Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3zrl | ZRL | Glycogen synthase kinase-3 beta | 2.7.11.26 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3zrl | ZRL | Glycogen synthase kinase-3 beta | 2.7.11.26 | 1.000 | |
| 3zrm | ZRM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.627 | |
| 3f7z | 34O | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.596 | |
| 3zrk | ZRK | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.595 | |
| 4acd | GR9 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.589 | |
| 4j1r | I5R | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.578 | |
| 4ach | KDI | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.576 | |
| 4afj | SJJ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.572 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.561 | |
| 2ow3 | BIM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.560 | |
| 4j71 | 1JX | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.555 | |
| 4nm0 | ADP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.547 | |
| 1pyx | ANP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.544 | |
| 4b7t | CWT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.544 | |
| 1q3d | STU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.540 | |
| 3q3b | 55E | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.540 | |
| 3sd0 | TSK | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.535 | |
| 1q3w | ATU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.534 | |
| 3gb2 | G3B | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.532 | |
| 1r0e | DFN | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.531 | |
| 3du8 | 553 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.530 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.530 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.525 | |
| 4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.525 | |
| 2vd5 | BI8 | Myotonin-protein kinase | 2.7.11.1 | 0.520 | |
| 3f88 | 3HT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.520 | |
| 4nm7 | ADP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.519 | |
| 1q5k | TMU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.512 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.512 | |
| 1j1c | ADP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.511 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.511 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.505 | |
| 1uv5 | BRW | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.502 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.502 | |
| 2wms | ZYS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.501 | |
| 3zep | 1NX | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.501 | |
| 1q4l | 679 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.500 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.498 | |
| 3i4b | Z48 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.498 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.496 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.495 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.494 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.494 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.494 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.493 | |
| 3l1s | Z92 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.493 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.492 | |
| 2bro | DF2 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.491 | |
| 3eb0 | DRK | Uncharacterized protein | / | 0.491 | |
| 3ckx | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.490 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.489 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.488 | |
| 2ym5 | YM5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.487 | |
| 4fsw | HK6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.487 | |
| 4ftu | 7HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.486 | |
| 2ym4 | 4YM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.485 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.485 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.485 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.484 | |
| 2e9o | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.484 | |
| 3ag9 | A02 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.484 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.484 | |
| 4nm5 | ADP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.484 | |
| 1oi9 | N20 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.483 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.483 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.481 | |
| 3mfs | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.481 | |
| 3vf9 | 477 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.481 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.481 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.480 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.479 | |
| 4qna | X11 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.479 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.478 | |
| 2gcd | STU | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.478 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.478 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.478 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.477 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.477 | |
| 2wmw | ZYW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.477 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.477 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.476 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.476 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 4ft0 | HK9 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.476 | |
| 1nxk | STU | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.475 | |
| 2wmx | ZY6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.475 | |
| 3ddq | RRC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.475 | |
| 3tnw | F18 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.475 | |
| 4wbo | ANW | Rhodopsin kinase | / | 0.475 | |
| 2hxq | 373 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.474 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.474 | |
| 3rm6 | 18Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.474 | |
| 4hvh | 19R | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.474 | |
| 4qmz | B49 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.474 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.473 | |
| 3iw4 | LW4 | Protein kinase C alpha type | 2.7.11.13 | 0.473 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.473 | |
| 4qmu | SKE | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.473 | |
| 1nvr | STU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.472 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.472 | |
| 2wih | P48 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.472 | |
| 4erw | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.472 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.472 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.471 | |
| 3m42 | HGF | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.471 | |
| 2ym3 | YM3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.470 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.470 | |
| 4dca | ADP | Aminoglycoside phosphotransferase | / | 0.470 | |
| 1pkd | UCN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.469 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.469 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.469 | |
| 3r7i | X9I | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.469 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.469 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.469 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.468 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.467 | |
| 2ym7 | YM7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.467 | |
| 4bcn | T9N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 4g17 | 0VN | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.467 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.466 | |
| 2b55 | D31 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.466 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 4dgo | 0JW | Casein kinase II subunit alpha | 2.7.11.1 | 0.466 | |
| 4fsz | HK8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 1h1r | 6CP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 1j1b | ANP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.465 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 2c6t | DT5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.465 | |
| 2r0u | M54 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 2wmu | ZYU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 2x1n | X1N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 3qx4 | X4B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 4eom | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 4oav | ACP | 2-5A-dependent ribonuclease | 3.1.26 | 0.465 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.464 | |
| 4ftc | H6K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.464 | |
| 4j97 | ACP | Fibroblast growth factor receptor 2 | / | 0.464 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.463 | |
| 4bco | T6Q | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.462 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.462 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.462 | |
| 3cjf | SAV | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.462 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
| 4fsm | HK1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.462 | |
| 1vyw | 292 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.461 | |
| 3c50 | ADP | Rhodopsin kinase | / | 0.461 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.461 | |
| 4eok | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 4qmy | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.461 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.460 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 3qc9 | ADP | Rhodopsin kinase | / | 0.460 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.460 | |
| 4oa9 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.460 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.459 | |
| 1yvj | 4ST | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.459 | |
| 2ym6 | YM6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 3blr | CPB | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.459 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.459 | |
| 3qqf | X07 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 3vid | 4TT | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.459 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 4ix6 | ADP | Uncharacterized protein | / | 0.459 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 2y3s | TIR | TamL | / | 0.458 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 3vjo | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.458 | |
| 4hyi | 1AO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.458 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.458 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.457 | |
| 1oiu | N76 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 1ouk | 084 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 2ayp | 43A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 2y4g | TIR | TamL | / | 0.457 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.457 | |
| 3ddp | RC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 3she | I85 | MAP kinase-activated protein kinase 3 | 2.7.11.1 | 0.457 | |
| 3zc6 | VFC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.457 | |
| 4ek6 | 10K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.457 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 2xch | CKG | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 3cyx | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.456 | |
| 3rjc | 06Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 3zdi | UGJ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.456 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 4mvf | STU | Calcium-dependent protein kinase 2 | 2.7.11.1 | 0.456 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.455 | |
| 1gij | 2PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2b52 | D42 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2uzl | C94 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 4qms | 1N1 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.455 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.455 | |
| 1ppj | ANY | Cytochrome b | / | 0.454 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.454 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.454 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.454 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.454 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.454 | |
| 2wmt | ZYT | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 4bcp | T3C | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 4nj3 | 2KD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 4qmt | H1N | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.454 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.454 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1sdu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2bqv | A1A | Protease | / | 0.453 | |
| 2fvd | LIA | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.453 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.453 | |
| 4dx7 | DM2 | Multidrug efflux pump subunit AcrB | / | 0.453 | |
| 4erk | OLO | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.453 | |
| 4f63 | 0S7 | Fibroblast growth factor receptor 1 | / | 0.453 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 5drd | ATP | Aurora kinase A | 2.7.11.1 | 0.453 | |
| 1uu3 | LY4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.452 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.452 | |
| 2gdo | 12C | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 3mfr | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.452 | |
| 4ftm | 1HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.452 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.452 | |
| 1v1k | 3FP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 1ykr | 628 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 2acx | ANP | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.451 | |
| 3r7u | X96 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3roy | 22Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3u8w | 09J | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 1fin | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.450 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 2f2c | AP9 | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.450 | |
| 3bht | MFR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.450 | |
| 4cd0 | AWJ | ALK tyrosine kinase receptor | 2.7.10.1 | 0.450 | |
| 1ung | ALH | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.449 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.449 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 3i60 | E86 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.449 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.449 | |
| 3rk9 | 09Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4fsy | HK7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 2izt | 23D | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.448 | |
| 3l9n | L9N | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 3r8l | Z30 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3rni | 21Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4bch | T7Z | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.448 | |
| 4czt | CPS | CBL-interacting serine/threonine-protein kinase 23 | 2.7.11.1 | 0.448 | |
| 4ftl | H0K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.448 | |
| 1e9h | INR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.447 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.447 | |
| 2aqu | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2cgv | 3B3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 3emg | 685 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.447 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.447 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 4gh2 | HK0 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 4hge | 15V | Tyrosine-protein kinase JAK2 | / | 0.447 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.446 | |
| 1ny3 | ADP | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.446 | |
| 2oh0 | 2PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2xvd | AS6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.446 | |
| 3c4x | ATP | Rhodopsin kinase | / | 0.446 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 3qzi | X72 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3rai | X85 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.446 | |
| 4eut | BX7 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.446 | |
| 4ft5 | H2K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 4i0s | 1B5 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.446 | |
| 4l52 | 1UL | Mitogen-activated protein kinase kinase kinase 7 | 2.7.11.25 | 0.446 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.446 | |
| 4qmn | DB8 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.446 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.446 | |
| 1hk2 | T44 | Serum albumin | / | 0.445 | |
| 1uvr | BI8 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2dwb | ANP | Aurora kinase A | 2.7.11.1 | 0.445 | |
| 2uzd | C85 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 2uze | C95 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 2wmq | ZYQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.445 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.445 | |
| 3fri | SAH | 16S rRNA methylase | / | 0.445 | |
| 3hl7 | I47 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.445 | |
| 3zvv | XAZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4dqh | 017 | Gag-Pol polyprotein | / | 0.445 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.445 | |
| 4p6w | MOF | Glucocorticoid receptor | / | 0.445 | |
| 1d7y | FAD | Ferredoxin reductase | / | 0.444 | |
| 1k2b | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1xjd | STU | Protein kinase C theta type | 2.7.11.13 | 0.444 | |
| 2bhh | RYU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2ijm | ATP | Focal adhesion kinase 1 | 2.7.10.2 | 0.444 | |
| 2pzi | AXX | Serine/threonine-protein kinase PknG | 2.7.11.1 | 0.444 | |
| 2xf0 | 4UB | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.444 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3qwk | X62 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3r7e | X88 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3r9h | Z67 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4ct1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 4jbo | WPH | Aurora kinase A | 2.7.11.1 | 0.444 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 4o0w | ADN | Aurora kinase A | 2.7.11.1 | 0.444 | |
| 4rqv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 5dr2 | ATP | Aurora kinase A | 2.7.11.1 | 0.444 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.443 | |
| 1g5s | I17 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1qvr | ANP | Chaperone protein ClpB | / | 0.443 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2r5t | ANP | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.443 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 2ym8 | YM8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.443 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3uli | 1N3 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4l9i | 8PR | Rhodopsin kinase | / | 0.443 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.443 | |
| 1fvv | 107 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1oky | STU | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 1ouy | 094 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2brh | DFW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 2py3 | ACP | Fibroblast growth factor receptor 2 | / | 0.442 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.442 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3a8w | ATP | Protein kinase C iota type | 2.7.11.13 | 0.442 | |
| 3mj5 | GRM | Replicase polyprotein 1a | 3.4.22 | 0.442 | |
| 3ncg | BK1 | Calmodulin-domain protein kinase 1, putative | / | 0.442 | |
| 3r0t | FU9 | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.442 | |
| 3t11 | 3T1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3tuc | FPW | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.442 | |
| 4ft9 | H4K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4ftq | 4HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4gub | 0Y4 | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.442 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.442 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.441 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 2vx0 | 7X7 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.441 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 2y3r | TRK | TamL | / | 0.441 | |
| 3bqc | EMO | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 3cgc | FAD | Coenzyme A disulfide reductase | / | 0.441 | |
| 3ezr | EZR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.441 | |
| 3my5 | RFZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3nww | 3NW | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3qtq | X35 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3qu0 | X40 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.441 | |
| 4acm | 7YG | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4aw0 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.441 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.441 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.441 | |
| 4fl1 | ANP | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.441 | |
| 4g16 | 0VM | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.441 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.441 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.441 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 1ke9 | LS5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1oec | AA2 | Fibroblast growth factor receptor 2 | / | 0.440 | |
| 1q8w | M77 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.440 | |
| 1uu8 | BI1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.440 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 2ojf | 4PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3at3 | ATK | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.440 | |
| 3h4l | ANP | DNA mismatch repair protein PMS1 | / | 0.440 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.440 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.440 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.440 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3sc1 | 3S1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3wbl | PDY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.440 | |
| 4dfn | 0K1 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.440 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.440 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4fsq | HK3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4gfo | 0X2 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.440 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.440 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 4ix5 | ANP | Uncharacterized protein | / | 0.440 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.440 | |
| 5cvh | ADP | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 |