing protein 2 | / | 0.445 | |
| 4b1f | KRH | Glutamate racemase | / | 0.445 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.445 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.445 | |
| 4uxq | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.445 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.445 | |
| 4y35 | F90 | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 4y57 | F63 | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 4zvl | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 6cox | S58 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.445 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.444 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.444 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2r4u | ADP | Glycogen synthase | 2.4.1.21 | 0.444 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.444 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.444 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.444 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.444 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.444 | |
| 5a3c | NAD | SIR2 family protein | / | 0.444 | |
| 5ikr | ID8 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.444 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.443 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.443 | |
| 1u8f | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.443 | |
| 2dbr | NAP | Glyoxylate reductase | 1.1.1.26 | 0.443 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.443 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.443 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.443 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.443 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.443 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.443 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.442 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.442 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.442 | |
| 1llq | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.442 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.442 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.442 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.442 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.442 | |
| 2owg | SAH | Diphthine synthase | / | 0.442 | |
| 3b9l | AZZ | Serum albumin | / | 0.442 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.442 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.442 | |
| 3pi0 | F91 | Endothiapepsin | 3.4.23.22 | 0.442 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4f9m | FCM | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 4hxy | NDP | Plm1 | / | 0.442 | |
| 4jdr | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.442 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 4xbo | SAH | tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ | 2.1.1.200 | 0.442 | |
| 1dbv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.441 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.441 | |
| 3elu | SAM | Methyltransferase | / | 0.441 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.441 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.441 | |
| 3ict | FAD | Coenzyme A disulfide reductase | / | 0.441 | |
| 3of4 | FMN | Nitroreductase | / | 0.441 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.441 | |
| 3ut5 | LOC | Tubulin beta chain | / | 0.441 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.441 | |
| 3w3o | ROE | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.441 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.441 | |
| 4bew | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.441 | |
| 4iv6 | FDA | Isovaleryl-CoA dehydrogenase | / | 0.441 | |
| 4l4x | NDP | AmphI | / | 0.441 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4zea | IMI | Endothiapepsin | 3.4.23.22 | 0.441 | |
| 1owm | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.440 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.440 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.440 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.440 | |
| 3gco | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.440 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.440 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.440 | |
| 3pll | F06 | Endothiapepsin | 3.4.23.22 | 0.440 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.440 | |
| 4irn | FAD | AnaB | / | 0.440 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.440 | |
| 4lb2 | DM5 | Serum albumin | / | 0.440 |